An efficient total synthesis of 6-oxodendrolasinolide 1, a new farnesane-based homosesquiterpene lactone, starting from geraniol 2 through twelve steps is described. Our work involved two key steps： （1） regioselect...An efficient total synthesis of 6-oxodendrolasinolide 1, a new farnesane-based homosesquiterpene lactone, starting from geraniol 2 through twelve steps is described. Our work involved two key steps： （1） regioselective alkylation of the anion of vinyldithian 5 with allylic chloride 31, （2） Corey＇s oxidative lactionization method2.展开更多
基金financially supported by the National Natural Science Foundation of China(Grant No.20072012)the Special Research Grant for Doctoral Sites in Chinese Universities(Grant No.20010730001).
文摘An efficient total synthesis of 6-oxodendrolasinolide 1, a new farnesane-based homosesquiterpene lactone, starting from geraniol 2 through twelve steps is described. Our work involved two key steps： （1） regioselective alkylation of the anion of vinyldithian 5 with allylic chloride 31, （2） Corey＇s oxidative lactionization method2.
