名校长工作室TRIMER研修模式助力乡村区域教育质量提升——以保定市贫困县(脱贫县)系列名校长工作室为例

如何以名校长工作室方式助推乡村教育质量提升,河北省保定市贫困县(脱贫县)系列名校长工作室项目组形成的TRIMER(三聚体)研修模式进行了很好的探索。TRIMER模式在研修功能定位上强调校长成长、学校提质与区域教育优化三位一体;在研修方式上,培训、改进、辐射等三线交织;在研修原则上,培训与改进、个人研修与团队研修、素养提升与辐射带动有机结合;在培养主体上,保定市本土优秀校长的示范、北京市双导师的引领与京保教育行政的保驾护航相得益彰;在运行力量上,行政力量、学术力量、校长自我发展力量密切配合。

One New A-type Proanthocyanidin Trimer from Lindera aggregata(Sims) Kosterm.

One new A - type proanthocyanidin trimer, lindetannin trimer, was isolated from the stems of Lindera aggregata (Sims) Kosterm.. Its structure was elucidated by spectral and chemical methods.

Insight into Medicinal Chemistry Behind Traditional Chinese Medicines: p-Hydroxybenzyl Alcohol-Derived Dimers and Trimers from Gastrodia elata

From an aqueous extract of“tian ma”(the steamed and dried rhizomes of Gastrodia elata),ten new compounds gastrodiben-zins A−D(1−4)and gastrotribenzins A−F(5−10),along with known analogues(11−20),having structure features coupling between two and three p-hydroxybenzyl-derived units via carbon-and/or ether-bonds,were isolated and characterized by spectroscopic data analysis.Meanwhile,the new compounds 5a,6a,8a,22,and 23,as well as the known derivatives 13a,14a,15,17−21,24,25,and p-hydroxybenzyl aldehyde were isolated and identified from a refluxed aqueous solution of p-hydroxybenzyl alcohol.Methylation of 5a and 6a in methanol and ethylation of 6a,8a,13a,and 14a in ethanol produced 5 and 6 and 7,8,13,and 14,respectively.using ultra-performance liquid chromatography high-resolution electrospray ioniza-tion mass spectrometry(UPLC-HRESIMS)analysis of the refluxed solutions of p-hydroxybenzyl alcohol and the refluxed extracts of the fresh G.elata rhizome and“tian ma”extracts indicated consistent production and variation of the dimeric and trimeric derivatives of p-hydroxybenzyl alcohol upon extracting solvents and refluxing time.In various assays,the dimeric and trimeric derivatives showed more potent activities than p-hydroxybenzyl alcohol itself and gastrodin,which are the main known active constituents of“tian ma”.These results revealed for the first time that the more effective dimers and trimers can be produced through condensation of the co-occurring p-hydroxybenzyl alcohol during processing and decocting of the G.elata rhizomes,demonstrating insights into medicinal chemistry behind application protocols of traditional Chinese medicines.

Synthesis, Crystal Structure and Gas Adsorption of a Trimeric Nickel-based Coordination Polymer

A trimeric porous coordination framework [Ni_3(TPTC)(IN)_2(μ_2-H_2O)_2(CH_3OH)_2)]n· x(solvents)(1, TPTC = terphenyl-3,3?,5,5??-tetracarboxylic acid, IN = isonicotinic acid) was synthesized and characterized by elemental analysis, infrared spectroscopy, thermogravimetric analysis, single-crystal and powder X-ray diffraction. It crystallizes in monoclinic space group C2/c with a = 33739(12), b = 14.820(5), c = 13.568(5) ?, β = 97.388(6)o, V = 6728(4) ?3, Z = 4, Mr = 965.35, Dc = 0.953 g·cm^(-3), F(000) = 1955.5, μ = 0.881 mm^(–1), GOOF = 1.072, the final R = 0.0859 and w R = 0.2424 for 5284 observed reflections with I > 2σ(I). The structure of 1 is constructed from the linkage of trinuclear {Ni_3} second building units through TPTC and IN spacers, forming a 4,8-connected network of Schl?fli symbol {32.42.52}{34.46.58.68.72}. The CO2 uptake values for 1 are 97.9 m^2·g^(-1) at 273 K and 66.2 m^2·g^(-1) at 298 K, while its N_2 adsorption values are 8.5 m^2·g^(-1) at 273 K and 4.9 m^2·g^(-1) at 298 K, respectively. These results show that 1 has high CO_2/N_2 adsorption selectivity at ambient conditions.

Dimer与Trimer的量子统计力学

本文根据Dimer与Trimer的特性,提出一个非理想量子气体的模型,并求得玻色子系统三阶维里系数的近似表达式。对~4He系统进行了具体计算,结果与实验值相符。

Synthesis,liquid crystalline and luminescent properties of trimeric phenylenevinylene with end-groups of(R)-(+)-2-methylbutyric acid ester

The trimeric phenylenevinylene with the symmetrical chiral end-groups （ChTPV） was synthesized. The liquid crystalline and luminescent properties of the ChTPV have been studied by differential scanning calorimetry （DSC）, polarized optical microscopy （POM）, absorption and photoluminescence spectra. The results indicated that the ChTPV exhibits mesophase over a wide temperature range and a typical optical texture of smectic phase. In contrast with the spectra of the solution, that of the film showed blue-shift in maximal absorption and red-shift in maximal emission due to H-type aggregation with parallel alignment of the TPV transition dipole moment.

Toughening Modification of Unsaturated Polyester Resin Using HDI Trimer

HDI trimer was firstly used to improve the mechanical properties of hydroxyl-terminated unsaturated polyester （UP）. Mechanical properties measurements performed on the cured materials demonstrate a distinct improvement in intensity and toughness in the presence of HDI trimer and shows the change trends of increase and then decrease. The morphological analysis of the fracture surfaces shows that the micro-phase separated structures appear in modified UPR systems and changed from dendritric, dimple and to cystiform structures with the increase of HDI trimer content. The presence of the cystiform structures made the modified UPR systems present the best properties.

Synthesis and Crystal Structure of a New μ-Oxamide Trimeric Hetero-tetranuclear Complex

A novel oxamide-bridged trimeric tetranuclear complex 1 incorporating a macro- cyclic oxamide of formula {[(CuL)3Mn](ClO4)2}3 (macrocyclic oxamide L = 2,3-dioxo-5,6,14,15- dibenzo-1,4,8,12-tetraazacyclopentadeca-7,12-diene) was prepared and structurally characterized. The compound [(CuL)3Mn](ClO4)2 crystallizes in the trigonal system, space group P 3 with a = 22.434(17), b = 22.434(17), c = 18.82(2) ?, α = β = 90, γ = 120o, V = 8203(13) ?3, Z = 6, Dc = 1.751g/cm3, μ(MoKα) = 1.557, F(000) = 4392, the final R = 0.083 and wR = 0.1727 for 9604 obser- ved reflections with I > 2σ(I). The single-crystal X-ray analysis shows that 1 is a trimeric complex. There are three similar constitutes, dissimilar conformations and asymmetrically independent ‘building-block’ [(CuL)3Mn] in one crystal cell of the title complex 1.

Investigation of Light-harvest Material:Synthesis and Characterization of Nanometer Porphyrin Trimer

ω -Bromopropylporphyrin ether synthesized from the raction of 1,3-dibromopropane as the bridge-linked reagent and 5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin (H_2MHTPP) as the matrix reacts with 5,15-di(4- hydroxyphenyl)-10,20-diphenyl porphyrin( trans -H_2DHDPP) to give the title nanometer porphyrin trimer. The characterization was carried out by means of elemental analyses,UV-Vis,IR, 1H NMR and XRD.

Fluorescence and Thermostability of Nanometer Porphyrin Trimer

A nanometer porphyrin trimer was firstly synthesized with 1 ,3-dibromopropane as a bridge-linked agent and the fluorescence property and thermostability were studied. The results show that the fluorescence property and thermostability of the trimer are different from those of monoporphyrin. The effects of the molecule structure on the optical property and the thermostability were also studied in detail.

Synergistic effect of salts on inducingobvious viscoelastic behavior of cationic trimeric surfactant solutions

A viscoelastic system formed by the solutions of di（2-hydroxyl-dimethylene ether）-α,ω, y-triple （ dimethyloctadecylammonium chlorine ） （ 18-4 （ OH ） -18-4 （ OH ） -18 ） is proposed to solve the problems of poor temperature and shear resistances of clean fracturing fluid. The apparent viscosity of 18-4（ OH）-18-4（ OH）-18 solution affected by inorganic salt, hydrotropic salt and their mixtures is investigated using steady state measurements. Meanwhile, the temperature and shear resistances of systems of 18-4（ OH）-18-4（ OH）-18 and several common single-chain surfactants are compared. The rheological experiments show that, the coexistence of NaSal and NaC1 makes it easier for the system to promote micellar growth yielding wormlike micelles than single NaSal or NaC1. The apparent vis- cosity of 18-4（OH） -18-4（OH） -18 solution maintains over 87. 5 mPa-s above 100 22. The results indi- cate that there exists a synergistic effect in solutions of 18-4 （ OH ） -18-4 （ OH ） -18 trimeric surfactant

Exciton transfer dynamics in a trimer system

We study exciton transfer dynamics in a trimer system by investigating excitation transfer probability （ETP）. We calculate ETP in the zero-temperature limit and theoretically predict the environment-assisted quantum critical effect, in which ETP exhibits a sudden change at the critical point of quantum phase transition for the trimer. In particular, we find that the steady-state ETP can be observed in the presence of the environment interaction.

Off-site trimer superfluid on a one-dimensional optical lattice

The Bose-Hubbard model with an effective off-site three-body tunneling,characterized by jumps towards one another,between one atom on a site and a pair atoms on the neighborhood site,is studied systematically on a one-dimensional（1D） lattice,by using the density matrix renormalization group method.The off-site trimer superfluid,condensing at momentum k = 0,emerges in the softcore Bose-Hubbard model but it disappears in the hardcore Bose-Hubbard model.Our results numerically verify that the off-site trimer superfluid phase derived in the momentum space from[Phys.Rev.A81,011601（R）（2010）]is stable in the thermodynamic limit.The off-site trimer superfluid phase,the partially off-site trimer superfluid phase and the Mott insulator phase are found,as well as interesting phase transitions,such as the continuous or first-order phase transition from the trimer superfluid phase to the Mott insulator phase.Our results are helpful in realizing this novel off-site trimer superfluid phase by cold atom experiments.

The Ground and Excitation Levels of the Trimer

The ground and excited levels of the trimer (4He)3 are obtained theoretically by solving the 2-D Faddeev integral equation in the momentum space. In solving the equation, the direct matrix inversion method (I. M.) is used instead of the iteration and Pade approximate method. The new HFD-B Aziz potential ν is used in the calculation.

Theoretical Study on the Optical Properties for 2,7- and 3,6-Linked Carbazole Trimers by Time-dependent Density Functional Theory

Electronic properties, such as HOMO and LUMO energies, band gaps, ionization potential （IP） and electron affinity （EA） of 2,7- and 3,6-1inked carbazole trimers, two conjugated oligomcrs with different linkages of carbazole, were studicd by the density functional theory with Becke-Lee-Young-Parr composite exchange correlation functional （B3LYP）. The absorption spectra of these compounds were also investigated by time-dependent density functional theory （TD-DFT） with 6-3 IG＊ basis set. The calculated results indicated that the HOMO and LUMO of the 2,7- and 3,6-1inked carbazole trimers are both slightly destabilized on going from methyl substitution to sec-butyl substitution. Both IP and EA exhibit their good hole-transporting but poor electronaccepting ability. The presence of alkyl groups on the nitrogen atoms does not affect the intra-chain electronic delocalization along the molecular frame. Thus no significant effect on the band gap and absorption spectra of compounds has been found.

Light focusing in linear arranged symmetric nanoparticle trimer on metal film system

Benefiting from the induced image charge on film surface,the nanoparticle aggregating on metal exhibits interesting optical properties.In this work,a linear metal nanoparticle trimer on metal film system has been investigated to explore the novel optical phenomenon.Both the electric field and surface charge distributions demonstrate the light is focused on film greatly by the nanoparticles at two sides,which could be strongly modulated by the wavelength of incident light.And the influence of nanoparticle in middle on this light focusing ability has also been studied here,which is explained by the plasmon hybridization theory.Our finding about light focusing in nanoparticle aggregating on metal film not only enlarges the novel phenomenon of surface plasmon but also has great application prospect in the field of surface-enhanced spectra,surface catalysis,solar cells,water splitting,etc.

A Fragmentation Study on Four Unusual Secoiridoid Trimers,Swerilactones H–K,by Electrospray Tandem Mass Spectrometry

Swerilactones H–K(1–4)as four unprecedented secoiridoid trimers represent a new type of natural product,which has attracted much interest of natural chemists due to their novel skeletons and promising bioactivity.In order to well understand their MS fragmentation behaviors,they were investigated by electrospray ionization ion-trap time-of-flight multistage product ion mass spectrometry(ESI-IT-TOF-MSn)for the first time.The protonated molecules([M?H]?)of swerilactones J and K,and deprotonated molecules([M-H]-)of swerilactones H,J and K were readily observed in the conventional single-stage mass spectra(MS);however only the[M?Cl]-ion for swerilactone I was obtained in negative mode.Based on the MSn study,the fragmentation pathways of swerilactones H and I in negative mode,and swerilactones J and K in both positive and negative modes were proposed.The neutral losses of H_(2)O,CO,CO_(2)and C_(2)H_(4)O moieties are the particular elimination from the precursor ions due to the presence of hydroxyl,d-lactone and 1-O-ethyl moieties in their structures,of which the retro-Diels–Alder cleavage was the most particular dissociation.The fragment ions at m/z 341 and 291 in negative mode can be considered as the diagnostic ions for secoiridoid trimers.This investigation will provide valuable information for their fast characterization from complicated natural mixtures and extensive understanding their structural architectures.

Theoretical investigation of the dispersion interaction in argon dimer and trimer

The ultimate aim of the present work is to establish an acceptable level of computation for the van der waals (vdw) complexes that is able to pick up appreciable amount of dispersion interaction energy, reproduce the equilibrium separation within the acceptable limits and at the same time cost and time effective. In order to reach this aim vdw clusters where pure isotropic dispersion interaction occur, namely, Ar dimer and trime were investigated. Computations using different basis sets and at different levels of theory have been carried out. Three basis sets, namely, the 6-31++G**, the 6-311++G** and the aug-cc-pvdz basis set, were found superior to all other basis sets used. The high performance and relative small CPU time of the 6-31++G** basis set make it a good candidate for use with large vdw clusters, especially those of interest in biology. Three compound methods were applied in the present work, namely G1, G2 and G2 Moller-Plesset (MP2) and the complete basis set method, CBS-Q. These methods failed to detect the attraction dispersion interaction in the dimer. The predicted repulsive interaction seems dominant in all these methods. Some of the recently developed Density Functional Theory (DFT) methods that were parameterized to account for the dispersion interaction were also evaluated in the present work. Results come to the conclusion that, in contrast to the claims made, state-of-the-art Density Functional Theory methods are incapable of accounting for dispersion effects in a quantitative way, although these methods predict correctly the inter-atomic separations and are?thus considered a real improvement over the conventional methods. BS-SE has been computed, analyzed and discussed.

Hexafluoropropylene oxide trimer acid,a perfluorooctanoic acid alternative,induces cardiovascular toxicity in zebrafish embryos

As an increasingly used alternative to perfluorooctanoic acid(PFOA),hexafluoropropylene oxide trimer acid(HFPO-TA)has been widely detected in global water environments.However,little is known regarding its toxic effects on cardiovascular development.Here,zebrafish embryos were treated with egg water containing 0,60,120,or 240 mg/L HFPO-TA.Results showed that HFPO-TA treatment led to a significant reduction in both larval survival percentage and heart rate.Furthermore,HFPO-TA exposure caused severe pericardial edema and elongation of the sinus venous to bulbus arteriosus distance(SV-BA)in Tg(myl7:GFP)transgenic larvae,disrupting the expression of genes involved in heart development and thus causing abnormal heart looping.Obvious sprouting angiogenesis was observed in the 120 and 240 mg/L exposed Tg(fli:GFP)transgenic larvae.HFPO-TA treatment also impacted the mRNA levels of genes involved in the vascular endothelial growth factor(VEGF)pathway and embryonic vascular development.HFPO-TA exposure significantly decreased erythrocyte number in Tg(gata1:DsRed)transgenic embryos and influenced gene expression associated with the heme metabolism pathway.HFPO-TA also induced oxidative stress and altered the transcriptional levels of genes related to cell cycle and apoptosis,inhibiting cell proliferation while promoting apoptosis.Therefore,HFPO-TA exposure may induce abnormal development of the cardiovascular and hematopoietic systems in zebrafish embryos,suggesting it may not be a suitable or safe alternative for PFOA.

The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development

TRAF7 serves as a crucial intracellular adaptor and E3 ubiquitin ligase involved in signal transduction pathways,contributing to immune responses,tumor progression,and embryonic development.Somatic mutations within the coiled-coil(CC)domain and WD40 repeat domain of TRAF7 could cause brain tumors,while germline pathogenic mutations contribute to severe developmental abnormalities.However,the precise molecular mechanism underlying TRAF7 involvement in embryonic development remains unclear.In this study,we employed zebrafish as an in vivo model system.TRAF7 knock down caused defects in zebrafish embryonic development.We determined the crystal structure of TRAF7 CC domain at 3.3Åresolution and found that the CC region trimerization was essential for TRAF7 functionality during zebrafish embryonic development.Additionally,disease-causing mutations in TRAF7 CC region could impair the trimer formation,consequently impacting early embryonic development of zebrafish.Therefore,our study sheds light on the molecular mechanism of TRAF7 CC trimer formation and its pivotal role in embryonic development.