In recent years,various transformable nanoparticles（NPs）were successfully prepared and widely utilized for biomedical applications.The sizes,surface charges or morphologies of transformable NPs would affect their be...In recent years,various transformable nanoparticles（NPs）were successfully prepared and widely utilized for biomedical applications.The sizes,surface charges or morphologies of transformable NPs would affect their behavior in physiological/pathological conditions including circulation,penetration,accumulation and retention etc.The other way round,the NPs could be precisely modulated in the specific physiological/pathological condition for precision theranostics of diseases.Herein,we summarized recent advances of transformable NPs for disease diagnostics and therapy.In this review,the transformation of NPs was divided into three groups including changes in size,surface charge and morphology,which was induced by internal stimuli,such as p H,enzyme,receptor or external stimuli,such as light,temperature etc.Moreover,we focused on the characterization of structural transformation in vivo,as well as the transformation-induced biological effects for theranostics of disease.展开更多
基金supported by the National Natural Science Foundation of China(Nos.51573031,21373726,21303723,21603028 and 21573036)Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.11621505)+1 种基金CAS Key Research Program for Frontier Sciences(No.QYZDJ-SSW-SLH022)Key Project of Chinese Academy of Sciences in Cooperation with Foreign Enterprises(No.GJHZ1541)
文摘In recent years,various transformable nanoparticles（NPs）were successfully prepared and widely utilized for biomedical applications.The sizes,surface charges or morphologies of transformable NPs would affect their behavior in physiological/pathological conditions including circulation,penetration,accumulation and retention etc.The other way round,the NPs could be precisely modulated in the specific physiological/pathological condition for precision theranostics of diseases.Herein,we summarized recent advances of transformable NPs for disease diagnostics and therapy.In this review,the transformation of NPs was divided into three groups including changes in size,surface charge and morphology,which was induced by internal stimuli,such as p H,enzyme,receptor or external stimuli,such as light,temperature etc.Moreover,we focused on the characterization of structural transformation in vivo,as well as the transformation-induced biological effects for theranostics of disease.
