AIM: To investigate the effect of early surgical intervention on the high surgical risk elderly patients who sustained femoral neck fracture(FNF) and taking concomitant antiplatelet agents. METHODS: Between 2010 and 2...AIM: To investigate the effect of early surgical intervention on the high surgical risk elderly patients who sustained femoral neck fracture(FNF) and taking concomitant antiplatelet agents. METHODS: Between 2010 and 2012, a prospective study was conducted on 49 geriatric patients, who took antiplatelet agents, sustained FNF and underwent surgery within 72 h [early surgery(ES) group], and these were compared with a retrospective consecutive case series of patients with similar characteristics(45 cases) who had delayed surgery(DS group) after 72 h during an earlier 3-year period. Postoperative outcomeswere followed for one year and compared. RESULTS: There were non-significant differences in perioperative blood loss, blood transfusion, intensive care unit requirement and postoperative mortality(P > 0.05 all). There were 2 patients(4%) in the DS group who died after surgery(P = 0.23). However, the ES group showed a significantly better postoperative outcome in terms of postoperative complications, length of hospital stay, and functional outcome(P < 0.05 all).CONCLUSION: Early hip surgery in geriatric hip fracture patients with ongoing antiplatelet treatment was not associated with a significant increase of perioperative blood loss and postoperative mortality. Moreover, ES resulted in a better postoperative surgical outcome. In early hip surgery protocol, the antiplatelet agents are discontinued and the patient is operated on within 72 h after admission, which is safe and effective for the medically fit patients.展开更多
Purpose By comparing the outcomes of total hip arthroplasty with hemiarthroplasty in elderly patients with a femoral neck fracture to investigate the one-year mortality,dislocation,infection,reoperation rate,and throm...Purpose By comparing the outcomes of total hip arthroplasty with hemiarthroplasty in elderly patients with a femoral neck fracture to investigate the one-year mortality,dislocation,infection,reoperation rate,and thromboembolic event.Methods The PubMed,EMBASE databases,and Cochrane library were systematically searched from the inception dates to April 1,2020 for relevant randomized controlled trials in English language using the keywords:“total hip arthroplasty”,“hemiarthroplasty”and“femoral neck fracture”to identify systematic reviews and meta-analyses.Two reviewers independently selected articles,extracted data,assessed the quality evidence and risk bias of included trials using the Cochrane Collaboration’stools,and discussed any disagreements.The third reviewer was consulted for any doubts or uncertainty.We derived risk ratios and 95%confidence intervals.Mortality was defined as the primary outcome.Secondary outcomes were other complications,dislocation,infection,reoperation rate,and thromboembolic event.Results This meta-analysis included 10 studies with 1419 patients,which indicated that there were no significant differences between hemiarthroplasty and total hip arthroplasty in reoperation,infection rate,and thromboembolic event.However,there was a lower mortality and dislocation rate association with total hip arthroplasty at the one-year follow-up.Conclusion Based on our results,we found that total hip arthroplasty was better than hemiarthroplasty for a hip fracture at one-year follow-up.展开更多
背景:关节置换是治疗老年移位性股骨颈骨折的主要手段,全髋关节置换与半髋关节置换的选择是目前具有较大争论的焦点。目的:基于倾向性评分匹配法对比直接前入路下全髋与半髋关节置换治疗老年移位性股骨颈骨折的中远期生存状态。方法:选...背景:关节置换是治疗老年移位性股骨颈骨折的主要手段,全髋关节置换与半髋关节置换的选择是目前具有较大争论的焦点。目的:基于倾向性评分匹配法对比直接前入路下全髋与半髋关节置换治疗老年移位性股骨颈骨折的中远期生存状态。方法:选择2016年1月至2021年1月收治的147例老年移位性股骨颈骨折患者(≥65岁),其中88例行全髋关节置换,59例行人工股骨头置换(半髋关节置换)。对于患者术前合并症采用年龄校正Charlson合并症评分表,计算患者虚弱度,并采用倾向性评分匹配法对两组患者进行1∶1匹配,比较匹配后两组患者的手术时间、出血量、术后住院时间、住院费用、营养指标、术后并发症、死亡率和术后生存时间,其中术后生存时间采用Kaplan-Meier生存分析。结果与结论:①倾向性评分匹配后,两组共有42对匹配成功,匹配后两组患者术前资料均衡可比(P>0.05);②与半髋关节置换组相比,全髋关节置换组手术时间(79.71 min vs.59.07 min,P<0.001)、出血量(839.64 mL vs.597.83 mL,P=0.001)、住院费用(56508.15元vs.41702.85元,P<0.001)明显增加,但全髋关节置换组死亡率低于半髋关节置换组(36%vs.57%,HR=0.44,95%CI:0.23-0.87,P=0.018),平均生存时间长于半髋关节置换组(59.4个月vs.43.7个月,P=0.024);③两组患者在术后住院时间、术前术后营养指标、术后整体并发症发生率上,差异均无显著性意义(P>0.05);但在术后疼痛方面,半髋关节置换组疼痛发生率明显高于全髋关节置换组(24%vs.7%,P=0.035);④整体来看,全髋关节置换具有更好的长期预后生存效果,但对于身体素质差的患者则更适合行半髋关节置换;同时,术后的疼痛可能很大程度上会对患者髋关节置换后的生活质量及存活时间产生影响。展开更多
文摘AIM: To investigate the effect of early surgical intervention on the high surgical risk elderly patients who sustained femoral neck fracture(FNF) and taking concomitant antiplatelet agents. METHODS: Between 2010 and 2012, a prospective study was conducted on 49 geriatric patients, who took antiplatelet agents, sustained FNF and underwent surgery within 72 h [early surgery(ES) group], and these were compared with a retrospective consecutive case series of patients with similar characteristics(45 cases) who had delayed surgery(DS group) after 72 h during an earlier 3-year period. Postoperative outcomeswere followed for one year and compared. RESULTS: There were non-significant differences in perioperative blood loss, blood transfusion, intensive care unit requirement and postoperative mortality(P > 0.05 all). There were 2 patients(4%) in the DS group who died after surgery(P = 0.23). However, the ES group showed a significantly better postoperative outcome in terms of postoperative complications, length of hospital stay, and functional outcome(P < 0.05 all).CONCLUSION: Early hip surgery in geriatric hip fracture patients with ongoing antiplatelet treatment was not associated with a significant increase of perioperative blood loss and postoperative mortality. Moreover, ES resulted in a better postoperative surgical outcome. In early hip surgery protocol, the antiplatelet agents are discontinued and the patient is operated on within 72 h after admission, which is safe and effective for the medically fit patients.
文摘Purpose By comparing the outcomes of total hip arthroplasty with hemiarthroplasty in elderly patients with a femoral neck fracture to investigate the one-year mortality,dislocation,infection,reoperation rate,and thromboembolic event.Methods The PubMed,EMBASE databases,and Cochrane library were systematically searched from the inception dates to April 1,2020 for relevant randomized controlled trials in English language using the keywords:“total hip arthroplasty”,“hemiarthroplasty”and“femoral neck fracture”to identify systematic reviews and meta-analyses.Two reviewers independently selected articles,extracted data,assessed the quality evidence and risk bias of included trials using the Cochrane Collaboration’stools,and discussed any disagreements.The third reviewer was consulted for any doubts or uncertainty.We derived risk ratios and 95%confidence intervals.Mortality was defined as the primary outcome.Secondary outcomes were other complications,dislocation,infection,reoperation rate,and thromboembolic event.Results This meta-analysis included 10 studies with 1419 patients,which indicated that there were no significant differences between hemiarthroplasty and total hip arthroplasty in reoperation,infection rate,and thromboembolic event.However,there was a lower mortality and dislocation rate association with total hip arthroplasty at the one-year follow-up.Conclusion Based on our results,we found that total hip arthroplasty was better than hemiarthroplasty for a hip fracture at one-year follow-up.
文摘背景:关节置换是治疗老年移位性股骨颈骨折的主要手段,全髋关节置换与半髋关节置换的选择是目前具有较大争论的焦点。目的:基于倾向性评分匹配法对比直接前入路下全髋与半髋关节置换治疗老年移位性股骨颈骨折的中远期生存状态。方法:选择2016年1月至2021年1月收治的147例老年移位性股骨颈骨折患者(≥65岁),其中88例行全髋关节置换,59例行人工股骨头置换(半髋关节置换)。对于患者术前合并症采用年龄校正Charlson合并症评分表,计算患者虚弱度,并采用倾向性评分匹配法对两组患者进行1∶1匹配,比较匹配后两组患者的手术时间、出血量、术后住院时间、住院费用、营养指标、术后并发症、死亡率和术后生存时间,其中术后生存时间采用Kaplan-Meier生存分析。结果与结论:①倾向性评分匹配后,两组共有42对匹配成功,匹配后两组患者术前资料均衡可比(P>0.05);②与半髋关节置换组相比,全髋关节置换组手术时间(79.71 min vs.59.07 min,P<0.001)、出血量(839.64 mL vs.597.83 mL,P=0.001)、住院费用(56508.15元vs.41702.85元,P<0.001)明显增加,但全髋关节置换组死亡率低于半髋关节置换组(36%vs.57%,HR=0.44,95%CI:0.23-0.87,P=0.018),平均生存时间长于半髋关节置换组(59.4个月vs.43.7个月,P=0.024);③两组患者在术后住院时间、术前术后营养指标、术后整体并发症发生率上,差异均无显著性意义(P>0.05);但在术后疼痛方面,半髋关节置换组疼痛发生率明显高于全髋关节置换组(24%vs.7%,P=0.035);④整体来看,全髋关节置换具有更好的长期预后生存效果,但对于身体素质差的患者则更适合行半髋关节置换;同时,术后的疼痛可能很大程度上会对患者髋关节置换后的生活质量及存活时间产生影响。
