Application and Practice of Traditional Chinese Medicine Characteristic Technology Inheritance in Research and Development of Traditional Chinese Medicine Preparations in Medical Institutions

Medical institution preparations play an important role in the development of hospitals,being one of the main forms of traditional Chinese medicine clinical characteristic medication,as well as an important carrier for the inheritance and innovation of traditional Chinese medicine.In recent years,the research and development of traditional Chinese medicine preparations has become a hot spot in the research and development of preparations by medical institutions.Traditional Chinese medicine preparations prepared by traditional processes and their entrusted preparation matters have changed from the current licensing management to filing management.The registration model of traditional Chinese medicine preparations has undergone significant changes,emphasizing more on real data and evaluation results from the objective world,respecting traditional medication experience,and emphasizing the inheritance and innovative development of traditional technological experience.In the process of following teachers in the inheritance project of traditional Chinese medicine,we combined the inheritance of traditional Chinese medicine characteristic technology with the research and development practice of traditional Chinese medicine preparations in medical institutions,and focused on the analysis and discussion of technical problems such as prescription screening,dosage form selection,process route design and clinical observation of traditional Chinese medicine preparations,hoping to provide reference for scholars in the same field of traditional Chinese medicine.

Drug Sensitive Test on Main Pathogenic Bacteria of Cow Recessiveness Mastitis Using Traditional Chinese Medicine Preparation “Zengrujianniusan”

According to the theory of Chinese veterinary medicine and characteristics of Chinese herbal medicine, four different preparations of compound Chinese medicine ＂Zengrujianniusan＂ were composed, and the prepared water decoction was used to carry on the bacteriostatic test on main pathogens of cow recessiveness mastitis. The results showed that the four different prescriptions of water decoction all had antibacterial effects. The prescription 3 was sensitive to Staphylococcus aureus and Streptococcus agalactiae, while the other three prescriptions showed high sensitivity, and the prescription 3 had the strongest bacteriostatic effects.

Prescription and treatment rules for the prescriptions containing Poria cocos and Atractylodes macrocephala couplet medicine based on traditional Chinese Medicine inheritance support platform

Objectives:To provide a theoretical basis for the development of the new products of Poria cocos-Atractylodes macrocephala couplet medicine.Methods:All prescription preparations containing Poria cocos and Atractylodes macrocephala were collected from the Drug Standards of the Ministry of Public Health Drug Standard·Traditional Chinese Medicine Set Prescription Preparation(called Traditional Chinese Medicine Set Prescription Preparation for short).After standardization,the information of each prescription preparation was input into the Chinese Traditional Medicine Inheritance Support Platform(V2.5),and the relevant rules of the software were adopted.Data mining methods were used to analyze the frequency of drugs,main symptoms and diseases in prescriptions,and to analyze the regularity of prescriptions.The prescription rules of top 2 high frequency attending syndromes and diseases were analyzed.Results:There were total of 337 prescription preparations containing couplet medicine of Poria cocos and Atractylodes macrocephala,107 kinds of main symptoms and 66 kinds of diseases.The high frequency syndromes were deficiency of Qi and blood and weakness of spleen and stomach,and the high frequency syndromes were anorexia and irregular menstruation.Conclusion:The couplet medicine of Poria cocos-atractylodes macrocephala prescription is mainly used to treat digestive tract diseases and gynecological diseases;it mostly takes tonifying deficiency efficat.It can treat different diseases being compatible with different medicinal materials.The study can provide theoretical basis for clinical application and new drug development of the couplet medicine of Poria cocos-atractylodes macrocephala.

Discussion on the Quality Evaluation Method of Traditional Chinese Medicine Compound Preparations

As an important representative of the modernization of the Chinese medicine industry,traditional Chinese medicine(TCM)compound preparations are an indispensable part of the development of TCM.The complex ingredients and unclear action mechanism of TCM compound preparations restrict the development of TCM.In line with this problem,the modern TCM research has made extensive remarkable achievements.From the single indicator in the past to multiple indicator,the research on the combination of TCM fingerprints and pharmacodynamics also has made great progress.The introduction of quality evaluation methods such as the"quantitative analysis of multi-components by a single marker","dose-effect"indicator,"Bioactive Equivalent Combinatorial Components"(BECCs)and TCM quality markers have brought new ideas for quality control of TCM compound preparations.

Screening and Efficacy Observation of Traditional Chinese Medicine Against Chicken Pathogenic Escherichia coli

[ Objective] The aim of this study was to lay a foundation for obtaining effective traditional Chinese medicine preparations controlling chicken colibacillosis. [ Method] With the western medicine Lomeflbxacin Hydrochloride and Sodium Chloride Injection as the control, drug sensitivity tests of 15 single traditional Chinese herbs and seven self-made Chinese herbal compounds were conducted. Subsequently, the single traditional Chinese herbs presenting good in vitro antibacterial effects against Escherichia coli and all the seven compounds were given to the chicks artificially infected with E. coil to observe their efficacies. [ Result] The results of drug sensitivity tests showed that all the 15 traditional Chinese herbs had certain antibacterial effect against E. coli, among which aloe, pomegranate rind and radix sanguisorbae were the best. Compound 1, 2 and 5 had good antibacterial effects in vitro. By in vivo test, traditional Chinese medicines showed superior efficacies on infected chicks than western medicine, and compound 1 and 2 performed well. [ConclusiOn] Traditional Chinese medicine preparations are good at controlling Chicken colibacillosis, but their bacteriostasis mechanism in vivo was different with that in vitro.

The efficacy of Xuefu Zhuyu prescription for diabetic encephalopathy: A meta-analysis of randomized controlled trials

Objective:To evaluate the safety and effectiveness of Xuefu Zhuyu Decoction in treating diabetic encephalopathy.Methods:Computer search and manual search of Pub Med,Web of Science,The Cochrane Library,CNKI,WF,VIP and CBM from January 2000 to April 2020 on the treatment of diabetic encephalopathy with Xuefu Zhuyu Decoction In randomized controlled clinical trials,select documents that meet the criteria for analysis using Rev Man 5.3 software.Results:A total of 11 articles and 838 patients were included in the study.Metaanalysis showed that Xuefu Zhuyu Decoction was effective(OR=3.71,95%CI[2.42,5.70],P<0.00001),and the patient’s neurological deficit score(MD=-4.52,95%CI[-5.10,-3.94],P<0.00001),fasting blood glucose(MD=-1.05,95%CI[-1.51,-0.59],P<0.00001),2 hours postprandial blood glucose(MD=-1.31,95%CI[-1.94,-0.69],P<0.00001),glycated hemoglobin(MD=-0.94,95%CI[-1.15,-0.72],P<0.00001),TCM symptom score(MD=-2.44,95%CI[-3.82,-1.06],P=0.0005<0.01),vitality score(MD=12.79,95%CI[8.79,16.79],P<0.00001),the improvement effect is obvious Better than conventional Western medicine treatment.Conclusion:Xuefu Zhuyu Decoction can improve the clinical efficiency of patients with diabetic encephalopathy,reduce brain damage,reduce blood sugar and glycated hemoglobin levels,and has good safety.However,the quality of some of the included literatures is low,and the number of clinical cases is small,which may affect the authenticity of the Meta analysis results.Still need to be further verified by clinical randomized controlled trials with high-quality large samples.

以岗位胜任力为导向的中医脑病住院医师规范化培训教学探析

以岗位胜任力为导向的理论和方法用于住院医师规范化培训,是提升临床医师专业素质和培养合格医疗人才的关键方法。如何运用有效的手段提升中医脑病住院医师规范化培训学员的岗位胜任力仍需要进一步探索与研究。本文基于脑病科住培医师培训实践,构建授课教学法(LBL)-案例教学法(CBL)-问题教学法(PBL)-研究教学法(RBL)“四轨并驱”的教学策略,提出以岗位胜任力为导向的中医脑病住培医师的培训方法,以期提高中医脑病专业住培医师的岗位胜任力,从而为临床锻炼出更为优秀的医疗队伍,使之更加符合新时代医疗工作的要求,也更好地提升中医住院医师的整体水平。

高职院校“教学考评”一体化教学改革实践思考——以“中药制剂技术”为例

在数字中国背景下,教育数字化是数字经济的重要组成部分之一。同时,随着数字技术的发展,职业教育也将逐步升级和转型。各高校都积极打造教学一体化平台,以迎接信息时代数字化教学变革。文章以教育教学一体化平台为依托,以开展“中药制剂技术”课程数字化教学改革为例,探索了“教学考评”一体化数字化教育教学改革实践,并对实施情况进行分析:数字化教学改变了传统教育教学环节,对教师的数字素养提出了更高要求,方便学生时时处处皆可学习,提倡师生在交流中共同进步;注重过程性考核评价,为学生个性化的学习改进和教师教学改进提供方案。同时,数字化技术时代,职业院校希望更多企业参与办学,通过校企合作开发更优质的教学及实训资源。希望本研究能为当前高职院校数字化教学评价改革提供参考。

超临界流体萃取技术在中药提取物制备中的应用

本文综述了超临界流体萃取技术在生物碱类、黄酮类、萜类和挥发油、多糖类、蒽醌类等中药有效成分制备中的应用,有针对性地提出了超临界流体萃取技术在中药提取工艺领域的发展建议,以期促进该技术在中药提取物制备中的推广应用。

基于高分辨质谱的中药学本科实验课程教学探索

中药制剂是由多种中药配伍组成的,是一个复杂的分子体系,其分析鉴定工作存在较大难度。高效液相色谱与高分辨质谱联用系统(HPLC-HRMS)在中药复方的定性研究中发挥着重要作用。本论文通过探索将高分辨液相色谱质谱联用系统应用到中药学本科生实验教学实践中,建立了对中药制剂参松养心胶囊中5种特征性成分进行鉴定的实验教学方法。使学生了解高分辨质谱在中药制剂分析和鉴定中的重要应用,开阔了本校中药学专业本科生的科研视野,提高了学生对仪器分析的理解,对培养高素质高水平的药学本科生起到了积极作用。

医疗机构基于“三结合”中药新药研发及管理体系的构建

目的:在中药审评审批制度改革的政策背景下,围绕医疗机构,探索中医药理论、人用经验和临床试验相结合(简称“三结合”)的审评证据体系落地举措,为医疗机构中药制剂及中药新药研发提供参考。方法:根据“三结合”审评证据体系下中药新药研发的相关要求,从机构层面加强人用经验研究相关配套建设,从管理层面搭建中药研发、成果转化服务平台,从临床层面规范开展人用经验研究,构建医疗机构中药新药研发及管理体系。结果:医疗机构中药新药研发及管理体系的构建,有助于将临床诊疗数据转变为支持中药新药注册的人用经验证据,通过提高中药研发水平促进中药新药转化。结论:在医疗机构构建基于“三结合”的中药新药研发及管理体系,是“三结合”审评证据体系落地、政策引导研发实践的路径之一。

中药调剂临方炮制对临床治疗效果的影响分析

目的 探讨中药调剂临方炮制对临床疗效的影响。方法 选取100例中药治疗的患者为研究对象,将其随机分为对照组与干预组,每组50例。对照组患者接受常规中药炮制治疗,干预组患者实行中药临方炮制治疗。对比两组治疗效果。结果 干预组患者治疗总有效率96.00%明显高于对照组的78.00%,差异有统计学意义(P<0.05)。结论 中药临方炮制对临床疗效具有积极影响,可以通过调整药物的配伍和炮制方法提高药材的活性成分和药效,以此提升治疗效果。

酵母硒复合制剂对蛋鸡生产性能及蛋品质的影响

为分析酵母硒复合制剂对蛋鸡生产性能及蛋品质的影响。试验选取300羽28周龄的海兰褐蛋鸡,随机分为4组,每组5个重复,每个重复15羽。对照组根据《海兰褐壳蛋鸡商品代饲养管理技术规程》(DB34/T1650~2012)配制基础日粮,试验组分别在基础日粮中添加100、200、300mg/kg酵母硒复合制剂。预饲期7d,正试期60d。结果表明:(1)1~30d阶段,随着基础日粮中酵母硒复合制剂添加水平的提高,产蛋率有增加趋势(P <0.10)。31~60d阶段,与对照组相比,基础日粮添加200、300mg/kg酵母硒复合制剂可显著提高蛋鸡的产蛋率、平均日产蛋重(P <0.05),且显著降低了蛋鸡的料蛋比(P <0.05)。(2)试验第30天,与对照组相比,基础日粮添加200、300mg/kg酵母硒复合制剂可显著提高蛋黄颜色(P <0.05)。试验第60天,与对照组相比,基础日粮添加200、300mg/kg酵母硒复合制剂可显著提高鸡蛋重量、蛋白高度(P <0.05),基础日粮添加100、200、300mg/kg酵母硒复合制剂可显著提高了蛋黄颜色(P <0.05)。由此可见,基础日粮中添加200、300mg/kg酵母硒复合制剂均能提高蛋鸡生产性能,有效改善蛋品质。

中医传统特色外治疗法在糖尿病周围神经病变患者中的应用进展研究

糖尿病周围神经病变(Diabetic Peripheral Neuropathy, DPN)广泛存在于糖尿病患者群体中,患者通常存在下肢麻木疼痛等感觉异常。DPN患者临床症状诸多,严重影响生活质量。临床针对DPN患者治疗方式多采用口服药物治疗为主,其临床应用效果具有一定局限性。中医传统特色外治法的出现为DPN治疗领域工作开展提供新思路,诸多特色外治疗法应用方式及功效均存在差异。该文主要从DPN发病机制及临床症状、中医对DPN的认识及中医传统特色外治疗法技术优势3个方面探究DPN及外治疗法临床应用意义,并从膏摩疗法、推拿疗法及针刺疗法3个维度探究外治法应用效果。以此为DPN患者治疗提供重要技术参考,满足DPN患者群体个性化治疗需求,凸显传统中医在治疗DPN领域中的价值。

医疗机构中药制剂立项评价体系的构建及应用

目的以新药转化为导向,构建医疗机构中药制剂备案立项评价体系,以提高医疗机构中药制剂的申报成功率,为后期新药转化奠定基础。方法我院研发小组运用文献研究法,采用头脑风暴法列举并整理医疗机构中药制剂立项评价的相关要素,确定初拟指标体系;采用德尔菲法进行专家函询,确定评价指标,根据各指标的重要性评分占比计算权重,赋予具体分值,并采用该指标体系对2023年4-7月我院各科室申请备案的31个中药制剂进行评价。结果向17位专家进行了两轮函询,最终确定的医疗机构中药制剂备案立项评价体系包括理论依据、临床研究基础、药学基础、处方、临床价值5项一级指标,以及处方来源、中医理论、临床定位等17项二级指标,其中人用经验为一票否决项。基于上述指标体系,我院进一步完善了医疗机构中药制剂备案立项流程,并从2023年4-7月各科室申请备案的31个中药制剂中,遴选出8个评分≥65分的中药制剂拟进行开发。结论本评价体系客观、全面,可操作性强,适用于医疗机构中药制剂研发前的遴选。

自拟清化止痛汤联合中药灌肠治疗湿热瘀结型急性盆腔炎的临床效果观察

目的分析湿热瘀结型急性盆腔炎患者临床治疗过程中使用自拟清化止痛汤联合中药灌肠治疗的效果。方法选取60例急性盆腔炎(湿热瘀结型)患者,根据随机数字表法将患者分为两组,每组30例。对照组接受常规西药治疗,治疗组在对照组基础上接受自拟清化止痛汤联合中药灌肠治疗。对比两组治疗效果。结果相比对照组,治疗后治疗组症状缓解时间明显缩短(P<0.05),且主症评分和次症评分明显降低(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论自拟清化止痛汤联合中药灌肠治疗湿热瘀结型急性盆腔炎具有较好的效果和安全性。

中药制剂在烧伤治疗中的应用进展

中药制剂主要分为中药合剂、方剂及单方等。其中,中药合剂具有抗休克、控制感染、促进创面愈合、控制瘢痕增生及瘙痒等作用,在烧伤治疗中应用广泛;方剂的剂型众多,临床上主要用于保护创面及促进创面修复;单方因其成分较为单一,故其种类繁多,多为民间流传,具有取材方便、用法简单等优点,主要应用于Ⅰ度Ⅱ度的烧伤创面的治疗。文章从中医角度辩证分析中药制剂的效用,并从促进皮肤组织生长、抑制炎症反应、抗休克、调控胶原蛋白代谢等角度阐述其加速创面愈合和抑制瘢痕增生的作用机制。未来,应进一步完善中药制剂作用机制和临床疗效评价体系的研究。

中药外用制剂在儿童变应性鼻炎中的应用及思考

变应性鼻炎是儿童常见的变态反应性疾病之一,全球高发且发病率逐年增高,无法根治且易反复发作,给患儿及其家庭带来很大的困扰和负担。中药外用制剂作为行之有效的治疗方法,尤其适合儿科临床应用。笔者通过检索数据库中关于应用中药外用制剂治疗儿童变应性鼻炎的临床及实验研究,总结了其临床应用及可能发挥作用的机制,并分析了当前中药外用制剂治疗该病的优势及问题,以期为儿童变应性鼻炎临床诊疗及研究方向临床提供一定参考。

基于中医传承辅助平台与网络药理学探析《中华人民共和国药典》中含生石膏成方制剂的证治规律及作用机制

目的:研究2020年版《中华人民共和国药典》中含生石膏成方制剂的证治规律及作用机制。方法:将符合纳入、排除标准的成方制剂录入中医传承辅助平台,并基于中医传承辅助平台的频率统计、关联规则与聚类算法功能,探析含生石膏成方制剂的配伍原则、组方规律及新方组合,并提取核心用药;同时采用网络药理学方法,对证治规律研究中所筛选的主要中医疾病进行生石膏作用机制研究。结果:最终共纳入50条含生石膏成方制剂,涉及肺咳、肺炎喘嗽、感冒等中医疾病24种,痰热壅肺、肺经风热、热毒内盛等适宜证型22项,生石膏、甘草、黄芩、杏仁、麻黄等中药170味,同时提取“生石膏-甘草”“生石膏-黄芩”等核心药对4项,“生石膏-五味子-枳实-桔梗-桑白皮”等新方组合7条,以及“生石膏、麻黄、甘草、杏仁、黄芩、桔梗、陈皮”等核心用药6组;并筛选获得ALB、IL-1B、1L-6等“生石膏-主要中医疾病”交集靶点18个,以及肿瘤坏死因子(TNF)、白细胞介素-17(IL-17)、缺氧诱导因子-1(HIF-1)等主要信号通路3条。结论:2020年版《中华人民共和国药典》中含生石膏成方制剂主要以麻杏石甘汤为基础方化裁,其机制可能与生石膏抑制TNF、IL-17、HIF-1等信号通路,下调炎症反应过程,减少促炎因子释放有关。

HPLC特征图谱技术在中药制剂质量控制中的应用进展

高效液相色谱特征图谱技术具有整体性的特点,与中药复杂的化学成分特征相符,已被国内外公认为中药质量控制的良好方法之一,是表征中药制剂质量和保证中药制剂临床疗效的重要手段。本文综述了近年高效液相色谱特征图谱技术在中药制剂质量控制中的应用特点,为持续提升中药制剂质控水平提供参考。