Acupuncture,a traditional oriental intervention for chronic pain,has been gaining worldwide popularity.Transient receptor potential vanilloid subfamily 1(TRPV1)is a key factor mediating pain production and sensitizati...Acupuncture,a traditional oriental intervention for chronic pain,has been gaining worldwide popularity.Transient receptor potential vanilloid subfamily 1(TRPV1)is a key factor mediating pain production and sensitization.According to multiple studies,TRPV1 is involved the acupuncture-induced relief of pathological pain.Herein,we systematically screened the experimental reports on TRPV1 involvement in acupuncture analgesia,and reviewed the role of TRPV1 in acupuncture in inhibiting different pathological pain and unresolved problems,including inflammatory pain,neuropathic pain,visceral pain,fibromyalgia and cancer pain.At localized acupoints,TRPV1 was involved in the initiation of acupuncture signals.Acupuncture could inhibit the development of pathological pain as well as the transmission of pain signals by suppressing TRPV1 expression and opening activity from the peripheral dorsal root ganglia to the central spinal cord.Furthermore,acupuncture can not only inhibit the expression of TRPV1,but also promote the expression of TRPV1 in the brain to alleviate pain sensation and depression-like behavior.Moreover,the mechanism by which acupuncture regulates TRPV1 may involve neuro-immune crosstalk.In conclusion,the regulation of TRPV1 expression and function may be one of the primary mechanisms by which acupuncture relieves pathological pain,laying the groundwork for future basic research on acupuncture's pain-relieving effects.展开更多
短暂性完全遗忘（transient global amnesia,TGA）是一种具有戏剧性特色的疾病，常有生理性和心理性诱发因素，表现为突发的顺行性遗忘，伴反复询问，持续数分钟至数小时后好转。TGA的研究主要集中在病因和病理学机制方面，目前主要有...短暂性完全遗忘（transient global amnesia,TGA）是一种具有戏剧性特色的疾病，常有生理性和心理性诱发因素，表现为突发的顺行性遗忘，伴反复询问，持续数分钟至数小时后好转。TGA的研究主要集中在病因和病理学机制方面，目前主要有以下几种假说：短暂性脑缺血发作学说、癫痫学说、偏头痛学说、脑静脉缺血或静脉栓塞学说、人格障碍或情绪刺激学说以及其他学说。TGA的预后较好，复发率低，无需特殊治疗措施。文章对TGA的研究进展做了综述。展开更多
基金Supported by the National Natural Science Foundation of China:No.8203012582105024+2 种基金the National Natural Science Foundation of Tianjin:No.20JCQNJC0028020JCQNJC00920the Tianjin Health Commission:No.2021056。
文摘Acupuncture,a traditional oriental intervention for chronic pain,has been gaining worldwide popularity.Transient receptor potential vanilloid subfamily 1(TRPV1)is a key factor mediating pain production and sensitization.According to multiple studies,TRPV1 is involved the acupuncture-induced relief of pathological pain.Herein,we systematically screened the experimental reports on TRPV1 involvement in acupuncture analgesia,and reviewed the role of TRPV1 in acupuncture in inhibiting different pathological pain and unresolved problems,including inflammatory pain,neuropathic pain,visceral pain,fibromyalgia and cancer pain.At localized acupoints,TRPV1 was involved in the initiation of acupuncture signals.Acupuncture could inhibit the development of pathological pain as well as the transmission of pain signals by suppressing TRPV1 expression and opening activity from the peripheral dorsal root ganglia to the central spinal cord.Furthermore,acupuncture can not only inhibit the expression of TRPV1,but also promote the expression of TRPV1 in the brain to alleviate pain sensation and depression-like behavior.Moreover,the mechanism by which acupuncture regulates TRPV1 may involve neuro-immune crosstalk.In conclusion,the regulation of TRPV1 expression and function may be one of the primary mechanisms by which acupuncture relieves pathological pain,laying the groundwork for future basic research on acupuncture's pain-relieving effects.
文摘短暂性完全遗忘（transient global amnesia,TGA）是一种具有戏剧性特色的疾病，常有生理性和心理性诱发因素，表现为突发的顺行性遗忘，伴反复询问，持续数分钟至数小时后好转。TGA的研究主要集中在病因和病理学机制方面，目前主要有以下几种假说：短暂性脑缺血发作学说、癫痫学说、偏头痛学说、脑静脉缺血或静脉栓塞学说、人格障碍或情绪刺激学说以及其他学说。TGA的预后较好，复发率低，无需特殊治疗措施。文章对TGA的研究进展做了综述。
