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Plant Tissue Culture and Biosynthesis Provide a Fast Way to Produce Active Constituents of Traditional Chinese Medicines 被引量:1
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作者 Chang-xiao Liu 《Chinese Herbal Medicines》 CAS 2017年第2期99-100,共2页
The plant kingdom has provided literally thousands of natural products with widely diverse chemical structures and a vast array of biological activities.Many of them have seen subsequent application in discovery of ne... The plant kingdom has provided literally thousands of natural products with widely diverse chemical structures and a vast array of biological activities.Many of them have seen subsequent application in discovery of new druids and the pharmaceutical industry and clinical therapeutic application. 展开更多
关键词 OVER Plant Tissue Culture and Biosynthesis Provide a Fast Way to Produce Active constituents of traditional chinese medicines
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Chinmedomics:Newer Theory and Application 被引量:4
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作者 Xi-jun Wang Ai-hua Zhang +1 位作者 Hui Sun Guang-li Yan 《Chinese Herbal Medicines》 CAS 2016年第4期299-307,共9页
The scientific interpretation of the effectiveness of traditional Chinese medicine(TCM) is a communication channel between Chinese medicine and modern medicine. The evaluation of TCM efficacy is an important prerequ... The scientific interpretation of the effectiveness of traditional Chinese medicine(TCM) is a communication channel between Chinese medicine and modern medicine. The evaluation of TCM efficacy is an important prerequisite for discovering active constituents. Therefore, there is an urgent need to establish a biological language for scientific explanation of the effectiveness of TCM, and modern scientists can further accept the significant value of TCM theory and its clinical practice. The syndrome and corresponding formulation are two important parts in TCM, and they are directly related to the effectiveness of TCM. Our team has taken syndrome and formulation as the research objects, integrated serum pharm-chemistry of TCM with metabolomics technology, developed a new platform termed Chinmedomics, which is capable of evaluating effectiveness of TCM and discovering the syndrome biomarkers as well as the effective substances. The correlation between the endogenous biomarkers of syndrome and exogenous constituents of formulation is analyzed to find the highly associated compounds as the effective substances, and further clarifying their activities, and may discover lead compounds. This effective strategy could speed the drug discovery from natural resources. This article systematically introduced the establishment and application of Chinmedomics theory, in order to provide references for studies on TCM, and some characteristic examples are presented to highlight the application of this new strategy for discovering the potential active constituents of TCM. 展开更多
关键词 active constituents biomarkers Chinmedomics effectiveness traditional chinese medicine
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