Hyperbaric oxygen therapy as a new treatment approach for Alzheimer's disease

Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease（AD）：Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the rise.For example,AD,the most common form of dementia in the elderly,accounts for 60–80%of all dementia cases.

Special Topics in Linguistics: A Review on Major Treatment Approaches to ChildPhonological Disorder

This review mainly compares the major treatment approaches to child phonological disorder,namely,Core Vocabulary Approach for the treatment of inconsistent phonological disorder,Distinctive Features Approach and ABAB-Withdrawal Approach for the treatment of consistent phonological disorder,and Eclectic Approach for real clinical treatment.Different approaches have different efficacy and the application of a certain treatment approach depends on the various conditions of the subjects.

Carbamazepine in osteoarthritis treatment:A novel approach targeting Nav1.7 channels

Osteoarthritis(OA)presents a growing health concern,with substantial societal and healthcare burdens.Current management focuses on symptom relief,lacking disease-modifying options.Emerging research suggests the sodium channel Nav1.7 as a pivotal target in OA treatment.Preclinical studies demonstrate carbamazepine's efficacy in Nav1.7 blockade,offering significant joint protection in animal models.However,human trials are needed to validate these findings.Carbamazepine's repurposing holds promise for OA management,potentially revolutionizing treatment paradigms.Further research is essential to bridge the gap between preclinical evidence and clinical application,offering hope for improved OA management and enhanced patient quality of life.

Patient-reported Outcomes (PROs): An Approach to Evaluate Treatment Efficacy of Chinese Medicine or Integrative Medicine

Chinese medicine (CM) has been an experience based practice over the past three thousand years. The safety and efficacy of CM has been practised through experience, rather than nowadays’ modern scientific measurements. In this way, the development of CM has not been keeping pace with the advance in science and technology and the progress in orthodox medicine. In order to meet the requirements of modern science and technology, an evidence based approach must be adopted. Reassurance is needed to convince people for safety and efficacy of CM and give confidence to the evidence based demands ——“Tradition is confirmed by Modern Science” (1) .

Effects of surface finish and treatment on the fatigue behaviour of vibrating cylinder block using frequency response approach

This paper presents the effects of surface finish and treatment on the high cycle fatigue behaviour of vibrating cylinder block of a new two-stroke free piston engine at complex variable amplitude loading conditions using frequency response approach. Finite element modelling and frequency response analysis was conducted using finite element analysis software Package MSC.PATRAN/MSC.NASTRAN and fatigue life prediction was carried out using MSC.FATIGUE software. Based on the finite element results, different frequency response approach was applied to predict the cylinder block fatigue life. Results for different load histories and material combinations are also discussed. Results indicated great effects for all surface finish and treatment. It is concluded that polished and cast surface finish conditions give the highest and lowest cylinder block lives, respectively; and that Nitrided treatment leads to longest cylinder block life. The results were used to draw contour plots of fatigue life and damage in the worst or most damaging case.

New approaches for prevention and treatment of Alzheimer's disease:a fascinating challenge

The prevention and treatment of neurodegenerative diseases is the new challenge for pharmaceutical industry,but also for public institutions,physicians,patients,and their families.The spread of these pathologies is,in fact,a real social problem,especially in the Western Countries where the population age is increasing and chronic diseases are more and more common.

Isolated dorsal approach for the treatment of neglected volar metacarpophalangeal joint dislocations

Here, we present the clinical and radiological results of three neglected volar metacarpophalangeal dislocations in 2 patients, which were treated with open reductions 10 and 24 mo after the dislocations. There was a mean of a 20°(range 10°-30°) limitation of extension and a 53.3°(range 30°-70°) limitation of flexion preoperatively. Postoperatively, there was no limitation of extension(at 8 and 12 mo) in any of the fingers. In terms of flexion, one finger had full function, one had a 10° and the last one had a 30° limitation of flexion. Two of the fingers presented anesthesia preoperatively, which improved to hypesthesia postoperatively. One finger had hypesthesia, which improved postoperatively. During surgery, a ruptured dorsal capsule was found to have interposed into the joint, making closed reduction impossible. Our experience with these two patients demonstrated that, even in neglected cases, open reduction using an isolated dorsal approach may result in satisfactory clinical andradiological outcomes.

Microsurgerical treatment of PCA aneurysms via subtemporal approach monitored by microvascular Doppler(10 cases report)

Objective To summarize the clinical features of intracranial aneurysms of posterior cerebral artery (PCA) ,and the surgical approaches and operative skills to treat them . Methods The aneurysms arose from the P1 segment in 3 patients,the P2 segment in 5 patients and the P3 segment in 2 patients.

Posterior articular process approach for the treatment of upper lumbar disc herniation

Objective To investigate the feasibility and surgical effects of posterior articular process approach for the treatment of L1-L3 lumbar disc herniation.Methods A retrospective study,of17patients with upper lumbar intervertebml disc

Decompression via posterior-anterior approach and anterior fixation in treatment of fracturedislocation of the lower cervical spine with bilateral facet joints dislocation

Objective To evaluate surgical strategy of decompression via posterior-anterior approach and anterior fixation in treatment fracture-dislocation of lower cervical spine with bilateral facet joints dislocation. Methods This

Surgical treatment of lower lumbar fracture with mini-incision via retroperitoneal anterior approach

Objective To investigate the clinical effects of surgical treatment of lower lumbar fracture with mini-incision via retroperitoneal anterior approach. Methods The data of 21 cases with serious lower lumbar burst fracture were analyzed retrospectively.

狼疮性肾炎的病因病机认识及中医辨治思路

本文通过探讨狼疮性肾炎(LN)的中医病因病机及辨治用药规律,为诊治LN提供思路与方法。首先从先天禀赋、外感六淫、日晒毒、药毒及情志失调等方面探讨中医病因病机,并结合诊治LN的临床验案,分析辨治思路及用药特色。笔者认为LN病因复杂,本虚标实为其基本病机,标实以热毒、湿浊、血瘀为主,本虚以肝肾阴虚、气阴两虚、脾肾亏虚为主。运用中医药治疗LN,不仅能够明显改善病情,同时能够减轻西药的不良反应,临床疗效显著。

张元素“从肺治膀胱病”应用体会

张元素在《脏腑标本寒热虚实用药式·膀胱》提出从肺治疗膀胱病的学术思想,笔者深刻领会这一观点,认为膀胱病其本在于肺气不利,宣降通调水道功能失职,而致膀胱气化不利,从而发生膀胱病变。故治疗上以清肺、补肺、润肺、宣肺为原则,使气机得畅,水液得布,膀胱气化功能恢复而愈。

经口腔前庭入路与经腋窝入路腔镜手术治疗甲状腺癌的效果对比

目的:分析比较经口腔前庭入路与经腋窝入路腔镜手术治疗甲状腺癌的临床效果。方法:回顾性分析2020年6月-2022年12月在笔者医院接受手术治疗的144例甲状腺癌患者临床资料,依据手术方式不同分为A组(n=45,传统开放手术)、B组(n=50,经口腔前庭入路腔镜手术)及C组(n=49,经腋窝入路腔镜手术),比较三组手术相关指标、术后不同时间点疼痛评分、美学效果[温哥华瘢痕量表(Vancouver scar scale,VSS)]及术后并发症发生率。结果:B组手术时间长于A、C两组(P<0.05);B、C两组术中出血量、引流量均少于A组,术中淋巴结清扫数目均多于A组,住院时间短于A组,差异均有统计学意义(P<0.05);B、C两组术后1 d、术后3 d、术后1个月、术后3个月疼痛VAS评分均低于A组,差异有统计学意义(P<0.05);术后3个月B、C两组VSS评分均低于A组,且B组VSS评分较C组更低,差异有统计学意义(P<0.05);三组间术后并发症比较差异无统计学意义(P>0.05)。结论:与传统开放术比较,经口腔前庭入路与经腋窝入路腔镜手术治疗效果均更好,均可有效减轻术后疼痛,同时经口腔前庭入路具有术中淋巴结清扫数目多,美学效果好等优势,经腋窝入路具有手术时间短的优点,临床可依据不同情况选择合适的手术方案。

新质生产力赋能数字医联体建设——内涵、逻辑与路径

新质生产力是新时代更具融合性、更体现新内涵的生产力,对构建优质高效的整合型医疗卫生服务体系具有重要的赋能作用。而医联体作为我国整合型医疗卫生服务体系的主要形态,是以数字化、智能化为核心驱动力不断发展建设的。本文基于新质生产力和数字医联体的内涵,分析数字医联体建设与新质生产力的内在逻辑,探讨新质生产力赋能数字医联体面临的挑战及实践路径。

脊髓型颈椎病颈前入路术后轴性症状治疗进展

脊髓型颈椎病是脊柱外科较为常见的颈椎退行性疾患,多数患者临床症状严重,保守治疗效果不满意。目前主要以手术治疗为主,部分患者由于脊髓神经长期受压等原因,术后仍存在颈肩部酸胀疼痛、麻木、胸腹部紧束感等症状,影响正常工作及生活。中医学采用多种疗法治疗术后脊髓神经功能恢复近年取得满意效果,或联用西药效果显著。文章就脊髓型颈椎病前路术后脊髓神经功能康复的中西医治疗研究进行综述。

膜生物反应器(MBR)技术在城市污水处理中的优化探讨

本文主要以某实际项目为例,对膜生物反应器技术在现代城市污水处理中的优化进行分析。包括本次所研究的某城市污水处理项目概况,以及城市污水处理中的膜生物反应器技术优化分析。经分析可知,在对膜生物反应器技术进行优化时,研究者与技术人员首先需要结合实际情况来确定基本的优化思路,然后再以此为依据,科学制定优化方案。通过这样的方式,才可以获得良好的优化效果,满足现代城市污水处理的实际需求。

经三角肌双间隙入路手术治疗肱骨近端骨折的疗效研究

针对肱骨近端骨折患者采取经三角肌双间隙入路手术治疗的效果进行比较分析。选取赤水华仁骨科医院2020年3月—2020年12月收治的60例肱骨近端骨折患者为研究对象,并将60例患者分为对比组与试验组,对比组患者接受常规手术治疗,试验组患者接受经三角肌双间隙入路手术治疗,对比两组患者临床治疗的效果、生活质量评分、手术时间、术中出血量、术后引流量。结果显示,试验组患者治疗总有效率高于对比组(P<0.05);试验组患者生活质量评分高于对比组(P<0.05);试验组手术时间短于对比组(P<0.05);试验组术中出血量少于对比组(P<0.05);试验组术后引流量少于对比组(P<0.05)。研究发现,经三角肌双间隙入路手术治疗肱骨近端骨折患者的临床治疗有效率较高,并且有助于提高患者的生活质量评分,可缩短手术时间,减少术中出血量及术后引流量。

城市污水处理厂中邻苯二甲酸酯的分布规律及去除途径

城市污水处理厂中邻苯二甲酸酯又称酞酸酯,缩写PAEs,是一类常见的有机污染物,主要来源于塑料制品、化妆品、医疗器械等生活用品的使用和排放。这些物质具有潜在的环境和健康风险,因此需要在污水处理过程中有效去除。本文探讨解决这一有机污染物在城市污水处理中的问题,从而减少其对环境和健康的潜在威胁。

后外侧手术入路联合体位改变在三踝骨折患者内固定手术中的治疗效果

目的分析后外侧手术入路联合体位改变在三踝骨折患者内固定手术中的治疗效果。方法选择2022年1月至8月抚州市第一人民医院收治的60例三踝骨折患者为研究对象,根据随机数字表法将患者分为常规组(n=30)及联合组(n=30),常规组行仰卧位传统入路内固定手术治疗,联合组行后外侧手术入路联合术中体位改变进行内固定手术治疗。比较两组患者围手术期指标、术后骨性愈合时间、Biard-Jackson踝关节评分系统情况及术后并发症发生情况。结果联合组患者手术时间、术后卧床时间、负重下床时间短于常规组,术中出血量少于常规组,差异有统计学意义(P<0.05)。联合组患者术后骨性愈合时间水平短于常规组,Biard-Jackson踝关节评分系统优良率高于常规组,差异有统计学意义(P<0.05)。联合组患者术后并发症发生率低于常规组,差异有统计学意义(P<0.05)。结论后外侧手术入路联合术中体位改变进行内固定可提高手术效率,帮助患者快速恢复,术后治疗效果较好,且安全性高,值得推广应用。