Helicobacter pylori(H.pylori)has a high rate of infection and antibiotic resistance and poses a serious threat to human life.One of the main strategies to overcome drug resistance is to develop new treatment plans.Tra...Helicobacter pylori(H.pylori)has a high rate of infection and antibiotic resistance and poses a serious threat to human life.One of the main strategies to overcome drug resistance is to develop new treatment plans.Traditional Chinese medicine(TCM)that is commonly used to treat many diseases in China can reduce drug resistance and increase the eradication rate of H.pylori.In this paper,we review the research progress on TCM in the treatment of H.pylori infection.The mechanism of action of TCM is reviewed and research and applications of TCM in the treatment of H.pylori are demonstrated.Finally,we discuss problems confronting the use of TCM for the treatment of H.pylori infection and propose possible solutions.In addition,the plans of TCM in H.pylori treatment were also screened:Dampness-heat syndrome in the spleen and stomach,deficiency of spleen and stomach,and cold-heat complicated syndrome,and the effective components therein are studied.The antibacterial effect of TCM is relatively slow;for rapid improvement of the treatment effect of refractory H.pylori gastritis,we provide an appropriate treatment regime combining TCM and Western medicine with immune-regulatory and synergistic antibacterial effects.展开更多
Disease control and health care with traditional Chinese veterinary medicine( TCVM) has attracted more and more attention in sheep green breeding. To promote healthy and smooth development of the work,the relationship...Disease control and health care with traditional Chinese veterinary medicine( TCVM) has attracted more and more attention in sheep green breeding. To promote healthy and smooth development of the work,the relationships between TCVM and antibiotics,and between TCVM and vaccines,were reviewed and analyzed. It was thought that TCVM and western medicine,such as antibiotics and vaccines,etc.,have their own characteristics and advantages,and should be mutually complemented rather than replaced. We should pay attention to the characteristics and advantages of the wholism concept and syndrome differentiation and treatment( diagnosis and treatment based on an overall analysis of the illness and the patient's condition) of TCVM,to develop and use TCVM health care agent or vaccine adjuvant,and their pertinence was improved according to different growth stages and physiological and pathological characteristics. Diagnosis and treatment based on an overall analysis of the illness and the population patient's condition must be attached importance to optimize the mode of administration,in order to adapt to disease prevention and control requirements in intensive and scale breeding of sheep.展开更多
目的:基于网状Meta分析,评价不同中药联合益生菌治疗抗生素相关性腹泻(AAD)的疗效及安全性,为临床安全用药方案提供循证医学依据。方法:在万方数据库、维普数据库、中国知网、中华医学期刊数据库、PubMed、Web of Science等数据库中检...目的:基于网状Meta分析,评价不同中药联合益生菌治疗抗生素相关性腹泻(AAD)的疗效及安全性,为临床安全用药方案提供循证医学依据。方法:在万方数据库、维普数据库、中国知网、中华医学期刊数据库、PubMed、Web of Science等数据库中检索中药联合益生菌治疗AAD的随机对照试验(观察组干预措施为中药联合益生菌,对照组干预措施为单纯使用益生菌),检索时间截至2023年1月。采用贝叶斯网状Meta分析方法,对不同中药联合益生菌治疗AAD的安全性和有效性进行评价。结果:筛选出21篇随机对照试验文献,涉及患者2 093例;使用的中药包括健脾补肾固摄汤、人参败毒散或健脾止泻汤、四逆汤联合四神汤、参术止泻汤、乌梅丸、巴特日-7味丸、胃肠安丸、参苓白术颗粒(参苓白术散)、小儿腹泻散、参苓白术散+补肺汤、醒脾养儿颗粒、儿泻停颗粒、黄芪建中汤、马齿苋煎煮液、固本益肠片共15种。以总有效率为基础指标进行贝叶斯网状Meta分析,结果显示,人参败毒散或健脾止泻汤的效果最佳(OR=12,95%CI=3.1~78.0),且差异有统计学意义(P<0.05)。结论:文献研究前后患者的身体指标未见异常,15种中药联合益生菌治疗AAD的研究方案未对患者造成伤害;同时在鼠类的AAD模型复现上也得到了相应的证实,可以认为本次网状Meta分析的结果是安全、可靠的。本研究中的中药联合益生菌治疗AAD的疗效均优于单纯使用益生菌,能有效缩短病程,为临床用药提供了循证医学证据,但仍需要更多的研究支持和验证。展开更多
Objective:To study the ecology of antibiotic resistant bacteria with emphasis on sucrose negative vibrios in water and sediments samples of traditional shrimp farming system(bhery)in West Bengal,India.Methods:The vibr...Objective:To study the ecology of antibiotic resistant bacteria with emphasis on sucrose negative vibrios in water and sediments samples of traditional shrimp farming system(bhery)in West Bengal,India.Methods:The vibrios were isolated from traditional shrimp farm samples on thiosulphate citrate bile salt sucrose agar and sucrose negative bacterial strains were used as biomarkers to assess the frequency of antibiotic resistance.Results:The incoming water brought presumptive vibrios ranging from 5.50×10^(1)to 1.00×10^(3)mL in to the bhery,and there appeared to build up vibrios in the culture system with days of culture,as there was about 9 fold increase in vibrios.The levels of vibrios were observed to be moderately higher in outlet water and ranged between 4.15×10^(2)and 4.15x10^(3)mL.The counts of vibrios in pond sediment was found to be 1.00x10^(2)-4.90×10^(3)g;while in inlet(2.00×10^(2)-4.20×10^(4)g)and outlet(3.00×10^(2)-6.85×10^(3)g)their levels were observed to be higher than the pond sediment.Thirteen different Vibrio species were encountered in traditional shrimp culture system and all vibrios were sensitive to chloramphenicol,followed by ciprofloxacin and gatifloxacin(98.24%),gentamicin(95.61%)and other antibiotics.The multiple antibiotic resistance(MAR),i.e.,resistance to at least two antibiotics,was noticed among 43.85%of the sucrose negative vibrios and 41.86%of the sucrose negative non--vibrios.All vibrios harveyi strains exhibited MAR.Although no antibiotic was used in the bhery,the prevalence of MAR in 44%of the sucrose negative vibrios and nonvibrios is a cause of concern.The MAR index was higher in inlet water and sediment samples.The MAR observed in biomarker strains of pond water and sediment(40%)was comparable to those of inlet samples,thus confirming the fact that incoming water was the major source of antibiotic resistant bacteria.Conclusions:It seems that the shrimp culture in bhery does not favour the proliferation and spread of antibiotic resistant bacteria.展开更多
基金National Natural Science Foundation of China,No.81760739 and No.32060018.
文摘Helicobacter pylori(H.pylori)has a high rate of infection and antibiotic resistance and poses a serious threat to human life.One of the main strategies to overcome drug resistance is to develop new treatment plans.Traditional Chinese medicine(TCM)that is commonly used to treat many diseases in China can reduce drug resistance and increase the eradication rate of H.pylori.In this paper,we review the research progress on TCM in the treatment of H.pylori infection.The mechanism of action of TCM is reviewed and research and applications of TCM in the treatment of H.pylori are demonstrated.Finally,we discuss problems confronting the use of TCM for the treatment of H.pylori infection and propose possible solutions.In addition,the plans of TCM in H.pylori treatment were also screened:Dampness-heat syndrome in the spleen and stomach,deficiency of spleen and stomach,and cold-heat complicated syndrome,and the effective components therein are studied.The antibacterial effect of TCM is relatively slow;for rapid improvement of the treatment effect of refractory H.pylori gastritis,we provide an appropriate treatment regime combining TCM and Western medicine with immune-regulatory and synergistic antibacterial effects.
基金Supported by Special Science and Technology Foundation of the Ministry of Science and Technology(2013FY110600-8)Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2017-LIHPS)Integration and Innovation of Mutton Sheep Green Quality and Efficiency Technology(CAAS-XTCX2016011-02)
文摘Disease control and health care with traditional Chinese veterinary medicine( TCVM) has attracted more and more attention in sheep green breeding. To promote healthy and smooth development of the work,the relationships between TCVM and antibiotics,and between TCVM and vaccines,were reviewed and analyzed. It was thought that TCVM and western medicine,such as antibiotics and vaccines,etc.,have their own characteristics and advantages,and should be mutually complemented rather than replaced. We should pay attention to the characteristics and advantages of the wholism concept and syndrome differentiation and treatment( diagnosis and treatment based on an overall analysis of the illness and the patient's condition) of TCVM,to develop and use TCVM health care agent or vaccine adjuvant,and their pertinence was improved according to different growth stages and physiological and pathological characteristics. Diagnosis and treatment based on an overall analysis of the illness and the population patient's condition must be attached importance to optimize the mode of administration,in order to adapt to disease prevention and control requirements in intensive and scale breeding of sheep.
文摘目的:基于网状Meta分析,评价不同中药联合益生菌治疗抗生素相关性腹泻(AAD)的疗效及安全性,为临床安全用药方案提供循证医学依据。方法:在万方数据库、维普数据库、中国知网、中华医学期刊数据库、PubMed、Web of Science等数据库中检索中药联合益生菌治疗AAD的随机对照试验(观察组干预措施为中药联合益生菌,对照组干预措施为单纯使用益生菌),检索时间截至2023年1月。采用贝叶斯网状Meta分析方法,对不同中药联合益生菌治疗AAD的安全性和有效性进行评价。结果:筛选出21篇随机对照试验文献,涉及患者2 093例;使用的中药包括健脾补肾固摄汤、人参败毒散或健脾止泻汤、四逆汤联合四神汤、参术止泻汤、乌梅丸、巴特日-7味丸、胃肠安丸、参苓白术颗粒(参苓白术散)、小儿腹泻散、参苓白术散+补肺汤、醒脾养儿颗粒、儿泻停颗粒、黄芪建中汤、马齿苋煎煮液、固本益肠片共15种。以总有效率为基础指标进行贝叶斯网状Meta分析,结果显示,人参败毒散或健脾止泻汤的效果最佳(OR=12,95%CI=3.1~78.0),且差异有统计学意义(P<0.05)。结论:文献研究前后患者的身体指标未见异常,15种中药联合益生菌治疗AAD的研究方案未对患者造成伤害;同时在鼠类的AAD模型复现上也得到了相应的证实,可以认为本次网状Meta分析的结果是安全、可靠的。本研究中的中药联合益生菌治疗AAD的疗效均优于单纯使用益生菌,能有效缩短病程,为临床用药提供了循证医学证据,但仍需要更多的研究支持和验证。
基金supported by Department of Aquatic Animal Health,Faculty of Fishery Sciences,West Bengal University of Animal and Fishery Sciences,West Bengal,India.(FFS/Adm-21/323)
文摘Objective:To study the ecology of antibiotic resistant bacteria with emphasis on sucrose negative vibrios in water and sediments samples of traditional shrimp farming system(bhery)in West Bengal,India.Methods:The vibrios were isolated from traditional shrimp farm samples on thiosulphate citrate bile salt sucrose agar and sucrose negative bacterial strains were used as biomarkers to assess the frequency of antibiotic resistance.Results:The incoming water brought presumptive vibrios ranging from 5.50×10^(1)to 1.00×10^(3)mL in to the bhery,and there appeared to build up vibrios in the culture system with days of culture,as there was about 9 fold increase in vibrios.The levels of vibrios were observed to be moderately higher in outlet water and ranged between 4.15×10^(2)and 4.15x10^(3)mL.The counts of vibrios in pond sediment was found to be 1.00x10^(2)-4.90×10^(3)g;while in inlet(2.00×10^(2)-4.20×10^(4)g)and outlet(3.00×10^(2)-6.85×10^(3)g)their levels were observed to be higher than the pond sediment.Thirteen different Vibrio species were encountered in traditional shrimp culture system and all vibrios were sensitive to chloramphenicol,followed by ciprofloxacin and gatifloxacin(98.24%),gentamicin(95.61%)and other antibiotics.The multiple antibiotic resistance(MAR),i.e.,resistance to at least two antibiotics,was noticed among 43.85%of the sucrose negative vibrios and 41.86%of the sucrose negative non--vibrios.All vibrios harveyi strains exhibited MAR.Although no antibiotic was used in the bhery,the prevalence of MAR in 44%of the sucrose negative vibrios and nonvibrios is a cause of concern.The MAR index was higher in inlet water and sediment samples.The MAR observed in biomarker strains of pond water and sediment(40%)was comparable to those of inlet samples,thus confirming the fact that incoming water was the major source of antibiotic resistant bacteria.Conclusions:It seems that the shrimp culture in bhery does not favour the proliferation and spread of antibiotic resistant bacteria.
