Crohn's disease(CD) represents a chronic transmural inflammatory condition of the gastrointestinal tract, which usually leads to structural damage and signific-ant disability. Deep remission--defined by both clini...Crohn's disease(CD) represents a chronic transmural inflammatory condition of the gastrointestinal tract, which usually leads to structural damage and signific-ant disability. Deep remission--defined by both clinical and endoscopic remission, signifying mucosal healing-represents the current endpoint in the treat--to--target strategy, significantly improving patients' long--term outcomes. Transmural healing(TH) could be a more effe-ctive target, but this possibility remains unclear. This narrative review aims to critically review and summarize the available literature relating TH to long--term outcomes, being the first of its kind and to the best of the author's knowledge. A systematic literature search(from incep-tion to March 31 2018) was performed, using multiple databases, and identifying seven full--text manuscripts. In those studies, long--term favorable outcomes(≥ 52 wk) included sustained clinical remission, as well as fewer therapeutic changes, CD--related hospitalizations, and surgeries. Despite heterogeneous design and me-thodological limitations, six of the studies demonstrated that TH or intestinal healing(TH plus mucosal healing) were predictive for the aforementioned favorable out-comes. Therefore, TH may become a reasonable the-rapeutic target and be included in the concept of deep remission. Further prospective, well-designed, multicenter trials aiming to better define the role of TH in personalized therapy for CD and to determine the long-term influence of TH on bowel damage and disability are warranted.展开更多
目的探究不同起始浓度氧复苏方案对足月新生儿窒息抢救的效果。方法选取2018年7月~2019年12月我院收入治疗的60例足月新生儿窒息患儿的临床资料,按照起始浓度氧复苏的不同分为对照组与观察组,每组各30例。对照组采用21%氧浓度复苏治疗,...目的探究不同起始浓度氧复苏方案对足月新生儿窒息抢救的效果。方法选取2018年7月~2019年12月我院收入治疗的60例足月新生儿窒息患儿的临床资料,按照起始浓度氧复苏的不同分为对照组与观察组,每组各30例。对照组采用21%氧浓度复苏治疗,观察组采用30%氧浓度复苏治疗。比较两组首次啼哭时间、自主呼吸时间、复苏抢救5 min时的心率、增氧复苏率、脑损伤发生率、复苏成功率、氧中毒发生率及治疗后的1、5、10 min的新生儿Apgar评分。结果两组脑损伤发生率、复苏成功率及复苏抢救5 min时的心率比较,差异无统计学意义(P>0.05);观察组增氧复苏率(3.33%)、氧中毒发生率(0.00%)低于对照组(26.66%、20.00%),差异有统计学意义(P<0.05);观察组首次啼哭时间、自主呼吸时间均短于对照组,差异有统计学意义(P<0.05);两组1 min Apgar评分比较,差异无统计学意义(P>0.05),而观察组5、10 min Apgar评分高于对照组,差异有统计学意义(P<0.05)。结论对足月新生儿窒息抢救治疗效果而言,采用30%氧浓度与21%氧浓度进行复苏治疗效果相当,且安全可靠,但采用30%氧浓度复苏治疗足月新生儿窒息可有效降低患儿脑损伤率,缩短患儿自主呼吸与首次啼哭时间,提高Apgar评分,值得临床推广应用。展开更多
文摘Crohn's disease(CD) represents a chronic transmural inflammatory condition of the gastrointestinal tract, which usually leads to structural damage and signific-ant disability. Deep remission--defined by both clinical and endoscopic remission, signifying mucosal healing-represents the current endpoint in the treat--to--target strategy, significantly improving patients' long--term outcomes. Transmural healing(TH) could be a more effe-ctive target, but this possibility remains unclear. This narrative review aims to critically review and summarize the available literature relating TH to long--term outcomes, being the first of its kind and to the best of the author's knowledge. A systematic literature search(from incep-tion to March 31 2018) was performed, using multiple databases, and identifying seven full--text manuscripts. In those studies, long--term favorable outcomes(≥ 52 wk) included sustained clinical remission, as well as fewer therapeutic changes, CD--related hospitalizations, and surgeries. Despite heterogeneous design and me-thodological limitations, six of the studies demonstrated that TH or intestinal healing(TH plus mucosal healing) were predictive for the aforementioned favorable out-comes. Therefore, TH may become a reasonable the-rapeutic target and be included in the concept of deep remission. Further prospective, well-designed, multicenter trials aiming to better define the role of TH in personalized therapy for CD and to determine the long-term influence of TH on bowel damage and disability are warranted.
文摘目的探究不同起始浓度氧复苏方案对足月新生儿窒息抢救的效果。方法选取2018年7月~2019年12月我院收入治疗的60例足月新生儿窒息患儿的临床资料,按照起始浓度氧复苏的不同分为对照组与观察组,每组各30例。对照组采用21%氧浓度复苏治疗,观察组采用30%氧浓度复苏治疗。比较两组首次啼哭时间、自主呼吸时间、复苏抢救5 min时的心率、增氧复苏率、脑损伤发生率、复苏成功率、氧中毒发生率及治疗后的1、5、10 min的新生儿Apgar评分。结果两组脑损伤发生率、复苏成功率及复苏抢救5 min时的心率比较,差异无统计学意义(P>0.05);观察组增氧复苏率(3.33%)、氧中毒发生率(0.00%)低于对照组(26.66%、20.00%),差异有统计学意义(P<0.05);观察组首次啼哭时间、自主呼吸时间均短于对照组,差异有统计学意义(P<0.05);两组1 min Apgar评分比较,差异无统计学意义(P>0.05),而观察组5、10 min Apgar评分高于对照组,差异有统计学意义(P<0.05)。结论对足月新生儿窒息抢救治疗效果而言,采用30%氧浓度与21%氧浓度进行复苏治疗效果相当,且安全可靠,但采用30%氧浓度复苏治疗足月新生儿窒息可有效降低患儿脑损伤率,缩短患儿自主呼吸与首次啼哭时间,提高Apgar评分,值得临床推广应用。
