AIM: To evaluate the clinical pnd optical outcomes after clear corneal incision cataract surgery (ClCS) with three different incision sizes (1.8, 2.0 and 3.0 mm). METHODS: Eyes of 150 patients with age-related c...AIM: To evaluate the clinical pnd optical outcomes after clear corneal incision cataract surgery (ClCS) with three different incision sizes (1.8, 2.0 and 3.0 mm). METHODS: Eyes of 150 patients with age-related cataract scheduled for coaxial cataract surgery were randomized to three groups: 1.8, 2.0, or 3.0 mm CICS. Intraoperative data and postoperative outcomes including surgically induced astigmatism (SIA), the corneal incision thickness, wavefront aberrations and modulation transfer function (MTF) of cornea were obtained. RESULTS: There were no significant differences among the three groups in demographic characteristics and intraoperative outcome. The 1.8 and 2.0 mm microincisions showed more satisfactory clinical outcomes than the 3.0 mm incision. The 1.8 mm incision showed significantly less SIA than the 2.0 mm incision until postoperative lmo (P〈0.05), but the difference was only 0.14-0.18 D. Combined with less increased incision thickness only at postoperative ld (P=0.013), the 1.8 mm incision presented better uncorrected distance visual acuity (UCDVA) than the 2.0 mm incision only at Id postoperatively (P=0.008). For higher-order aberrations and other Zernike coefficients, there were no significant differences between the 1.8 mm group and 2.0 mm group (P 〉0.05). CONCLUSION: Converting from 3.0 mm CICS to 1.8 or 2.0 mm CICS result in better clinical and optical outcomes. However, when incision is 1.8 mm, the benefits from further reduction in size compared with2.0 mm are limited. The necessity to reduce the incision size is to be deliberated.展开更多
OBJECTIVE: To observe the clinical effects of the Lixujieyu recipe combined with Five Elements music therapy on chronic fatigue syndrome(CFS) identified as the symptom patterns of liver stagnation and spleen deficienc...OBJECTIVE: To observe the clinical effects of the Lixujieyu recipe combined with Five Elements music therapy on chronic fatigue syndrome(CFS) identified as the symptom patterns of liver stagnation and spleen deficiency in terms of Traditional Chinese Medicine.METHODS: Patients with CFS were randomly divided into treatment group 1(Lixujieyu recipe combined with Gong-Tune, n = 15); treatment group 2(Lixujieyu recipe combined with Jiao-Tune, n = 15);treatment group 3(Lixujieyu recipe combined with Yu-Tune, n = 15); treatment group 4(Lixujieyu recipe combined with Shang-Tune, n = 15); treatment group 5(Lixujieyu recipe combined with Zhi-Tune,n = 15); and the control group(Lixujieyu recipe alone, n = 15). Chinese medicine was given twice daily, and music was listened to for 45 minutes daily, 5 days a week. All patients were treated for4 weeks. Patients were assessed via the Fatigue Scale, the Hamilton Depression Rating Scale, and the Hamilton Anxiety Rating Scale before and after treatment.RESULTS: Treatment groups 1 and 2 had better effects on relieving the symptoms of physical fatigue related to anxiety and depression than the control group(P < 0.05).CONCLUSION: Lixujieyu recipe combined with Gong-Tune or Jiao-Tune significantly relieved the symptoms of CFS.展开更多
Abstract The purpose of this study was to investigate the blood levels of methadone in participants receiving methadone for the treatment of opioid dependence. After stabilization on methadone for four weeks, blood sa...Abstract The purpose of this study was to investigate the blood levels of methadone in participants receiving methadone for the treatment of opioid dependence. After stabilization on methadone for four weeks, blood samples from 95 participants were collected between treatment weeks 4 and 12, before and after receiving doses of methadone, and its blood levels were measured. A multiple linear regression model was used to examine the associa- tion between methadone blood levels and the outcomes of methadone maintenance treatment (MMT). Outcome dif- ferences between participants who had high (≥2) or low (〈2) peak-to-trough ratios were also compared using an independent sample t-test. The blood level of methadone was not correlated with the clinical outcome of MMT with the moderate range of doses given. However, the retention of patients who had a free peak-to-trough ratio 〉2 was significantly poorer than those whose ratio was 〈2. Thus, monitoring plasma methadone levels is unlikely to be effective for guiding dosing decisions in situations where compliance with MMT is already very high or when themethadone dose is no longer the dominant factor in determining the clinical outcome. However, monitoring plasma methadone levels is still helpful for guiding the dosage for patients with a rapid metabolism.展开更多
基金Supported by the Key Program of the National Natural Science Foundation of China(No.81130018)National Twelfth Five-Year Plan Foundation of China(No. 2012BAI08B01)+1 种基金Zhejiang Key Innovation Team Project of China(No.2009R50039)Zhejiang Key Laboratory Fund of China(No.2011E10006)
文摘AIM: To evaluate the clinical pnd optical outcomes after clear corneal incision cataract surgery (ClCS) with three different incision sizes (1.8, 2.0 and 3.0 mm). METHODS: Eyes of 150 patients with age-related cataract scheduled for coaxial cataract surgery were randomized to three groups: 1.8, 2.0, or 3.0 mm CICS. Intraoperative data and postoperative outcomes including surgically induced astigmatism (SIA), the corneal incision thickness, wavefront aberrations and modulation transfer function (MTF) of cornea were obtained. RESULTS: There were no significant differences among the three groups in demographic characteristics and intraoperative outcome. The 1.8 and 2.0 mm microincisions showed more satisfactory clinical outcomes than the 3.0 mm incision. The 1.8 mm incision showed significantly less SIA than the 2.0 mm incision until postoperative lmo (P〈0.05), but the difference was only 0.14-0.18 D. Combined with less increased incision thickness only at postoperative ld (P=0.013), the 1.8 mm incision presented better uncorrected distance visual acuity (UCDVA) than the 2.0 mm incision only at Id postoperatively (P=0.008). For higher-order aberrations and other Zernike coefficients, there were no significant differences between the 1.8 mm group and 2.0 mm group (P 〉0.05). CONCLUSION: Converting from 3.0 mm CICS to 1.8 or 2.0 mm CICS result in better clinical and optical outcomes. However, when incision is 1.8 mm, the benefits from further reduction in size compared with2.0 mm are limited. The necessity to reduce the incision size is to be deliberated.
基金Supported by General Program of the National Natural Science Foundation(Research on the Synergistic Mechanism of Jiao-Tune Music Therapy Combined with Chinese Medicine in Treating Chronic Fatigue Syndrome,No.81173227)The National Key Disciplines in the Twelfth Five Year Plan "Subject of Preventive Treatment of Disease" supported by the State Administration of Traditional Chinese MedicineProject of the Shanghai Three Year Action Plan for Chinese Medicine(No.ZYSNXD-YL-CTXK)
文摘OBJECTIVE: To observe the clinical effects of the Lixujieyu recipe combined with Five Elements music therapy on chronic fatigue syndrome(CFS) identified as the symptom patterns of liver stagnation and spleen deficiency in terms of Traditional Chinese Medicine.METHODS: Patients with CFS were randomly divided into treatment group 1(Lixujieyu recipe combined with Gong-Tune, n = 15); treatment group 2(Lixujieyu recipe combined with Jiao-Tune, n = 15);treatment group 3(Lixujieyu recipe combined with Yu-Tune, n = 15); treatment group 4(Lixujieyu recipe combined with Shang-Tune, n = 15); treatment group 5(Lixujieyu recipe combined with Zhi-Tune,n = 15); and the control group(Lixujieyu recipe alone, n = 15). Chinese medicine was given twice daily, and music was listened to for 45 minutes daily, 5 days a week. All patients were treated for4 weeks. Patients were assessed via the Fatigue Scale, the Hamilton Depression Rating Scale, and the Hamilton Anxiety Rating Scale before and after treatment.RESULTS: Treatment groups 1 and 2 had better effects on relieving the symptoms of physical fatigue related to anxiety and depression than the control group(P < 0.05).CONCLUSION: Lixujieyu recipe combined with Gong-Tune or Jiao-Tune significantly relieved the symptoms of CFS.
基金supported by the Research Project of Shanghai Municipal Health and Family Planning Commission, China(2013SY011 and 2014ZYJB0002)the National Natural Science Foundation of China(81271468)+1 种基金Doctoral Supervisor Funding from the Ministry of Education of China(20120073110089)Research Funding from Shanghai Key Laboratory of Severe Mental illness,China(13dz2260500)
文摘Abstract The purpose of this study was to investigate the blood levels of methadone in participants receiving methadone for the treatment of opioid dependence. After stabilization on methadone for four weeks, blood samples from 95 participants were collected between treatment weeks 4 and 12, before and after receiving doses of methadone, and its blood levels were measured. A multiple linear regression model was used to examine the associa- tion between methadone blood levels and the outcomes of methadone maintenance treatment (MMT). Outcome dif- ferences between participants who had high (≥2) or low (〈2) peak-to-trough ratios were also compared using an independent sample t-test. The blood level of methadone was not correlated with the clinical outcome of MMT with the moderate range of doses given. However, the retention of patients who had a free peak-to-trough ratio 〉2 was significantly poorer than those whose ratio was 〈2. Thus, monitoring plasma methadone levels is unlikely to be effective for guiding dosing decisions in situations where compliance with MMT is already very high or when themethadone dose is no longer the dominant factor in determining the clinical outcome. However, monitoring plasma methadone levels is still helpful for guiding the dosage for patients with a rapid metabolism.