Antioxidant Activity of 50 Traditional Chinese Medicinal Materials Varies with Total Phenolics

This study was designed to determine the total phenolic content of 50 herbs and to examine their antioxidant potential. In the sample preparation, 60% ethanol was chosen as the extraction solvent for the subsequent experiments. Folin-Cicolteau phenol reagent and a colorimetric method were used to determine the total phenolic content of the selected herbs. The result showed that total phenolic content of those herbs ranged from 2 to 185 mg/g. In antioxidant assay, the ferric reducing/antioxidant power (FRAP) values ranged from 2 to 134 mg GAE/g;the IC50 values of DPPH?·, ·OH and ?scavenging were in the range of 0.06 - 5.50 mg/mL, 0.017 - 0.636 mg/mL and 0.050 - 0.681 mg/mL respectively. Flos caryophylli was the exceptant in the ?scavenging assay because there was no linear relation between the concentration and the scavenging percentage. Compared to gallic acid, ascorbic acid and butylated hydroxytoluene (BHT) in antioxidant assay as positive control, the most potential antioxidant herbs were Cacumen platycladi, Radix et Rhizoma rhei, Rhizoma rhodiolae crenulatae, and Rhizoma sanguisorbae with considerable content of phenolics. Especially, a positive and significant correlation was found between the total phenolic content and FRAP value or DPPH· scavenging percentage.

Reason Analysis and Risk Prevention of Soaring Price of Traditional Chinese Medicinal Materials

In recent years,the price of traditional Chinese medicinal materials soars continuously,and the resulting price risk increasingly looms large,which has critically affected midstream and downstream industries and peoples' demand for drug,and imperiled healthy and orderly development of traditional Chinese medicinal industries.Based on the status quo of continuous skyrocketing price of traditional Chinese medicinal materials at present,we winkle out the root cause of soaring price as follows:the supply and demand lose balance;the production costs hike up;there are other factors responsible for soaring price.This paper further analyses the impact of sharp increase in price of traditional Chinese medicinal materials on all links of industry chain as follows:the medicinal herb growers never benefit from soaring price;the counterfeiters and forgers in midstream industry increase;the gross profit rate of Chinese medicine enterprises declines.In accordance with the risk arising from abnormal fluctuation in price of traditional Chinese medicinal materials,corresponding precautionary measures are put forward as follows:promote the quality of traditional Chinese medicinal materials through management of value chain;curtail the production and management cost of traditional Chinese medicinal materials through management of organization chain;stabilize price of traditional Chinese medicinal materials through management of information chain;reduce transaction cost of traditional Chinese medicinal materials through management of logistics chain.

Problems in the Development of Traditional Chinese Medicinal Materials Planting Industry in Shiyan City and Countermeasures

Through the analysis on the cultivation advantages and development problems of traditional Chinese medicinal planting industry in Shiyan City, Hubei Province, some measures were proposed to enlarge and enhance the traditional Chinese medicinal planting industry, namely, large-scale, standardized, market-oriented and regionalized planting, thereby making it the pillar industry for farmers to increase income.

Systems Theory-Driven Framework for AI Integration into the Holistic Material Basis Research of Traditional Chinese Medicine

This paper introduces a systems theory-driven framework to integration artificial intelligence(AI)into traditional Chinese medicine(TCM)research,enhancing the understanding of TCM’s holistic material basis while adhering to evidence-based principles.Utilizing the System Function Decoding Model(SFDM),the research progresses through define,quantify,infer,and validate phases to systematically explore TCM’s material basis.It employs a dual analytical approach that combines top-down,systems theory-guided perspectives with bottom-up,elements-structure-function methodologies,provides comprehensive insights into TCM’s holistic material basis.Moreover,the research examines AI’s role in quantitative assessment and predictive analysis of TCM’s material components,proposing two specific AIdriven technical applications.This interdisciplinary effort underscores AI’s potential to enhance our understanding of TCM’s holistic material basis and establishes a foundation for future research at the intersection of traditional wisdom and modern technology.

中药有效成分结合骨组织工程材料用于骨修复

背景:如何修复骨缺损一直以来是临床难题,中药有效成分在骨修复方面具有良好的生物活性与治疗效果,将中药有效成分与组织工程材料相结合在骨修复领域具有广阔的前景。不同中药有效成分与支架的组合在作用关系方面具有相似之处。目的:搜集常见的中药有效成分与支架材料组合的案例,基于七情配伍的启发将组织工程支架与中药有效成分类比为产生配伍关系的两类中药,以二者的作用关系为纲进行归纳总结。方法:检索1998年1月至2024年1月Pub Med和中国知网数据库中发表的相关文献,英文检索词:“traditional Chinese medicine,Chinese medicine,traditional Chinese medicine monomers,bone defect,bone repair,bone tissue engineering,tissue engineering,scaffold”,中文检索词:“中药,中药有效成分,中药单体,骨组织工程,骨组织工程支架,支架,组织工程,骨缺损,骨修复”,最终纳入88篇文献进行综述分析。结果与结论:(1)组织工程支架材料与中药有效成分各自均在骨修复领域有广泛的运用,二者在成骨方面优势明显但仍有许多缺陷,许多研究致力于将二者制备成复合材料,希望通过二者间的相互作用发挥减毒增效作用。(2)一些药物与材料在成骨、抗菌、促血管生成方面能互相促进,增强原有的效果,受到传统方剂配伍观念的启发,文章将其归纳为“相须”关系,并举实例佐证。(3)一些药物能提高材料的强度,而某些材料能对负载于其上的药物实现缓释控释效果、增加载药量与稳定性,或是进行靶向递送,文章将这种单方面的提升效果归纳为“相使”关系。(4)一些中药与材料搭配使用能减少对方的毒副反应,文章将这种减毒关系归纳为“相畏相杀”。(5)文章得出了一个由七情配伍关系启发、基于作用关系分类的关于中药复合支架的全新视角,将中药传统观念引入组织工程领域,为后续复合支架的研究者提供新的研究思路,并在选材搭配方面提供一定的便利。

21世纪前传统中药人参在俄国的认识与传播

中医药历来是中俄交流的重要组成部分。17-20世纪,受欧洲“中国热”以及中国本土文化的影响,俄国对中药人参的认识先后经历了传教士团初步了解、医药学家临床试验和全民广泛栽种培育三个主要阶段。凭借地缘优势,俄国先于欧洲各国开展人参实验,并进行广泛应用,但纵观国内学界,关于人参在俄传播史的研究成果有限。通过探索自中俄交往以来各个时期人参在俄国的认识特点和传播特征,可以揭示传统中医药在传播过程中对中俄交流产生的深远影响,并为“中医药文化走出去”提供参考。

Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer:opportunities and challenges

Breast cancer is globally the most common invasive cancer in women and remains one of the leading causes of cancer-related deaths.Surgery,radiotherapy,chemotherapy,immunotherapy,and endocrine therapy are currently the main treatments for this cancer type.However,some breast cancer patients are prone to drug resistance related to chemotherapy or immunotherapy,resulting in limited treatment efficacy.Consequently,traditional Chinese medicinal materials(TCMMs)as natural products have become an attractive source of novel drugs.In this review,we summarized the current knowledge on the active components of animal-derived TCMMs,including Ophiocordyceps sinensis-derived cordycepin,the aqueous and ethanolic extracts of O.sinensis,norcantharidin(NCTD),Chansu,bee venom,deer antlers,Ostrea gigas,and scorpion venom,with reference to marked anti-breast cancer effects due to regulating cell cycle arrest,proliferation,apoptosis,metastasis,and drug resistance.In future studies,the underlying mechanisms for the antitumor effects of these components need to be further investigated by utilizing multi-omics technologies.Furthermore,large-scale clinical trials are necessary to validate the efficacy of bioactive constituents alone or in combination with chemotherapeutic drugs for breast cancer treatment.

Gaps and feasibility of fixed-dose combination strategy in the development of modern Chinese medicine

isTraditional Chinese medicine(TCM)is a highly complex chemical substance system,which not only reflected in the complexity of the chemical components and their interrelationships,but also in the intricacy of the prescription’s connection with the human body.Component compatibility strategy has been proposed for developing modern TCM since 2005 and established comprehensive relevant technologies and research approaches.Moreover,to meet the safety and efficacy of current pharmaceuticals,research on fixed-dose combination drugs is directed by modern scientific theories,conforms to TCM compatibility principles and clarifies material basis and pharmacological mechanisms and component-effect correlations.This review summarized gaps and feasibility of fixed-dose combination strategy in the development of modern TCM research and assessed their advantages and disadvantages in light of contemporary drug combination research practices.

四川省重点中药材资源品种及蕴藏量调查研究

目的 调查四川省重点中药材的种类和蕴藏量信息,为四川省中药资源可持续利用提供科学依据。方法 采用野外样方调查、市场走访调查、栽培走访调查相结合的方法,调查四川省183个县级行政区域内重点中药材的品种和蕴藏量信息。结果 四川省有《中国药典》2020版一部收载重点品种358种,其中市场重点调查药材133种、野外重点调查药材225种。调查发现了重点植物药材325种,重点动物药材14种,重点矿物药材14种,重点菌类药材5种。完成了134种重点中药材的数量和重量调查,通过全国中药资源普查数据库系统计算得到134种重点药材的蕴藏量信息。结论 四川省重点中药资源种类丰富,占全国重点品种数量的51.3%。资源蕴藏量大,在2000万吨以上,但部分品种资源破坏严重,急需加强保护。

从医书到讲义:清季民初中医教材的转型

清季民初,在西方医学影响之下,中国医者开始关注到医学知识传承中的不足。传统中医基本通过阅读经典医籍来学习,习医者除家传师授外基本是主动找书来读;西式医学的知识传授则更注重学校教育,不少人主张通过编辑教科书来改良中医、增进中医的竞争力,并有实际的行动。中医教科书(讲义)从形式到内容都与传统医书有很大差异,是医学传承的一种创造性革新,既反映了西学影响下自我认知的变迁,也是传统中医走向近代不可忽视的一环。

中西医结合桥梁课程思政素材库的构建与实践

为落实立德树人根本任务,以中西医结合桥梁课程为例,系统介绍课程思政素材库构建思路,围绕政治素养、职业素养、科学素养、道德素养、文化素养5个素养挖掘思政元素,构建中西医结合桥梁课程思政素材库,以发挥出课程的育人功能,为培养高素质的中西医结合人才打下坚实基础。

葫芦岛地区中药材产业发展及装备需求分析

我国中药材种植业从播种到采收仍以传统的人工作业方式为主,劳动效率低下,会影响中药产业的长期健康稳定发展。阐述我国中药材产业发展及机械化配套现状,分析中药材机械化发展中存在的问题及其生产所需的配套装备,探讨中药材机械化的综合效益。

山东省济南市钢城区中药资源现状调查及分析

为摸清山东省济南市钢城区中药资源分布现状,按照全国第四次中药资源普查的统一要求,通过野外调查、内业整理、数据分析等过程对钢城区野外药用植物资源的分布、中药材栽培等进行调查梳理。结果表明:钢城区现有野生中药资源180种,隶属于65科、151属,其中优势科有菊科、豆科、十字花科等,野生商陆、茜草、益母草的蕴藏量较大,野生中药资源中有69种被《中国药典》2020版收录;栽培品种丹参、黄芩、山楂、花椒、金银花、生姜的种植面积较大,其中白花丹参为地理标志性资源。本次资源普查对钢城区的野生药用植物资源种类和分布进行了全面了解,为区域性中药资源的开发利用以及中药产业可持续发展提供了科学依据。

基于“身份证”数字表征的中药鉴定思路及其应用价值探讨

目的:针对当前难以对未知的中药样品或混合样品进行盲检的情况,提出中药非靶向鉴定的新思路,并对其应用价值进行探讨。方法:通过文献调研法、理论分析法、系统科学法等,理清当前中药鉴定存在的问题与不足,并在理论层面提出具有针对性的解决方案,探讨其应用价值。结果:从系统科学的角度,提出了基于“身份证”数字表征的中药鉴定思路,主要包括基于液相色谱-质谱法的中药材“身份证”信息获取和基于数据库技术的智能化匹配鉴定。此外,基于“身份证”数字表征的鉴定思路亦可用于中药材真伪、基原等鉴定。结论:基于“身份证”数字表征的中药鉴定思路具备理论可行性,具有较大的应用价值,有利于中药质量控制及质量监管,但仍须从实践角度进一步探索。

中药物质基础新形式及其药动/药效研究

中药作为中华民族的瑰宝,拥有悠久的历史和丰富的文化内涵。过去几百年,大量结构明确、活性显著、机制清楚的活性化合物被发现,其研究初步明晰了中药的效应物质基础。然而,中药的天然成分具有骨架多样性和结构复杂性,除了单体小分子化合物,近年来越来越多的研究发现中药存在发挥药效的物质基础新形式,如活性单体化合物形成的超分子,以及具有药理活性的生物大分子等。聚焦中药物质基础新形式,通过新技术、新机制、新应用的分析,以期为中药药效物质基础、药动/药效相关性研究提供新思路。

基于双波长差示融合图谱的中药陈皮“质-量”双标质量分析方法研究

目的建立以对照药材为对照物质的定性和不依赖多种对照品定量的陈皮药材“质-量”双标控制方法。方法采用高效液相色谱(HPLC)法,以对照药材为基准建立陈皮特征图谱,结合双波长差示融合技术,确定15批陈皮药材共有特征峰,根据陈皮对照药材和供试药材特征峰的相似度,明确药材真伪,即“质”。采用质谱技术鉴定特征峰的化学成分,选取“橙皮苷”作为基准物质,进行准确定量分析,并通过基准物质对其余特征峰的化学成分进行相对定量,区分陈皮药材的优劣,即“量”。结果共确定了9个共有特征峰,鉴定出4个化学成分,分别为芸香柚皮苷、橙皮苷、川陈皮素以及橘皮素。10批陈皮与对照药材相似度为0.487~0.556,5批广陈皮药材相似度为0.992~0.996,规定了陈皮及广陈皮药材特征峰化学成分相对含量下限。结论本方法不依赖多种对照品,能精确、高效地判断药材的真伪优劣,可为中药的质量控制提供技术支持。

基于“质-量”双标的连翘质量分析方法研究

目的建立以对照药材为对照物质的定性和不依赖多种对照品定量的连翘药材“质-量”双标控制方法。方法采用高效液相色谱(HPLC)法建立连翘对照药材特征图谱,并通过质谱技术鉴定特征峰成分;通过比较对照药材和供试药材特征峰的相似度,明确药材的真伪,即“质”;其余特征峰的化学成分均通过基准物质相对定量,以区别药材的优劣,即“量”。结果建立的连翘药材“质-量”分析方法符合方法学考察要求,每批药材与对照药材相似度均在0.910以上,并规定了连翘药材特征峰化学成分的相对含量下限。结论该方法不依赖于多种对照品,能清晰、快速地判断连翘药材的真伪优劣,弥补了目前连翘药材在质量控制上的不足,完善了中药材质量控制体系,以期推动中医药事业可持续发展。

基于“质-量”双标的菊花质量分析方法研究

目的建立以对照药材为对照物质的定性和不依赖多种对照品定量的菊花药材“质-量”双标控制方法。方法采用高效液相色谱技术(HPLC)建立菊花药材特征图谱,并通过质谱技术鉴定特征峰成分,以对照药材和供试药材特征峰的相似度,明确药材真伪,即“质”;对基准物质“异绿原酸A”准确定量并通过基准物质对其余特征峰的化学成分进行相对定量,区分药材的优劣,即“量”。结果建立的菊花药材“质-量”分析方法符合方法学考察要求,各供试药材与对照药材相似度均大于0.900,规定了菊花药材特征峰化学成分相对含量下限。结论该方法不依赖多种对照品,能清晰、快速地判断菊花药材的真伪优劣,为菊花药材的质量控制提供了参考,完善了中药材质量控制体系,为中医药事业发展提供了新思路。

中药材的不同产地鉴别技术研究概况

目的探讨中药材不同产地鉴别技术的研究现状和发展趋势,为中药材产地研究拓展思路。方法以“中药”“产地”“鉴别”等为关键字,在中国知网、维普网、PubMed、Web of Science等数据库中查询近10年发表的相关研究论文,并以“不同产地”和“鉴别技术”为主旨进行文献综述。结果中药材的不同产地鉴别技术包括性状与显微鉴别、理化鉴别、指纹图谱技术、DNA分子标记鉴别、生物效价评价和结合计算机算法的人工智能鉴别技术等多种方法,其中经验鉴别、显微鉴别和一般理化鉴别等传统鉴别方法简便易行,但依赖经验、专属性差;光谱法、指纹图谱、DNA标记技术等方法用于中药材产地鉴别克服了以上缺点,准确可靠、操作简便;结合计算机算法的人工智能鉴别技术更加准确高效,极大地降低了人工和时间成本,将成为未来发展的重要方向。结论中药材的不同产地鉴别存在一定的难度和不确定性,可以结合多种方法进行综合鉴别,发挥每种鉴别方法的优势,以确保结果的准确性。未来,中药材鉴别将更加智能化和自动化,利用人工智能、机器学习等技术可以提高鉴别效率和准确性。

中药有效成分结合支架材料促进骨组织再生

背景:随着淫羊藿苷、黄连素等中药被证实可以促进骨再生,研究者将中药活性成分与骨组织工程相结合,发现其在骨缺损的修复中具有独特优势。目的:从促进成骨的中药有效成分出发,筛选其与不同载药支架材料有效结合的案例,归纳总结有潜力应用于骨组织工程的中药有效成分。方法:应用计算机检索中国知网、万方、PubMed、Web of Science等数据库,以“骨组织工程,骨组织工程支架材料,骨缺损,骨修复,骨再生,中医药”为中文检索词,以“bone tissue engineering,bone tissue-engineered scaffold materials,bone defect,bone repair,bone regeneration,traditional Chinese medicine”为英文检索词,检索时限限定为2000-2023年,根据纳入和排除标准进行筛选,最终纳入87篇文献进行综述。结果与结论:促进骨再生的中药有效成分种类繁多,主要包括黄酮类化合物、非黄酮类多酚、生物碱、苷类,有消炎止痛、促进成骨细胞和抑制破骨细胞以及促进血管早期生成的作用。中药有效成分与骨组织工程结合后在抗炎、加速胶原蛋白和骨骼形成、促进成骨基因表达等方面效果显著,为中药在骨组织再生中的应用提供了理论依据,同时为骨缺损修复提供了新的思路。