This study was intended to investigate into the incidence rates of deep vein thrombosis (DVT) in patients who used prophylactic antithrombotic medications after total knee arthroplasty (TKA), and to compare clinical r...This study was intended to investigate into the incidence rates of deep vein thrombosis (DVT) in patients who used prophylactic antithrombotic medications after total knee arthroplasty (TKA), and to compare clinical results in groups treated with Rivaroxaban versus Dalteparin sodium as prophylactic antithrombotic medications. This prospective study was performed in 300 patients who underwent TKA between November 2011 and December 2012. The prophylactic therapy was given to 150 patients in Rivaroxaban group and Dalteparin sodium group, respectively. In addition, intermittent compression pump and stocking were used in all the groups immediately after TKA. In order to determine the incidence of DVT, color Doppler ultrasonography, D-dimer, and clinical symptom examination were conducted. There were 17 cases (11.3%) of DVT in Rivaroxaban group and 18 cases (12.0%) of DVT in Dalteparin sodium group after TKA, and no significant difference was seen between both groups. Between patients with DVT and those without DVT after TKA at 4 days in both groups, there was a significant difference in the swelling indices. Moreover, a significant difference was observed in the evaluation of bruise. The early signs of DVT after TKA are unknown, however, some initial clinical signs such as swelling have been observed. After using the said prophylactic drugs, the lower incidence of DVT was seen, and there was no difference between the types of drugs. Pharmacological therapy (either Rivaroxaban or Dalteparin sodium) after TKA is considered effective for DVT prevention. There is also a need to consider constant monitoring of clinical symptoms.展开更多
This study evaluated the effects of sodium hypochlorite（NaOCl） with different concentrations and exposure time on the structural, compositional and mechanical properties of human dentin in vitro. Sixty dentin slabs ...This study evaluated the effects of sodium hypochlorite（NaOCl） with different concentrations and exposure time on the structural, compositional and mechanical properties of human dentin in vitro. Sixty dentin slabs were obtained from freshly extracted premolars, randomly distributed into four groups（n=15）, and treated with 1%, 5%, 10% NaOCl and distilled water（control group）, respectively, for a total of 60 min. Attenuated total reflection infrared（ATR-IR） spectroscopy, Raman spectroscopy and X-ray diffraction（XRD） were carried out before, 10 min and 60 min after the treatment. Scanning electron microscopy（SEM） and flexural strength test were conducted as well. The results showed that dentins experienced morphological alterations in the NaOCl groups, but not in the control group. Two-way repeated-measures analysis of variance revealed that the carbonate：mineral ratio（C：M）, Raman relative intensity（RRI）, a-axis, c-axis length and full width at half maximum（FWHM） with the increase of time and concentration in the NaOCl groups were not significantly different from those in the control group（P〉0.05）. Nevertheless, the mineral：matrix ratio（M：M） increased and the flexural strength declined with the increase of concentration and the extension of time in the NaOCl groups（P〈0.05）. Additionally, it was found that the M：M and the flexural strength remained unchanged after 1% NaOCl treatment（P〉0.05）, and the morphology changes were unnoticeable within 10 min in 1% NaOCl group. These results indicated that NaOCl has no significant effects on the inorganic mineral of human dentin; but it undermines and eliminates the organic content concentration-and time-dependently, which in turn influences the flexural strength and toughness of dentins. In addition, an irrigation of 1% NaOCl within 10 min can minimize the effects of NaOCl on the structural and mechanical properties of dentin during root canal treatment.展开更多
AIM：To compare the potential protective effects of epigallocatechin gallate（EGCG） and ellagic acid（EA） in an experimental cataract model.●METHODS：Twenty-eight Spraque-Dawley rat pups were assigned into four gro...AIM：To compare the potential protective effects of epigallocatechin gallate（EGCG） and ellagic acid（EA） in an experimental cataract model.●METHODS：Twenty-eight Spraque-Dawley rat pups were assigned into four groups.All the rats,except for those in the control group,were injected subcutaneously sodium selenite to induce experimental cataract on the postpartum ninth day,and between 10 th and 14 th days.Rats in the sham,EGCG,and EA groups were intraperitoneally administered 50 mg/（kg·d） saline solution,50 mg/（kg·d） EGCG and 200 mg/（kg·d） EA,respectively.The reduced glutathione（GSH） and malondialdehyde（MDA） levels,total antioxidant status（TAS） and total oxidant status（TOS） in lens supernatants were measured.RESULTS：The mean cataract gradings in EGCG and EA groups were found to be significantly lower than that in sham group（P〈0.001）.The mean GSH levels and TASs in EGCG and EA groups were significantly higher than that in sham group while mean MDA levels and TOSs in EGCG and EA groups were significantly lower than that in the sham group（P〈0.001）.CONCLUSION：EGCG and EA have protective effects on cataract development via the inhibition of oxidative stress.展开更多
目的系统评价帕瑞昔布钠超前镇痛用于全膝/髋关节置换术后的有效性和安全性。方法计算机检索PubMed、Embase、Cochrane Library、Medline、Web of Science、中国知网、维普、万方数据库从建库至2022年5月的帕瑞昔布钠超前镇痛用于全膝/...目的系统评价帕瑞昔布钠超前镇痛用于全膝/髋关节置换术后的有效性和安全性。方法计算机检索PubMed、Embase、Cochrane Library、Medline、Web of Science、中国知网、维普、万方数据库从建库至2022年5月的帕瑞昔布钠超前镇痛用于全膝/髋关节置换术患者的随机对照试验相关文献。筛选文献、提取资料并使用改良的Jadad量表评价纳入文献的方法学质量,采用Rev Man 5.2软件进行Meta分析。结果共纳入27项随机对照试验,1816例患者。Meta分析结果显示,帕瑞昔布钠超前镇痛可有效降低术后疼痛视觉模拟评分[术后24h:均数差(mean difference,MD)=-0.70,95%置信区间(confidence interval,CI):-0.92~-0.47,P<0.001;术后48h:MD=-0.55,95%CI:-0.84~-0.27,P<0.001]、减少术后PCA药物消耗量(术后24h:MD=-24.30,95%CI:-34.69~-13.92,P<0.001;术后48h:MD=-11.94,95%CI:-17.61~-6.27,P<0.001),降低术后恶心、呕吐不良反应的发生率[相对危险度(relative risk,RR)=0.74,95%CI:0.58~0.94,P=0.020]。结论帕瑞昔布钠超前镇痛用于全膝/髋关节置换术后疼痛具有较好的疗效和较低的不良反应发生率。展开更多
文摘This study was intended to investigate into the incidence rates of deep vein thrombosis (DVT) in patients who used prophylactic antithrombotic medications after total knee arthroplasty (TKA), and to compare clinical results in groups treated with Rivaroxaban versus Dalteparin sodium as prophylactic antithrombotic medications. This prospective study was performed in 300 patients who underwent TKA between November 2011 and December 2012. The prophylactic therapy was given to 150 patients in Rivaroxaban group and Dalteparin sodium group, respectively. In addition, intermittent compression pump and stocking were used in all the groups immediately after TKA. In order to determine the incidence of DVT, color Doppler ultrasonography, D-dimer, and clinical symptom examination were conducted. There were 17 cases (11.3%) of DVT in Rivaroxaban group and 18 cases (12.0%) of DVT in Dalteparin sodium group after TKA, and no significant difference was seen between both groups. Between patients with DVT and those without DVT after TKA at 4 days in both groups, there was a significant difference in the swelling indices. Moreover, a significant difference was observed in the evaluation of bruise. The early signs of DVT after TKA are unknown, however, some initial clinical signs such as swelling have been observed. After using the said prophylactic drugs, the lower incidence of DVT was seen, and there was no difference between the types of drugs. Pharmacological therapy (either Rivaroxaban or Dalteparin sodium) after TKA is considered effective for DVT prevention. There is also a need to consider constant monitoring of clinical symptoms.
基金supported by the National Natural Science Foundation of China(No.81470771,No.81500887)the Natural Science Foundation of Hubei Province(No.2013CFA068)
文摘This study evaluated the effects of sodium hypochlorite（NaOCl） with different concentrations and exposure time on the structural, compositional and mechanical properties of human dentin in vitro. Sixty dentin slabs were obtained from freshly extracted premolars, randomly distributed into four groups（n=15）, and treated with 1%, 5%, 10% NaOCl and distilled water（control group）, respectively, for a total of 60 min. Attenuated total reflection infrared（ATR-IR） spectroscopy, Raman spectroscopy and X-ray diffraction（XRD） were carried out before, 10 min and 60 min after the treatment. Scanning electron microscopy（SEM） and flexural strength test were conducted as well. The results showed that dentins experienced morphological alterations in the NaOCl groups, but not in the control group. Two-way repeated-measures analysis of variance revealed that the carbonate：mineral ratio（C：M）, Raman relative intensity（RRI）, a-axis, c-axis length and full width at half maximum（FWHM） with the increase of time and concentration in the NaOCl groups were not significantly different from those in the control group（P〉0.05）. Nevertheless, the mineral：matrix ratio（M：M） increased and the flexural strength declined with the increase of concentration and the extension of time in the NaOCl groups（P〈0.05）. Additionally, it was found that the M：M and the flexural strength remained unchanged after 1% NaOCl treatment（P〉0.05）, and the morphology changes were unnoticeable within 10 min in 1% NaOCl group. These results indicated that NaOCl has no significant effects on the inorganic mineral of human dentin; but it undermines and eliminates the organic content concentration-and time-dependently, which in turn influences the flexural strength and toughness of dentins. In addition, an irrigation of 1% NaOCl within 10 min can minimize the effects of NaOCl on the structural and mechanical properties of dentin during root canal treatment.
基金Funded by an unrestricted grant from Firat University Scientific Research Unit
文摘AIM：To compare the potential protective effects of epigallocatechin gallate（EGCG） and ellagic acid（EA） in an experimental cataract model.●METHODS：Twenty-eight Spraque-Dawley rat pups were assigned into four groups.All the rats,except for those in the control group,were injected subcutaneously sodium selenite to induce experimental cataract on the postpartum ninth day,and between 10 th and 14 th days.Rats in the sham,EGCG,and EA groups were intraperitoneally administered 50 mg/（kg·d） saline solution,50 mg/（kg·d） EGCG and 200 mg/（kg·d） EA,respectively.The reduced glutathione（GSH） and malondialdehyde（MDA） levels,total antioxidant status（TAS） and total oxidant status（TOS） in lens supernatants were measured.RESULTS：The mean cataract gradings in EGCG and EA groups were found to be significantly lower than that in sham group（P〈0.001）.The mean GSH levels and TASs in EGCG and EA groups were significantly higher than that in sham group while mean MDA levels and TOSs in EGCG and EA groups were significantly lower than that in the sham group（P〈0.001）.CONCLUSION：EGCG and EA have protective effects on cataract development via the inhibition of oxidative stress.
文摘目的系统评价帕瑞昔布钠超前镇痛用于全膝/髋关节置换术后的有效性和安全性。方法计算机检索PubMed、Embase、Cochrane Library、Medline、Web of Science、中国知网、维普、万方数据库从建库至2022年5月的帕瑞昔布钠超前镇痛用于全膝/髋关节置换术患者的随机对照试验相关文献。筛选文献、提取资料并使用改良的Jadad量表评价纳入文献的方法学质量,采用Rev Man 5.2软件进行Meta分析。结果共纳入27项随机对照试验,1816例患者。Meta分析结果显示,帕瑞昔布钠超前镇痛可有效降低术后疼痛视觉模拟评分[术后24h:均数差(mean difference,MD)=-0.70,95%置信区间(confidence interval,CI):-0.92~-0.47,P<0.001;术后48h:MD=-0.55,95%CI:-0.84~-0.27,P<0.001]、减少术后PCA药物消耗量(术后24h:MD=-24.30,95%CI:-34.69~-13.92,P<0.001;术后48h:MD=-11.94,95%CI:-17.61~-6.27,P<0.001),降低术后恶心、呕吐不良反应的发生率[相对危险度(relative risk,RR)=0.74,95%CI:0.58~0.94,P=0.020]。结论帕瑞昔布钠超前镇痛用于全膝/髋关节置换术后疼痛具有较好的疗效和较低的不良反应发生率。
