With the development of the rhetoric study from the origins in ancient Athens and The Rhetoric of Aristotle to the formation of modern Communication Study at the beginning of the twentieth century,the Rhetoric Study c...With the development of the rhetoric study from the origins in ancient Athens and The Rhetoric of Aristotle to the formation of modern Communication Study at the beginning of the twentieth century,the Rhetoric Study changed in dynamic and its concepts and theories merged and formed the foundations of Communication Study which focused on personal communication and speech rhetoric skills at that time.At the beginning of the twentieth century,although the Neo-Aristotelian rhetorical scholars from classic rhetoric approach created methodologies and enriched the content of Communication Study under the influence of humanistic study and social science study,but the Communication discipline was still in the embarrassing position.During World War I and World War II,most scholars with backgrounds of social science,history and anthropology carried out the studies of propaganda wars and the message disseminating,and explored the military powers and governments’access to the media and developed serial communication modes from the social science perspective,which laid the foundation for Communication discipline in the academic field.The author analyzed the Rhetoric and Social Science origins of Communication study in Boxing Plato’s Shadow:an Introduction to the Study of Human Communication,which is beneficial and helpful to understand the academic origins of Communication study and its cross-disciplined and embarrassing positions.展开更多
There have been controversies over differing opinions in the source of the American Indians. In this paper, the writer criticized the so-called classical theory that the remote ancestors of the American Indians entere...There have been controversies over differing opinions in the source of the American Indians. In this paper, the writer criticized the so-called classical theory that the remote ancestors of the American Indians entered America from Asia through the Bering Straits 14,000 ~ 20,000 years ago, worn their “clothes” and carried kindling during the late Paleolithic, no matter how by “boat” across the Bering Sea or by foot through a “Bering Land Bridge” which might once link up Asia and North America during glacial period;and independently proposed a new hypothesis that American Indians might be originated from the Western Rift Valley of North America. On the basis of locus distribution of American ancient human’s remnants, the writer pointed out that American ancient humans might be first originated at Yukon Territory of Canada within the Western Rift Valley of North America (the Basin & Range Province), and then migrated south ward (Yukon Territory → Mojave Desert → Mexico → Peru → Chile). Moreover, American Indians would have long been a presence for 40,000 years, or even 100,000 ~ 200,000 years in the American continents. So far, the logical basis which American Indians came from Asia 14,000 ~ 20,000 years ago was crushed, and derived two inferences: 1) American Indians might be originated from the Western Rift Valley of North America;2) Only the Eskimo might be the mover eastward from Asia, because of their gene B.展开更多
I.The History of the Drafting of the Universal Declaration of Human Rights:the Position and Role of the UN Economic and Social Council and the General Assembly of the United Nations should not be Ignored The reason fo...I.The History of the Drafting of the Universal Declaration of Human Rights:the Position and Role of the UN Economic and Social Council and the General Assembly of the United Nations should not be Ignored The reason for me to use the term "source"in the discussion on the right to subsistence展开更多
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by infection with human coronavirus 2019 (HCoV-19/SARS-CoV-2/2019-nCoV), is a global threat to the human population. Here, we briefly summarize the a...The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by infection with human coronavirus 2019 (HCoV-19/SARS-CoV-2/2019-nCoV), is a global threat to the human population. Here, we briefly summarize the available data for the zoonotic origins of HCoV-19, with reference to the other two epidemics of highly virulent coronaviruses, SARSCoV and MERS-CoV, which cause severe pneumonia in humans. We propose to intensify future efforts for tracing the origins of HCoV-19, which is a very important scientific question for the control and prevention of the pandemic.展开更多
Human origins have always been a hot topic of research in academia,focusing on the controversy between“single African origin”and“multiregional evolution.”The evolution from ancient ape to modern humans was a compl...Human origins have always been a hot topic of research in academia,focusing on the controversy between“single African origin”and“multiregional evolution.”The evolution from ancient ape to modern humans was a complex process,which required the co-existence of diverse favorable factors.Based on a review of existing research findings,this paper argues that modern humans originated in the Himalayas and presents multi-dimensional evidence from the perspectives of geology,seismology,climatology,archaeology,biology,genetics,and others.The evolution from ape to man may have also existed in regions other than the Himalayas.However,such evolution falls under“invalid origin”due to the lack of essential conditions for evolution,and particularly,the evolutionary process was interrupted by the erosion of frequent Quaternary glaciations.The homo sapiens originating in the Himalayas gradually migrated and settled down across the world several times during the interglacial periods,creating local cultures and colorful civilizations in parallel.The findings of this paper provide new orientations and approaches for the studies of human origins and the development of civilizations.展开更多
The developmental origins of health and diseases(DOHaD)is a concept stating that adverse intrauterine environments contribute to the health risks of offspring.Since the theory emerged more than 30 years ago,many epide...The developmental origins of health and diseases(DOHaD)is a concept stating that adverse intrauterine environments contribute to the health risks of offspring.Since the theory emerged more than 30 years ago,many epidemiological and animal studies have confirmed that in utero exposure to environmental insults,including hyperglycemia and chemicals,increased the risk of developing noncommunicable diseases(NCDs).These NCDs include metabolic syndrome,type 2 diabetes,and complications such as diabetic cardiomyopathy.Studying the effects of different environmental insults on early embryo development would aid in understanding the underlying mechanisms by which these insults promote NCD development.Embryonic stem cells(ESCs)have also been utilized by researchers to study the DOHaD.ESCs have pluripotent characteristics and can be differentiated into almost every cell lineage;therefore,they are excellent in vitro models for studying early developmental events.More importantly,human ESCs(hESCs)are the best alternative to human embryos for research because of ethical concerns.In this review,we will discuss different maternal conditions associated with DOHaD,focusing on the complications of maternal diabetes.Next,we will review the differentiation protocols developed to generate different cell lineages from hESCs.Additionally,we will review how hESCs are utilized as a model for research into the DOHaD.The effects of environmental insults on hESC differentiation and the possible involvement of epigenetic regulation will be discussed.展开更多
Objective Through the metaphorical archetypal spirit and mythological semantics of Chinese character structure, this paper explores the metaphorical mythological gene and the moral order of the Chinese character struc...Objective Through the metaphorical archetypal spirit and mythological semantics of Chinese character structure, this paper explores the metaphorical mythological gene and the moral order of the Chinese character structure, geographical thinking and aesthetic orientation of the mythological prototypes derived from the Chinese characters. Method The cultural archetypes and the theories of big and small traditions are adopted to sort out the mythological beliefs in the former architectural forms of the big traditions and the ethical narrative system carried by the buildings in the small cultural traditional societies. In the architectural archetypes dominated by big and small cultural traditions, the thinking of “archetypes and ethics” is found to be a homologous gene, which confirms the universal significance of the spirit of Chinese Confucian ethics to the power of Chinese civilization flowing and inheriting and human morality. Conclusion The structure of Chinese characters has the function of “recording” and “interpreting”, and the mythological thinking of architectural form materials, understands the ultimate transformation of cultural archetypes in creation, and guides the value of the traditional architectural design of “bringing out goodness and symbiosis” in the contemporary era. To relieve the material pursuit of spiritual enjoyment at that moment, to promote cultural heritage and the role of social treatment, to build cultural identity and the spiritual transcendence of the existence value of space ethics and the overall social and cultural identity.展开更多
The draft of the Basic Healthcare and Health Promotion Law directly incorporates the concept of the right to health,which will have a positive significance in realizing the constitutional norms of the right to health ...The draft of the Basic Healthcare and Health Promotion Law directly incorporates the concept of the right to health,which will have a positive significance in realizing the constitutional norms of the right to health protection.China’s Constitution stipulates the general policy,concrete duties and specific obligations of the state to protect citizens’ right to health,which is the most fundamental logical starting point of legislative design.The implementation of state obligations requires the legislation to follow the principles as follows:people-centered public welfare,respecting and protecting the principle of citizens’ right to health,equitable access to basic medical and health services and the government responsibility for the purpose of the people’s health.展开更多
The posterior communicating artery (PCoA) arises from the cerebral part of the internal carotid artery and reaching the interpeduncular cistern unites with the posterior cerebral artery, marking the beginning of its p...The posterior communicating artery (PCoA) arises from the cerebral part of the internal carotid artery and reaching the interpeduncular cistern unites with the posterior cerebral artery, marking the beginning of its post-communicating part. We accidentally found a case of an unusual origin and termination of the right PCoA associated with a presence of the right olfactory artery remnant in a 35-year-old male cadaver routinely dis-sected at Institute of Forensic Medicine. Presented vascular variations have not been reported previously in the literature. In the event of PCoA origin from the right middle cerebral artery normally developed from the cra-nial end of primitive internal carotid artery, as well as the PCoA junction with basilar tip, this PCoA could be the most cranial carotid-basilar anastomosis. Simultaneously, here presented right olfactory artery remnant could be the third variant of this persistent embryonic artery.展开更多
[Objective] This paper aims to confirm that Yunnan is one origin center of rice and human in the world.[Method] The complicated and unique ecological environment in Yunnan makes Yunnan Province the largest center of g...[Objective] This paper aims to confirm that Yunnan is one origin center of rice and human in the world.[Method] The complicated and unique ecological environment in Yunnan makes Yunnan Province the largest center of genetic diversity and cultural diversity of rice and human being as well as the cradle of human childhood.[Result] The genetic diversity and cultural diversity of rice and human being is closely related to the ecosystem diversity.Rice civilization in Yunnan can be divided into four types,including the diversity center region of rice civilization in southwestern Yunnan,diffusion region of rice civilization of Hani-Zhuang in southern Yunnan,rice civilization region of water-drought rotation in central Yunnan and poverty region of rice civilization in northern Yunnan.Southwestern Yunnan is not only the center of genetic ecological diversity and rice cultural diversity,but also the center of origin and diversity of crop genetic diversity.It is not only a transitional region among East Asia continent,South Asian sub-continent and Indo-China Peninsula,but also a core integration area of Chinese culture,Indian culture and Mid-south Peninsula culture which all merge with the local culture.[Conclusion] Yunnan is one common sphere where the origin of human evolution is closely related to the origin of rice evolution.展开更多
Recent histological and molecular characterization of cholangiocarcinoma(CCA) highlights the heterogeneity of this cancer that may emerge at different sites of the biliary tree and with different macroscopic or morpho...Recent histological and molecular characterization of cholangiocarcinoma(CCA) highlights the heterogeneity of this cancer that may emerge at different sites of the biliary tree and with different macroscopic or morphological features.Furthermore,different stem cell niches have been recently described in the liver and biliarytree,suggesting this as the basis of the heterogeneity of intrahepatic(IH)-and extrahepatic(EH)-CCAs,which are two largely different tumors from both biological and epidemiological points of view.The complexity of the organization of the liver stem cell compartments could underlie the CCA clinical-pathological heterogeneity and the criticisms in classifying primitive liver tumors.These recent advances highlight a possible new classification of CCAs based on cells of origin and this responds to the need of generating homogenous diagnostic,prognostic and,hopefully,therapeutic categories of IH-and EH-CCAs.展开更多
Under the background of the fact that human rights protection has become an important part of the socialist construction with Chinese characteristics in the new era, and with the international background of the streng...Under the background of the fact that human rights protection has become an important part of the socialist construction with Chinese characteristics in the new era, and with the international background of the strengthened trend of mainstreaming of human rights, Xi Jinping’s series of speeches and the 19 th CPC national Congress reports comprehensively explained the construction of human rights in China and the development of the international human rights. The important discourse on human rights by General Secretary Xi Jinping is people-centered: people’s yearning for a better life is our goal and reveals the source of human rights. Chinese dream is a dream of the country, of the nation, and of everyone in China. The close integration of individual and collective human rights points out that the state and people are important parts of collective human rights and it is an effective response to the "human rights over sovereignty" of Western countries. That there are not the best human rights, but the better ones; fighting for human rights is not always done, but always doing scientifically reveals the operational form of human rights. The right of survival and development is the primary human right; to attach importance to the right of peace conforms to the reality of our country and it has the support of the vast number of developing countries. Building a community with a shared future for human beings is a new vision for the development of the international human rights. only when the perfection and implementation of Constitution and law are paid attention to, and the democratization and legalization of the international human rights cause are promoted, can the guarantee be provided for the realization of human rights. The important discourse on human rights by General Secretary Xi Jinping is guided by Marxism, carries the communist party member’s original intention of serving people and is deeply rooted in the masses of the people. It inherits the theory of "benevolence" and "harmony" in Chinese culture,stands at the height of history and times, and points out the direction for the all-round development of Chinese people and the overall progress of society, and for the liberation of all mankind. This scientific theory is successfully guiding China’s human rights construction constantly towards new achievements and has had a profound and extensive impact on the international human rights cause.展开更多
Objective:To carry out the genetic characterization and evolutionary analysis of three avian orthoavulavirus 1(AOAV-1)isolates from poultry workers with respiratory symptoms.Methods:Using Illumina Mi Seq,whole-genome ...Objective:To carry out the genetic characterization and evolutionary analysis of three avian orthoavulavirus 1(AOAV-1)isolates from poultry workers with respiratory symptoms.Methods:Using Illumina Mi Seq,whole-genome sequencing was carried out to assess the evolutionary dynamics of three AOAV-1 isolates.A phylogenetic and comparative analysis of all coding genes was done using bioinformatics tools.Results:Phylogenetic analysis and genetic distance estimation suggested a close relationship among human-and avian-originated velogenic strains of genotypeⅩⅢ,sub-genotypeⅩⅢ.2.1.Several substitutions in the significant structural and biological motifs were exclusively identified in the human-originated strains.Conclusions:To our knowledge,this is the first report of a velogenic AOAV-1 isolate from natural infection of the human upper respiratory tract.Our findings highlight the evolution and zoonotic potential of velogenic AOAV-1 in a disease endemic setting.展开更多
The Chinese Dream is not only the dream of rejuvenation of the Chinese nation,but also the dream of human rights of the Chinese people.To accurately understand the shared root and origin of the Chinese Dream and the p...The Chinese Dream is not only the dream of rejuvenation of the Chinese nation,but also the dream of human rights of the Chinese people.To accurately understand the shared root and origin of the Chinese Dream and the protection of human rights in China,we must understand that the Chinese Dream provides new strategic guidance for the protection of human rights in China,and the protection of human rights in China is an important measure to promote the realization of the Chinese Dream.To realize the Chinese Dream in the new era,Chinass human rights protection must always be people-centered,and adhere to the resolution of the main social contradictions in the new era.On the basis of raising the awareness of the whole Party and society to respect and protect human rights,we should remove obstacles and barriers to human rights protection and promote the building of a community with a shared future for human beings.At the same time,the protection of human rights in China in the new era must be guided by Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era.We must adhere to the path of human rights development with Chinese characteristics,and study and solve various practical problems of human rights protection in China in the course of upholding integrity and innovation,so as to promote the realization of the Chinese Dream.Upholding the leadership of the Communist Party of China is the fundamental guarantee for realizing the Chinese Dream and protecting human rights in China.We must unswervingly follow the CPC’s lead and open up a new stage in the development of Chinas’human rights cause in the new era on the great journey to the Chinese Dream.展开更多
文摘With the development of the rhetoric study from the origins in ancient Athens and The Rhetoric of Aristotle to the formation of modern Communication Study at the beginning of the twentieth century,the Rhetoric Study changed in dynamic and its concepts and theories merged and formed the foundations of Communication Study which focused on personal communication and speech rhetoric skills at that time.At the beginning of the twentieth century,although the Neo-Aristotelian rhetorical scholars from classic rhetoric approach created methodologies and enriched the content of Communication Study under the influence of humanistic study and social science study,but the Communication discipline was still in the embarrassing position.During World War I and World War II,most scholars with backgrounds of social science,history and anthropology carried out the studies of propaganda wars and the message disseminating,and explored the military powers and governments’access to the media and developed serial communication modes from the social science perspective,which laid the foundation for Communication discipline in the academic field.The author analyzed the Rhetoric and Social Science origins of Communication study in Boxing Plato’s Shadow:an Introduction to the Study of Human Communication,which is beneficial and helpful to understand the academic origins of Communication study and its cross-disciplined and embarrassing positions.
文摘There have been controversies over differing opinions in the source of the American Indians. In this paper, the writer criticized the so-called classical theory that the remote ancestors of the American Indians entered America from Asia through the Bering Straits 14,000 ~ 20,000 years ago, worn their “clothes” and carried kindling during the late Paleolithic, no matter how by “boat” across the Bering Sea or by foot through a “Bering Land Bridge” which might once link up Asia and North America during glacial period;and independently proposed a new hypothesis that American Indians might be originated from the Western Rift Valley of North America. On the basis of locus distribution of American ancient human’s remnants, the writer pointed out that American ancient humans might be first originated at Yukon Territory of Canada within the Western Rift Valley of North America (the Basin & Range Province), and then migrated south ward (Yukon Territory → Mojave Desert → Mexico → Peru → Chile). Moreover, American Indians would have long been a presence for 40,000 years, or even 100,000 ~ 200,000 years in the American continents. So far, the logical basis which American Indians came from Asia 14,000 ~ 20,000 years ago was crushed, and derived two inferences: 1) American Indians might be originated from the Western Rift Valley of North America;2) Only the Eskimo might be the mover eastward from Asia, because of their gene B.
文摘I.The History of the Drafting of the Universal Declaration of Human Rights:the Position and Role of the UN Economic and Social Council and the General Assembly of the United Nations should not be Ignored The reason for me to use the term "source"in the discussion on the right to subsistence
文摘The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by infection with human coronavirus 2019 (HCoV-19/SARS-CoV-2/2019-nCoV), is a global threat to the human population. Here, we briefly summarize the available data for the zoonotic origins of HCoV-19, with reference to the other two epidemics of highly virulent coronaviruses, SARSCoV and MERS-CoV, which cause severe pneumonia in humans. We propose to intensify future efforts for tracing the origins of HCoV-19, which is a very important scientific question for the control and prevention of the pandemic.
文摘Human origins have always been a hot topic of research in academia,focusing on the controversy between“single African origin”and“multiregional evolution.”The evolution from ancient ape to modern humans was a complex process,which required the co-existence of diverse favorable factors.Based on a review of existing research findings,this paper argues that modern humans originated in the Himalayas and presents multi-dimensional evidence from the perspectives of geology,seismology,climatology,archaeology,biology,genetics,and others.The evolution from ape to man may have also existed in regions other than the Himalayas.However,such evolution falls under“invalid origin”due to the lack of essential conditions for evolution,and particularly,the evolutionary process was interrupted by the erosion of frequent Quaternary glaciations.The homo sapiens originating in the Himalayas gradually migrated and settled down across the world several times during the interglacial periods,creating local cultures and colorful civilizations in parallel.The findings of this paper provide new orientations and approaches for the studies of human origins and the development of civilizations.
文摘The developmental origins of health and diseases(DOHaD)is a concept stating that adverse intrauterine environments contribute to the health risks of offspring.Since the theory emerged more than 30 years ago,many epidemiological and animal studies have confirmed that in utero exposure to environmental insults,including hyperglycemia and chemicals,increased the risk of developing noncommunicable diseases(NCDs).These NCDs include metabolic syndrome,type 2 diabetes,and complications such as diabetic cardiomyopathy.Studying the effects of different environmental insults on early embryo development would aid in understanding the underlying mechanisms by which these insults promote NCD development.Embryonic stem cells(ESCs)have also been utilized by researchers to study the DOHaD.ESCs have pluripotent characteristics and can be differentiated into almost every cell lineage;therefore,they are excellent in vitro models for studying early developmental events.More importantly,human ESCs(hESCs)are the best alternative to human embryos for research because of ethical concerns.In this review,we will discuss different maternal conditions associated with DOHaD,focusing on the complications of maternal diabetes.Next,we will review the differentiation protocols developed to generate different cell lineages from hESCs.Additionally,we will review how hESCs are utilized as a model for research into the DOHaD.The effects of environmental insults on hESC differentiation and the possible involvement of epigenetic regulation will be discussed.
文摘Objective Through the metaphorical archetypal spirit and mythological semantics of Chinese character structure, this paper explores the metaphorical mythological gene and the moral order of the Chinese character structure, geographical thinking and aesthetic orientation of the mythological prototypes derived from the Chinese characters. Method The cultural archetypes and the theories of big and small traditions are adopted to sort out the mythological beliefs in the former architectural forms of the big traditions and the ethical narrative system carried by the buildings in the small cultural traditional societies. In the architectural archetypes dominated by big and small cultural traditions, the thinking of “archetypes and ethics” is found to be a homologous gene, which confirms the universal significance of the spirit of Chinese Confucian ethics to the power of Chinese civilization flowing and inheriting and human morality. Conclusion The structure of Chinese characters has the function of “recording” and “interpreting”, and the mythological thinking of architectural form materials, understands the ultimate transformation of cultural archetypes in creation, and guides the value of the traditional architectural design of “bringing out goodness and symbiosis” in the contemporary era. To relieve the material pursuit of spiritual enjoyment at that moment, to promote cultural heritage and the role of social treatment, to build cultural identity and the spiritual transcendence of the existence value of space ethics and the overall social and cultural identity.
基金a preliminary result of the project “Research on Mental Health Legislationin Beijing from Perspective of Public Governance”(Project No.15FXB029)sponsored by Beijing Social Science Fund
文摘The draft of the Basic Healthcare and Health Promotion Law directly incorporates the concept of the right to health,which will have a positive significance in realizing the constitutional norms of the right to health protection.China’s Constitution stipulates the general policy,concrete duties and specific obligations of the state to protect citizens’ right to health,which is the most fundamental logical starting point of legislative design.The implementation of state obligations requires the legislation to follow the principles as follows:people-centered public welfare,respecting and protecting the principle of citizens’ right to health,equitable access to basic medical and health services and the government responsibility for the purpose of the people’s health.
基金supported by Ministry of Science and Technological Development of Republic of Serbia(contract grant numbers:41018 and 175092).
文摘The posterior communicating artery (PCoA) arises from the cerebral part of the internal carotid artery and reaching the interpeduncular cistern unites with the posterior cerebral artery, marking the beginning of its post-communicating part. We accidentally found a case of an unusual origin and termination of the right PCoA associated with a presence of the right olfactory artery remnant in a 35-year-old male cadaver routinely dis-sected at Institute of Forensic Medicine. Presented vascular variations have not been reported previously in the literature. In the event of PCoA origin from the right middle cerebral artery normally developed from the cra-nial end of primitive internal carotid artery, as well as the PCoA junction with basilar tip, this PCoA could be the most cranial carotid-basilar anastomosis. Simultaneously, here presented right olfactory artery remnant could be the third variant of this persistent embryonic artery.
基金Supported by National Natural Science Foundation of China(31060186)Exploitue of Emphases New Production from Yunnan Provincial Scientific and Technology Department(2010BB001)Project for Innovative Pilot Enterprises from Science and Technology Bureau of Kunming City(Kunkejizi10N060204)~~
文摘[Objective] This paper aims to confirm that Yunnan is one origin center of rice and human in the world.[Method] The complicated and unique ecological environment in Yunnan makes Yunnan Province the largest center of genetic diversity and cultural diversity of rice and human being as well as the cradle of human childhood.[Result] The genetic diversity and cultural diversity of rice and human being is closely related to the ecosystem diversity.Rice civilization in Yunnan can be divided into four types,including the diversity center region of rice civilization in southwestern Yunnan,diffusion region of rice civilization of Hani-Zhuang in southern Yunnan,rice civilization region of water-drought rotation in central Yunnan and poverty region of rice civilization in northern Yunnan.Southwestern Yunnan is not only the center of genetic ecological diversity and rice cultural diversity,but also the center of origin and diversity of crop genetic diversity.It is not only a transitional region among East Asia continent,South Asian sub-continent and Indo-China Peninsula,but also a core integration area of Chinese culture,Indian culture and Mid-south Peninsula culture which all merge with the local culture.[Conclusion] Yunnan is one common sphere where the origin of human evolution is closely related to the origin of rice evolution.
基金Supported by Research Project Grant from the University "Sapienza" of RomeFIRB grant No. RBAP10Z7FS_001+3 种基金FIRB grant No. RBAP10Z7FS_004PRIN grant No. 2009X84L84_001 (to Gaudio E)PRIN grant No. 2009X84L84_002 (to Alvaro D)Consorzio Interuniversitario Trapianti d'Organo,Rome,Italy
文摘Recent histological and molecular characterization of cholangiocarcinoma(CCA) highlights the heterogeneity of this cancer that may emerge at different sites of the biliary tree and with different macroscopic or morphological features.Furthermore,different stem cell niches have been recently described in the liver and biliarytree,suggesting this as the basis of the heterogeneity of intrahepatic(IH)-and extrahepatic(EH)-CCAs,which are two largely different tumors from both biological and epidemiological points of view.The complexity of the organization of the liver stem cell compartments could underlie the CCA clinical-pathological heterogeneity and the criticisms in classifying primitive liver tumors.These recent advances highlight a possible new classification of CCAs based on cells of origin and this responds to the need of generating homogenous diagnostic,prognostic and,hopefully,therapeutic categories of IH-and EH-CCAs.
文摘Under the background of the fact that human rights protection has become an important part of the socialist construction with Chinese characteristics in the new era, and with the international background of the strengthened trend of mainstreaming of human rights, Xi Jinping’s series of speeches and the 19 th CPC national Congress reports comprehensively explained the construction of human rights in China and the development of the international human rights. The important discourse on human rights by General Secretary Xi Jinping is people-centered: people’s yearning for a better life is our goal and reveals the source of human rights. Chinese dream is a dream of the country, of the nation, and of everyone in China. The close integration of individual and collective human rights points out that the state and people are important parts of collective human rights and it is an effective response to the "human rights over sovereignty" of Western countries. That there are not the best human rights, but the better ones; fighting for human rights is not always done, but always doing scientifically reveals the operational form of human rights. The right of survival and development is the primary human right; to attach importance to the right of peace conforms to the reality of our country and it has the support of the vast number of developing countries. Building a community with a shared future for human beings is a new vision for the development of the international human rights. only when the perfection and implementation of Constitution and law are paid attention to, and the democratization and legalization of the international human rights cause are promoted, can the guarantee be provided for the realization of human rights. The important discourse on human rights by General Secretary Xi Jinping is guided by Marxism, carries the communist party member’s original intention of serving people and is deeply rooted in the masses of the people. It inherits the theory of "benevolence" and "harmony" in Chinese culture,stands at the height of history and times, and points out the direction for the all-round development of Chinese people and the overall progress of society, and for the liberation of all mankind. This scientific theory is successfully guiding China’s human rights construction constantly towards new achievements and has had a profound and extensive impact on the international human rights cause.
基金supported by the startup research grant of the Pennsylvania State University(S.V.K.)
文摘Objective:To carry out the genetic characterization and evolutionary analysis of three avian orthoavulavirus 1(AOAV-1)isolates from poultry workers with respiratory symptoms.Methods:Using Illumina Mi Seq,whole-genome sequencing was carried out to assess the evolutionary dynamics of three AOAV-1 isolates.A phylogenetic and comparative analysis of all coding genes was done using bioinformatics tools.Results:Phylogenetic analysis and genetic distance estimation suggested a close relationship among human-and avian-originated velogenic strains of genotypeⅩⅢ,sub-genotypeⅩⅢ.2.1.Several substitutions in the significant structural and biological motifs were exclusively identified in the human-originated strains.Conclusions:To our knowledge,this is the first report of a velogenic AOAV-1 isolate from natural infection of the human upper respiratory tract.Our findings highlight the evolution and zoonotic potential of velogenic AOAV-1 in a disease endemic setting.
基金a sub-project of the major human rights subject of Marxism Project“Theoretical Research on Human Rights with Chinese Characteristics”
文摘The Chinese Dream is not only the dream of rejuvenation of the Chinese nation,but also the dream of human rights of the Chinese people.To accurately understand the shared root and origin of the Chinese Dream and the protection of human rights in China,we must understand that the Chinese Dream provides new strategic guidance for the protection of human rights in China,and the protection of human rights in China is an important measure to promote the realization of the Chinese Dream.To realize the Chinese Dream in the new era,Chinass human rights protection must always be people-centered,and adhere to the resolution of the main social contradictions in the new era.On the basis of raising the awareness of the whole Party and society to respect and protect human rights,we should remove obstacles and barriers to human rights protection and promote the building of a community with a shared future for human beings.At the same time,the protection of human rights in China in the new era must be guided by Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era.We must adhere to the path of human rights development with Chinese characteristics,and study and solve various practical problems of human rights protection in China in the course of upholding integrity and innovation,so as to promote the realization of the Chinese Dream.Upholding the leadership of the Communist Party of China is the fundamental guarantee for realizing the Chinese Dream and protecting human rights in China.We must unswervingly follow the CPC’s lead and open up a new stage in the development of Chinas’human rights cause in the new era on the great journey to the Chinese Dream.
