Hyperbaric oxygen therapy as a new treatment approach for Alzheimer's disease

Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease（AD）：Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the rise.For example,AD,the most common form of dementia in the elderly,accounts for 60–80%of all dementia cases.

Special Topics in Linguistics: A Review on Major Treatment Approaches to ChildPhonological Disorder

This review mainly compares the major treatment approaches to child phonological disorder,namely,Core Vocabulary Approach for the treatment of inconsistent phonological disorder,Distinctive Features Approach and ABAB-Withdrawal Approach for the treatment of consistent phonological disorder,and Eclectic Approach for real clinical treatment.Different approaches have different efficacy and the application of a certain treatment approach depends on the various conditions of the subjects.

Carbamazepine in osteoarthritis treatment:A novel approach targeting Nav1.7 channels

Osteoarthritis(OA)presents a growing health concern,with substantial societal and healthcare burdens.Current management focuses on symptom relief,lacking disease-modifying options.Emerging research suggests the sodium channel Nav1.7 as a pivotal target in OA treatment.Preclinical studies demonstrate carbamazepine's efficacy in Nav1.7 blockade,offering significant joint protection in animal models.However,human trials are needed to validate these findings.Carbamazepine's repurposing holds promise for OA management,potentially revolutionizing treatment paradigms.Further research is essential to bridge the gap between preclinical evidence and clinical application,offering hope for improved OA management and enhanced patient quality of life.

Patient-reported Outcomes (PROs): An Approach to Evaluate Treatment Efficacy of Chinese Medicine or Integrative Medicine

Chinese medicine (CM) has been an experience based practice over the past three thousand years. The safety and efficacy of CM has been practised through experience, rather than nowadays’ modern scientific measurements. In this way, the development of CM has not been keeping pace with the advance in science and technology and the progress in orthodox medicine. In order to meet the requirements of modern science and technology, an evidence based approach must be adopted. Reassurance is needed to convince people for safety and efficacy of CM and give confidence to the evidence based demands ——“Tradition is confirmed by Modern Science” (1) .

New approaches for prevention and treatment of Alzheimer's disease:a fascinating challenge

The prevention and treatment of neurodegenerative diseases is the new challenge for pharmaceutical industry,but also for public institutions,physicians,patients,and their families.The spread of these pathologies is,in fact,a real social problem,especially in the Western Countries where the population age is increasing and chronic diseases are more and more common.

Isolated dorsal approach for the treatment of neglected volar metacarpophalangeal joint dislocations

Here, we present the clinical and radiological results of three neglected volar metacarpophalangeal dislocations in 2 patients, which were treated with open reductions 10 and 24 mo after the dislocations. There was a mean of a 20°(range 10°-30°) limitation of extension and a 53.3°(range 30°-70°) limitation of flexion preoperatively. Postoperatively, there was no limitation of extension(at 8 and 12 mo) in any of the fingers. In terms of flexion, one finger had full function, one had a 10° and the last one had a 30° limitation of flexion. Two of the fingers presented anesthesia preoperatively, which improved to hypesthesia postoperatively. One finger had hypesthesia, which improved postoperatively. During surgery, a ruptured dorsal capsule was found to have interposed into the joint, making closed reduction impossible. Our experience with these two patients demonstrated that, even in neglected cases, open reduction using an isolated dorsal approach may result in satisfactory clinical andradiological outcomes.

Microsurgerical treatment of PCA aneurysms via subtemporal approach monitored by microvascular Doppler(10 cases report)

Objective To summarize the clinical features of intracranial aneurysms of posterior cerebral artery (PCA) ,and the surgical approaches and operative skills to treat them . Methods The aneurysms arose from the P1 segment in 3 patients,the P2 segment in 5 patients and the P3 segment in 2 patients.

Posterior articular process approach for the treatment of upper lumbar disc herniation

Objective To investigate the feasibility and surgical effects of posterior articular process approach for the treatment of L1-L3 lumbar disc herniation.Methods A retrospective study,of17patients with upper lumbar intervertebml disc

Decompression via posterior-anterior approach and anterior fixation in treatment of fracturedislocation of the lower cervical spine with bilateral facet joints dislocation

Objective To evaluate surgical strategy of decompression via posterior-anterior approach and anterior fixation in treatment fracture-dislocation of lower cervical spine with bilateral facet joints dislocation. Methods This

Surgical treatment of lower lumbar fracture with mini-incision via retroperitoneal anterior approach

Objective To investigate the clinical effects of surgical treatment of lower lumbar fracture with mini-incision via retroperitoneal anterior approach. Methods The data of 21 cases with serious lower lumbar burst fracture were analyzed retrospectively.

经腹膜后入路单孔腹腔镜全脾切除术的临床应用效果

目的探讨经腹膜后入路单孔腹腔镜全脾切除术的安全性和可行性。方法回顾性分析2017年1月1日至2022年12月30日云南省第一人民医院行经腹膜后入路单孔腹腔镜全脾切除术治疗的10例患者的围手术期情况及术后恢复情况。结果本组10例患者全部顺利施行经腹膜后入路单孔腹腔镜全脾切除术,无中转开腹病例,手术时间56~260 min,术中出血量20~400 mL,无术中并发症发生。术后第1天引流液淀粉酶值53~5400 U/L(中位数652.9 U/L);9例于术后第3天淀粉酶水平基本恢复正常;1例出现胰瘘(生化漏),经通畅引流后未出现后续并发症。2例出现血小板升高,经抗凝治疗后未出现后续并发症。术后住院时间5~17 d(中位时间9.2 d)。10例患者均门诊随访观察2~12个月,中位随访时间6个月,均无后续并发症。结论对于仅单纯行脾脏切除术的患者,经腹膜后入路单孔腹腔镜全脾切除术是安全可行的。

基于癌毒性质及强弱探析中医分型论治乳腺癌临床思路

癌毒是导致乳腺癌异质性的特异病机。癌毒的性质和毒力的强弱变化决定了乳腺癌异质性的差异变化,其可随时间、空间动态演变,表现为肿瘤的侵袭能力和侵袭特点不一致。原发灶的癌细胞具备靶向特定脏腑转移的“毒性”,癌毒可影响不同分型乳腺癌的转移嗜性。基于癌毒理论的乳腺癌治疗策略强调全程攻伐癌毒,重在辨癌毒强弱和性质,先安未受邪之地,以证为态,识态定靶,以对抗源自肿瘤内异质性的阻力。文章旨在为不同分型乳腺癌的治疗策略提供新的理论基础。

下焦积聚类病分期辨治特点

历代医家对下焦积聚的发生形成了不同病因理论,结合不同的病程阶段与病人体质,提出各种治疗理念,积之始起属寒,当顺气通络化痰瘀、平调寒热解恶气、解毒调血散固结,用辛暖药物消导之。积若久化为热,用辛凉药以推之,并鼓舞胃气、固护真阴,攻消补散,因势利导。若积病新起,正气未伤,当以积聚为急,速功为宜,若积久伤元,当以恢复元气为要,缓行其法。临床分期拟定其治则治法,达到扶正固本祛邪等目的。

多学科诊疗模式下翻转课堂在头颈肿瘤临床教学中的应用

目的探讨多学科诊疗(multidisciplinary diagnosis and treatment,MDT)模式下翻转课堂在头颈肿瘤临床教学中的应用效果。方法于2022年9月—2023年3月选取重庆医科大学附属第一医院耳鼻咽喉头颈外科2020年9月、2021年9月及2022年9月入学的36名专业学位研究生,采用随机数字表法分为对照组和试验组,每组各18名。对照组采用传统的教学模式,试验组采用MDT模式下翻转课堂教学模式。教学完成后,采用试卷答题的形式评价2组的知识点掌握情况,通过问卷调查形式完成学生对教学模式的满意度的评价。结果试验组的理论成绩[(40.22±4.43)分]、临床病例分析成绩[(36.11±4.34)分]均高于对照组[(41.11±3.43)分、(34.22±4.30)分],差异有统计学意义(P<0.05)。试验组的自主学习能力[(88.06±5.10)分]、主动参与感[(88.61±4.00)分]、团队协作能力[(89.78±3.57)分]、医患沟通能力[(87.44±5.20)分]、创新实践能力[(82.83±4.21)分]、临床思维能力[(89.83±3.45)分]、理论联系实践能力[(88.28±3.67)分]、教学模式满意度[(91.00±3.51)分]、对带教老师的满意度[(90.33±4.36)分]、学习兴趣[(90.22±3.44)分]等方面的评分均高于对照组[(67.39±5.79)分、(71.44±4.07)分、(66.06±5.15)分、(78.61±4.57)分、(71.50±3.67)分、(67.89±4.23)分、(67.89±3.48)分、(78.72±4.75)分、(80.56±4.89)分、(80.94±2.30)分],差异有统计学意义(P<0.05)。结论MDT模式下翻转课堂在头颈肿瘤临床教学中的教学效果良好,能够充分调动学生的主观能动性,培养学生的自主学习能力。

基于“治痿独取阳明”理论辨治女性压力性尿失禁

以“治痿独取阳明”为指导,探讨女性压力性尿失禁的病因病机及辨治思路。女性压力性尿失禁的主要病机为阳明经元气虚少,脾胃功能减退,累及肾和膀胱,最终出现尿失禁等症状。临证治疗以针灸结合用药治疗为主,针灸重取阳明,调其虚实;用药补中益气,升提起痿,如此则脏体同调,标本兼治。

狼疮性肾炎的病因病机认识及中医辨治思路

本文通过探讨狼疮性肾炎(LN)的中医病因病机及辨治用药规律,为诊治LN提供思路与方法。首先从先天禀赋、外感六淫、日晒毒、药毒及情志失调等方面探讨中医病因病机,并结合诊治LN的临床验案,分析辨治思路及用药特色。笔者认为LN病因复杂,本虚标实为其基本病机,标实以热毒、湿浊、血瘀为主,本虚以肝肾阴虚、气阴两虚、脾肾亏虚为主。运用中医药治疗LN,不仅能够明显改善病情,同时能够减轻西药的不良反应,临床疗效显著。

脊髓型颈椎病颈前入路术后轴性症状治疗进展

脊髓型颈椎病是脊柱外科较为常见的颈椎退行性疾患,多数患者临床症状严重,保守治疗效果不满意。目前主要以手术治疗为主,部分患者由于脊髓神经长期受压等原因,术后仍存在颈肩部酸胀疼痛、麻木、胸腹部紧束感等症状,影响正常工作及生活。中医学采用多种疗法治疗术后脊髓神经功能恢复近年取得满意效果,或联用西药效果显著。文章就脊髓型颈椎病前路术后脊髓神经功能康复的中西医治疗研究进行综述。

张元素“从肺治膀胱病”应用体会

张元素在《脏腑标本寒热虚实用药式·膀胱》提出从肺治疗膀胱病的学术思想,笔者深刻领会这一观点,认为膀胱病其本在于肺气不利,宣降通调水道功能失职,而致膀胱气化不利,从而发生膀胱病变。故治疗上以清肺、补肺、润肺、宣肺为原则,使气机得畅,水液得布,膀胱气化功能恢复而愈。

人工湿地深度处理市政尾水研究进展

我国市政污水厂尾水排放量大、回用率低、氮磷浓度较高,是造成水体富营养化的主要原因。尾水中较高浓度的氮磷易导致水中藻类等浮游生物大量繁殖,破坏水体耗氧和复氧平衡,使水质恶化。尾水总氮中主要以硝氮为主,其去除需要有机物作为电子供体,而尾水C/N较低,常规工艺往往难以有效净化,需要进一步的深度处理。因此,该文围绕城市污水厂尾水特点,通过文献归纳法,总结强化人工湿地深度处理市政尾水效能的途径,并从优化基质、外加缓释碳源、优化工艺3个方面来主要分析其强化机理,提出了人工湿地深度净化市政尾水的研究重点和难点问题,为提高市政尾水水质和保护水生态环境提供一些途径。

膜生物反应器(MBR)技术在城市污水处理中的优化探讨

本文主要以某实际项目为例,对膜生物反应器技术在现代城市污水处理中的优化进行分析。包括本次所研究的某城市污水处理项目概况,以及城市污水处理中的膜生物反应器技术优化分析。经分析可知,在对膜生物反应器技术进行优化时,研究者与技术人员首先需要结合实际情况来确定基本的优化思路,然后再以此为依据,科学制定优化方案。通过这样的方式,才可以获得良好的优化效果,满足现代城市污水处理的实际需求。