A new compound, subglain B, was isolated from the stems of Uvaria tonkinensis var. subglabra and its structure was identified as 1S, 2R, 3S, 6R-1-benzoyloxymethylene-1,2- dihydroxy-3-benzoyloxy-6-chlorocyclohex-4-ene ...A new compound, subglain B, was isolated from the stems of Uvaria tonkinensis var. subglabra and its structure was identified as 1S, 2R, 3S, 6R-1-benzoyloxymethylene-1,2- dihydroxy-3-benzoyloxy-6-chlorocyclohex-4-ene (1), by spectral evidences.展开更多
Objective:To investigate the antitumor effect of maesopsin 4-O-β-glucoside(TAT2) isolated from the leaves of Artocarpus tonkinensis(A.tonkinensis) A.Chev.ex Gagnep.Methods:The antitumor activity of TAT2 was evaluated...Objective:To investigate the antitumor effect of maesopsin 4-O-β-glucoside(TAT2) isolated from the leaves of Artocarpus tonkinensis(A.tonkinensis) A.Chev.ex Gagnep.Methods:The antitumor activity of TAT2 was evaluated in Lewis lung carcinoma(LLC) tumor-bearing mice.BALB/c mice had tumors induced by implantation with 2× 10~6 LLC cells into the subcutaneous right posterior Hank.Tumor-bearing mice were treated orally with a range of doses of TAT2 and a standard drug,doxorubicin.Animals were observed for tumor growth and mortality rate.Blood was collected to determine hematological and biochemical parameters.Results TAT2 was isolated from an ethanolic extract of 1.tonkinensis leaves.Its structure was determined by MS and NMR spectroscopy,and identified as TAT2.The compound did not show acute toxicity at the highest dose tested(2 OIK) mg/kg body weight).TAT2 exhibited antitumor activity by decreasing tumor growth,increasing the survival rale,and ameliorating some hematological and biochemical parameters at doses of 100 and 200 mg/kg body weight(P<0.05).Conclusions:These results indicate that TAT2 possesses clear antitumor activity.Due to its bioavailability and low toxicity,and the fact that it could be isolated in a large scale from A.tonkinensis leaves,the compound shows promise as a potential anticancer drug.展开更多
[Objectives]To explore the response characteristics of chlorophyll and photosynthesis in Styrax tonkinensis under different concentrations of copper and cadmium stress and analyze the internal mechanism of the effects...[Objectives]To explore the response characteristics of chlorophyll and photosynthesis in Styrax tonkinensis under different concentrations of copper and cadmium stress and analyze the internal mechanism of the effects of copper and cadmium pollution stress on photosynthesis.[Methods]Taking seedlings of S.tonkinensis as the research object,the response characteristics of chlorophyll and photosynthesis of S.tonkinensis were compared under different concentrations of copper and cadmium.[Results]With the increase of copper and cadmium treatment concentrations,the chlorophyll content first rose and then fell.With the increase of cadmium concentration,the net photosynthetic rate of S.tonkinensis plants increased from decrease to increase,and the stomatal conductance,transpiration rate and intercellular CO_(2) concentration all increased.[Conclusions]Under the stress of different concentrations of cadmium,the photosynthetic characteristics of S.tonkinensis were not obviously inhibited.Copper stress has inhibitory effect on photosynthesis of S.tonkinensis.展开更多
基金the National Natural Science Foundation of China(No.39970084)the Chinese Doctoral Grants of the Ministry of Science and Technology of China(No.96-901-96-54)for financial support
文摘A new compound, subglain B, was isolated from the stems of Uvaria tonkinensis var. subglabra and its structure was identified as 1S, 2R, 3S, 6R-1-benzoyloxymethylene-1,2- dihydroxy-3-benzoyloxy-6-chlorocyclohex-4-ene (1), by spectral evidences.
文摘Objective:To investigate the antitumor effect of maesopsin 4-O-β-glucoside(TAT2) isolated from the leaves of Artocarpus tonkinensis(A.tonkinensis) A.Chev.ex Gagnep.Methods:The antitumor activity of TAT2 was evaluated in Lewis lung carcinoma(LLC) tumor-bearing mice.BALB/c mice had tumors induced by implantation with 2× 10~6 LLC cells into the subcutaneous right posterior Hank.Tumor-bearing mice were treated orally with a range of doses of TAT2 and a standard drug,doxorubicin.Animals were observed for tumor growth and mortality rate.Blood was collected to determine hematological and biochemical parameters.Results TAT2 was isolated from an ethanolic extract of 1.tonkinensis leaves.Its structure was determined by MS and NMR spectroscopy,and identified as TAT2.The compound did not show acute toxicity at the highest dose tested(2 OIK) mg/kg body weight).TAT2 exhibited antitumor activity by decreasing tumor growth,increasing the survival rale,and ameliorating some hematological and biochemical parameters at doses of 100 and 200 mg/kg body weight(P<0.05).Conclusions:These results indicate that TAT2 possesses clear antitumor activity.Due to its bioavailability and low toxicity,and the fact that it could be isolated in a large scale from A.tonkinensis leaves,the compound shows promise as a potential anticancer drug.
基金Young Talents Training Project of Jiangxi Academy of Forestry(2015520801).
文摘[Objectives]To explore the response characteristics of chlorophyll and photosynthesis in Styrax tonkinensis under different concentrations of copper and cadmium stress and analyze the internal mechanism of the effects of copper and cadmium pollution stress on photosynthesis.[Methods]Taking seedlings of S.tonkinensis as the research object,the response characteristics of chlorophyll and photosynthesis of S.tonkinensis were compared under different concentrations of copper and cadmium.[Results]With the increase of copper and cadmium treatment concentrations,the chlorophyll content first rose and then fell.With the increase of cadmium concentration,the net photosynthetic rate of S.tonkinensis plants increased from decrease to increase,and the stomatal conductance,transpiration rate and intercellular CO_(2) concentration all increased.[Conclusions]Under the stress of different concentrations of cadmium,the photosynthetic characteristics of S.tonkinensis were not obviously inhibited.Copper stress has inhibitory effect on photosynthesis of S.tonkinensis.
