The goal of this review is to provide a comprehensive picture of the role,clinical applications and future perspectives of the most widely used non-invasive techniques for the evaluation of hepatitis B virus(HBV)infec...The goal of this review is to provide a comprehensive picture of the role,clinical applications and future perspectives of the most widely used non-invasive techniques for the evaluation of hepatitis B virus(HBV)infection.During the past decade many non-invasive methods have been developed to reduce the need for liver biopsy in staging fibrosis and to overcome whenever possible its limitations,mainly:invasiveness,costs,low reproducibility,poor acceptance by patients.Elastographic techniques conceived to assess liver stiffness,in particular transient elastography,and the most commonly used biological markers will be assessed against their respective role and limitations in staging hepatic fibrosis.Recent evidence highlights that both liver stiffness and some bio-chemical markers correlatewith survival and major clinical end-points such as liver decompensation,development of hepatocellular carcinoma and portal hypertension.Thus the non-invasive techniques here discussed can play a major role in the management of patients with chronic HBV-related hepatitis.Given their prognostic value,transient elastography and some bio-chemical markers can be used to better categorize patients with advanced fibrosis and cirrhosis and assign them to different classes of risk for clinically relevant outcomes.Very recent data indicates that the combined measurements of liver and spleen stiffness enable the reliable prediction of portal hypertension and esophageal varices development.展开更多
The cooling and heating load distribution of large area air-conditioned room such as “open” offices, shopping malls and waiting rooms is usually assumed to be even in air conditioning system design. However, it is n...The cooling and heating load distribution of large area air-conditioned room such as “open” offices, shopping malls and waiting rooms is usually assumed to be even in air conditioning system design. However, it is not the case in reality, and a low efficient air conditioning system results from this assumption. A simulation and analysis of the cooling load distribution of an office building in Hong Kong with TRANSYS software is provided in this paper. A typical office is divided into 13 zones for simulation, including external zone, medial zone and internal zone in the north, the south, the east and the west respectively and a central zone, instead of 4 directional zone. The result shows there is much cooling load difference between each zone, and more attention should be paid to uneven indoor cooling and heating load distribution to further guide the design.展开更多
文摘The goal of this review is to provide a comprehensive picture of the role,clinical applications and future perspectives of the most widely used non-invasive techniques for the evaluation of hepatitis B virus(HBV)infection.During the past decade many non-invasive methods have been developed to reduce the need for liver biopsy in staging fibrosis and to overcome whenever possible its limitations,mainly:invasiveness,costs,low reproducibility,poor acceptance by patients.Elastographic techniques conceived to assess liver stiffness,in particular transient elastography,and the most commonly used biological markers will be assessed against their respective role and limitations in staging hepatic fibrosis.Recent evidence highlights that both liver stiffness and some bio-chemical markers correlatewith survival and major clinical end-points such as liver decompensation,development of hepatocellular carcinoma and portal hypertension.Thus the non-invasive techniques here discussed can play a major role in the management of patients with chronic HBV-related hepatitis.Given their prognostic value,transient elastography and some bio-chemical markers can be used to better categorize patients with advanced fibrosis and cirrhosis and assign them to different classes of risk for clinically relevant outcomes.Very recent data indicates that the combined measurements of liver and spleen stiffness enable the reliable prediction of portal hypertension and esophageal varices development.
文摘The cooling and heating load distribution of large area air-conditioned room such as “open” offices, shopping malls and waiting rooms is usually assumed to be even in air conditioning system design. However, it is not the case in reality, and a low efficient air conditioning system results from this assumption. A simulation and analysis of the cooling load distribution of an office building in Hong Kong with TRANSYS software is provided in this paper. A typical office is divided into 13 zones for simulation, including external zone, medial zone and internal zone in the north, the south, the east and the west respectively and a central zone, instead of 4 directional zone. The result shows there is much cooling load difference between each zone, and more attention should be paid to uneven indoor cooling and heating load distribution to further guide the design.