Background:This study explores the relationship between endoplasmic reticulum(ER)stress and diabetes,particularly focusing on the impact of physical exercise on ER stress mechanisms and identifying potential therapeut...Background:This study explores the relationship between endoplasmic reticulum(ER)stress and diabetes,particularly focusing on the impact of physical exercise on ER stress mechanisms and identifying potential therapeutic drugs and targets for diabetes-related sepsis.The research also incorporates traditional physical therapy perspectives,emphasizing the genomic insights gained from exercise therapy in disease management and prevention.Methods:Gene analysis was conducted on the GSE168796 and GSE94717 datasets to identify ER stress-related genes.Gene interactions and immune cell correlations were mapped using GeneCard and STRING databases.A screening of 2,456 compounds from the TCMSP database was performed to identify potential therapeutic agents,with a focus on their docking potential.Techniques such as luciferase reporter gene assay and RNA interference were used to examine the interactions between microRNA-149-5p and MMP9.Results:The study identified 2,006 differentially expressed genes and 616 miRNAs.Key genes like MMP9,TNF-α,and IL1B were linked to an immunosuppressive state.Licorice glycoside E demonstrated high affinity for MMP9,suggesting its potential effectiveness in treating diabetes.The constructed miRNA network highlighted the regulatory roles of MMP9,IL1B,IFNG,and TNF-α.Experimental evidence confirmed the binding of microRNA-149-5p to MMP9,impacting apoptosis in diabetic cells.Conclusion:The findings highlight the regulatory role of microRNA-149-5p in managing MMP9,a crucial gene in diabetes pathophysiology.Licorice glycoside E emerges as a promising treatment option for diabetes,especially targeting MMP9 affected by ER stress.The study also underscores the significance of physical exercise in modulating ER stress pathways in diabetes management,bridging traditional physical therapy and modern scientific understanding.Our study has limitations.It focuses on the microRNA-149-5p-MMP9 network in sepsis,using cell-based methods without animal or clinical trials.Despite strong in vitro findings,in vivo studies are needed to confirm licorice glycoside E’s therapeutic potential and understand the microRNA-149-5p-MMP9 dynamics in real conditions.展开更多
The traditional Chinese medicine(TCM)theory of traditional Chinese health exercise(TCHE)is analyzed.The effect of meridians and acupoints contained in TCHE is summarized,the treatment methods of tonifying deficiencies...The traditional Chinese medicine(TCM)theory of traditional Chinese health exercise(TCHE)is analyzed.The effect of meridians and acupoints contained in TCHE is summarized,the treatment methods of tonifying deficiencies and reducing excesses applied in TCHE are discussed,the regulation of Zang-fu organs are emphasized,and the leading role of Qi is introduced.The exercise prescription and proper timing of TCHE are described and reported.TCHEs,such as Baduanjin,Liuzijue,and Tai Chi,possess strong TCM characteristics.展开更多
In the reading course, especially the so-called intensive reading course or integrative English reading course, there are some vocabulary exercises which intend to consolidate the active vocabulary emerging in the rea...In the reading course, especially the so-called intensive reading course or integrative English reading course, there are some vocabulary exercises which intend to consolidate the active vocabulary emerging in the reading passages. Mostly, these exercises are in the form of blank-filling or rewriting sentences with the words given. The problem with such exercises lies in the de-contextualization of the sentences. On the one hand, without the proper context, it is not easy for students to fill in the blanks, even though they know the meanings of the words. To finish the exercises, most students have to resort to the teacher＇s reference book for help. On the other hand, students will forget the words soon after they have finished the exercises for lack of the context to aid their recalling of the vocabulary. The author therefore finds that doing such exercises in class is unproductive and time-consuming. In order to solve this problem and make the vocabulary exercises more productive, the author attempts to reform the traditional exercises by transforming them into collaborative writing activities. Students are required to work in groups to write a short passage with the words given. After a 2-year practice, the author has concluded that the collaborative writing activities not only help students learn to use the words in a discourse, but also offer the opportunity to learn interdependently and help each other. Students have learnt to negotiate meanings in the course of the activity, which is a necessary skill in their daily life. Moreover, they have learnt to monitor their production in the course of revision and edition.展开更多
Objective:Parkinson’s disease(PD)is the second most common neurodegenerative disease in the world.In 2004,approximately 13,000 individuals in Hong Kong,China,had PD.PD greatly affects quality of life and conventional...Objective:Parkinson’s disease(PD)is the second most common neurodegenerative disease in the world.In 2004,approximately 13,000 individuals in Hong Kong,China,had PD.PD greatly affects quality of life and conventional medication can produce severe side effects.The traditional Chinese medicine(TCM)practices of conduction exercise(CE)and selfacupressure(SA)may relieve PD symptoms.This paper presents a protocol for a randomized controlled trial to determine the effectiveness of CE and SA in treating PD.Methods:Patients with primary PD were recruited.Eligible patients were randomly assigned to either a treatment or control group.The assessor and data analysts were blind.The treatment phase duration was 8 weeks,with 8 weekly sessions of CE and SA practice.Baseline,midpoint,and final assessments were carried out during the treatment phase.The primary outcome is scores on the 39-item Parkinson’s Disease Questionnaire(PDQ-39),and the secondary outcome is scores on a custom-designed questionnaire based on TCM“Deficiency of Spleen Qi”scores and scores on a non-motor PD symptoms scale.Discussion:This trial is the first rigorous study of the effectiveness of CE and SA in relieving PD symptoms.The aim is to examine the effectiveness of CE and SA in treating a disease that is difficult to treat conventionally.The data obtained will form the foundation for future related studies.Trial registration:Chinese Clinical Trial Registry(ChiCTR-IPR-17011987,Date of registration:14 July,2017).展开更多
目的系统评价中医传统功法对卒中后认知障碍患者的干预效果。方法利用计算机检索The Cochrane Library、PubMed、Embase、Web of Science、中国生物医学文献数据库、中国知网、万方数据知识服务平台、维普中文科技期刊数据库中有关中医...目的系统评价中医传统功法对卒中后认知障碍患者的干预效果。方法利用计算机检索The Cochrane Library、PubMed、Embase、Web of Science、中国生物医学文献数据库、中国知网、万方数据知识服务平台、维普中文科技期刊数据库中有关中医传统功法干预卒中后认知障碍患者的随机对照试验,检索时限为建库至2023年12月31日,采用RevMan 5.4软件进行Meta分析。结果共纳入15项随机对照试验研究,包括918例研究对象。Meta分析结果显示,中医传统功法在提高卒中后认知障碍患者的认知功能[SMD=0.86,95%CI(0.68,1.04),P<0.001]、缩短P300检测的潜伏时间[MD=-11.52,95%CI(-16.06,-6.98),P<0.001]、增加P300检测的波幅高度[MD=1.06,95%CI(0.44,1.67),P<0.001]等方面均优于对照组。结论中医传统功法可有效提高卒中后认知障碍患者的认知功能。展开更多
目的:采用网状Meta分析法评价中国传统功法(CTE)治疗膝骨关节炎(KOA)的效果。方法:检索PubMed、Web of Science、Embase、Cochrane Library、国家知识基础设施数据库(CNKI)、中文科技期刊数据库(CCD)中国学术期刊数据库(CSPD)和中国生...目的:采用网状Meta分析法评价中国传统功法(CTE)治疗膝骨关节炎(KOA)的效果。方法:检索PubMed、Web of Science、Embase、Cochrane Library、国家知识基础设施数据库(CNKI)、中文科技期刊数据库(CCD)中国学术期刊数据库(CSPD)和中国生物医学文献数据库(SinoMed)中发表的CTE治疗KOA的随机对照试验(Randomized Controlled Trials,RCT),检索时间截至2022年8月。结局指标包括骨关节炎指数(WOMAC)、VAS。用Cochrane偏倚风险评估工具ROB2对纳入文献进行偏倚风险评估。用Revman5.4对文献进行质量评价,制作文献风险偏倚图;用Stata16.0进行Meta分析,当结局指标纳入文献数量≥10,绘制“比较-校正”漏斗图并进行egger检验,确定发表偏倚和小样本效应。结果:共纳入13篇文献,包括5种CTE:太极、易筋经、八段锦、五禽戏、站桩功。结果显示纳入文献整体质量较高。网状Meta分析结果显示:在缓解僵硬和疼痛方面,五禽戏效果最好;在改善功能活动方面,易筋经效果最好。在缓解僵硬方面:与太极拳相比,五禽戏的效果更好(MD=-64.69,95%CI为-107.07~-22.31,P<0.05),五禽戏的效果最好。纳入文献均未报道CTE的安全性。结论:基于现有证据,CTE治疗KOA的效果优于传统康复训练,其中五禽戏和易筋经的效果优于其他CTE。展开更多
文摘Background:This study explores the relationship between endoplasmic reticulum(ER)stress and diabetes,particularly focusing on the impact of physical exercise on ER stress mechanisms and identifying potential therapeutic drugs and targets for diabetes-related sepsis.The research also incorporates traditional physical therapy perspectives,emphasizing the genomic insights gained from exercise therapy in disease management and prevention.Methods:Gene analysis was conducted on the GSE168796 and GSE94717 datasets to identify ER stress-related genes.Gene interactions and immune cell correlations were mapped using GeneCard and STRING databases.A screening of 2,456 compounds from the TCMSP database was performed to identify potential therapeutic agents,with a focus on their docking potential.Techniques such as luciferase reporter gene assay and RNA interference were used to examine the interactions between microRNA-149-5p and MMP9.Results:The study identified 2,006 differentially expressed genes and 616 miRNAs.Key genes like MMP9,TNF-α,and IL1B were linked to an immunosuppressive state.Licorice glycoside E demonstrated high affinity for MMP9,suggesting its potential effectiveness in treating diabetes.The constructed miRNA network highlighted the regulatory roles of MMP9,IL1B,IFNG,and TNF-α.Experimental evidence confirmed the binding of microRNA-149-5p to MMP9,impacting apoptosis in diabetic cells.Conclusion:The findings highlight the regulatory role of microRNA-149-5p in managing MMP9,a crucial gene in diabetes pathophysiology.Licorice glycoside E emerges as a promising treatment option for diabetes,especially targeting MMP9 affected by ER stress.The study also underscores the significance of physical exercise in modulating ER stress pathways in diabetes management,bridging traditional physical therapy and modern scientific understanding.Our study has limitations.It focuses on the microRNA-149-5p-MMP9 network in sepsis,using cell-based methods without animal or clinical trials.Despite strong in vitro findings,in vivo studies are needed to confirm licorice glycoside E’s therapeutic potential and understand the microRNA-149-5p-MMP9 dynamics in real conditions.
基金supported by the National Nature Science Foundation in China(No.81170323)Shanghai Key Lab of Human Performance(Shanghai University of Sport)(No.11DZ2261100),Shanghai,China
文摘The traditional Chinese medicine(TCM)theory of traditional Chinese health exercise(TCHE)is analyzed.The effect of meridians and acupoints contained in TCHE is summarized,the treatment methods of tonifying deficiencies and reducing excesses applied in TCHE are discussed,the regulation of Zang-fu organs are emphasized,and the leading role of Qi is introduced.The exercise prescription and proper timing of TCHE are described and reported.TCHEs,such as Baduanjin,Liuzijue,and Tai Chi,possess strong TCM characteristics.
文摘In the reading course, especially the so-called intensive reading course or integrative English reading course, there are some vocabulary exercises which intend to consolidate the active vocabulary emerging in the reading passages. Mostly, these exercises are in the form of blank-filling or rewriting sentences with the words given. The problem with such exercises lies in the de-contextualization of the sentences. On the one hand, without the proper context, it is not easy for students to fill in the blanks, even though they know the meanings of the words. To finish the exercises, most students have to resort to the teacher＇s reference book for help. On the other hand, students will forget the words soon after they have finished the exercises for lack of the context to aid their recalling of the vocabulary. The author therefore finds that doing such exercises in class is unproductive and time-consuming. In order to solve this problem and make the vocabulary exercises more productive, the author attempts to reform the traditional exercises by transforming them into collaborative writing activities. Students are required to work in groups to write a short passage with the words given. After a 2-year practice, the author has concluded that the collaborative writing activities not only help students learn to use the words in a discourse, but also offer the opportunity to learn interdependently and help each other. Students have learnt to negotiate meanings in the course of the activity, which is a necessary skill in their daily life. Moreover, they have learnt to monitor their production in the course of revision and edition.
基金the following grants:RGC/GRF/HKBU121006/18,RGC/GRF/HKBU121014/17,NSFC/81773926,NSFC/81703487,HMRF/15163481,HMRF14150811,HKBU/RC-IRCs/17-18/03,HKBU/RC-IRMS/15-16/04 and FRGII/17-18/021.
文摘Objective:Parkinson’s disease(PD)is the second most common neurodegenerative disease in the world.In 2004,approximately 13,000 individuals in Hong Kong,China,had PD.PD greatly affects quality of life and conventional medication can produce severe side effects.The traditional Chinese medicine(TCM)practices of conduction exercise(CE)and selfacupressure(SA)may relieve PD symptoms.This paper presents a protocol for a randomized controlled trial to determine the effectiveness of CE and SA in treating PD.Methods:Patients with primary PD were recruited.Eligible patients were randomly assigned to either a treatment or control group.The assessor and data analysts were blind.The treatment phase duration was 8 weeks,with 8 weekly sessions of CE and SA practice.Baseline,midpoint,and final assessments were carried out during the treatment phase.The primary outcome is scores on the 39-item Parkinson’s Disease Questionnaire(PDQ-39),and the secondary outcome is scores on a custom-designed questionnaire based on TCM“Deficiency of Spleen Qi”scores and scores on a non-motor PD symptoms scale.Discussion:This trial is the first rigorous study of the effectiveness of CE and SA in relieving PD symptoms.The aim is to examine the effectiveness of CE and SA in treating a disease that is difficult to treat conventionally.The data obtained will form the foundation for future related studies.Trial registration:Chinese Clinical Trial Registry(ChiCTR-IPR-17011987,Date of registration:14 July,2017).
