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Recent progress in sono-photodynamic cancer therapy:From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies 被引量:8
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作者 Yilin Zheng Jinxiang Ye +2 位作者 Ziying Li Haijun Chen Yu Gao 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2021年第8期2197-2219,共23页
Many sensitizers have not only photodynamic effects,but also sonodynamic effects.Therefore,the combination of sonodynamic therapy(SDT)and photodynamic therapy(PDT)using sensitizers for sonophotodynamic therapy(SPDT)pr... Many sensitizers have not only photodynamic effects,but also sonodynamic effects.Therefore,the combination of sonodynamic therapy(SDT)and photodynamic therapy(PDT)using sensitizers for sonophotodynamic therapy(SPDT)provides alternative opportunities for clinical cancer therapy.Although significant advances have been made in synthesizing new sensitizers for SPDT,few of them are successfully applied in clinical settings.The anti-tumor effects of the sensitizers are restricted by the lack of tumor-targeting specificity,incapability in deep intratumoral delivery,and the deteriorating tumor microenvironment.The application of nanotechnology-based drug delivery systems(NDDSs)can solve the above shortcomings,thereby improving the SPDT efficacy.This review summarizes various sensitizers as sono/photosensitizers that can be further used in SPDT,and describes different strategies for enhancing tumor treatment by NDDSs,such as overcoming biological barriers,improving tumor-targeted delivery and intratumoral delivery,providing stimuli-responsive controlled-release characteristics,stimulating anti-tumor immunity,increasing oxygen supply,employing different therapeutic modalities,and combining diagnosis and treatment.The challenges and prospects for further development of intelligent sensitizers and translational NDDSs for SPDT are also discussed. 展开更多
关键词 SENSITIZERS Sonodynamic therapy Photodynamic therapy Sono-photodynamic therapy Nanoparticles Drug delivery Cancer efficacy-enhancing strategies
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Cure for HIV/AIDS with Medicinal Synthetic Aluminum-Magnesium Silicate {Al<sub>4</sub>(SiO<sub>4</sub>)<sub>3</sub>+ 3Mg<sub>2</sub>SiO<sub>4</sub>→ 2Al<sub>2</sub>Mg<sub>3</sub>(SiO<sub>4</sub>)<sub>3</sub>}—A Case Report 被引量:1
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作者 M.C.O.Ezeibe N.K.Aneke +11 位作者 T.N.Obarezi F.Onyeachonam M.E.Sanda I.J.Ogbonna E.Kalu U.N.Njoku M.Udobi O.E.Ekundayo O.I.O.Ifenkwe M.C.Igwe T.O.Ogbodo U.C.Agu 《World Journal of AIDS》 2019年第3期161-166,共6页
HIV/AIDS is an immune deficiency disease, caused by an RNA virus (positively charged pathogen). It is still being regarded as mysteriously incurable but in Nigeria many patients have been cured (they became HIV-antibo... HIV/AIDS is an immune deficiency disease, caused by an RNA virus (positively charged pathogen). It is still being regarded as mysteriously incurable but in Nigeria many patients have been cured (they became HIV-antibody and antigen negative) by exploiting electrostatic attraction between pathogens and opposite electrical charges that are on Nanoparticles of Medicinal synthetic Aluminum-magnesium silicate (MSAMS) and by using antioxidants to relieve oxidative stress. To confirm the cure, as permanent, a patient (adult male) whose CD4 count increased (P < 0.05) from 685 to 820 while his viral load became undetectable (<20) and he became HIV-negative (antibody and antigen) following the treatment, was tested, every month, post treatment, for HIV-antibody. He has remained HIV-negative for 10 months without being on any antiretroviral medicine (ARV). Longest window period (period HIV-infected person may test antibody-negative) is only 6 months. These results confirm that treatment with the MSAMS and antioxidants normalizes immunity and terminates HIV-infections. 展开更多
关键词 MSAMS Antiviral/Anticancer Features/Mechanisms Size (Smaller than Viruses/Cancer-Cells) Electrostatic-Bonding Immune-Stimulation efficacy-enhancing
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