Granulomatous lobular mastitis treated by a combined internal and external treatment of traditional Chinese medicine:A case report

BACKGROUND Granulomatous lobular mastitis(GLM)is a rare benign inflammatory disease of the breast and is classified under comedo mastitis in traditional Chinese medicine(TCM).The etiology of this disease is unknown,and it mainly occurs in women of childbearing age.The diagnosis depends on histopathological biopsy.At present,there is no systematic and standardized treatment plan for GLM.In the absence of evidence supporting an infectious etiology,affected patients might continue to receive multiple courses of antibiotics and unnecessary surgery.CASE SUMMARY A 37-year-old Chinese woman with a history of coronavirus disease 2019 infection presented with swelling and pain in the left breast.She also had erythema,nodules in the lower extremities,arthritis in both knees,cough,and headache.In the early stage of GLM,the mass was not significantly reduced by conservative treatment with internal application of TCM;hence,surgical treatment was carried out.The aim of postoperative treatment was to drain the pus,eliminate the necrosed tissue,and expand the muscles;fumigation and washing using TCM was applied.CONCLUSION Combined internal and external treatment with TCM,following the principle of“Prioritize internal treatment before ulceration and emphasize external treatment after ulceration”was effective in our patient with GLM.The prognosis was good.We believe that TCM offered valuable therapeutic benefits in this disease.

Research progress on the anti-colorectal cancer effect of traditional Chinese medicine active ingredients based on ferroptosis

Ferroptosis is defined as an iron-dependent form of regulated cell death that is initiated by the toxic accumulation of lipid peroxides on cellular membranes.In the past decade,ferroptosis has aroused considerable interest in comprehensive treatment of colorectal cancer,mainly as it is a specific cell death mode that is mechanistically and morphologically differ from other forms of cell death such as autophagy,apoptosis,and pyroptosis,following by holding a giant potential for the therapy of colorectal cancer.Research has found that various active ingredients in traditional Chinese medicine possess the ability of inducing ferroptosis in colorectal cancer cells through pathways such as lipid metabolism,iron metabolism,or cysteine/glutamate transporter system,which demonstrating enormous clinical therapeutic potential.In this review,the metabolic regulatory network of ferroptosis is introduced from the perspective of ferroptosis mechanism,and the information on the induction of ferroptosis in colorectal cancer cells by active ingredients of traditional Chinese medicine is also be retrospected,which the purpose is to provide novel strategies for the anti-colorectal cancer therapy of active ingredients in traditional Chinese medicine.

Advances in the management of arteriosclerosis of the lower extremity:Integrating Western and Chinese medicine approaches

This editorial provides a commentary on the recent article.The paper reviews current literature and explores innovative treatment strategies for lower extremity arteriosclerosis obliterans(LEASO)through an integrative approach.It highlights the effectiveness of combination therapies that merge traditional Chinese medicine(TCM)with Western medical practices,suggesting that such integrative methods may improve patient compliance and outcomes through personalized care.This paper stresses the importance of rigorous clinical trials to evaluate the efficacy and safety of TCM interventions within LEASO treatment protocols,advocating for evidence-based validation of these combined therapies.Our recommendations emphasize accurate diagnosis,appropriate pharmacological in-terventions,the use of advanced surgical and endovascular techniques,and the inclusion of TCM to address underlying dysfunctions.Additionally,continuous monitoring,patient education,and lifestyle modifications are essential to slow disease progression and achieve optimal patient outcomes.The paper concludes by calling for further research to develop standardized treatment protocols that effectively integrate both Western and Chinese medical approaches in managing LEASO.

Therapeutic strategy in colorectal cancer based on Traditional Chinese and Western Medicine: from the lipid metabolism perspective

Colorectal cancer(CRC)is a major cause of morbidity and mortality and is closely associated with lipid metabolism,of which fatty acid metabolism,the release of fat factors and the abnormal level of blood lipids are all important pathogenic mechanisms.With the increasing awareness of lipid metabolism,advances in lipid-regulating therapy have made it possible for anti-tumor effect in CRC.However,there are still many research gaps and limitations.Given the complexity and uncertainty of targeted lipid-regulating therapy for CRC,traditional Chinese medicine(TCM)may have a leg up when it comes to the theory of“holistic concept”and“treatment based on syndrome differentiation”.Meanwhile,proper dietary direction,healthy lifestyles,and normal serum lipid levels contribute directly to the prognosis of CRC patients.

Combined effect of Traditional Chinese Medicine decoction and low-molecular-weight heparin calcium on the postoperative deep venous thrombosis in patients with lower limb fracture

OBJECTIVE: To investigate the combined effect of Traditional Chinese Medicine(TCM) decoction and low-molecular-weight heparin calcium on deep vein thrombosis(DVT) induced by surgery in patients with lower limb fracture.METHODS: Totally 86 hospitalized patients with DVT after surgery of lower limb fracture between September 2012 and January 2015 were recruited and randomly divided into control group and observation group, 43 cases in each group. The patients in the control group were treated with subcutaneous injection of low-molecular-weight heparin calcium, and those in the observation group were additionally given Danshen Injection and TCM decoction. The differences between two groups in occurrence rate, medication time, therapeutic effects,recurrence rate of thrombosis, activated partial thromboplastin time(APTT), and prothrombin time(PT) were compared.RESULTS: The occurrence rate of DVT in observation group(4.65%, 2/43) was lower than that in control group(27.91%,12/43)(P<0.05). The medication time of observation group was(6.15±2.94) d, shorter than(9.76±3.12) d in the control group(P<0.05). In observation group, 2 cases of DVT were cured(2/2); in the control group, 9 cases presented therapeutic effects and the total effective rate was 75.00%(9/12). The improvement of APTT and PT in the observation group was better than that in the control group(P<0.05).CONCLUSION: Integrative TCM decoction plus low-molecularweight heparin calcium is superior to applicaton of low-molecularweight heparin calcium alone in reducing and treating DVT in the postoperative patients with lower limb fracture.

Effect of Traditional Chinese Medicine combined with Western Medicine on blood lipid levels and inflammatory factors in patients with angina pectoris in coronary heart disease identified as intermingled phlegm and blood stasis syndrome:a network Meta-anal

OBJECTIVE:To evaluate the clinical efficacy of Traditional Chinese Medicine prescriptions for resolving phlegm in the treatment of angina pectoris of phlegmstasis coronary heart disease by a network Meta-analysis.METHODS:Randomized controlled trials(RCTs)on clinical efficacy of CHD angina pectoris with interaction of phlegm and blood stasis were searched in PubMed,Springer,the Cochrane Library and Chinese-language databases China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Data from their inception to December 2021.Literature was screened and literature bias risk was assessed by RevMan5.4 software.The overall response rate,the duration of angina attack,the levels of serum lipids such as total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),and high density lipoprotein cholesterol(HDL-C),and expression of hypersensitive C-reactive protein(hs-CRP)were selected as outcome indicators for network Meta-analysis and mapped using Stata15.1 software.RESULTS:Totally,26 RCTs were included,involving 2098 participants.There were 6 TCM formulas with the effects of dispelling phlegm and removing blood stasis.Taking conventional Western Medicine as the common intervention measures,the results showed that the overall response improvement rate from high to low was displayed as modified Xiaoxianxiong decoction(小陷胸汤,MXD),Danlou tablet(丹蒌片,DT),modified Gualou Xiebai Banxia decoction(瓜蒌薤白半夏汤,MGXBD),modified Wendan decoction(温胆汤,MWD),modified Zhishi Xiebai Guizhi decoction(枳实薤白桂枝汤,MZXGD),and modified Erchen decoction(二陈汤,MED).The sequence of angina attack duration improvement from high to low was MZXGD,MGXBD,DT,MWD,MXD.The sequence of TC improvement from high to low was MZXGD,MED,DT,and MGXBD.Sequence of improving TG from high to low was MED,MZXGD,MGXBD,and DT.For LDL-C improvement,the effect from good to poor was MZXGD,MGXBD,DT,and MED.With regard to HDL-C improvement,the effect was ranked as MED,MZXGD,MGXBD,and DT from good to poor.hs-CRP expression from high to low was MZXGD,MXD,MED,MWD,and MGXBD.CONCLUSION:TCM formula with the effects of dispelling phlegm and removing blood stasis combined with conventional Western Medicine has obvious advantages in treating CHD angina pectoris with interaction of phlegm and blood stasis.MZXGD has great potential in increasing the overall response rate,reducing Duration of angina attack improving blood lipids,and reducing inflammatory factors.However,due to the limitations of extant studies,the conclusions of this study need to be confirmed by numerous reasonably-designed RCTs.

中药复方干预肥胖型多囊卵巢综合征糖脂代谢异常的Meta分析

目的:通过文献研究阐述中药干预肥胖型多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者代谢异常的有效性及安全性。方法:计算机检索国内外主流医药数据库中关于中医、中西医结合对比单纯西药治疗PCOS的随机对照试验(randomized controlled trial,RCT)。参照Cochrane系统评价手册对全文的设计方案进行质量评价,采用RevMan 5.4软件进行Meta分析。结果:纳入22项RCT进行Meta分析,中药或中西药联合治疗不仅在提升排卵率这一主要研究指标上优于单纯西药治疗(P<0.05),还在改善胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMA-IR)、空腹胰岛素(fasting insulin,FINS)、体质量指数(body mass index,BMI)、三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白(low density lipoprotein,LDL)、高密度脂蛋白(high density lipoprotein,HDL)等方面优于单纯西药治疗(均P<0.05),但在调节空腹血糖(fasting blood glucose,FBG)和腰臀比(waist-to-hip ratio,WHR)方面与西药治疗差异无统计学意义(均P>0.05)。结论:中药或中西药联合干预肥胖型PCOS糖脂代谢异常,具有多途径、多靶点调控作用,无严重不良反应,优于单纯西药治疗。

西藏门巴族人群胰岛细胞功能、脂质代谢、炎症反应与中医体质的相关性研究

目的探讨西藏门巴族人群胰岛细胞功能、脂质代谢和炎症反应与中医体质的相关性。方法选取2023年1月—2023年6月墨脱村、亚东村、朗杰岗村、巴日村、德吉村、玛迪村6个门巴族乡的门巴族人群进行调查,共计237例。分析人群中医体质分布情况,同时比较前三位中医体质人群的胰岛细胞功能、脂质代谢和炎症因子水平。结果中医体质类型中以痰湿质、湿热质和气虚质为主,分别占32.07%、26.16%和18.57%。痰湿质组、湿热质组和气虚质组性别、年龄、体质量指数比较,差异均无统计学意义(P>0.05)。湿热质组空腹血糖和胰岛素抵抗指数分别为(4.98±0.83)mmol/L和(1.75±0.32),均低于痰湿质组和气虚质组(P<0.05),湿热质组胰岛β细胞功能指数为(94.45±9.11),均高于痰湿质和气虚质组(P<0.05);湿热质组总胆固醇和甘油三酯分别为(3.98±0.99)mmol/L和(1.02±0.29)mmol/L,均低于痰湿质组和气虚质组(P<0.05),湿热质组高密度脂蛋白胆固醇为(1.26±0.20)mmol/L,均高于痰湿质组和气虚质组(P<0.05)。痰湿质、湿热质和气虚质组血清白细胞介素-6、超敏c反应蛋白、肿瘤坏死因子-α比较,差异均无统计学意义(P>0.05)。结论西藏门巴族人群中医体质以痰湿质、湿热质和气虚质为主,其中湿热质人群胰岛细胞功能、脂质代谢优于痰湿质和气虚质人群,炎症因子比较无差异。

下肢洗剂治疗膝骨关节炎临床观察

目的探讨下肢洗剂治疗膝骨关节炎的效果。方法选择60例膝骨关节炎患者作为研究对象,将其随机分成试验组和对照组,各30例。对照组给予双氯芬酸二乙胺乳胶剂外用,试验组给予下肢洗剂外用,2组均持续治疗2周。观察2组的临床疗效,比较2组治疗前后西安大略大学和麦克马斯特大学骨关节炎指数(WOMAC)量表评分、膝关节综合评分、血清学指标变化情况,以及不良反应发生情况。结果试验组的愈显率为66.67%(20/30),高于对照组的50.00%(15/30),差异有统计学意义(P<0.05)。治疗后,2组患者的WOMAC量表评分、膝关节综合评分及白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)水平均有不同程度下降,且试验组下降程度大于对照组,差异有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论下肢洗剂对于阳虚寒凝型膝骨关节炎具有治疗作用,可以很好地改善其临床症状,使血清炎性因子水平降低,在临床有一定的应用推广价值。

针刺结合引火归元穴位贴敷治疗上实下虚型颈性眩晕临床观察

目的观察针刺结合引火归元穴位贴敷治疗上实下虚型颈性眩晕的临床效果。方法选取120例上实下虚型颈性眩晕患者,按随机数字表法分为针刺组、引火归元组、针刺+引火归元组与西药组并行相应治疗,每组30例。比较四组治疗前后颈性眩晕症状与功能评估量表评分、血清内皮型一氧化氮合酶(eNOS)及人降钙素基因相关肽(CGRP)水平变化,治疗结束后3个月进行回访比较复发率。结果治疗后,四组颈性眩晕症状与功能评估量表评分均较治疗前显著升高,且针刺+引火归元组升高幅度大于其余三组(P<0.05);四组血清eNOS、CGRP水平均较治疗前显著升高,且针刺+引火归元组升高幅度大于其余三组。治疗结束3个月后,针刺+引火归元组复发率为26.67%(8/30),低于其余三组。结论常规针刺、引火归元穴位贴敷、针刺结合引火归元穴位贴敷与口服甲磺酸倍他司汀片等方法对上实下虚型颈性眩晕患者均疗效确切,且针刺结合引火归元穴位贴敷效果最优、复发率最低,值得推广。

清金化痰汤治疗糖尿病合并下呼吸道感染临床观察

目的分析清金化痰汤加减治疗糖尿病合并下呼吸道感染的可行性。方法拟选取宜丰县人民医院2021年1月—2022年12月收治的糖尿病合并下呼吸道感染患者60例,分为对照组、观察组,各30例。统计分析两组临床症状恢复时间(发热、咳嗽、全身症状、局部症状)、血糖情况、炎症因子水平[白细胞、C反应蛋白(CRP)]、并发症发生情况(消化道反应、皮疹、心动过缓等)、临床疗效。结果治疗后,观察组患者的发热、咳嗽、局部症状、全身症状恢复时间均短于对照组(P<0.05);观察组空腹血糖水平、餐后2 h血糖水平、白细胞计数、CRP水平均低于对照组(P<0.05);观察组并发症总发生率3.33%(1/30)低于对照组的26.67%(8/30)(P<0.05);观察组治疗总有效率96.67%(29/30)高于对照组的73.33%(22/30)(P<0.05)。结论清金化痰汤加减治疗糖尿病合并下呼吸道感染的可行性高。

改良冰肌散联合气压疗法预防股骨骨折下肢深静脉血栓临床观察

目的探究改良冰肌散联合气压疗法预防股骨骨折下肢深静脉血栓(LDVT)的临床疗效。方法采用回顾性观察性研究,选取2019年1月—2020年6月江西中医药大学附属医院骨科收治的股骨骨折患者60例。其中对照组30例行冰肌散涂药治疗,研究组30例行冰肌散涂药联合气压治疗。比较两组患者LDVT的发生率、疼痛视觉模拟量表(VAS)评分、下肢肿胀的变化及不良反应发生率。结果与对照组比较,研究组患者LDVT的发生率、下肢肿胀发生率及VAS评分均显著降低(P<0.05)。研究组治疗总有效率为93.33%(28/30),高于对照组的80.00%(24/30)(P<0.05)。两组患者治疗期间均未出现不良反应。结论改良冰肌散联合气压疗法预防股骨骨折LDVT的临床显著。

铁死亡在骨关节炎中的作用机制及其中医药干预研究进展

背景:有研究发现,软骨细胞铁死亡可作为重要的发病机制诱导骨关节炎的发生与发展。随着祖国医学的不断发展,有学者发现某些中药单体、中药复方等可通过多种作用机制抑制软骨细胞发生铁死亡,最终起到治疗骨关节炎的作用。目的:探讨铁死亡与骨关节炎的关系及中医药干预铁死亡治疗骨关节炎的作用机制,以期为骨关节炎的治疗及预防提供新的思路。方法:以“铁死亡,骨关节炎,软骨细胞,脂质代谢,中医药,活性氧,谷胱甘肽过氧化物酶”为中文检索词,以“osteoarthritis,ferroptosis,chondrocytes,lipid metabolism,traditional Chinese medicine,ROS,GPX4”为英文检索词,检索中国知网、PubMed、万方、维普等数据库,筛选各数据库建库至2022年铁死亡与骨关节炎及其中医药干预研究的相关文章,并进行系统的整理分析。结果与结论:①细胞内铁超载会引发脂质过氧化反应,造成活性氧积累,最终导致铁死亡的发生,而铁过量会加速软骨细胞凋亡,影响软骨细胞的稳态,进而诱导骨关节炎的发生。②氨基酸代谢异常时,谷氨酸与胱氨酸交换失衡,导致谷氨酸在细胞外积聚,进而导致谷胱甘肽被耗尽,间接抑制了铁死亡相关因子的功能,对铁死亡起到促进作用。③细胞脂质代谢异常时,细胞膜的重要组成部分不饱和脂肪酸失去双烯丙基氢原子,导致细胞被破坏诱发铁死亡,而脂质代谢与骨关节炎的发生发展密切相关。④中医药可以通过干预诱导铁死亡发生的相关机制对骨关节炎起到防治作用。目前对铁死亡的研究仍不成熟,继续深入研究其作用机制,有望为临床治疗骨关节炎开辟新途径。

参葛方联合生活饮食运动干预治疗肝功能异常代谢相关脂肪性肝病的临床观察

目的观察参葛方联合生活饮食运动干预治疗肝功能异常代谢相关脂肪性肝病(MAFLD)的临床疗效及对患者血清CD44水平的影响。方法将70例脾虚痰湿兼有血瘀型肝功能异常MAFLD患者随机分为对照组和治疗组,每组35例,两组均给予生活饮食运动干预,治疗组加用参葛方,对照组加用参葛方安慰剂,疗程均为12周。观察临床疗效,比较磁共振成像质子密度脂肪含量(MRI-PDFF)及血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、γ-谷氨酰转移酶(GGT)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、CD44水平的变化情况。结果(1)最终完成试验者64例,其中治疗组32例、对照组32例。(2)治疗组、对照组总有效率分别为75.0%、46.9%,治疗组临床疗效优于对照组(P<0.05)。(3)治疗前后组内比较,两组MRI-PDFF值降低(P<0.05),治疗组血清CD44水平降低(P<0.05);组间治疗后比较,治疗组MRI-PDFF值、血清CD44水平低于对照组(P<0.05)。(4)治疗前后组内比较,治疗组血清ALT、AST、GGT水平降低(P<0.05),对照组AST水平降低(P<0.05);组间治疗后比较,治疗组血清ALT、AST、GGT水平低于对照组(P<0.05)。(5)治疗前后组内比较,治疗组血清TG、TC、LDL水平降低(P<0.05),对照组TG水平降低(P<0.05);组间治疗后比较,治疗组TG水平低于对照组(P<0.05)。结论参葛方联合生活饮食运动干预治疗脾虚痰湿兼有血瘀型肝功能异常MAFLD患者疗效满意,能有效缓解患者的临床症状,改善肝脏脂质沉积及肝功能异常,调节血脂水平,其机制可能与调节血清CD44表达有关。

糖尿病肾脏疾病合并脂代谢紊乱的中西医治疗进展

糖尿病肾脏疾病(DKD)发病机制复杂,涉及代谢紊乱、氧化应激、炎症等多个方面。脂代谢作为人体重要的代谢过程之一,与DKD患者疾病进展密切相关。现代医学多通过干预生活方式,使用降糖、降脂药物等手段调节DKD患者糖脂代谢,在一定程度上改善患者预后。中医药治疗DKD合并脂代谢紊乱,在临床制剂及有效成分提取物开发方面,取得一定成果。

1例宫颈癌术后双下肢淋巴水肿患者的中医特色护理体会

本文总结1例宫颈癌术后双下肢淋巴水肿患者的中医特色护理经验。基于辨证分型,在完善护理评估、用药指导等常规护理的基础上,采用穴位贴敷、刺络拔罐等中医特色护理措施,,积极改善微循环,加强皮肤护理,减轻患者水肿程度,促进患者日常活动能力恢复。

代谢综合征中医证型与脂质蓄积指数相关性研究

目的探讨代谢综合征(metabolic syndrome,MS)中医证型与脂质蓄积指数(lipid accumulation product,LAP)的关系。方法研究旨在回顾分析2021年9月—2023年3月黑龙江中医药大学附属第一医院心血管一科收治的160例MS患者的临床资料。根据中医辨证分型方法进行分类,研究将患者分为4组,即气滞湿阻型组、痰瘀互结型组、脾肾气虚型组和气阴两虚型组,各40例患者,另设40例体检患者为健康对照组。比较不同中医证型MS患者LAP等代谢指标水平的差异。结果MS患者的LAP水平明显高于健康对照组(P<0.05);LAP水平从低到高顺序依次为健康对照组<脾肾气虚型组<气阴两虚型组<气滞湿阻型组<痰瘀互结型组。结论①LAP水平与MS具有相关性。②LAP水平可以作为MS中医辨证分型的重要参考指标。

基于CiteSpace的中医药治疗下肢缺血性疾病的文献计量学研究

目的探讨中医药治疗下肢缺血性疾病的研究情况,研究该领域的热点与发展趋势。方法检索2012年1月至2022年12月中国知网(CNKI)和科学引文索引数据库(WOS)相关文献,应用CiteSpace软件分析纳入文献的发文量、国家、机构、作者、共被引文献和关键词等信息并生成知识图谱。结果共纳入1447篇中文文献和58篇英文文献,年发文量总体稳步增长,但中文文献2020年来有所下降。祛腐生新、益气活血等是关键治疗原则,糖尿病足是热点研究病种,中药泡足、穴位按摩等外治方法关注度较高,黄芪和地黄药对以及肉桂醛、阿魏酸、黄芪甲苷等有效成分极受关注,胱硫醚γ裂解酶(CSE)-硫化氢(H2S)-血管内皮生长因子(VEGF)轴以及磷脂酰肌醇3激酶(PI3K)/蛋白激酶B(AKT)和丝裂原活化蛋白激酶(MAPK)信号通路受高度关注。结论当前本领域形成以中国为中心的国际合作网,并逐步发展。但各机构、作者间交流合作不足,需加强。糖尿病足的治疗为研究热点,结果多为临床疗效报道,相关机制值得深入挖掘。

加味柴胡疏肝散辅助治疗冠脉痉挛心绞痛随机对照研究

目的探讨加味柴胡疏肝散辅助治疗冠脉痉挛心绞痛的疗效。方法随机将126例2019年10月—2022年8月河南中医药大学第二附属医院心内科收治的冠脉痉挛心绞痛患者分为对照组(63例)和试验组(63例)。对照组给予阿托伐他汀钙片、酒石酸美托洛尔缓释片、阿司匹林肠溶片、硝酸甘油片,试验组在此基础上加用加味柴胡疏肝散,两组均治疗4周。比较两组治疗4周后的疗效,对比两组治疗前和4周后的临床相关指标、中医症状评分、血脂水平、心功能及治疗期间的安全性。结果与对照组治疗4周后的总有效率(79.37%,50/63)比较,试验组总有效率更高[93.65%(59/63),P<0.05]。治疗4周后,两组心绞痛持续时间与治疗前比较均缩短,试验组短于对照组(P<0.05);两组心绞痛发作次数、硝酸甘油片用量与治疗前比较均减少,试验组少于对照组(P<0.05);两组胸闷胸痛、心烦急躁、心悸、口干口苦评分及血清低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、总胆固醇(total cholesterol,TC)、三酰甘油(triacylglycerol,TG)、心肌肌钙蛋白I(cardiac troponin I,CTnI)、缺血修饰蛋白(ischemic modification protein,IMA)、心脏型脂肪酸结合蛋白(cardiac fatty acid binding protein,H-FABP)水平与治疗前比较降低,试验组低于对照组(P<0.05);两组血清高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)水平及左心射血分数(left ventricular ejection fraction,LVEF)、心脏指数(cardiac index,CI)、心输出量(cardiac output,CO)与治疗前比较升高,试验组高于对照组(P<0.05)。试验组和对照组治疗期间的不良反应总发生率比较差异无统计学意义(P>0.05)。结论加味柴胡疏肝散辅助治疗冠脉痉挛心绞痛可有效调节患者血脂水平,改善心功能,进而可促进患者中医症状及临床症状的改善,提高疗效,且具有良好的安全性。

以lipid A为靶点应用生物传感器技术筛选抗炎中药

目的应用生物传感器跟踪检测技术从传统抗炎中药中筛选具有拮抗内毒素作用的中药,并对其进行活性物质含量排序。方法将lipid A包被于生物传感器的非衍生板,建立靶点,测定22种去鞣质后的中药水煎液与lipid A的亲和力;选择具有较高亲和力的药物与定量脂多糖(5ng/mL)于37℃混合孵育30min,再测定其与lipid A的亲和力,以评价药物水提液中活性物质的含量。结果22种中药均具有与lipid A较高的亲和力(大于100RU);侧柏叶、地骨皮、石榴皮等16种中药中与lipid A特异性结合的活性物质含量较高。结论应用生物传感器技术建立的筛选平台快速而客观,筛选出的16种中药均含有能与lipid A发生特异性结合作用的非鞣质类活性物质。