Androgenic alopecia, also known as seborrheic alopecia, is the most common hair loss disorder in dermatology clinics, mainly characterized by hair follicle miniaturization and progressive hair loss. The etiology and p...Androgenic alopecia, also known as seborrheic alopecia, is the most common hair loss disorder in dermatology clinics, mainly characterized by hair follicle miniaturization and progressive hair loss. The etiology and pathogenesis of androgenic alopecia are not clear, but may be related to heredity and androgen metabolism. Currently, minoxidil and finasteride are the only two drugs approved by the U.S. Food and Drug Administration (FDA) for AGA treatment, other treatments include oral minoxidil, hair transplantation, low energy laser therapy (LLLT), platelet-rich plasma (PRP), Chinese medicine microneedles, and combination therapy. With the development of medicine and science, we have ushered in the era of biologics and targeted therapy. In recent years, a variety of signaling pathways for androgenic alopecia have been found, which may provide a basis for targeted therapy for androgenic alopecia.展开更多
This paper reviews the causes of knee osteoarthritis, traditional Chinese and Western medicine therapies and nursing research progress and indicates that traditional Chinese and Western medicine have gradually recogni...This paper reviews the causes of knee osteoarthritis, traditional Chinese and Western medicine therapies and nursing research progress and indicates that traditional Chinese and Western medicine have gradually recognized the cause of knee osteoarthritis. Knee osteoarthritis has been treated with various treatments and nursing care planning, and the combination of traditional Chinese and Western medicine has constantly been improved. Nurses should instruct the discharged patient to correctly treat their disease, adopt the health education, and, via the establishment of a healthy lifestyle, insist on a functional exercise to relieve the pain, delay disease progression, and improve quality of life.展开更多
Hyperlipidemia(HLP)is a long-known risk factor for a series of cardiovascular and cerebrovascular diseases,such as atherosclerosis,coronary heart disease,hypertension and so on.With its increasing incidence,the preven...Hyperlipidemia(HLP)is a long-known risk factor for a series of cardiovascular and cerebrovascular diseases,such as atherosclerosis,coronary heart disease,hypertension and so on.With its increasing incidence,the prevention and treatment of HLP has also become an important research topic around the world.Traditional Chinese medicine(TCM)has been used to treat HLP for a long time with its better therapeutic efficacy,less side effects and wider indications compared with western medicine.In this review,we summarized the pathogenesis of HLP,the research situation of disease-related targets,and the treatment progress of TCM by conducting literature research and sorting out relevant information,in order to provide reference for further research of HLP and prevent the occurrence of cardiovascular and cerebrovascular diseases.展开更多
With the development of medicine,people are becoming more and more aware of the quality of medical water supply,such as dial ysis water,dental water,preparation water,operating room water,supply room water.Therefore,P...With the development of medicine,people are becoming more and more aware of the quality of medical water supply,such as dial ysis water,dental water,preparation water,operating room water,supply room water.Therefore,People are constantly improving the water treatment system and its standardized,and the demand for dialysis water is also becoming more and more strict.Hemodialysis is an effective means of maintaining the life of renal failure patients,120~180L water will be used for a conventional dialysis treatment,and high flux dialysis will consume more.展开更多
Lung cancer is one of the most common major diseases that seriously threaten human health,lung cancer includes small cell lung cancer(SCLC)and non-small cell lung cancer(NSCLC).Although patients with SCLC account for ...Lung cancer is one of the most common major diseases that seriously threaten human health,lung cancer includes small cell lung cancer(SCLC)and non-small cell lung cancer(NSCLC).Although patients with SCLC account for about 20%of the total number of patients with lung cancer,the mortality rate is much higher than that of patients with NSCLC.Integrated traditional Chinese and Western medicine has obvious advantages in the treatment of patients with SCLC.According to the relevant literature reports on the treatment of SCLC in recent years,this article will summarize the research progress of integrated traditional Chinese and western medicine in the treatmentof SCLC from the aspects of traditional Chinese medicine(TCM)combined with surgery,chemotherapy,radiotherapy,and molecular targeted therapy.展开更多
Cancer-related fatigue,which is a common symptom among colorectal cancer patients,has a high incidence and it affects the quality of life of these patients.Western medicine still lacks effective treatment means.Howeve...Cancer-related fatigue,which is a common symptom among colorectal cancer patients,has a high incidence and it affects the quality of life of these patients.Western medicine still lacks effective treatment means.However,with various methods of intervention and treatment,Chinese medicine has made certain progress in this area,where辻has good curative effect in improving fatigue and the quality of life of patients.This article briefly summarizes the main TCM treatment methods for cancer-related fatigue in patients with colorectal cancer in order to provide reference and suggestions for clinical practice.展开更多
Heart failure with preserved ejection fraction(HFpEF)is a special and common clinical heart failure with left ventricular diastolic dysfunction.It has attracted much attention at home and abroad in recent years becaus...Heart failure with preserved ejection fraction(HFpEF)is a special and common clinical heart failure with left ventricular diastolic dysfunction.It has attracted much attention at home and abroad in recent years because of its high heterogeneity and complex pathogenesis.Compared with heart failure with reduced ejection fraction(HFrEF),HFpEF has complex clinical manifestations,many complications,limited clinical treatment,and poor prognosis.In recent years,the research on the pathogenesis and treatment of HFpEF has made certain progress,but there are no specific guidelines for clinical practice.By combing the latest research at home and abroad,the pathogenesis and treatment of HFpEF are systematically reviewed in order to provide a relevant basis for reference its clinical treatment.展开更多
The recognition of headache by human being has gone through a long period of time.Headache was sorted into three kinds early in first century A.D. by Aretaeus(81-138),who named mild repeated headache as"cephalalg...The recognition of headache by human being has gone through a long period of time.Headache was sorted into three kinds early in first century A.D. by Aretaeus(81-138),who named mild repeated headache as"cephalalgia",frequently attacking chronic headache as"cephalaea",and unilateral severe headache"heterocrania".Christian Ludwig展开更多
Altogether 27716 cystic hydatid cases and 445 alveolar hydatid cases slinically diagnosed and surgically treated in China were retrospectively studied.
At present,there is no unified clinical approach for the treatment of radiation enteritis(RE).Clinically,its treatment is mainly based on nutritional support,mucosal protective agents,somatostatin,and microecological ...At present,there is no unified clinical approach for the treatment of radiation enteritis(RE).Clinically,its treatment is mainly based on nutritional support,mucosal protective agents,somatostatin,and microecological preparations.On the basis of syndrome differentiation and treatment,traditional Chinese medicine(TCM)is mainly used for internal administration,enteroclysis,acupuncture,and Tuina.It shows significant advantages in relieving the adverse reactions of radiotherapy and exhibits significant preventive and therapeutic effects against RE.This article reviews two aspects of TCM on RE,including internal and external administration,to explore and develop an effective and reliable standardized Chinese medicine program.展开更多
Aim:Immune checkpoint inhibitors(ICIs)have dramatically changed the treatment paradigm in patients with non-small-cell lung cancer(NSCLC).However,progression patterns with immunotherapy are currently unclear and thera...Aim:Immune checkpoint inhibitors(ICIs)have dramatically changed the treatment paradigm in patients with non-small-cell lung cancer(NSCLC).However,progression patterns with immunotherapy are currently unclear and therapeutic options beyond resistance remain challenging.Methods:We reviewed advanced NSCLC patients between January 2016 and December 2019 who were treated with anti-PD-1/PD-L1 inhibitors in our center and identified those who developed disease progression.Later-line treatment strategies were collected and objective response rate,progression-free survival(PFS),and overall survival(OS)were assessed.Results:Of the 118 patients,46(39.0%)showed oligoprogression and 72(61.0%)showed systemic progression.No difference in progression patterns was observed between monotherapy and combination therapy.Systemic progression was strongly associated with never-smokers(51.4%vs.21.7%,P=0.001)and ECOG PS=2(13.9%vs.2.2%,P=0.048)at baseline.The distribution of progression sites was roughly similar between oligoprogression and systemic progression,and the most commonly affected anatomic site was lung(66.9%),followed by bone(12.7%)and lymph nodes(11.0%).For patients beyond first disease progression,checkpoint inhibitor-based combinations could lead to a significantly longer PFS2 compared with ICIs monotherapy(9.63 months vs.4.23 months,P=0.004,HR=0.394,95%CI:0.174-0.893)and other therapy(9.63 months vs.4.07 months,P=0.046,HR=0.565,95%CI:0.326-0.980).Median OS of the ICIs combination group was not reached but was significantly longer than other therapy group(NR vs.14.37 months,P=0.010,HR=0.332,95%CI:0.167-0.661).Conclusion:Systemic progression occurs more frequently among NSCLC patients receiving ICIs.Checkpoint inhibitor-based combinations show favorable outcomes as subsequent treatment strategies after the failure of previous ICIs treatment.展开更多
文摘Androgenic alopecia, also known as seborrheic alopecia, is the most common hair loss disorder in dermatology clinics, mainly characterized by hair follicle miniaturization and progressive hair loss. The etiology and pathogenesis of androgenic alopecia are not clear, but may be related to heredity and androgen metabolism. Currently, minoxidil and finasteride are the only two drugs approved by the U.S. Food and Drug Administration (FDA) for AGA treatment, other treatments include oral minoxidil, hair transplantation, low energy laser therapy (LLLT), platelet-rich plasma (PRP), Chinese medicine microneedles, and combination therapy. With the development of medicine and science, we have ushered in the era of biologics and targeted therapy. In recent years, a variety of signaling pathways for androgenic alopecia have been found, which may provide a basis for targeted therapy for androgenic alopecia.
基金supported by the health and family planning committee of Shanghai(No.2014LP093A)
文摘This paper reviews the causes of knee osteoarthritis, traditional Chinese and Western medicine therapies and nursing research progress and indicates that traditional Chinese and Western medicine have gradually recognized the cause of knee osteoarthritis. Knee osteoarthritis has been treated with various treatments and nursing care planning, and the combination of traditional Chinese and Western medicine has constantly been improved. Nurses should instruct the discharged patient to correctly treat their disease, adopt the health education, and, via the establishment of a healthy lifestyle, insist on a functional exercise to relieve the pain, delay disease progression, and improve quality of life.
文摘Hyperlipidemia(HLP)is a long-known risk factor for a series of cardiovascular and cerebrovascular diseases,such as atherosclerosis,coronary heart disease,hypertension and so on.With its increasing incidence,the prevention and treatment of HLP has also become an important research topic around the world.Traditional Chinese medicine(TCM)has been used to treat HLP for a long time with its better therapeutic efficacy,less side effects and wider indications compared with western medicine.In this review,we summarized the pathogenesis of HLP,the research situation of disease-related targets,and the treatment progress of TCM by conducting literature research and sorting out relevant information,in order to provide reference for further research of HLP and prevent the occurrence of cardiovascular and cerebrovascular diseases.
基金Guangdong Obers Blood Purification Aca demician Work station(2013B090400004)Science and technology plan project of Guangdong industrial high and new technology field(2013B010203019)+3 种基金Guangzhou entrepreneurial leader talent/LCY201215Guangdong Inno vation Fund Project(2014A010101123)Guangdong Provincial Center for clinical en gineering of blood purification(507204531040)Guangdong University blood purification technology and Engineering Research Center(GCZX-A1104)
文摘With the development of medicine,people are becoming more and more aware of the quality of medical water supply,such as dial ysis water,dental water,preparation water,operating room water,supply room water.Therefore,People are constantly improving the water treatment system and its standardized,and the demand for dialysis water is also becoming more and more strict.Hemodialysis is an effective means of maintaining the life of renal failure patients,120~180L water will be used for a conventional dialysis treatment,and high flux dialysis will consume more.
文摘Lung cancer is one of the most common major diseases that seriously threaten human health,lung cancer includes small cell lung cancer(SCLC)and non-small cell lung cancer(NSCLC).Although patients with SCLC account for about 20%of the total number of patients with lung cancer,the mortality rate is much higher than that of patients with NSCLC.Integrated traditional Chinese and Western medicine has obvious advantages in the treatment of patients with SCLC.According to the relevant literature reports on the treatment of SCLC in recent years,this article will summarize the research progress of integrated traditional Chinese and western medicine in the treatmentof SCLC from the aspects of traditional Chinese medicine(TCM)combined with surgery,chemotherapy,radiotherapy,and molecular targeted therapy.
文摘Cancer-related fatigue,which is a common symptom among colorectal cancer patients,has a high incidence and it affects the quality of life of these patients.Western medicine still lacks effective treatment means.However,with various methods of intervention and treatment,Chinese medicine has made certain progress in this area,where辻has good curative effect in improving fatigue and the quality of life of patients.This article briefly summarizes the main TCM treatment methods for cancer-related fatigue in patients with colorectal cancer in order to provide reference and suggestions for clinical practice.
文摘Heart failure with preserved ejection fraction(HFpEF)is a special and common clinical heart failure with left ventricular diastolic dysfunction.It has attracted much attention at home and abroad in recent years because of its high heterogeneity and complex pathogenesis.Compared with heart failure with reduced ejection fraction(HFrEF),HFpEF has complex clinical manifestations,many complications,limited clinical treatment,and poor prognosis.In recent years,the research on the pathogenesis and treatment of HFpEF has made certain progress,but there are no specific guidelines for clinical practice.By combing the latest research at home and abroad,the pathogenesis and treatment of HFpEF are systematically reviewed in order to provide a relevant basis for reference its clinical treatment.
文摘The recognition of headache by human being has gone through a long period of time.Headache was sorted into three kinds early in first century A.D. by Aretaeus(81-138),who named mild repeated headache as"cephalalgia",frequently attacking chronic headache as"cephalaea",and unilateral severe headache"heterocrania".Christian Ludwig
文摘Altogether 27716 cystic hydatid cases and 445 alveolar hydatid cases slinically diagnosed and surgically treated in China were retrospectively studied.
文摘At present,there is no unified clinical approach for the treatment of radiation enteritis(RE).Clinically,its treatment is mainly based on nutritional support,mucosal protective agents,somatostatin,and microecological preparations.On the basis of syndrome differentiation and treatment,traditional Chinese medicine(TCM)is mainly used for internal administration,enteroclysis,acupuncture,and Tuina.It shows significant advantages in relieving the adverse reactions of radiotherapy and exhibits significant preventive and therapeutic effects against RE.This article reviews two aspects of TCM on RE,including internal and external administration,to explore and develop an effective and reliable standardized Chinese medicine program.
基金This study was supported by National Natural Science Foundation of China(grant number:81874036,82072568)Science and Technology Commission of Shanghai Municipality(19411971100)Shanghai Shenkang Hospital Development Center(SHDC12020110).
文摘Aim:Immune checkpoint inhibitors(ICIs)have dramatically changed the treatment paradigm in patients with non-small-cell lung cancer(NSCLC).However,progression patterns with immunotherapy are currently unclear and therapeutic options beyond resistance remain challenging.Methods:We reviewed advanced NSCLC patients between January 2016 and December 2019 who were treated with anti-PD-1/PD-L1 inhibitors in our center and identified those who developed disease progression.Later-line treatment strategies were collected and objective response rate,progression-free survival(PFS),and overall survival(OS)were assessed.Results:Of the 118 patients,46(39.0%)showed oligoprogression and 72(61.0%)showed systemic progression.No difference in progression patterns was observed between monotherapy and combination therapy.Systemic progression was strongly associated with never-smokers(51.4%vs.21.7%,P=0.001)and ECOG PS=2(13.9%vs.2.2%,P=0.048)at baseline.The distribution of progression sites was roughly similar between oligoprogression and systemic progression,and the most commonly affected anatomic site was lung(66.9%),followed by bone(12.7%)and lymph nodes(11.0%).For patients beyond first disease progression,checkpoint inhibitor-based combinations could lead to a significantly longer PFS2 compared with ICIs monotherapy(9.63 months vs.4.23 months,P=0.004,HR=0.394,95%CI:0.174-0.893)and other therapy(9.63 months vs.4.07 months,P=0.046,HR=0.565,95%CI:0.326-0.980).Median OS of the ICIs combination group was not reached but was significantly longer than other therapy group(NR vs.14.37 months,P=0.010,HR=0.332,95%CI:0.167-0.661).Conclusion:Systemic progression occurs more frequently among NSCLC patients receiving ICIs.Checkpoint inhibitor-based combinations show favorable outcomes as subsequent treatment strategies after the failure of previous ICIs treatment.
