Background: Alzheimer’s disease (AD), commonly known as senile dementia, is a neurodegenerative disease with clinical manifestations of memory impairment, personality and behavior changes. The pathogenesis of AD is c...Background: Alzheimer’s disease (AD), commonly known as senile dementia, is a neurodegenerative disease with clinical manifestations of memory impairment, personality and behavior changes. The pathogenesis of AD is complex and inconclusive in the point of view of western medicine, which is the fundamental reason for the lack of drugs that can reverse the course of the disease. People have gradually shifted from simple amyloid hypothesis to new pathogenesis theories, such as gamma oscillation, prion like transmission, and so on. As an effective means to treat AD, traditional Chinese medicine has made some research progress in recent years. This article mainly reviews the etiology, pathogenesis and treatment of AD, so as to provide reference for the prevention and treatment of AD. Methods: Through systematic literature research, comparison and analysis, the main pathogenesis, influencing factors, progress and development tendency of traditional Chinese medicine and Western medicine in the treatment of AD are presented. Results: Alzheimer’s disease is a kind of multiple neurodegenerative diseases. The pathogenesis and related targets of AD still need to be further explored. The main pathological phenomenon of AD is senile plaques formed by intracellular neurofibrillary tangles and extracellular amyloid protein aggregation. Existing possible pathogenesis includes β-amyloid cascade hypothesis, tau protein hypothesis, cholinergic hypothesis and so on. As the pathogenesis of AD has not been clarified, so far no effective therapeutic drugs or means have been found. The traditional drugs used to treat AD mainly include acetylcholinesterase inhibitor kabbalatin, galantamine, donepezil, and N-methyl-D-aspartate receptor antagonist memantine. However, although these marketed drugs can slow down the course of the disease and alleviate symptoms, they cannot totally cure the disease. Traditional Chinese medicine has the characteristics of personalized differentiation and treatment. The Western medicine can accurately determine the lesion location and target. Conclusions: Integrated traditional Chinese medicine and West medicine is the most promising direction in the treatment of Alzheimer’s disease.展开更多
Insomnia is a prominent problem.The current mainstream therapy for insomnia is cognitive behavioral therapy.Traditional Chinese medicine has rich clinical experience in treating insomnia,but we have ignored the contri...Insomnia is a prominent problem.The current mainstream therapy for insomnia is cognitive behavioral therapy.Traditional Chinese medicine has rich clinical experience in treating insomnia,but we have ignored the contribution of traditional Chinese medicine to behavioral therapy in the past.Completed in the Qing Dynasty in China,Laolao Hengyan is a comprehensive book on the management of the elderly's self-health.The book describes many ways to promote sleep health.This book inherits the traditional Chinese medical treatment concept and reflects traditional Chinese culture.By comparing this book with cognitive behavioral therapy,we find that the Chinese Qing Dynasty literature has documented some cognitive and behavioral aspects of sleep that are consistent with modern medical concepts.Moreover,this method is superior to modern medicine in some aspects,so this is worthy of our in-depth study to complement and enrich modern medical theory.展开更多
To systematically evaluate the clinical efficacy and safety of acupuncture in treating cancer-related insomnia.Methods:Randomized controlled trials(RCTs)and quasi-randomized controlled trials of acupuncture in the tre...To systematically evaluate the clinical efficacy and safety of acupuncture in treating cancer-related insomnia.Methods:Randomized controlled trials(RCTs)and quasi-randomized controlled trials of acupuncture in the treatment of cancer-related insomnia were searched by computer in a Pubmed database,and the retrieved literature was screened according to inclusion and exclusion criteria.After the literature screening was completed,two reviewers read the literature titles independently and extracted effective information.The migration risk assessment was performed by Cochrane.All statistical calculation requirements for this study were fully completed by RevMan5.3 software.Results:Among the 68 selected works of literature,3 RCTs were finally included,with a total of 133 patients.The risk of research bias is generally very low.In 3 RCTs,the sleep score of the experimental group was decreased by 0.48 more than that of the control group in 3 RCTs,with a 95%confidence interval of-0.82 and-0.13,and the degree of decrease was statistically significant(Z=2.70,P<0.05).Conclusion:Higher levels may indicate that acupuncture-related therapies are more effective in improving cancer-related insomnia.Although the included literatures feature low bias and no heterogeneity,the number may have reduced its clinical significance.Therefore,more studies on high-quality randomized controlled trials should be conducted in the future to better clarify the therapeutic effect of acupuncture and moxibustion on cancer-related insomnia.展开更多
文摘Background: Alzheimer’s disease (AD), commonly known as senile dementia, is a neurodegenerative disease with clinical manifestations of memory impairment, personality and behavior changes. The pathogenesis of AD is complex and inconclusive in the point of view of western medicine, which is the fundamental reason for the lack of drugs that can reverse the course of the disease. People have gradually shifted from simple amyloid hypothesis to new pathogenesis theories, such as gamma oscillation, prion like transmission, and so on. As an effective means to treat AD, traditional Chinese medicine has made some research progress in recent years. This article mainly reviews the etiology, pathogenesis and treatment of AD, so as to provide reference for the prevention and treatment of AD. Methods: Through systematic literature research, comparison and analysis, the main pathogenesis, influencing factors, progress and development tendency of traditional Chinese medicine and Western medicine in the treatment of AD are presented. Results: Alzheimer’s disease is a kind of multiple neurodegenerative diseases. The pathogenesis and related targets of AD still need to be further explored. The main pathological phenomenon of AD is senile plaques formed by intracellular neurofibrillary tangles and extracellular amyloid protein aggregation. Existing possible pathogenesis includes β-amyloid cascade hypothesis, tau protein hypothesis, cholinergic hypothesis and so on. As the pathogenesis of AD has not been clarified, so far no effective therapeutic drugs or means have been found. The traditional drugs used to treat AD mainly include acetylcholinesterase inhibitor kabbalatin, galantamine, donepezil, and N-methyl-D-aspartate receptor antagonist memantine. However, although these marketed drugs can slow down the course of the disease and alleviate symptoms, they cannot totally cure the disease. Traditional Chinese medicine has the characteristics of personalized differentiation and treatment. The Western medicine can accurately determine the lesion location and target. Conclusions: Integrated traditional Chinese medicine and West medicine is the most promising direction in the treatment of Alzheimer’s disease.
文摘Insomnia is a prominent problem.The current mainstream therapy for insomnia is cognitive behavioral therapy.Traditional Chinese medicine has rich clinical experience in treating insomnia,but we have ignored the contribution of traditional Chinese medicine to behavioral therapy in the past.Completed in the Qing Dynasty in China,Laolao Hengyan is a comprehensive book on the management of the elderly's self-health.The book describes many ways to promote sleep health.This book inherits the traditional Chinese medical treatment concept and reflects traditional Chinese culture.By comparing this book with cognitive behavioral therapy,we find that the Chinese Qing Dynasty literature has documented some cognitive and behavioral aspects of sleep that are consistent with modern medical concepts.Moreover,this method is superior to modern medicine in some aspects,so this is worthy of our in-depth study to complement and enrich modern medical theory.
文摘To systematically evaluate the clinical efficacy and safety of acupuncture in treating cancer-related insomnia.Methods:Randomized controlled trials(RCTs)and quasi-randomized controlled trials of acupuncture in the treatment of cancer-related insomnia were searched by computer in a Pubmed database,and the retrieved literature was screened according to inclusion and exclusion criteria.After the literature screening was completed,two reviewers read the literature titles independently and extracted effective information.The migration risk assessment was performed by Cochrane.All statistical calculation requirements for this study were fully completed by RevMan5.3 software.Results:Among the 68 selected works of literature,3 RCTs were finally included,with a total of 133 patients.The risk of research bias is generally very low.In 3 RCTs,the sleep score of the experimental group was decreased by 0.48 more than that of the control group in 3 RCTs,with a 95%confidence interval of-0.82 and-0.13,and the degree of decrease was statistically significant(Z=2.70,P<0.05).Conclusion:Higher levels may indicate that acupuncture-related therapies are more effective in improving cancer-related insomnia.Although the included literatures feature low bias and no heterogeneity,the number may have reduced its clinical significance.Therefore,more studies on high-quality randomized controlled trials should be conducted in the future to better clarify the therapeutic effect of acupuncture and moxibustion on cancer-related insomnia.
