In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one ...In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one antimalarial (quinine) and two antibiotics (amoxicillin and metronidazole) have been developed and validated according to the total error strategy using the accuracy profiles as a decision tool. The dosing range was 2 - 10 μg/mL (for quinine sulfate in tablet), 4 - 12 μg/mL (for quinine bichlorhydrate in oral drop-metronidazole benzaote in oral suspension) and 15 - 35 μg/mL (for amoxicillin trihydrate in capsule). The validated methods were then applied in determining the content of some analogous medicines sold in the Democratic Republic of Congo. Thus, the proposed UV-Visible spectrophotometric methods are simple and suitable to quantify quinine, amoxicillin and metronidazole in different pharmaceutical forms.展开更多
This study investigates the use of dynamic a priori error information according to atmospheric moistness and the use of quality controls in temperature and water vapor profile retrievals from hyperspectral infrared ...This study investigates the use of dynamic a priori error information according to atmospheric moistness and the use of quality controls in temperature and water vapor profile retrievals from hyperspectral infrared （IR） sounders. Temperature and water vapor profiles are retrieved from Atmospheric InfraRed Sounder （AIRS） radiance measurements by applying a physical iterative method using regression retrieval as the first guess. Based on the dependency of first-guess errors on the degree of atmospheric moistness, the a priori first-guess errors classified by total precipitable water （TPW） are applied in the AIRS physical retrieval procedure. Compared to the retrieval results from a fixed a priori error, boundary layer moisture retrievals appear to be improved via TPW classification of a priori first-guess errors. Six quality control （QC） tests, which check non-converged or bad retrievals, large residuals, high terrain and desert areas, and large temperature and moisture deviations from the first guess regression retrieval, are also applied in the AIRS physical retrievals. Significantly large errors are found for the retrievals rejected by these six QCs, and the retrieval errors are substantially reduced via QC over land, which suggest the usefulness and high impact of the QCs, especially over land. In conclusion, the use of dynamic a priori error information according to atmospheric moistness, and the use of appropriate QCs dealing with the geographical information and the deviation from the first-guess as well as the conventional inverse performance are suggested to improve temperature and moisture retrievals and their applications.展开更多
A new and convenient method is presented to calculate the total sensitivity indices defined by variance-based sensitivity analysis. By decomposing the output variance using error propagation equations, this method can...A new and convenient method is presented to calculate the total sensitivity indices defined by variance-based sensitivity analysis. By decomposing the output variance using error propagation equations, this method can transform the ＂double-loop＂ sampling procedure into ＂single-loop＂ one and obviously reduce the computation cost of analysis. In contrast with Sobors and Fourier amplitude sensitivity test （FAST） method, which is limited in non-correlated variables, the new approach is suitable for correlated input variables. An application in semiconductor assembling and test manufacturing （ATM） factory indicates that this approach has a good performance in additive model and simple non-additive model.展开更多
A stochastic error process of curves is proposed as the error model to describe the errors of curves in GIS. In terms of the stochastic process, four characteristics concerning the local error of curves, namely, mean ...A stochastic error process of curves is proposed as the error model to describe the errors of curves in GIS. In terms of the stochastic process, four characteristics concerning the local error of curves, namely, mean error function, standard error function, absolute error function, and the correlation function of errors , are put forward. The total error of a curve is expressed by a mean square integral of the stochastic error process. The probabilistic meanings and geometric meanings of the characteristics mentioned above are also discussed. A scan digitization experiment is designed to check the efficiency of the model. In the experiment, a piece of contour line is digitized for more than 100 times and lots of sample functions are derived from the experiment. Finally, all the error characteristics are estimated on the basis of sample functions. The experiment results show that the systematic error in digitized map data is not negligible, and the errors of points on curves are chiefly dependent on the curvature and the concavity of the curves.展开更多
Introduction: The Six Sigma methodology is an opportunity for a better understanding of the performance of analytical methods and for a better adaptation of the quality control management policy of the medical biology...Introduction: The Six Sigma methodology is an opportunity for a better understanding of the performance of analytical methods and for a better adaptation of the quality control management policy of the medical biology laboratory. Using the sigma metric, this study assessed the performance of the Biochemistry analytical system of a medical biology laboratory in Côte d'Ivoire. Methods: Six Sigma methodology was applied to 3 analytes (alanine aminotransferase, glucose and creatinine). Performance indicators such as measurement imprecision and bias were determined based on the results of internal and external quality controls. The sigma number was calculated using the total allowable error values proposed by Ricos et al. Results: For both control levels, ALT had a sigma number greater than 6 (7.6 for normal control and 7.9 for pathological control). However, low sigma numbers, less than or equal to 2 for creatinine (1.4 for normal control and 2 for pathological control) and less than 1 for glucose were found. Conclusion: This study revealed good analytical performance of ALT from the point of view of 6 sigma analysis. However, modifications to the overall quality control procedure for glucose and creatinine are needed to improve their analytical performance. The study should be extended to the entire laboratory’s analytes in order to modify the strategies of quality control procedures based on metric analysis for an overall improvement in analytical performance.展开更多
Because the real input acceleration cannot be obtained during the error model identification of inertial navigation platform, both the input and output data contain noises. In this case, the conventional regression mo...Because the real input acceleration cannot be obtained during the error model identification of inertial navigation platform, both the input and output data contain noises. In this case, the conventional regression model and the least squares （LS） method will result in bias. Based on the models of inertial navigation platform error and observation error, the errors-in-variables （EV） model and the total least squares （TLS） method axe proposed to identify the error model of the inertial navigation platform. The estimation precision is improved and the result is better than the conventional regression model based LS method. The simulation results illustrate the effectiveness of the proposed method.展开更多
文摘In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one antimalarial (quinine) and two antibiotics (amoxicillin and metronidazole) have been developed and validated according to the total error strategy using the accuracy profiles as a decision tool. The dosing range was 2 - 10 μg/mL (for quinine sulfate in tablet), 4 - 12 μg/mL (for quinine bichlorhydrate in oral drop-metronidazole benzaote in oral suspension) and 15 - 35 μg/mL (for amoxicillin trihydrate in capsule). The validated methods were then applied in determining the content of some analogous medicines sold in the Democratic Republic of Congo. Thus, the proposed UV-Visible spectrophotometric methods are simple and suitable to quantify quinine, amoxicillin and metronidazole in different pharmaceutical forms.
基金supported by GOES-R Algorithm Working Group Program and GOES-R High Impact Weather Project (Grant No NA10NES4400013)supported by the Korea Meteorological Administration Research and Development Program under Grant CATER 2006-2103the BK21 Project of the Korean Government
文摘This study investigates the use of dynamic a priori error information according to atmospheric moistness and the use of quality controls in temperature and water vapor profile retrievals from hyperspectral infrared （IR） sounders. Temperature and water vapor profiles are retrieved from Atmospheric InfraRed Sounder （AIRS） radiance measurements by applying a physical iterative method using regression retrieval as the first guess. Based on the dependency of first-guess errors on the degree of atmospheric moistness, the a priori first-guess errors classified by total precipitable water （TPW） are applied in the AIRS physical retrieval procedure. Compared to the retrieval results from a fixed a priori error, boundary layer moisture retrievals appear to be improved via TPW classification of a priori first-guess errors. Six quality control （QC） tests, which check non-converged or bad retrievals, large residuals, high terrain and desert areas, and large temperature and moisture deviations from the first guess regression retrieval, are also applied in the AIRS physical retrievals. Significantly large errors are found for the retrievals rejected by these six QCs, and the retrieval errors are substantially reduced via QC over land, which suggest the usefulness and high impact of the QCs, especially over land. In conclusion, the use of dynamic a priori error information according to atmospheric moistness, and the use of appropriate QCs dealing with the geographical information and the deviation from the first-guess as well as the conventional inverse performance are suggested to improve temperature and moisture retrievals and their applications.
文摘A new and convenient method is presented to calculate the total sensitivity indices defined by variance-based sensitivity analysis. By decomposing the output variance using error propagation equations, this method can transform the ＂double-loop＂ sampling procedure into ＂single-loop＂ one and obviously reduce the computation cost of analysis. In contrast with Sobors and Fourier amplitude sensitivity test （FAST） method, which is limited in non-correlated variables, the new approach is suitable for correlated input variables. An application in semiconductor assembling and test manufacturing （ATM） factory indicates that this approach has a good performance in additive model and simple non-additive model.
文摘A stochastic error process of curves is proposed as the error model to describe the errors of curves in GIS. In terms of the stochastic process, four characteristics concerning the local error of curves, namely, mean error function, standard error function, absolute error function, and the correlation function of errors , are put forward. The total error of a curve is expressed by a mean square integral of the stochastic error process. The probabilistic meanings and geometric meanings of the characteristics mentioned above are also discussed. A scan digitization experiment is designed to check the efficiency of the model. In the experiment, a piece of contour line is digitized for more than 100 times and lots of sample functions are derived from the experiment. Finally, all the error characteristics are estimated on the basis of sample functions. The experiment results show that the systematic error in digitized map data is not negligible, and the errors of points on curves are chiefly dependent on the curvature and the concavity of the curves.
文摘Introduction: The Six Sigma methodology is an opportunity for a better understanding of the performance of analytical methods and for a better adaptation of the quality control management policy of the medical biology laboratory. Using the sigma metric, this study assessed the performance of the Biochemistry analytical system of a medical biology laboratory in Côte d'Ivoire. Methods: Six Sigma methodology was applied to 3 analytes (alanine aminotransferase, glucose and creatinine). Performance indicators such as measurement imprecision and bias were determined based on the results of internal and external quality controls. The sigma number was calculated using the total allowable error values proposed by Ricos et al. Results: For both control levels, ALT had a sigma number greater than 6 (7.6 for normal control and 7.9 for pathological control). However, low sigma numbers, less than or equal to 2 for creatinine (1.4 for normal control and 2 for pathological control) and less than 1 for glucose were found. Conclusion: This study revealed good analytical performance of ALT from the point of view of 6 sigma analysis. However, modifications to the overall quality control procedure for glucose and creatinine are needed to improve their analytical performance. The study should be extended to the entire laboratory’s analytes in order to modify the strategies of quality control procedures based on metric analysis for an overall improvement in analytical performance.
基金supported by the National Security Major Basic Research Project of China (973-61334).
文摘Because the real input acceleration cannot be obtained during the error model identification of inertial navigation platform, both the input and output data contain noises. In this case, the conventional regression model and the least squares （LS） method will result in bias. Based on the models of inertial navigation platform error and observation error, the errors-in-variables （EV） model and the total least squares （TLS） method axe proposed to identify the error model of the inertial navigation platform. The estimation precision is improved and the result is better than the conventional regression model based LS method. The simulation results illustrate the effectiveness of the proposed method.
