BACKGROUND Endoscopic evaluation in diagnosing and managing ulcerative colitis(UC)is becoming increasingly important.Several endoscopic scoring systems have been established,including the Ulcerative Colitis Endoscopic...BACKGROUND Endoscopic evaluation in diagnosing and managing ulcerative colitis(UC)is becoming increasingly important.Several endoscopic scoring systems have been established,including the Ulcerative Colitis Endoscopic Index of Severity(UCEIS)score and Mayo Endoscopic Subscore(MES).Furthermore,the Toronto Inflammatory Bowel Disease Global Endoscopic Reporting(TIGER)score for UC has recently been proposed;however,its clinical value remains unclear.AIM To investigate the clinical value of the TIGER score in UC by comparing it with the UCEIS score and MES.METHODS This retrospective study included 166 patients with UC who underwent total colonoscopy between January 2017 and March 2023 at the Affiliated Hospital of Qingdao University(Qingdao,China).We retrospectively analysed endoscopic scores,laboratory and clinical data,treatment,and readmissions within 1 year.Spearman’s rank correlation coefficient,receiver operating characteristic curve,and univariate and multivariable logistic regression analyses were performed using IBM SPSS Statistics for Windows,version 26.0(IBM Corp.,Armonk,NY,United States)and GraphPad Prism version 9.0.0 for Windows(GraphPad Software,Boston,Massachusetts,United States).RESULTS The TIGER score significantly correlated with the UCEIS score and MES(r=0.721,0.626,both P<0.001),showed good differentiating values for clinical severity among mild,moderate,and severe UC[8(4-112.75)vs 210(109–219)vs 328(219–426),all P<0.001],and exhibited predictive value in diagnosing patients with severe UC[area under the curve(AUC)=0.897,P<0.001].Additionally,the TIGER(r=0.639,0,551,0.488,0.376,all P<0.001)and UCEIS scores(r=0.622,0,540,0.494,and 0.375,all P<0.001)showed stronger correlations with laboratory and clinical parameters,including C-reactive protein,erythrocyte sedimentation rate,length of hospitalisation,and hospitalisation costs,than MES(r=0.509,0,351,0.339,and 0.270,all P<0.001).The TIGER score showed the best predictability for patients'recent advanced treatment,including systemic corticosteroids,biologics,or immunomodulators(AUC=0.848,P<0.001)and 1-year readmission(AUC=0.700,P<0.001)compared with the UCEIS score(AUC=0.762,P<0.001;0.627,P<0.05)and MES(AUC=0.684,P<0.001;0.578,P=0.132).Furthermore,a TIGER score of≥317 was identified as an independent risk factor for advanced UC treatment(P=0.011).CONCLUSION The TIGER score may be superior to the UCIES score and MES in improving the accuracy of clinical disease severity assessment,guiding therapeutic decision-making,and predicting short-term prognosis.展开更多
腹膜透析(简称腹透)已成为治疗慢性肾功能衰竭的主要方法之一,慢性腹透的成功主要取决于腹透管的通畅。在与腹透管有关的机械并发症中,最常见的是导管阻塞和移位,后者随着腹透管及手术方式的不断改进,发生率已明显降低,前者已成为换管...腹膜透析(简称腹透)已成为治疗慢性肾功能衰竭的主要方法之一,慢性腹透的成功主要取决于腹透管的通畅。在与腹透管有关的机械并发症中,最常见的是导管阻塞和移位,后者随着腹透管及手术方式的不断改进,发生率已明显降低,前者已成为换管的最主要原因。倘使换管无需手术而又极其简便,自较理想。双套管即能适应这一要求。1985～1988年我们使用双套管治疗12例,与同期使用的仿 Toronto 管22例进行比较,效果尚满意,报告如下。展开更多
Time-series of weekly total carbon （TC） concentrations of fine aerosol particles （PM2.5） in Beijing and Toronto were compared to investigate their respective levels and temporal patterns over two years from August...Time-series of weekly total carbon （TC） concentrations of fine aerosol particles （PM2.5） in Beijing and Toronto were compared to investigate their respective levels and temporal patterns over two years from August 2001 through July 2003. In addition to this comparison, differences in the factors contributing to the observed concentrations and their temporal variations are discussed. Based upon past knowledge about the two megacities with highly contrasting air pollutant levels, it is not surprising that the average TC concentration in Belling （31.5 μg C m^-3） was greater than that in Toronto by a factor of 8.3. Despite their large concentration differences, in both cities TC comprised a similarly large component of PM2.5. TC concentrations exhibited very different seasonal patterns between the two cities. In Beijing, TC experienced higher levels and greater weekly fluctuations in winter whereas in Toronto this behavior was seen in summer. As a result, the greatest gap in TC concentrations between Beijing and Toronto （by a factor of 12.7） occurred in winter, while the smallest gap （a factor of 4.6） was in summer. In Beijing, seasonal variations in the emissions probably played a greater role than meteorology in influencing the TC seasonality, while in Toronto during the warm months more than 80% of the hourly winds were recorded from the south, along with many potential anthropogenic sources for the days with high TC concentrations. This comparison of the differences provides insight into the major factors affecting carbonaceous aerosol in each city.展开更多
The 37th Language Testing Research Colloquium(LTRC 2015①)was held at Eaton Chelsea Hotel in Toronto Canada during March 16-20,2015.The first two days of March 16-17 were preconference workshop days with March 18-20 a...The 37th Language Testing Research Colloquium(LTRC 2015①)was held at Eaton Chelsea Hotel in Toronto Canada during March 16-20,2015.The first two days of March 16-17 were preconference workshop days with March 18-20 as the three main conference days.More than 300 participants from 27 countries and regions joined the conference.The top numbers of the展开更多
Evidence-based conservation seeks to incorporate sound scientific information into environmental decision making. The application of this concept in urban forest management has tremendous potential, but to date has be...Evidence-based conservation seeks to incorporate sound scientific information into environmental decision making. The application of this concept in urban forest management has tremendous potential, but to date has been little applied, largely because existing scientific studies emphasize the importance of urban forests in large-scale ecological and anthropogenic processes, but in practice, scientific evidence is ostensibly incorporated into North American urban forest management only when deciding the fate of individual trees. Even under these disjunctive conditions, the degree to which evidence influences tree-level decisions remains debatable. In analyzing preliminary data from a case study from Toronto, Canada, we sought to test if and how scientific evidence factored into the decision to remove or preserve 53 trees, located in close proximity to a provincially significant area of natural and scientific interest (ANSI). We found that by far the strongest tree-level correlate of the recommendation to remove or preserve trees was whether or not an individual tree was in conflict with proposed development. In comparison, species identity, tree condition, and suitability for conservation were statistically unrelated to the final recommendation. Our findings provide the basis to expand our analysis to multiple case studies across Canada, and internationally. Furthermore, when interpreted with available research and policy, our preliminary (and future) analysis highlights clear opportunities where scientific evidence can and should be readily incorporated into urban forestry management and policy.展开更多
The application of artificial intelligence algorithms in public services brings with it issues such as algorithmic discrimination and inequality.The discussion of the ethics and regulation of algorithms,from the legal...The application of artificial intelligence algorithms in public services brings with it issues such as algorithmic discrimination and inequality.The discussion of the ethics and regulation of algorithms,from the legal perspective,is actually the relationship between intelligent algorithms and the protection of human rights.In response to the discrimination and prejudice of algorithmic violations of human rights,a coalition of nonprofit organizations released the Toronto Declaration on Machine Learning regulates the development and use of algorithms with the principle of"due process."The Ethics Guidelines for Trustworthy AI issued by the European Union in 2019 focus on the participants in algorithm development.While US courts that the algorithms enjoy the right to"freedom of speech".China should learn from the foreign algorithm regulation experience,and seek to establish an overall framework of government regulation that balances the need for technological innovation and commercial competition with human rights protection.展开更多
加拿大的共享电动滑板还没启动,多伦多市政厅已经开始讨论不允许这些滑板车停在人行道上了。Barring e-scooters from city sidewalks,recom mendedb yacitycom mitteeon M onday, wouldmake it impossib le to introduce the concept t...加拿大的共享电动滑板还没启动,多伦多市政厅已经开始讨论不允许这些滑板车停在人行道上了。Barring e-scooters from city sidewalks,recom mendedb yacitycom mitteeon M onday, wouldmake it impossib le to introduce the concept to Toronto,according to the CEO of Bird Canada, an e-scooter company hoping to launch here in the spring of2 0 2 0.展开更多
Toronto is a big,beautiful and efficient city,one that has emerged from relative obscurity(不引人注目)over the past half century to become the center of culture,com-merce and communications in Canada.
Toronto is the largest city in Canada.People sometimes call it"the world in one city."Why?Because you can hear more than 180 languages onthestreetsthere.
基金Clinical Medicine+X Research Project of the Affiliated Hospital of Qingdao University in 2021,No.QDFY+X202101036Qingdao Medical and Health Research Program in 2021,No.2021-WJZD166and Youth Project of Natural Science Foundation of Shandong Province,No.ZR2020QH031.
文摘BACKGROUND Endoscopic evaluation in diagnosing and managing ulcerative colitis(UC)is becoming increasingly important.Several endoscopic scoring systems have been established,including the Ulcerative Colitis Endoscopic Index of Severity(UCEIS)score and Mayo Endoscopic Subscore(MES).Furthermore,the Toronto Inflammatory Bowel Disease Global Endoscopic Reporting(TIGER)score for UC has recently been proposed;however,its clinical value remains unclear.AIM To investigate the clinical value of the TIGER score in UC by comparing it with the UCEIS score and MES.METHODS This retrospective study included 166 patients with UC who underwent total colonoscopy between January 2017 and March 2023 at the Affiliated Hospital of Qingdao University(Qingdao,China).We retrospectively analysed endoscopic scores,laboratory and clinical data,treatment,and readmissions within 1 year.Spearman’s rank correlation coefficient,receiver operating characteristic curve,and univariate and multivariable logistic regression analyses were performed using IBM SPSS Statistics for Windows,version 26.0(IBM Corp.,Armonk,NY,United States)and GraphPad Prism version 9.0.0 for Windows(GraphPad Software,Boston,Massachusetts,United States).RESULTS The TIGER score significantly correlated with the UCEIS score and MES(r=0.721,0.626,both P<0.001),showed good differentiating values for clinical severity among mild,moderate,and severe UC[8(4-112.75)vs 210(109–219)vs 328(219–426),all P<0.001],and exhibited predictive value in diagnosing patients with severe UC[area under the curve(AUC)=0.897,P<0.001].Additionally,the TIGER(r=0.639,0,551,0.488,0.376,all P<0.001)and UCEIS scores(r=0.622,0,540,0.494,and 0.375,all P<0.001)showed stronger correlations with laboratory and clinical parameters,including C-reactive protein,erythrocyte sedimentation rate,length of hospitalisation,and hospitalisation costs,than MES(r=0.509,0,351,0.339,and 0.270,all P<0.001).The TIGER score showed the best predictability for patients'recent advanced treatment,including systemic corticosteroids,biologics,or immunomodulators(AUC=0.848,P<0.001)and 1-year readmission(AUC=0.700,P<0.001)compared with the UCEIS score(AUC=0.762,P<0.001;0.627,P<0.05)and MES(AUC=0.684,P<0.001;0.578,P=0.132).Furthermore,a TIGER score of≥317 was identified as an independent risk factor for advanced UC treatment(P=0.011).CONCLUSION The TIGER score may be superior to the UCIES score and MES in improving the accuracy of clinical disease severity assessment,guiding therapeutic decision-making,and predicting short-term prognosis.
文摘腹膜透析(简称腹透)已成为治疗慢性肾功能衰竭的主要方法之一,慢性腹透的成功主要取决于腹透管的通畅。在与腹透管有关的机械并发症中,最常见的是导管阻塞和移位,后者随着腹透管及手术方式的不断改进,发生率已明显降低,前者已成为换管的最主要原因。倘使换管无需手术而又极其简便,自较理想。双套管即能适应这一要求。1985～1988年我们使用双套管治疗12例,与同期使用的仿 Toronto 管22例进行比较,效果尚满意,报告如下。
基金funded by National Natural Science Foundation of China(NSFC)projects(Grant Nos.20322203 and 40675079)the National Science Fund for Distinguished Young Scholars of NSFC(Grant No.20625722)
文摘Time-series of weekly total carbon （TC） concentrations of fine aerosol particles （PM2.5） in Beijing and Toronto were compared to investigate their respective levels and temporal patterns over two years from August 2001 through July 2003. In addition to this comparison, differences in the factors contributing to the observed concentrations and their temporal variations are discussed. Based upon past knowledge about the two megacities with highly contrasting air pollutant levels, it is not surprising that the average TC concentration in Belling （31.5 μg C m^-3） was greater than that in Toronto by a factor of 8.3. Despite their large concentration differences, in both cities TC comprised a similarly large component of PM2.5. TC concentrations exhibited very different seasonal patterns between the two cities. In Beijing, TC experienced higher levels and greater weekly fluctuations in winter whereas in Toronto this behavior was seen in summer. As a result, the greatest gap in TC concentrations between Beijing and Toronto （by a factor of 12.7） occurred in winter, while the smallest gap （a factor of 4.6） was in summer. In Beijing, seasonal variations in the emissions probably played a greater role than meteorology in influencing the TC seasonality, while in Toronto during the warm months more than 80% of the hourly winds were recorded from the south, along with many potential anthropogenic sources for the days with high TC concentrations. This comparison of the differences provides insight into the major factors affecting carbonaceous aerosol in each city.
文摘The 37th Language Testing Research Colloquium(LTRC 2015①)was held at Eaton Chelsea Hotel in Toronto Canada during March 16-20,2015.The first two days of March 16-17 were preconference workshop days with March 18-20 as the three main conference days.More than 300 participants from 27 countries and regions joined the conference.The top numbers of the
文摘Evidence-based conservation seeks to incorporate sound scientific information into environmental decision making. The application of this concept in urban forest management has tremendous potential, but to date has been little applied, largely because existing scientific studies emphasize the importance of urban forests in large-scale ecological and anthropogenic processes, but in practice, scientific evidence is ostensibly incorporated into North American urban forest management only when deciding the fate of individual trees. Even under these disjunctive conditions, the degree to which evidence influences tree-level decisions remains debatable. In analyzing preliminary data from a case study from Toronto, Canada, we sought to test if and how scientific evidence factored into the decision to remove or preserve 53 trees, located in close proximity to a provincially significant area of natural and scientific interest (ANSI). We found that by far the strongest tree-level correlate of the recommendation to remove or preserve trees was whether or not an individual tree was in conflict with proposed development. In comparison, species identity, tree condition, and suitability for conservation were statistically unrelated to the final recommendation. Our findings provide the basis to expand our analysis to multiple case studies across Canada, and internationally. Furthermore, when interpreted with available research and policy, our preliminary (and future) analysis highlights clear opportunities where scientific evidence can and should be readily incorporated into urban forestry management and policy.
文摘The China Tourism and Culture Week kicked off in Toronto on June 15 to showcase China's landscapes, culture and food, attracting hundreds of visitors.
文摘The application of artificial intelligence algorithms in public services brings with it issues such as algorithmic discrimination and inequality.The discussion of the ethics and regulation of algorithms,from the legal perspective,is actually the relationship between intelligent algorithms and the protection of human rights.In response to the discrimination and prejudice of algorithmic violations of human rights,a coalition of nonprofit organizations released the Toronto Declaration on Machine Learning regulates the development and use of algorithms with the principle of"due process."The Ethics Guidelines for Trustworthy AI issued by the European Union in 2019 focus on the participants in algorithm development.While US courts that the algorithms enjoy the right to"freedom of speech".China should learn from the foreign algorithm regulation experience,and seek to establish an overall framework of government regulation that balances the need for technological innovation and commercial competition with human rights protection.
文摘加拿大的共享电动滑板还没启动,多伦多市政厅已经开始讨论不允许这些滑板车停在人行道上了。Barring e-scooters from city sidewalks,recom mendedb yacitycom mitteeon M onday, wouldmake it impossib le to introduce the concept to Toronto,according to the CEO of Bird Canada, an e-scooter company hoping to launch here in the spring of2 0 2 0.
文摘Toronto is a big,beautiful and efficient city,one that has emerged from relative obscurity(不引人注目)over the past half century to become the center of culture,com-merce and communications in Canada.
文摘Toronto is the largest city in Canada.People sometimes call it"the world in one city."Why?Because you can hear more than 180 languages onthestreetsthere.
