Based on the process management of traditional Chinese medicine comprehensive intervention method on outcomes in patients with mild/moderate chronic obstructive pulmonary disease:study protocol for a practical randomized controlled trial

Background:The prevalence,morbidity and mortality of chronic obstructive pulmonary disease(COPD)is very high,so it has become a public health problem.The early stage of COPD has been paid much attention before it develops severely.As well,traditional Chinese medicine has some advantages in relieving symptoms and reducing the incidence of COPD exacerbations.Methods:A practical randomized controlled trial will be designed to test the clinical effects of traditional Chinese medicine treatment according to syndrome differentiation.A total of 80 patients with mild/moderate COPD will participate in this study,40 in the treatment group and 40 in the control group.On the basis of the lifestyle intervention,traditional Chinese medicine formula granules for treatment group and the placebo simulation of traditional Chinese medicine granules for control group.The exacerbation and the improvement of pulmonary function will be used as the primary outcome measures.The improvement of clinical symptoms and signs,the quality of life and Dyspnea will be used as the secondary outcomes measures.Conclusion:We assume that the COPD patients will be benefit from therapy with Traditional Chinese medicine treatment.

Progress of mitochondrial and endoplasmic reticulum-associated signaling and its regulation of chronic liver disease by Chinese medicine

The endoplasmic reticulum(ER)is connected to mitochondria through mitochondria-associated ER membranes(MAMs).MAMs provide a framework for crosstalk between the ER and mitochondria,playing a crucial role in regulating cellular calcium balance,lipid metabolism,and cell death.Dysregulation of MAMs is involved in the development of chronic liver disease(CLD).In CLD,changes in MAMs structure and function occur due to factors such as cellular stress,inflammation,and oxidative stress,leading to abnormal interactions between mitochondria and the ER,resulting in liver cell injury,fibrosis,and impaired liver function.Traditional Chinese medicine has shown some research progress in regulating MAMs signaling and treating CLD.This paper reviews the literature on the association between mitochondria and the ER,as well as the intervention of traditional Chinese medicine in regulating CLD.

Effects of traditional Chinese medicine nursing combined with conventional nursing in patients with chronic obstructive pulmonary disease:a meta-analysis

Objective: This meta-analysis aims to evaluate the effects of traditional Chinese medicine(TCM) nursing combined with conventional nursing in patients with chronic obstructive pulmonary disease(COPD).Methods: Data were collected from the databases of PubMed, Embase, the Cochrane Library, Web of Science, Google Scholar,China National Knowledge Infrastructure(CNKI), WanFang Data(WF) and VIP Database, including literature regarding the effects of TCM nursing combined with conventional nursing in patients with COPD published before January 2017. The Jadad scale was used to assess the quality of the eligible literature. The weighted mean differences and odds ratios were used to analyze St. George's Respiratory Questionnaire(SGRQ) scores, pulmonary function, hospital stay, and clinical efficacy.Results: Twenty-three randomized controlled trials comprising 3116 cases(TCM nursing combined with the conventional nursing group: 1559; conventional nursing group: 1557) met the inclusion criteria. TCM nursing combined with conventional nursing was associated with a lower SGRQ score, higher forced expiratory volume in 1 second(FEV1) value, higher FEV1/forced vital capacity(FVC) value, higher FEV1% value, higher FEV1 predicted value, shorter hospital stay, and preferable clinical efficacy.Conclusions: TCM nursing combined with conventional nursing emphasized that dialectical nursing can be performed preferably in patients with COPD.

Traditional Chinese medicine nursing protocols for chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease(COPD)is a complex respiratory disorder,characterized by chronic airflow limitation and an elevated inflammatory response of the airways.The people with COPD are more likely to develop comorbidities,with significant impacts on patients'quality of life,exacerbation frequency,and survival.Traditional Chinese medicine(TCM)exhibits good therapeutic effects on improving the clinical symptoms,lung function and quality of life in patients with COPD.Herein,this article primarily summarized the key points of common syndromes,TCM nursing methods and healthy guidance of COPD,aiming at maintaining and developing the strengths of TCM,improving its efficacy and standardizing its behavior.

Research advances concerning the mechanism of glucocorticoid resistance in relation to traditional Chinese medicine for patients with chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease is a common,highly disabling,and burdensome disease.Anti-inflammatory glucocorticoid medication plays a key role in its treatment;however,glucocorticoid resistance in patients with chronic obstructive pulmonary disease considerably weakens the effects of the treatment.Despite recent advances in determining the mechanism of glucocorticoid resistance in patients with chronic obstructive pulmonary disease,the role of traditional Chinese medicine in treating such patients remains unclear.In this review,we reviewed the mechanism of chronic obstructive pulmonary disease-related glucocorticoid resistance with reference to the glucocorticoid receptor,the important signaling pathways(phosphatidylinositol-3-kinase/protein kinase B signaling pathway,p38 mitogen-activated protein kinase signaling pathway,and interferon-γ/Janus kinase/stransducer and activator of transcription signaling pathway),histone deacetylase,nuclear transcription factor-κB,exosomes,and microRNA.Moreover,the methods of establishing the glucocorticoid resistance model associated with chronic obstructive pulmonary disease and advances in therapeutic approaches including traditional Chinese medicine to restore chronic obstructive pulmonary disease glucocorticoid sensitivity have also been reviewed.This review shows that traditional Chinese medicine reverses glucocorticoid resistance mainly by regulating the expression of glucocorticoid receptor,p38 mitogen-activated protein kinase signaling,histone deacetylase 2,and nuclear transcription factor-κB in chronic obstructive pulmonary disease models.Future research is suggested to evaluate traditional Chinese medicine understanding of chronic obstructive pulmonary disease-related glucocorticoid resistance in relation to exosomes,microRNA,and other signaling pathways.

A new perspective of traditional Chinese and western medicine as a potential remedy to improve intestinal flora in the treatment of chronic kidney disease

Intestinal flora imbalance is closely related to the occurrence and development of various diseases,however,the relationship between intestinal flora and chronic kidney disease has also become a hot topic.Intestinal flora imbalance,intestinal pathogenic bacteria and toxins increase,causing renal damage,chronic kidney disease patients also have a decrease in intestinal beneficial bacteria,an increase in pathogenic bacteria,more and more experimental studies show that the treatment of chronic Kidney disease is closely related to maintaining the balance of intestinal flora.However,at this stage,it has not been widely used in clinical practice by improving the protection of intestinal flora imbalance and delaying the deterioration of renal function.Therefore,this paper mainly discusses the research on the improvement of intestinal flora imbalance in the treatment of chronic kidney disease by traditional Chinese and Western medicine,and provides a new perspective for the treatment of chronic kidney disease.

New treatment for gastroesophageal reflux disease:Traditional Chinese medicine Xiaochaihu decoction

Gastroesophageal reflux disease(GERD)has a high prevalence worldwide.Li et al performed a well-designed study on the efficacy of modified Xiaochaihu decoction(MXD)for GERD,which showed that MXD is an optional therapy for GERD beyond proton pump inhibitors(PPIs).The herbal granule administration mode minimized the bias from traditional herbal formula in clinical trials.One limitation of that study was that it lacked records of side effects and rescue medication.As a chronic disease with recurrent symptoms,GERD rehabilitation requires prolonged observation of the clinical course with MXD therapy.

Traditional Chinese medicine nursing protocols for leukorrheal disease( pelvic inflammatory disease)

Leukorrheal disease is an ascending infection of the female genital tract,with high morbidity among reproductive age women. Antibiotics are usually used to treat leukorrheal disease in clinic,but they can lead to a variety of side effects if improper use or long-time use. In recent years,traditional Chinese medicine( TCM) has shown its unique advantages in the treatment of leukorrheal disease. This article mainly explored the key points of common syndromes,TCM nursing methods and health guidance of leukorrheal disease in order to further develop the advantages of TCM,improve its efficacy and standardized its nursing behavior.

Traditional Chinese medicine nursing protocols for chronic renal failure

Chronic renal failure(CRF) is defined as the loss of renal function over a period of several years, finally progressing into the end-stage renal disease(ESRD). Nowadays, there are no effective methods to alleviate the process from the initial CRF to ESRD. In clinic, the integrated therapy of traditional Chinese and western medicine is frequently adopted for CRF in combination with hemodialysis, but in the process of treatment, traditional Chinese medicine(TCM) nursing plays a key role. This article mainly explored the key points of common syndromes, TCM nursing methods and health guidance of CRF in order to further develop the advantages of TCM, improve its efficacy and standardized its nursing behavior.

Advances in the Study on"Simmering Pus and Forming Flesh"in Treating Anorectal Diseases by External Treatment in Traditional Chinese Medicine

Due to the special perianal location,anorectal diseases are prone to form chronic refractory wounds after surgery,with Qi(气)deficiency and blood stasis as the main cause.As a classical theory in TCM medicine,"simmering pus and forming flesh"attaches great importance to harmonizing Qi and blood in the wound healing period,which gradually achieves significant efficacy in clinical application after anorectal disease surgery.Literatures in recent years on"simmering pus and forming flesh"method being applied to postoperative wound healing in all kinds of anorectal diseases(such as anal fistula,perianal abscess,anal fissure,mixed hemorrhoid,etc.)were reviewed,and advantages and characteristics of its clinical efficacy in anorectal diseases were summarized,so as to provide reference for postoperative wound healing and repair treatment in anorectal diseases.

Effects of acetylcysteine on micro-inflammation and pulmonary ventilation in chronic obstructive pulmonary disease exacerbation

BACKGROUND Acute exacerbation of chronic obstructive pulmonary disease(AECOPD)is a serious complication of chronic obstructive pulmonary disease,often characterized by increased morbidity and mortality.In traditional Chinese medicine,AECOPD is linked to phlegm-heat and blood-stasis,presenting symptoms like thick sputum,fever,and chest pain.It has been shown that acetylcysteine inhalation in conjunction with conventional therapy significantly reduced inflammatory markers and improved lung function parameters in patients with AECOPD,suggesting that acetylcysteine may be an important adjunctive therapy for patients with phlegm-heat-blood stasis type AECOPD.AIM To investigate the effect of acetylcysteine on microinflammation and lung ventilation in patients with phlegm-heat and blood-stasis-type AECOPD.METHODS One hundred patients with phlegm-heat and blood-stasis-type AECOPD were randomly assigned to two groups.The treatment group received acetylcysteine inhalation(10%solution,5 mL,twice daily)along with conventional therapy,whereas the control group received only conventional therapy.The treatment duration was 14 d.Inflammatory markers(C-reactive protein,interleukin-6,and tumor necrosis factor-alpha)in the serum and sputum as well as lung function parameters(forced expiratory volume in one second,forced vital capacity,and peak expiratory flow)were assessed pre-and post-treatment.Acetylcysteine inhalation led to significant reductions in inflammatory markers and improvements in lung function parameters compared to those in the control group(P<0.05).This suggests that acetylcysteine could serve as an effective adjunct therapy for patients with phlegm-heat and blood-stasis-type AECOPD.RESULTS Acetylcysteine inhalation significantly reduced inflammatory markers in the serum and sputum and improved lung ventilation function parameters in patients with phlegm-heat and blood-stasis type AECOPD compared with the control group.These differences were statistically significant(P<0.05).The study concluded that acetylcysteine inhalation had a positive effect on microinflammation and lung ventilation function in patients with this type of AECOPD,suggesting its potential as an adjuvant therapy for such cases.CONCLUSION Acetylcysteine inhalation demonstrated significant improvements in reducing inflammatory markers in the serum and sputum,as well as enhancing lung ventilation function parameters in patients with phlegm-heat and bloodstasis type AECOPD.These findings suggest that acetylcysteine could serve as a valuable adjuvant therapy for individuals with this specific type of AECOPD,offering benefits for managing microinflammation and optimizing lung function.

Anti-inflammatory effects of Tao Hong Si Wu Tang in mice with lung cancer and chronic obstructive pulmonary disease

BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.

Effect of a traditional Chinese medicine theory-based mobile app on improving symptoms in patients with type 2 diabetes mellitus:A randomized controlled trial

Objective:The aim of this study was to evaluate the effect of the Traditional Chinese Medicine(TCM)theory-based mobile app on improving symptoms in patients with type 2 diabetes mellitus(T2DM)in China.Materials and Methods:A randomized controlled trial was conducted.Ninety-seven patients with T2DM were enrolled and they were randomized into the control group and the experimental group.The control group was given usual diabetes education and follow-up with telephone call,while the experimental group was followed up by using the TCM theory-based mobile app.After 6-month intervention,the diabetic symptom scores,the blood glucose levels,and self-management ability of the two groups were compared.Results:Compared with intervention before,the levels of fasting blood glucose(FBG),2-h postprandial blood glucose(2hPG),and glycated hemoglobin(HbA1c)decreased in the control group(9.28±3.05 vs.8.26±2.73 mmol/L,12.65±4.18 vs.10.65±3.79 mmol/L,and 8.78%±1.76%vs.7.96%±1.47%,respectively,all P<0.05)and also decreased in the experimental group(8.36±2.64 vs.7.35±2.45 mmol/L,11.50±4.29 vs.9.85±2.71 mmol/L,and 8.64%±2.04%vs.7.29%±1.56%,respectively,all P<0.05)after 6-month intervention,while the summary of diabetes self-care activities(SDSCAs)scale scores after 6-month intervention increased significantly in the control group(35.20±14.68 vs.44.78±10.21,P<0.05)and the experimental group(32.16±13.21 vs.50.37±10.06,P<0.05).After 6-month intervention,the diabetic symptom scores(18.16±2.74 vs.22.18±4.77)and HbA1c(7.29±1.56%vs.7.96%±1.47%)were lower,and SDSCA scale scores(50.37±10.06 vs.44.78±10.21)were higher in the experimental group than the control group(all P<0.05).Conclusion:The mobile app based on TCM theory can effectively improve diabetes-related symptoms in patients with T2DM and help control their blood glucose as well as enhance their self-management ability.

Multifactor dimensionality reduction analysis of syndrome characteristics of chronic persistent asthma

Objective:To analyze the syndrome characteristics in patients with chronic persistent asthma.Methods:365 patients(121 males,244 females,60.829.1 years old)with chronic persistent asthma were enrolled in this cross-sectional study.The information of syndrome,symptoms,signs,tongue coating and pulse were collected from all patients.The syndrome characteristics of chronic persistent asthma were examined through the multifactor dimensionality reduction(MDR)analysis and the results were verified by the Chi-square test.Results:The results of the MDR analysis and the Chi-square test showed the following positive correlation of the interaction among:the deficiency syndrome of the lung and spleen and deep pulse,disinclination to talk due to lack of qi,fatigue,lassitude and thick tongue coating;the deficiency syndrome of the lung and kidney and dizziness and disinclination to talk due to lack of qi,fatigue,lassitude and pallid complexion;the syndrome of phlegm-heat obstructing the lung and rapid pulse,abdominal distension,disinclination to talk due to lack of qi,frequent urination and lassitude;the syndrome of phlegm-dampness obstructing the lung and disinclination to talk due to lack of qi,greasy coating,fatigue and lassitude.(P<.05 for all).Conclusion:The syndrome of chronic persistent asthma is characterized by fatigue and lassitude due to dysfunction of the lung,spleen and kidney.

Professor Zhang Hongchun's medication rule in treating patients with stable chronic obstructive pulmonary diseases

Based on the Traditional Chinese Medicine Inheritance Support System(TCMISS),the medication rule of Professor Zhang Hongchun in treating patients with chronic obstructive pulmonary diseases(COPD)in stable period was carried out.The prescriptions of Professor Zhang Hongchun in treating COPD patients in stable period were collected and analyzed by frequency statistics,association rules and complex system entropy clustering.A total of 111 prescriptions were screened out,including 106 kinds of traditional Chinese medicine,which were mainly warm,cold and flat,and mainly sweet,bitter and pungent.The meridians were mostly attributed to lung,spleen,liver and kidney meridians.34 core combinations of drugs were extracted,and 38 association rules with confidence level of one were obtained.Three new prescriptions were obtained.The core prescriptions were:Angelicae Sinensis Radix(15g),Pseudostellariae Radix(30g),Cornus Officinalis Sieb Et Zucc(15g),Schisandrae Chinensis Fructus(15g),Farfarae Flos(15g),Asteris Radix Et Rhizoma(15g),Poria Cocos(Schw.)Wolf(15g),Perillae Fructus(15g),Perilla Frutescens(15g),Ephedra Herba(10g),Licorice(3g).Professor Zhang Hongchun's treatment methods of COPD patients in stable stage are to invigorate lung,spleen and kidney,and to stop cough,eliminate phlegm and asthma,promote Qi,activate blood circulation and dissipate blood stasis.

The progress of nutritional support for chronic obstructive pulmonary disease

The patients with chronic obstructive pulmonary disease (COPD) often occur weight loss and reduced muscle mass, which leads to decreased exercise capacity and vital capacity. The nutritional status is closely related to the prognosis of patients with COPD and nutritional support has played an important role in the treatment of COPD. In order to provide proper nutritional support, this article reviews the progress of nutritional support in COPD from the causes of malnutrition, energy demand assessment, assessment of nutritional risk and nutritional support methods. Moreover, this review specially reviewed the application of traditional Chinese medicine diet.

发酵虫草菌粉治疗慢性肾脏病4期患者的预后效果:基于回顾性队列研究

背景慢性肾脏病(CKD)是世界性公共卫生问题,CKD 4期是CKD病程中一个关键的阶段,标志着肾功能的显著下降和症状的明显出现。发酵虫草菌粉虽然长期应用于CKD的治疗之中,但其对CKD的预后影响尤其是CKD 4期的疗效缺乏循证医学证据。目的 探索发酵虫草菌粉治疗CKD 4期患者的长期预后情况及影响预后的潜在相关因素。方法 选取2013—2022年于上海中医药大学附属龙华医院肾病科住院诊断为CKD 4期的患者631例为研究对象。在中西医结合治疗的基础上,根据是否使用发酵虫草菌粉分为虫草治疗组(339例)和中西医结合治疗组(252例)。收集患者基本信息、是否伴随糖尿病、发生终点事件情况及进入终点事件时间、确诊CKD 4期时间及确诊时相关实验室指标等资料。采用倾向性得分匹配消除组间基线差异后,通过Cox比例风险回归分析影响CKD 4期患者预后的潜在相关因素;采用Kaplan-Meier法绘制CKD 4期患者预后的生存曲线,采用Log-rank检验比较组间生存情况差异。结果 按1∶1比例匹配后最终共纳入378例患者。多因素Cox比例风险回归分析结果显示,使用发酵虫草菌粉(HR=0.79,95%CI=0.64~0.98,P=0.030),估算肾小球滤过滤(HR=0.97,95%CI=0.94~1.00,P=0.025)、血清白蛋白(HR=0.97,95%CI=0.96~0.99,P=0.002)水平升高可延长CKD 4期患者的生存时间;男性(HR=1.37,95%CI=1.09~1.71,P=0.006)、脑利钠肽(HR=1.00,95%CI=1.00~1.00,P=0.003)、血磷(HR=2.44,95%CI=1.63~3.67,P<0.001)和24 h尿蛋白(HR=1.00,95%CI=1.00~1.00,P<0.001)水平升高可缩短CKD 4期患者的生存时间。生存曲线分析结果显示,虫草治疗组累积生存率高于中西医结合治疗组(HR=0.70,95%CI=0.57~0.86,P<0.001);低尿蛋白水平亚组中,虫草治疗患者累积生存率高于中西医结合治疗患者(HR=0.67,95%CI=0.52~0.85,P=0.001);高尿蛋白水平亚组中,两治疗组累积生存率比较,差异无统计学意义(P=0.518)。结论 长期使用发酵虫草菌粉能够延缓CKD 4期患者肾功能进展,在积极控制尿蛋白的前提下可发挥更好的临床疗效。较低水平的脑利钠肽和血磷、较高水平的血清白蛋白也是CKD 4期患者良好预后的潜在因素。

结肠透析联合中药保留灌肠治疗慢性肾脏病3b~4期患者的疗效观察

目的观察结肠透析联合中药保留灌肠治疗慢性肾脏病(CKD)3b~4期患者的临床疗效。方法将82例患者随机分为治疗组42例(结肠透析+中药保留灌肠)与对照组(结肠透析)40例,疗程8周,记录治疗前后中医症状积分、检测血肌酐(SCr)、尿素氮(BUN)、胱抑素-C(Cys-C)、尿酸(UA)、白蛋白(ALB)、肾小球滤过率(eGFR)、尿白蛋白/肌酐比值(ACR)、24 h尿蛋白定量(UTP)等指标的变化并进行统计分析,评价结肠透析联合中药保留灌肠治疗CKD 3b-4期患者的临床效果。结果与治疗前比较,两组治疗后腰膝酸软、气短懒言、倦怠乏力、面浮肢肿、纳呆腹胀、大便秘结症状积分下降(P<0.05);治疗后,治疗组中医症状积分明显低于对照组(P<0.05)。组内比较,治疗组治疗后SCr、BUN、CyS-C、UA、ACR、UTP下降,ALB、eGFR升高(P<0.05)。对照组治疗后CyS-C、ACR、UTP下降,eGFR升高(P<0.05);治疗后组间比较:治疗组SCr、BUN、CyS-C、UA、ACR、UTP下降明显,ALB升高明显(P<0.05)。中医症候疗效:治疗组80.95%,对照组60.00%,治疗组疗效明显优于对照组(P<0.05);临床总有效率:治疗组85.71%、对照组60.00%,治疗组总有效率明显优于对照组(P<0.05)。结论结肠透析联合中药保留灌肠治疗可改善CKD 3b~4期患者的中医症状及肾功能,延缓病情进展,临床疗效确切。

赵氏雷火灸腧穴疗法对慢性肾脏病3~4期脾肾气虚证患者的护理效果观察

目的探究赵氏雷火灸腧穴疗法联合中药汤剂治疗慢性肾脏病3~4期脾肾气虚证患者的疗效及护理对策。方法选取启东市中医院肾病内分泌科2023年5月—2024年3月收治的慢性肾脏病3~4期脾肾气虚证患者80例,按照组间基线资料均衡可比的原则将其分为对照组和观察组,每组40例。在常规治疗和护理的基础上,对照组给予自拟肾衰方合香砂六君子汤加减方;观察组在对照组基础上联合使用赵氏雷火灸腧穴疗法。比较两组患者的临床疗效,干预前后中医证候积分、肾功能指标[肾小球滤过率(eGFR)、尿素氮(BUN)和血肌酐(Scr)]、自我效能和生活质量,以及治疗期间不良反应发生情况。结果干预后,观察组患者中医证候积分均低于对照组,差异有统计学意义(P<0.05)。观察组中医证候疗效评估总有效率高于对照组,差异有统计学意义(P<0.05)。干预后,观察组患者Scr和BUN均低于对照组,eGFR高于对照组,差异有统计学意义(P<0.05)。干预后,观察组患者一般自我效能感量表(GSES)及肾脏疾病生活质量简表(KDQOL-SFTM)各维度评分均高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者均未出现不良反应。结论赵氏雷火灸腧穴疗法联合使用中药汤剂,不仅可以有效改善治疗慢性肾脏病3~4期脾肾气虚证患者的临床症状和生活质量,还具有良好的安全性。

Traditional Chinese Practice,A Promising Integrative Intervention for Chronic Non-Infectious Disease Management

The number of people with chronic diseases rises rapidly in recent years worldwide. Except for drug medication, mind-body exercises are indispensable for chronic disease management. Traditional Chinese practice （TCP）, as an integrative intervention, is known as an effective means to keep in good health and fitness, as well as help regulate emotion. This paper introduces the domestic and overseas studies on effectiveness of TCP for chronic diseases, and explores the key action links from three aspects, including functional training of multiple-joint guided by consciousness, relieving psychological risk factors, improving respiratory and digestive function, blood and lymph circulation through respiratory training, and regulation of nerve, metabolic, and immune system. Finally, the authors discussed how to integrate TCP in the chronic disease management, and put forward that the practice methods and evaluation standard should be assessed academically.