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食管癌患者血清TGF-α水平检测的临床价值 被引量:1
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作者 梁启廉 陈小东 +4 位作者 李杰 何悦慨 李建文 揭育丽 康旭 《实用癌症杂志》 2005年第2期158-160,共3页
目的探讨食管癌患者手术前后血清转化生长因子α(TGF-α)水平检测的临床意义。方法应用放射免疫分析法(RIA法)检测30例正常人,58例食管癌患者血清TGF-α水平,并比较40例食管癌患者手术前后血清TGF-α水平。结果血清TGF-α水平与临床分... 目的探讨食管癌患者手术前后血清转化生长因子α(TGF-α)水平检测的临床意义。方法应用放射免疫分析法(RIA法)检测30例正常人,58例食管癌患者血清TGF-α水平,并比较40例食管癌患者手术前后血清TGF-α水平。结果血清TGF-α水平与临床分期、细胞分化程度有关;与食管癌患者性别、年龄无关。食管癌患者血清TGF-α水平(9.01ng/L±1.37ng/L)明显高于正常对照组(6.77ng/L±0.72ng/L)(P<0.01);Ⅳ期食管癌血清TGF-α(11.03ng/L±0.48ng/L)明显高于Ⅰ、Ⅱ、Ⅲ期(7.23ng/L±0.45ng/L、8.73ng/L±0.47ng/L、9.35ng/L±0.44ng/L)(P<0.01),Ⅲ期明显高于Ⅱ期(P<0.05),Ⅱ期明显高于Ⅰ期(P<0.01),低分化食管鳞癌患者血清TGF-α水平(9.96ng/L±1.19ng/L)显著高于中、高分化食管鳞癌患者(9.00ng/L±1.10ng/L、8.35ng/L±1.06ng/L)(P<0.05~0.01);食管癌患者术后血清TGF-α水平(7.45ng/L±0.90ng/L)明显低于术前(8.38ng/L±1.00ng/L)(P<0.01)。结论血清TGFα检测对食管癌疗效观察、病情监测及和和预后判断有重要的参考意义。 展开更多
关键词 癌患者 水平检测 临床价值 血清转化生长因子-α tgf 放射免疫分析法 细胞分化程度 正常对照组 临床意义 手术前后 RIA法 方法应用 临床分期 0.05 疗效观察 预后判断 病情监测 后血清 食管癌 正常人 低分化 高分化
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血清TGF-α水平对肝癌临床诊断的意义 被引量:1
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作者 梁启廉 揭育丽 +2 位作者 银正民 张英 梁伟娟 《临床肿瘤学杂志》 CAS 2002年第1期8-9,13,共3页
目的 :检测血清TGF -α在肝癌临床的应用价值。方法 :采用放射免疫法检测 38例原发性肝癌、16例肝转移癌、2 0例肝硬化及 2 5例正常人的血清TGF -α含量 ,并与AFP值进行比较。数据用x±s表示 ,以正常人x± 2s作为上限计算TGF -... 目的 :检测血清TGF -α在肝癌临床的应用价值。方法 :采用放射免疫法检测 38例原发性肝癌、16例肝转移癌、2 0例肝硬化及 2 5例正常人的血清TGF -α含量 ,并与AFP值进行比较。数据用x±s表示 ,以正常人x± 2s作为上限计算TGF -α阳性率 ,以 4 0 0 μg/L为上限计算AFP阳性率。 结果 :肝硬化组与正常对照组血清TGF -α比较无显著性差异 (P >0 0 5 )。原发性肝癌组、肝转移组血清TGF -α水平显著高于正常对照组 (分别P <0 0 5、P <0 0 1) ;原发性肝癌Ⅲ期组血清TGF-α水平高于Ⅱ期 ,但无明显差别 (P >0 0 5 ) ;原发性肝癌组肝转移组血清TGF -α水平无显著性差异 (P >0 0 5 ) ;肝转移组血清TGF -α和AFP阳性率分别为 6 8 8%和 0 % ;原发性肝癌组血清TGF -α和AFP阳性率分别为 78 9%和 6 8 4 %。结论 :肝癌患者血清TGF -α明显升高 ,血清TGF -α检测有助于肝癌的诊断、鉴别诊断 ,效果优于AFP 。 展开更多
关键词 转化生长因子Α 血清检测 甲胎蛋白 原发性肝癌 肝转移癌 诊断
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胃溃疡患者血清TGF-β_1和T淋巴细胞亚群检测的临床意义 被引量:4
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作者 漆以芹 《放射免疫学杂志》 CAS 2010年第2期139-140,共2页
目的:探讨了胃溃疡患者血清TGF-β1和T淋巴细胞亚群的水平。方法:应用放免法测定32例胃溃疡患者血清TGF-β1水平,单克隆抗体法测定T淋巴细胞亚群水平,并与35名正常健康人作比较。结果:胃溃疡患者血清TGF-β1和CD8水平均非常显著地高于... 目的:探讨了胃溃疡患者血清TGF-β1和T淋巴细胞亚群的水平。方法:应用放免法测定32例胃溃疡患者血清TGF-β1水平,单克隆抗体法测定T淋巴细胞亚群水平,并与35名正常健康人作比较。结果:胃溃疡患者血清TGF-β1和CD8水平均非常显著地高于正常人组(P<0.01),而CD3、CD4、CD4/CD8水平则显著地低于正常人组(P<0.01),相关分析显示,血清TGF-β1与CD4细胞、CD4/CD8呈负相关,与CD8细胞呈正相关。结论:胃溃疡患者血清TGF-β1水平明显升高,而细胞免疫功能低下。TGF-β1对细胞免疫功能抑制作用是胃溃疡患者细胞免疫功能低下的原因之一。 展开更多
关键词 胃溃疡 转化生长因子-Β1 T-淋巴细胞亚群
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The gene expression patterns of BMPR2,EP300,TGFβ2,and TNFAIP3 in B-Lymphoma cells 被引量:1
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作者 Dong-Mei He Hong Wu +3 位作者 Xiu-Li Wu Li Ding Ling Xu Yang-Qiu Li 《Cancer Biology & Medicine》 SCIE CAS CSCD 2014年第3期202-207,共6页
Objective: The results of a previous study showed that a clear dysregulation was evident in the global gene expression of the BCL11A-suppressed B-lymphoma cells. In this study, the bone morphogenetic protein receptor,... Objective: The results of a previous study showed that a clear dysregulation was evident in the global gene expression of the BCL11A-suppressed B-lymphoma cells. In this study, the bone morphogenetic protein receptor, type II(BMPR2), E1 A binding protein p300(EP300), transforming growth factor-β2(TGFβ2), and tumor necrosis factor, and alpha-induced protein 3(TNFAIP3) gene expression patterns in B-cell malignancies were studied. Methods: The relative expression levels of BMPR2, EP300, TGFβ2, and TNFAIP3 mRNA in B-lymphoma cell lines, myeloid cell lines, as well as in cells from healthy volunteers, were determined by real-time quantitative reverse transcriptpolymerase chain reaction(qRT-PCR) with SYBR Green Dye. Glyceraldehyde-3-phosphate dehydrogenase(GAPDH) was used as reference. Results: The expression level of TGFβ2 mRNA in B-lymphoma cell lines was significantly higher than those in the cells from the healthy control(P<0.05). However, the expression level of TNFAIP3 mRNA in B-malignant cells was significantly lower than that of the healthy control(P<0.05). The expression levels of BMPR2 and EP300 mRNA showed no significant difference between B-malignant cell lines and the healthy group(P>0.05). In B-lymphoma cell lines, correlation analyses revealed that the expression of BMPR2 and TNFAIP3(r=0.882, P=0.04) had significant positive relation. The expression levels of BMPR2, EP300, and TNFAIP3 mRNA in cell lines from myeloid leukemia were significantly lower than those in the cells from the healthy control(P<0.05). The expression levels of TGFβ2 mRNA showed no significant difference between myeloid leukemia cell lines and the healthy control or B-malignant cell lines(P>0.05). The expression levels of BMPR2, EP300, and TNFAIP3 mRNA in B-lymphoma cells were significantly higher than those of the myeloid leukemia cells(P<0.05).Conclusion: Different expression patterns of BMPR2, EP300, TGFβ2, and TNFAIP3 genes in B-lymphoma cells exist. 展开更多
关键词 Bone morphogenetic protein receptor type II(BMPR2) E1A binding protein p300(EP300) transforming growth factor-β2(tgfβ2) tumor necrosis factor and alpha-induced protein 3(TNFAIP3) B-lymphoma cells myeloid leukemia cells quantitative reverse transcription polymerase chain reaction(qRT-PCR)
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