Transition-metal-catalyzed C–H bond activation represents one of the most attractive research areas in organic synthesis.In contrast to the great developments made in directed C–H bond functionalization of arenes,th...Transition-metal-catalyzed C–H bond activation represents one of the most attractive research areas in organic synthesis.In contrast to the great developments made in directed C–H bond functionalization of arenes,the directing group-assisted activation of non-aromatic vinylic C–H bonds still remains challenging.During the recent years,significant progress has been made in this fascinating field with various functionalized alkenes,heterocycles and carbocycles being obtained.This article will focus on the recent achievements in the field of directing-group-assisted vinylic C–H bond functionalization.展开更多
Transition-metal-catalyzed C–H bond functionalization has attracted tremendous attention as an increasingly important protocol for the construction of C–C and C–X bonds.In particular,C–H bond functionalization ass...Transition-metal-catalyzed C–H bond functionalization has attracted tremendous attention as an increasingly important protocol for the construction of C–C and C–X bonds.In particular,C–H bond functionalization assisted by the phosphorus-containing directing groups has made significant progress in the past few years.A series of valuable phosphorous compounds,especially phosphine ligands have been provided conveniently.This review comprehensively describes recent advances in transition-metal-catalyzed C–H bond functionalization assisted by the phosphorus-containing directing groups,highlights its potential applications in organic synthesis,and gives some insights into future advances.展开更多
基金supported by the National Basic Research Program of China(2015CB856600)the National Natural Science Foundation of China(21332002,21272010)
文摘Transition-metal-catalyzed C–H bond activation represents one of the most attractive research areas in organic synthesis.In contrast to the great developments made in directed C–H bond functionalization of arenes,the directing group-assisted activation of non-aromatic vinylic C–H bonds still remains challenging.During the recent years,significant progress has been made in this fascinating field with various functionalized alkenes,heterocycles and carbocycles being obtained.This article will focus on the recent achievements in the field of directing-group-assisted vinylic C–H bond functionalization.
基金supported by the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2022R01007)the National Natural Science Foundation of China(Nos.21971062 and 22171082.)the Start-up Research Grant from Zhejiang Normal University.
文摘Transition-metal-catalyzed C–H bond functionalization has attracted tremendous attention as an increasingly important protocol for the construction of C–C and C–X bonds.In particular,C–H bond functionalization assisted by the phosphorus-containing directing groups has made significant progress in the past few years.A series of valuable phosphorous compounds,especially phosphine ligands have been provided conveniently.This review comprehensively describes recent advances in transition-metal-catalyzed C–H bond functionalization assisted by the phosphorus-containing directing groups,highlights its potential applications in organic synthesis,and gives some insights into future advances.
