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Comprehensive effects of traditional Chinese medicine treatment on heart failure and changes in B-type natriuretic peptide levels: A meta-analysis
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作者 Li-Li Xia Shu-Yun Yang +2 位作者 Jun-Yao Xu Han-Qing Chen Zhu-Yuan Fang 《World Journal of Clinical Cases》 SCIE 2024年第4期766-776,共11页
BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and mortality.While traditional Chinese medicine(TCM)is often used as a complementary approach in HF management,... BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and mortality.While traditional Chinese medicine(TCM)is often used as a complementary approach in HF management,systematic evalua-tions of its impact on clinical outcomes,TCM syndrome scores,and B-type natriuretic peptide(BNP)levels are lacking.This study fills this gap through a comprehensive analysis of randomized controlled trials(RCTs)focusing on TCM for HF treatment.It encompasses an assessment of methodological quality,a meta-analysis,and an evaluation of evidence quality based on established standards.The results offer crucial insights into the potential advantages and constraints of TCM in HF management.RCTs on TCM for HF treatment published since the establishment of the database were searched in four Chinese and English databases,including China National Knowledge Infrastructure,Wanfang,VIP Information Chinese Science and Technology Journal,and PubMed.Methodological quality was assessed for the included studies with the Cochrane risk-of-bias assessment tool,and the meta-analysis and publication bias assessment was performed with the RevMan5.3 software.Finally,the quality of evidence was rated according to the GRADE criteria.RESULTS A total of 1098 RCTs were initially retrieved.After screening,16 RCTs were finally included in our study,which were published between 2020 and 2023.These RCTs involved 1660 HF patients,including 832 in the TCM group[TCM combined with conventional Western medicine(CMW)treatment]and 828 in the CWM group(CWM treatment).The course of treatments varied from 1 wk to 3 months.TCM syndrome differentiation was analyzed in 11 of the included RCTs.In all included RCTs,outcome indicators included comprehensive clinical outcomes,TCM syndrome scores,and BNP levels.The meta-analysis results showed significant differences between the TCM and CWM groups in terms of comprehensive clinical outcomes[risk ratio=-0.54;95%confidence interval(CI)=-0.61,-0.47;P<0.00001],TCM syndrome scores[weighted mean difference(WMD)=-142.07;95%CI=-147.56,-136.57;P<0.00001],and BNP levels(WMD=-142.07;95%CI=-147.56,-136.57;P<0.00001).According to the GRADE criteria,RCTs where"TCM improves clinical comprehensive outcomes"were rated as low-quality evidence,and RCTs where"TCM reduces TCM syndrome scores"or"TCM decreases BNP levels"were rated as medium-quality evidence.CONCLUSION TCM combined with CWM treatment effectively improves comprehensive clinical outcomes and diminishes TCM syndrome scores and BNP levels in HF patients.Given the low and medium quality of the included RCTs,the application of these results should be cautious. 展开更多
关键词 traditional chinese medicine Heart failure Comprehensive clinical outcomes traditional chinese medicine syndrome score B-type natriuretic peptide level Meta-analysis©The Author(s)2024.Published by Baishideng Publishing Group Inc.
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Clinical Observation of the Hot and Humid Compress Therapy of Traditional Chinese Medicine in the Treatment of Qi Stagnation and Blood Stasis Type of Lumbar Disc Herniation
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作者 Hailin Song Kui Xu +3 位作者 Hong Zhu Zengwu Xu Peng Li Runkai Wang 《Open Journal of Orthopedics》 2024年第7期312-324,共13页
Background: Although a number of studies have reported that the hot and humid compress from traditional Chinese medicine (TCM) is effective in treating lumbar disc herniation (LDH) with qi stagnation and blood stasis,... Background: Although a number of studies have reported that the hot and humid compress from traditional Chinese medicine (TCM) is effective in treating lumbar disc herniation (LDH) with qi stagnation and blood stasis, clinical evidence is limited. Objective: The purpose of this study is to provide high-quality evidence to support the effectiveness of the traditional Chinese hot and humid compress in the treatment of LDH with qi stagnation and blood stasis. Methods: From October 2021 to November 2023, 86 patients with LDH of qi stagnation and blood stasis type were recruited in our hospital and divided into a control (n = 43) and an observation group (n = 43) according to the random number table method. The control group was given routine clinical treatment, and the observation group was treated with the hot and humid compress therapy for two weeks. The visual analogue scale (VAS) score, Japanese Orthopaedic Association (JOA) score, TCM syndrome score, serum interleukin-6 (IL-6), serum interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were observed and compared between the two groups before and after treatment, and the clinical efficacy of the two groups was evaluated. Results: After treatment, the VAS score, TCM symptom score, and serum IL-6, IL-1β, and TNF-α levels decreased in both groups (P P P P P Conclusions: The hot and humid compress of traditional Chinese medicine can effectively relieve pain, restore lumbar function, improve TCM syndromes, reduce the level of inflammatory factors, and have a curative effect in treating LDH. 展开更多
关键词 chinese medicine Hot and Humid Compress Lumbar Disc Herniation Qi Stagnation and Blood Stasis Type TCM symptom score Clinical Efficacy
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Traditional Chinese medicine ointment combined with tuina therapy in treatment of pain and swelling after total knee arthroplasty 被引量:4
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作者 Liang Xing Hui-Rong Xu +7 位作者 Qing-Lin Wang Hua Kong Hua Zhang Jing Tian Ying Ding Ru-Xin Yang Lei Zhang Bo Jiang 《World Journal of Orthopedics》 2022年第10期932-939,共8页
BACKGROUND The most effective treatment for knee joint pain is total knee arthroplasty(TKA),but the risk of pain and swelling in patients after surgery is high.Ice application,ankle pump exercise and non-steroidal ant... BACKGROUND The most effective treatment for knee joint pain is total knee arthroplasty(TKA),but the risk of pain and swelling in patients after surgery is high.Ice application,ankle pump exercise and non-steroidal anti-inflammatory painkillers are the primary clinical treatments after surgery.However,long-term use of nonsteroidal anti-inflammatory pain relievers can easily cause gastrointestinal damage.Traditional Chinese medicine(TCM)ointments and tuina therapy integrate TCM and manipulation,which effectively promotes the penetration of TCM into the skin lesions,improves local blood circulation and inflammatory reaction and has good long-term effects on patients.AIM To evaluate the efficacy of TCM ointment combined with tuina therapy in the treatment of pain and swelling after TKA.METHODS The randomized controlled clinical trial enrolled 80 patients who underwent TKA via the same procedure.The patients were randomly divided among the treatment group(n=40)and the control group(n=40).The control group was given an analgesia pump in addition to oral painkillers as the postoperative intervention.The treatment group received TCM ointment with tuina therapy in addition to the analgesia pump and oral painkillers in the postoperative period.The following variables were recorded 3 d before surgery and 3 d,7 d and 14 d after surgery:Visual analogue scale(VAS)score;skin temperature;circumferences at 15 cm above and below the patella;maximum active knee flexion angle;and the knee injury and Osteoarthritis Outcome score(KOOS).RESULTS After treatment,VAS was significantly lower in the treatment group than the control group at 7 d(t=7.536,P<0.001)and 14 d(t=8.563,P<0.001).The skin temperature of participants in the treatment group was significantly lower than that in the control group at 7 d(t=2.968,P=0.004)and 14 d(t=4.423,P<0.001).The circumference values of the two positions in the treatment group were lower than those in the control group at 7 d[t=2.315,P=0.023(above);t=2.121,P=0.037(below)]and 14 d[t=2.374,P=0.020(above);t=2.095,P=0.039(below)].After 14 d of treatment,the maximum active knee flexion angle and KOOS of the two groups were significantly improved but were significantly higher in the treatment group(P<0.05 for both).CONCLUSION TCM ointment and tuina therapy have significant advantages over standard care in the treatment of pain and swelling after TKA.This additional treatment may improve knee function but additional studies are needed to confirm our observations. 展开更多
关键词 traditional chinese medicine ointment Tuina therapy total knee arthroplasty PAIN SWELLING
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Effect of Traditional Chinese Medicine inImproving Hot Flashes Symptom ofBreast Cancer 被引量:1
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作者 李萍萍 《Chinese Journal of Integrated Traditional and Western Medicine》 2004年第3期166-167,共2页
Breast cancer (BC) is the most common malignant tumor in women. Around 50% of BC receptor-positive patients are hormone-dependent cases, and it is necessary for them to use endocrine after operation. Through inhibitio... Breast cancer (BC) is the most common malignant tumor in women. Around 50% of BC receptor-positive patients are hormone-dependent cases, and it is necessary for them to use endocrine after operation. Through inhibition of estrogen level 展开更多
关键词 BC Effect of traditional chinese medicine inImproving Hot Flashes symptom ofBreast Cancer TAM QOL
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Antioxidant Activity of 50 Traditional Chinese Medicinal Materials Varies with Total Phenolics 被引量:1
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作者 Zhengyou He Minbo Lan +2 位作者 Dongying Lu Hongli Zhao Huihui Yuan 《Chinese Medicine》 2013年第4期148-156,共9页
This study was designed to determine the total phenolic content of 50 herbs and to examine their antioxidant potential. In the sample preparation, 60% ethanol was chosen as the extraction solvent for the subsequent ex... This study was designed to determine the total phenolic content of 50 herbs and to examine their antioxidant potential. In the sample preparation, 60% ethanol was chosen as the extraction solvent for the subsequent experiments. Folin-Cicolteau phenol reagent and a colorimetric method were used to determine the total phenolic content of the selected herbs. The result showed that total phenolic content of those herbs ranged from 2 to 185 mg/g. In antioxidant assay, the ferric reducing/antioxidant power (FRAP) values ranged from 2 to 134 mg GAE/g;the IC50 values of DPPH?·, ·OH and ?scavenging were in the range of 0.06 - 5.50 mg/mL, 0.017 - 0.636 mg/mL and 0.050 - 0.681 mg/mL respectively. Flos caryophylli was the exceptant in the ?scavenging assay because there was no linear relation between the concentration and the scavenging percentage. Compared to gallic acid, ascorbic acid and butylated hydroxytoluene (BHT) in antioxidant assay as positive control, the most potential antioxidant herbs were Cacumen platycladi, Radix et Rhizoma rhei, Rhizoma rhodiolae crenulatae, and Rhizoma sanguisorbae with considerable content of phenolics. Especially, a positive and significant correlation was found between the total phenolic content and FRAP value or DPPH· scavenging percentage. 展开更多
关键词 traditional chinese MEDICINAL Material total Phenolics ANTIOXIDANT ACTIVITY Ferric Reducing/Antioxidant Power Free Radical SCAVENGING ACTIVITY
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Systematic evaluation on curative effects of traditional Chinese medicine retention enemas for patients with radiation proctitis 被引量:1
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作者 Xin-Man Wang Song-Ge An +1 位作者 Lin Yang Fan-Jie Meng 《Chinese Nursing Research》 CAS 2016年第4期176-180,共5页
Objectives: To systematically evaluate the curative effects of traditional Chinese medicine retention enemas for patients with radiation proctitis. Methods: Reports on randomized controlled trials (RCTs) on tradit... Objectives: To systematically evaluate the curative effects of traditional Chinese medicine retention enemas for patients with radiation proctitis. Methods: Reports on randomized controlled trials (RCTs) on traditional Chinese medicine retention enemas in the treatment of radiation proctitis were searched in the Cochrane Library, PubMed, EMBASE, EBSCO, ISI, CNKI, V1P, WanFang Data and CBM databases. The publication dates were from inception to May 2014, and a literature screening, data extraction, quality evaluation and cross checks were inde- pendently conducted by two reviewers in accordance with the inclusion and exclusion criteria. A meta- analysis was then carried out using RevMan 5.3 software. Remits: In total, 14 RCTs were included, and of these, only 10 RCTs involving 702 patients were included in the meta-analysis. The meta-analysis showed that the total efficacy of traditional Chinese medicine retention enemas was higher for patients with radiation proctitis compared with that in control group, RR - 4.83, 95% C1 (2.98, 7.84), P 〈 0.000 01 ; the results from four studies indicated that the improvement of clinical symptoms due to traditional Chinese medicine retention enemas was higher than that of the control group. Conclusions: The implementation of traditional Chinese medicine retention enemas could improve the total efficacy of treatment and provide relief in patients with radiation proctitis. 展开更多
关键词 traditional chinese medicine retentionenemaRadiation proctitisSystematic evaluationMeta-analysisClinical efficiencyClinical symptoms
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基于SCORE-TCM的中医药团体标准抽样评价方案设计
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作者 宗星煜 李慧珍 +13 位作者 赵学尧 程瑾瑞 李军 王丁熠 林甲昊 陈琳 王晶亚 梁宁 张海力 王梦琪 车前子 王丽颖 王燕平 史楠楠 《中国中医基础医学杂志》 CAS CSCD 2024年第1期66-70,共5页
目前,各社会团体积极参与中医药标准的制定和发布,特别是“十四五”以来,中医药团体标准化工作更是迎来了提质增效的关键阶段。深入评估社会团体发布的中医药标准质量,是推进中医药团体标准工作的关键环节和重点任务。前期已研制并形成... 目前,各社会团体积极参与中医药标准的制定和发布,特别是“十四五”以来,中医药团体标准化工作更是迎来了提质增效的关键阶段。深入评估社会团体发布的中医药标准质量,是推进中医药团体标准工作的关键环节和重点任务。前期已研制并形成了中医药团体标准评价体系(System of Consortium Standards Rating and Evaluation of Traditional Chinese Medicine, SCORETCM)。在上述背景下,本研究通过专家共识法,设计了一套基于SCORE-TCM的中医药团体标准抽样评价方案,应用场景为对于特定社会团体发布的标准,或各团体发布的特定技术类别的标准进行快速评估。该方案涵盖了标准抽样、材料收集、标准评价、结果解读的完整流程,为中医药团体标准的抽样评价工作提供了参考方案。 展开更多
关键词 中医药 团体标准 抽样 中医药团体标准评价体系 评价方案
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中医药团体标准评价体系(SCORE-TCM)解读
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作者 宗星煜 王丁熠 +15 位作者 王丽颖 赵学尧 林甲昊 刘斌 虞雪云 郭旸 梁宁 车前子 蒋寅 张海力 龚照元 李安 王巍力 李慧珍 史楠楠 王燕平 《中国中医基础医学杂志》 CAS CSCD 2024年第4期622-626,共5页
本文全面解读了中医药团体标准评价体系(System of Consortium Standards Rating and Evaluation of Traditional Chinese Medicine,SCORE-TCM)。SCORE-TCM是结合定性与定量评价,全面评估中医药团体标准在制定主体、文本编写、技术内容... 本文全面解读了中医药团体标准评价体系(System of Consortium Standards Rating and Evaluation of Traditional Chinese Medicine,SCORE-TCM)。SCORE-TCM是结合定性与定量评价,全面评估中医药团体标准在制定主体、文本编写、技术内容、推广应用和实施效益等几方面特征的综合评价工具。文中详述了SCORE-TCM的构建目的、定义和构建过程,解释了评价指标体系中的各项指标,并对每项指标的评价材料进行介绍。本文旨在帮助中医药团体标准的制定者、第三方评价机构和其他相关方更好地理解SCORE-TCM各评价条目的含义,更有效地运用于中医药团体标准的自评价或第三方评价,SCORE-TCM将为《中医药团体标准管理办法》的贯彻实施,以及中医药团体标准的高质量发展提供技术支持。 展开更多
关键词 中医药 团体标准 score-TCM 评价工具 解读
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脓毒症中医证型分布、死亡因素分析及AT-Ⅲ联合NT-proBNP、SOFA评分对预后的评估价值
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作者 叶森青 苏懿 +2 位作者 张云海 马明远 张斌 《新中医》 CAS 2024年第7期86-91,共6页
目的:探讨脓毒症中医证型分布规律及影响脓毒症患者预后的因素,并分析抗凝血酶原-Ⅲ(AT-Ⅲ)、N-末端脑钠肽前体(NT-proBNP)及序贯性器官衰竭(SOFA)评分对脓毒症患者预后的评估价值。方法:选取148例脓毒症患者作为研究对象,总结中医证型... 目的:探讨脓毒症中医证型分布规律及影响脓毒症患者预后的因素,并分析抗凝血酶原-Ⅲ(AT-Ⅲ)、N-末端脑钠肽前体(NT-proBNP)及序贯性器官衰竭(SOFA)评分对脓毒症患者预后的评估价值。方法:选取148例脓毒症患者作为研究对象,总结中医证型分布规律。根据预后情况分为存活组115例及死亡组33例。通过单因素及多因素逻辑(logistic)回归分析影响脓毒症患者预后的相关因素。绘制受试者工作特征(ROC)曲线评价AT-Ⅲ、NT-proBNP及SOFA评分对其预后的评估价值。结果:148例脓毒症患者的中医证型分布按频次从高到低排序依次为急性虚证64例(43.24%)、毒热证35例(23.65%)、血瘀证31例(20.95%)、腑气不通证18例(12.16%)。死亡组患者中急性虚证比例高于存活组(P<0.05)。急性虚证、AT-Ⅲ降低、NT-proBNP升高、SOFA评分、男性均为脓毒症患者死亡的危险因素(P<0.05)。AT-Ⅲ、NTproBNP、SOFA评分预测脓毒症患者死亡的ROC曲线下面积分别为0.676、0.715、0.724。当三者联合诊断时,ROC曲线下面积提高到0.8,敏感度高达90.9%。结论:脓毒症中医证型分布依次是急性虚证、毒热证、血瘀证和腑气不通证,急性虚证、AT-Ⅲ降低、NT-proBNP升高、SOFA评分、男性均为脓毒症患者死亡的危险因素。AT-Ⅲ联合NT-proBNP及SOFA评分可有效提升脓毒症患者死亡的早期预测准确性。 展开更多
关键词 脓毒症 中医证型 抗凝血酶原-Ⅲ N-末端脑钠肽前体 序贯性器官衰竭评分 预后
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Effects of ginger moxibustion combined with Chinese medicine iontophoresis on patients with primary dysmenorrhea
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作者 Jie-Li Guo Tian Yu +3 位作者 Feng-Chao Dao Mei-Rong Du Xiu-Min Liu Xiu-Ling Xing 《Journal of Hainan Medical University》 2019年第22期49-54,共6页
Objective:To observe the effects of Ginger moxibustion combined with iontophoresis with traditional Chinese medicine on the improvement of symptoms, serum platelet activating factor (PAF) level and uterine artery puls... Objective:To observe the effects of Ginger moxibustion combined with iontophoresis with traditional Chinese medicine on the improvement of symptoms, serum platelet activating factor (PAF) level and uterine artery pulsation index in patients with primary dysmenorrhea.Methods 114 patients with primary dysmenorrhea who were treated in our hospital from August 2017 to February 2019 were divided into two groups according to the different treatment schemes. 57 patients in the control group were treated with ibuprofen capsules, and 57 patients in the study group were treated with Ginger moxibustion combined with iontophoresis with traditional Chinese medicine. After three menstrual cycles of treatment, the curative effect was evaluated and the improvement of symptoms was counted. PAF, PAF-AH and platelet adhesion rate were compared, uterine artery hemodynamics was measured, and levels of serum hs-CRP and IL-6 were measured.Results The overall response rate of the study group was significantly higher than that of the control group (P < 0.05). After treatment, the scores of different symptoms in the two groups were significantly lower than those before treatment (P < 0.05), and the scores of different symptoms in the study group were significantly lower than those in the control group (P < 0.05). After treatment, PAF and platelet adhesion rate in the two groups were significantly lower than those before treatment (P < 0.05), PAF-AH was significantly higher than that before treatment (P < 0.05), and PAF and platelet adhesion rate in the study group were significantly lower than those in the control group (P < 0.05), PAF-AH was significantly higher than that in the control group (P < 0.05). After treatment, the pulsation index, resistance index and peak systolic-diastolic ratio in the study group were significantly lower than those before treatment (P < 0.05), and the pulsation index, resistance index and peak systolic-diastolic ratio in the study group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of serum hs-CRP and IL-6 in the two groups were significantly lower than those before treatment (P < 0.05), and the levels of serum hs-CRP and IL-6 in the study group were significantly lower than those in the control group (P < 0.05).Conclusions Ginger moxibustion combined with iontophoresis with traditional Chinese medicine is helpful to improve the overall response rate of primary dysmenorrhea treatment, reduce the score levels of different symptoms, rationally improve PAF, PAF-AH, platelet adhesion rate, and the pulse index, resistance index, peak systolic-diastolic ratio are decreased significantly, and serum hs-CRP and IL-6 levels tend to be normal. 展开更多
关键词 GINGER moxibustion IONTOPHORESIS with traditional chinese medicine primary DYSMENORRHEA improvement of symptoms serum PLATELET activating factor level UTERINE artery PULSATION index
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Analysis of the application of Chinese medicine nursing technology in obstetrics
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作者 Hua-Ping Han 《TMR Integrative Nursing》 2018年第4期165-168,共4页
Objective:To analyze the application value of traditional Chinese medicine(TCM)nursing technology in obstetrics.Methods:204 patients with obstetrics were enrolled in the study and entered into the Chinese medicine gro... Objective:To analyze the application value of traditional Chinese medicine(TCM)nursing technology in obstetrics.Methods:204 patients with obstetrics were enrolled in the study and entered into the Chinese medicine group and thereference group according to the random number(n=102).The reference group received routine care,and the Chinesemedicine group received Chinese medicine nursing.The anxiety and depression scores of the two groups of patientsand the patient's nursing satisfaction status were compared.Results:There was no difference in the scores betweenthe pre-treatment groups.The value of the reduction in anxiety and depression scores in the TCM group wassignificantly higher than that in the reference group.The numerical comparison was statistically significant(P<0.05).The comprehensive nursing satisfaction rate of patients in the Chinese medicine group was 99.02%,and the comprehensivenursing satisfaction rate of the reference group was 80.39%.The numerical comparison was statistically significant(P<0.05).Conclusion:The application of TCM nursing technology in obstetrics helps to improve the negativeemotions of patients and improve the overall satisfaction rate of patients.The value of nursing intervention is higher 展开更多
关键词 traditional chinese medicine nursing technology OBSTETRICS Anxiety and depression score Nursing satisfactionrate
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Combination of symptoms, syndrome and disease: Treatment of refractory diabetic gastroparesis 被引量:13
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作者 Jun-Ling Li Min Li +5 位作者 Bing Pang Qiang Zhou Jia-Xing Tian Hong-Xing Liu Xi-Yan Zhao Xiao-Lin Tong 《World Journal of Gastroenterology》 SCIE CAS 2014年第26期8674-8680,共7页
AIM: To assess effect of combination of symptoms, syndrome and disease on treatment of diabetic gastroparesis with severe nausea and vomiting.
关键词 Diabetic gastroparesis Refractory nausea and vomiting traditional chinese medicine TREATMENT Gastroparesis Cardinal symptom Index
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Symptom Assessment and Management in Patients with Lung Cancer Undergoing Conventional or Traditional Chinese Medicine Care
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作者 Bao-Jin Han Ya-Jie Liu +5 位作者 Jia-Yue Jin Hong-Kun Xu Wen-Zheng Zhang Si-Meng Ren Xin Shelley Wang Jie Liu 《World Journal of Traditional Chinese Medicine》 CAS CSCD 2023年第3期235-242,共8页
Patients with lung cancer may experience various symptoms as the disease progresses,which may reduce the benefits of cancer treatment,reduce treatment compliance,delay cancer treatment,reduce the quality of life(QoL),... Patients with lung cancer may experience various symptoms as the disease progresses,which may reduce the benefits of cancer treatment,reduce treatment compliance,delay cancer treatment,reduce the quality of life(QoL),and impact survival.This review discusses comprehensive symptom assessment and management,which are crucial for high-quality lung cancer treatment.Traditional Chinese medicine(TCM)is important in relieving cancer-related symptoms in patients with lung cancer.Including patient-reported outcomes(PROs)in clinical trials and practice can provide a better assessment of symptom burden and the effectiveness of symptom management.Patient-centered care with TCM in lung cancer patients may include six steps:Symptom screening,etiology investigation,comprehensive assessment,integrative management,reassessment,and regular symptom follow-up monitoring.PRO measures can be used to evaluate symptom intensity,the degree to which symptoms interfere with activities of daily living,and the QoL.Clearly defined and reliable PRO measures can enhance patient satisfaction and improve symptom control.Quantitative PRO measures developed from the TCM perspective should be considered one of the important outcome measurements in TCM care.A multidisciplinary collaborative symptom management model,including TCM and conventional therapy,will be the future goal for treating patients with lung cancer. 展开更多
关键词 Lung cancer symptom assessment symptom burden symptom management traditional chinese medicine
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畅尔舒方联合针刺治疗脾肾阳虚型便秘临床研究 被引量:1
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作者 陈立平 侯静玥 +2 位作者 周艳阳 李阳 张东岳 《新中医》 CAS 2024年第1期72-77,共6页
目的:观察畅尔舒方联合针刺治疗脾肾阳虚型便秘的疗效。方法:选取70例脾肾阳虚型便秘患者,按随机数字表法分为治疗组及对照组各35例。治疗组给予畅尔舒方联合针刺治疗,对照组给予乳果糖口服溶液治疗。比较2组临床疗效,比较2组治疗前后... 目的:观察畅尔舒方联合针刺治疗脾肾阳虚型便秘的疗效。方法:选取70例脾肾阳虚型便秘患者,按随机数字表法分为治疗组及对照组各35例。治疗组给予畅尔舒方联合针刺治疗,对照组给予乳果糖口服溶液治疗。比较2组临床疗效,比较2组治疗前后便秘症状积分、中医证候积分、生活质量评分标准(PAC-QOL)、血清胃泌素(GAS)、胃动素(MTL)、P物质(SP)、血管活性肽(VIP)、一氧化氮(NO)水平的变化。结果:治疗后,2组便秘状积分及中医证候积分均较治疗前下降(P<0.05),治疗组上述2项积分均低于对照组(P<0.05)。治疗后,2组血清SP、GAS、MTL水平均较治疗前升高(P<0.05),NO、VIP水平均较治疗前下降(P<0.05);治疗组血清SP、GAS、MTL水平均高于对照组(P<0.05),NO、VIP水平均低于对照组(P<0.05)。治疗后,2组PAC-QOL评分均较治疗前下降,治疗组PAC-QOL评分低于对照组(P<0.05)。治疗组临床疗效总有效率为91.43%,对照组为68.57%,2组比较,差异有统计学意义(P<0.05)。结论:畅尔舒方联合针刺治疗脾肾阳虚型便秘能较好地改善患者临床症状,提高生活质量。 展开更多
关键词 便秘 脾肾阳虚证 畅尔舒方 针灸 中医证候积分
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个体化中医证候积分与传统中医证候积分在中医临床疗效评价中的应用对比研究
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作者 肖蕾 欧洋 +4 位作者 陈智慧 王建华 李京 姜钧文 闵冬雨 《中华中医药学刊》 CAS 北大核心 2024年第8期68-72,共5页
目的评价个体化中医证候积分在中医临床疗效评价中的优势。方法在中药干预双心疾病的临床试验中,分别使用个体化中医证候积分和传统中医证候积分,对患者主观症状进行疗效评价。结果在评价准确性上,两种评价方法整体疗效相似,但分别计算... 目的评价个体化中医证候积分在中医临床疗效评价中的优势。方法在中药干预双心疾病的临床试验中,分别使用个体化中医证候积分和传统中医证候积分,对患者主观症状进行疗效评价。结果在评价准确性上,两种评价方法整体疗效相似,但分别计算两种评价方法与实际主观感受的符合率,则个体化中医证候积分明显高于传统中医证候积分,差异有统计学意义(P<0.05);在评价全面性上,传统中医证候积分中仅包含7个固定症状,而个体化中医证候积分中出现了74个症状,几乎没有症状群完全相同的患者,两组出现频率均>30次的症状有10个,均与肝郁气滞证及其变证相关,且单个症状疗效试验组优于对照组,差异有统计学意义(P<0.05)。结论与传统中医证候积分相比,个体化中医证候积分能够更加准确、全面地反映中医药干预前后患者主观感受的变化。 展开更多
关键词 临床疗效评价 中医 个体化 证候积分
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内异方联合米非司酮片治疗子宫内膜异位症临床研究 被引量:1
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作者 董亚娜 李燕红 +3 位作者 唐亚辉 丁玉 李高申 周艳艳 《新中医》 CAS 2024年第3期93-98,共6页
目的:观察内异方联合米非司酮片治疗子宫内膜异位症(EMT)的临床疗效。方法:选取108例EMT患者作为研究对象,按随机数字表法分为对照组和观察组各54例。对照组给予米非司酮片治疗,观察组在对照组基础上联合内异方治疗,治疗3个月经周期。比... 目的:观察内异方联合米非司酮片治疗子宫内膜异位症(EMT)的临床疗效。方法:选取108例EMT患者作为研究对象,按随机数字表法分为对照组和观察组各54例。对照组给予米非司酮片治疗,观察组在对照组基础上联合内异方治疗,治疗3个月经周期。比较2组治疗前后中医证候评分、疼痛介质、血液黏度、血清相关因子水平。结果:治疗后,2组小腹胀痛、经血量少、经血夹血块评分均较治疗前降低(P<0.05),且观察组小腹胀痛、经血量少、经血夹血块评分均低于对照组(P<0.05)。治疗后,2组神经生长因子(NGF)、前列腺素F_(2α)(PGF_(2α))、前列腺素E2 (PGE2)水平均较治疗前降低(P<0.05),且观察组NGF、PGF_(2α)、PGE2水平均低于对照组(P<0.05)。治疗后,2组血浆黏度、高切全血黏度、低切全血黏度均较治疗前降低(P<0.05),且观察组血浆黏度、高切全血黏度、低切全血黏度均低于对照组(P<0.05)。治疗后,2组血清视黄醇结合蛋白4 (RBP4)、单核细胞趋化蛋白1 (MCP-1)、细胞间黏附相关因子(ICAM-1)水平均较治疗前降低(P<0.05),且观察组血清RBP4、MCP-1、ICAM-1水平均低于对照组(P<0.05)。结论:内异方可改善EMT患者临床症状,调节疼痛介质及血液黏度,调控血清相关因子水平。 展开更多
关键词 子宫内膜异位症 内异方 疼痛介质 血液黏度 中医证候评分 视黄醇结合蛋白4 单核细胞趋化蛋白1 细胞间黏附相关因子
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中医药辨证论治对Ⅱ~Ⅲ期结直肠癌术后早期复发转移的影响研究
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作者 苑军正 李楷威 +2 位作者 韩璐 张兆宏 张楠 《中国肿瘤临床》 CAS CSCD 北大核心 2024年第10期514-521,共8页
目的:探讨Ⅱ~Ⅲ期结直肠癌(colorectal cancer,CRC)根治术后服用≥6个月的个体化辨证论治汤药在预防早期复发转移方面是否优于未服用中药(traditional Chinese medicine,TCM)者。方法:回顾性分析河南中医药大学第一附属医院及河南大学... 目的:探讨Ⅱ~Ⅲ期结直肠癌(colorectal cancer,CRC)根治术后服用≥6个月的个体化辨证论治汤药在预防早期复发转移方面是否优于未服用中药(traditional Chinese medicine,TCM)者。方法:回顾性分析河南中医药大学第一附属医院及河南大学第一附属487例Ⅱ~Ⅲ期接受CRC根治术的患者,以是否服用≥6个月的个体化辨证论治汤药(TCM vs.Non-TCM)后早期(2年)复发转移的发生率为主要结局,采用多因素修正泊松回归评估是否服用中药与主要结局之间的关联。利用倾向评分匹配(propensity score matching,PSM)方法进行敏感性分析。结果:纳入分析TCM组103例,Non-TCM组384例。多因素修正泊松回归分析显示,TCM组发生早期复发转移的风险较低10.7%(12/103)vs.21.4%(82/384),相对危险度(relative risk,RR)为0.448,95%CI:0.261~0.769。经过1∶2比例的PSM,敏感性分析结果与多因素修正泊松回归分析的结果一致,TCM组仍显示出较低的早期复发转移风险11.1%(11/99)vs.21.2%(42/198),RR为0.464,95%CI:0.227~0.948。亚组分析显示在男性、N2(有4枚或以上区域淋巴结转移)、中-高分化的患者中,Non-TCM组和TCM组之间主要结局的差异较大(P<0.05)。生存分析显示TCM组无早期复发转移生存期显著高于Non-TCM组(P<0.05)。结论:对于Ⅱ~Ⅲ期CRC根治术后的患者,接受≥6个月的个体化辨证论治汤药后早期(2年)复发转移的风险低于未服用中药者,表明中医药辨证论治可作为CRC患者有效的选择。 展开更多
关键词 中医药 结直肠癌 复发转移 倾向性匹配分析
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体质与围绝经期症状及生活质量的相关性分析
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作者 杨丹华 陈超 +2 位作者 李秀燕 李中洲 章松娟 《健康研究》 CAS 2024年第3期276-281,共6页
目的分析围绝经期妇女体质与围绝经期症状及生活质量的相关性,为提高围绝经期妇女的生活质量提供依据。方法采用多级分层随机抽样方法,选择绍兴市越城区斗门街道244名围绝经期妇女为研究对象,收集一般资料,应用中医体质检测仪并参照《... 目的分析围绝经期妇女体质与围绝经期症状及生活质量的相关性,为提高围绝经期妇女的生活质量提供依据。方法采用多级分层随机抽样方法,选择绍兴市越城区斗门街道244名围绝经期妇女为研究对象,收集一般资料,应用中医体质检测仪并参照《体质判断标准表》进行体质信息采集和体质判断,采用改良Kupperman评分量表及世界卫生组织生活质量测定量表简表对围绝经妇女进行围绝经期症状评分和生活质量评分,分析相关影响因素,以及体质与围绝经期症状及生活质量的相关性。结果偏颇体质(OR=7.192)、慢性疾病(OR=2.829)是围绝经期症状严重程度的影响因素(均P<0.05),围绝经期症状严重程度与生活质量呈负相关(r=-0.178,P<0.01);平和质、偏颇质的围绝经期妇女生活质量得分为(99.44±10.00)分、(94.40±13.58)分,2者差异有统计学意义(t=-2.897,P=0.005)。结论偏颇体质、患有慢性病加重围绝经期症状,围绝经期症状严重程度与妇女生活质量负相关。加强围绝经期妇女慢性病的监测及治疗,积极调理其偏颇体质,可能对改善围绝经期症状,提高生活质量有一定的临床价值。 展开更多
关键词 围绝经期 症状 中医体质 生活质量
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自拟健脾除积方联合信迪利单抗及化疗对晚期非小细胞肺癌患者的影响
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作者 李金红 蒋玥 +4 位作者 孟雅楠 张振山 张志涛 胡志伟 刘非 《中国中西医结合外科杂志》 CAS 2024年第3期299-303,共5页
目的:探讨自拟健脾除积方联合信迪利单抗及化疗对晚期非小细胞肺癌患者疾病控制率、中医症候积分及不良反应的影响。方法:选取2020年10月—2022年10月在我院就诊的102例晚期非小细胞肺癌患者,随机分为观察组和对照组,每组各51例,对照组... 目的:探讨自拟健脾除积方联合信迪利单抗及化疗对晚期非小细胞肺癌患者疾病控制率、中医症候积分及不良反应的影响。方法:选取2020年10月—2022年10月在我院就诊的102例晚期非小细胞肺癌患者,随机分为观察组和对照组,每组各51例,对照组在吉西他滨+顺铂化疗的基础上给予信迪利单抗,观察组在对照组基础上联合自拟健脾除积方治疗。比较两组患者临床疗效、治疗前后中医症候积分、肿瘤标志物水平及不良反应。结果:观察组有效率和疾病控制率明显高于对照组(P<0.05);观察组和对照组治疗后中医症候积分均显著低于治疗前;治疗后,观察组中医症候积分显著低于对照组(P<0.05)。两组治疗后血清铁蛋白(SF)、鳞状细胞癌抗原(SCCA)及癌胚抗原(CEA)水平均显著低于同组治疗前,观察组SF、SCCA、CEA水平均显著低于对照组。观察组白细胞计数减少、恶心、呕吐症状总发生率显著低于对照组(P<0.05)。结论:自拟健脾除积方联合信迪利单抗对晚期非小细胞肺癌患者治疗效果较好,可改善患者中医症候,具有较高的安全性。 展开更多
关键词 晚期非小细胞肺癌 自拟健脾除积方 信迪利单抗 疾病控制率 中医症候积分
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炙甘草汤对顽固性复发性口腔溃疡患者的疗效研究
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作者 刘云 肖菲 关振群 《辽宁中医杂志》 CAS 北大核心 2024年第8期110-113,共4页
目的探讨炙甘草汤对顽固性复发性口腔溃疡患者的疗效。方法按照随机数字表法分配原则将196例2019年1月—2021年12月该院收治的复发性口腔溃疡患者分为对照组(98例)和治疗组(98例)。对照组给予复合维生素B片、维生素C片、西地碘片进行治... 目的探讨炙甘草汤对顽固性复发性口腔溃疡患者的疗效。方法按照随机数字表法分配原则将196例2019年1月—2021年12月该院收治的复发性口腔溃疡患者分为对照组(98例)和治疗组(98例)。对照组给予复合维生素B片、维生素C片、西地碘片进行治疗,治疗组在对照组基础上给予炙甘草汤进行治疗,两组均持续治疗2周,并随访1年。比较两组治疗2周后的疗效,临床症状改善情况及复发情况,治疗前、治疗2周后的中医证候积分、疼痛程度、睡眠质量、生活质量、炎症、免疫指标水平及治疗期间的安全性情况。结果与对照组治疗2周后的总有效率(84.69%,83/98)比较,治疗组总有效率更高(93.88%,92/98)(P<0.05)。与对照组比较,治疗组溃疡疼痛改善时间、溃疡愈合时间更短(P<0.05);与对照组随访期间的总复发率比较(13.27%,13/98),治疗组总复发率(5.10%,5/98)更低(P<0.05)。治疗2周后,两组溃疡隐痛、反复发作、口干口苦、胃脘痞闷、视觉模拟评分法(VAS)、匹兹堡睡眠质量量表(PSQI)评分、全血CD_(8)^(+)、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)水平与治疗前比较降低,治疗组更低(P<0.05);两组生存质量测定量表(QOL-100)评分、全血CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)水平与治疗前比较升高,治疗组更高(P<0.05)。治疗组和对照组治疗期间均未发生恶心呕吐、皮疹、头晕等情况。结论炙甘草汤可有效调节顽固性复发性口腔溃疡患者炎症及免疫指标水平,减轻机体炎症,改善免疫功能,并可改善疼痛程度、睡眠和生活质量,进而可促进患者中医证候及临床症状的改善,预防复发,疗效显著,安全性良好。 展开更多
关键词 口腔溃疡 顽固性 复发性 炙甘草汤 中医证候 炎症 免疫功能
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