The authors aimed the study at examining macro- and trace elements content in elderly people of the 1 period of middle age （21-35） residing in Magadan town to assess the content of 25 trace elements in hair samples ...The authors aimed the study at examining macro- and trace elements content in elderly people of the 1 period of middle age （21-35） residing in Magadan town to assess the content of 25 trace elements in hair samples on individual and population levels by atom-emission spectrometry with inductively-bonded argon plasma. It turned out that the majority of surveyed subjects were characterized by deformation of element status demonstrated by excess and deficit of the basic essential elements of different degrees of manifestation. Deficit of Co （68% of surveyed people）, Mg （67%）, Ca （64%）, Cu （47%）, K （46%）, Zn （44%）, I （41%）, Na （33%）, P （27%） and Se （24%） was typical for female subjects as well as excess of Si （28%）, Zn （22%） and P （20%）. Male residents were characterized by deficit of Co （81%）, Ca （66%）, Mg （65%）, I （50%）, Cu （37%）, K and Na （27%） and excess of Zn （41%）. In individual cases it was noted excess concentration of nominally essential and toxic elements in both examined groups. They were： A1, As, Cd, Li, Ni, Pb, Sn, V and B. While analyzing of medians of chemical concentration it was stated reliable sex-related differences （P 〈 0.05）： content of Ca, Mg and Mn was higher in hair samples of women, and content of As, B, Cd, Cr, K, Li, Na, P, Pb and V, on the contrary, was higher in male samples.展开更多
Background: Alterations of trace elements, could induce metabolic disorders as they forthwith participating in the metabolic pathways and play different roles modulating it as well as many enzymes require trace elemen...Background: Alterations of trace elements, could induce metabolic disorders as they forthwith participating in the metabolic pathways and play different roles modulating it as well as many enzymes require trace elements for their activation and functions. Of these elements, selenium (Se), zinc (Zn), copper (Cu) and manganese (Mn) have been recognized as essentials for metabolism. Hyperglycemia and diabetes mellitus are important causes of mortality and morbidity worldwide, and their global prevalence are growing from 2.8% in 2000 projecting to be 4.4% in 2030. Diabetes is prevalent in Saudi Arabia with high incidence in urbanized areas and its prevalence is estimated to expand 3 times by 2030. Patients and Methods: In total, 75 diabetic women and 80 aberrantly healthy women were recruited. Clinical and familial history was recorded. Hair Se, Zn, Cu and Mn levels were analyzed as well as fasting blood sugar (FBS), glycated hemoglobin (HbA1c). Results: Our findings revealed a marked decrease of Zn and Mn levels in diabetic women hair compared to control group (p < 0.05, p <0.005 respectively). Otherwise, Se and Cu levels were significantly elevated in hair of diabetic patients (p < 0.005, p <0.05 respectively). Conclusion: Diabetes may disrupt the trace elements balance as well as their alterations can affect glucose metabolism and insulin action. Chronic hyperglycemia can cause disturbance of some trace elements which, in turn, can modulate glucose homeostasis. The metabolic dysregulation occurring in hyperglycemia may influence trace element status by increasing excretion, diminishing availability or redistribution of trace elements among different body pools. Hair trace elements can be useful long-term markers for metabolic disturbance;however, larger prospective studies are required to validate their role in diagnosis and follow up applications.展开更多
To clarify whether the urinary excretion of calcium, magnesium, phosphorus, iron, zinc, copper, manganese, selenium and molybdenum can be used as an index of their intake, the association between urinary excretion and...To clarify whether the urinary excretion of calcium, magnesium, phosphorus, iron, zinc, copper, manganese, selenium and molybdenum can be used as an index of their intake, the association between urinary excretion and intake in free-living individuals was examined. A total of 102 healthy free-living female university dietetics students aged 18 - 33 years voluntarily participated in this study, of which 76 students were eligible for this assessment. All food consumed for four consecutive days was recorded accurately by a weighed food record method. A 24-h urine sample was collected on the fourth day, and the urinary levels of sodium, potassium, calcium, magnesium, phosphorus, iron, zinc, copper, manganese, selenium and molybdenum were measured. Significant correlation between urinary excretion and intake was observed in sodium (r = 0.596, p < 0.001), potassium (r = 0.583, p < 0.001), calcium (r = 0.402, p < 0.001), magnesium (r = 0.365, p < 0.01), phosphorus (r = 0.509, p < 0.001), selenium (r = 0.349, p < 0.01) and molybdenum (r = 0.265, p < 0.01). On the other hand, urinary excretion was very low and completely independent of the intake in iron, zinc, copper and manganese. These results indicate that urinary calcium, magnesium, phosphorus, selenium and mo-lybdenum can be used as an index of their intake, similarly to sodium and potassium.展开更多
文摘The authors aimed the study at examining macro- and trace elements content in elderly people of the 1 period of middle age （21-35） residing in Magadan town to assess the content of 25 trace elements in hair samples on individual and population levels by atom-emission spectrometry with inductively-bonded argon plasma. It turned out that the majority of surveyed subjects were characterized by deformation of element status demonstrated by excess and deficit of the basic essential elements of different degrees of manifestation. Deficit of Co （68% of surveyed people）, Mg （67%）, Ca （64%）, Cu （47%）, K （46%）, Zn （44%）, I （41%）, Na （33%）, P （27%） and Se （24%） was typical for female subjects as well as excess of Si （28%）, Zn （22%） and P （20%）. Male residents were characterized by deficit of Co （81%）, Ca （66%）, Mg （65%）, I （50%）, Cu （37%）, K and Na （27%） and excess of Zn （41%）. In individual cases it was noted excess concentration of nominally essential and toxic elements in both examined groups. They were： A1, As, Cd, Li, Ni, Pb, Sn, V and B. While analyzing of medians of chemical concentration it was stated reliable sex-related differences （P 〈 0.05）： content of Ca, Mg and Mn was higher in hair samples of women, and content of As, B, Cd, Cr, K, Li, Na, P, Pb and V, on the contrary, was higher in male samples.
文摘Background: Alterations of trace elements, could induce metabolic disorders as they forthwith participating in the metabolic pathways and play different roles modulating it as well as many enzymes require trace elements for their activation and functions. Of these elements, selenium (Se), zinc (Zn), copper (Cu) and manganese (Mn) have been recognized as essentials for metabolism. Hyperglycemia and diabetes mellitus are important causes of mortality and morbidity worldwide, and their global prevalence are growing from 2.8% in 2000 projecting to be 4.4% in 2030. Diabetes is prevalent in Saudi Arabia with high incidence in urbanized areas and its prevalence is estimated to expand 3 times by 2030. Patients and Methods: In total, 75 diabetic women and 80 aberrantly healthy women were recruited. Clinical and familial history was recorded. Hair Se, Zn, Cu and Mn levels were analyzed as well as fasting blood sugar (FBS), glycated hemoglobin (HbA1c). Results: Our findings revealed a marked decrease of Zn and Mn levels in diabetic women hair compared to control group (p < 0.05, p <0.005 respectively). Otherwise, Se and Cu levels were significantly elevated in hair of diabetic patients (p < 0.005, p <0.05 respectively). Conclusion: Diabetes may disrupt the trace elements balance as well as their alterations can affect glucose metabolism and insulin action. Chronic hyperglycemia can cause disturbance of some trace elements which, in turn, can modulate glucose homeostasis. The metabolic dysregulation occurring in hyperglycemia may influence trace element status by increasing excretion, diminishing availability or redistribution of trace elements among different body pools. Hair trace elements can be useful long-term markers for metabolic disturbance;however, larger prospective studies are required to validate their role in diagnosis and follow up applications.
文摘To clarify whether the urinary excretion of calcium, magnesium, phosphorus, iron, zinc, copper, manganese, selenium and molybdenum can be used as an index of their intake, the association between urinary excretion and intake in free-living individuals was examined. A total of 102 healthy free-living female university dietetics students aged 18 - 33 years voluntarily participated in this study, of which 76 students were eligible for this assessment. All food consumed for four consecutive days was recorded accurately by a weighed food record method. A 24-h urine sample was collected on the fourth day, and the urinary levels of sodium, potassium, calcium, magnesium, phosphorus, iron, zinc, copper, manganese, selenium and molybdenum were measured. Significant correlation between urinary excretion and intake was observed in sodium (r = 0.596, p < 0.001), potassium (r = 0.583, p < 0.001), calcium (r = 0.402, p < 0.001), magnesium (r = 0.365, p < 0.01), phosphorus (r = 0.509, p < 0.001), selenium (r = 0.349, p < 0.01) and molybdenum (r = 0.265, p < 0.01). On the other hand, urinary excretion was very low and completely independent of the intake in iron, zinc, copper and manganese. These results indicate that urinary calcium, magnesium, phosphorus, selenium and mo-lybdenum can be used as an index of their intake, similarly to sodium and potassium.
