Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ven...Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ventricular function via echocardiography in the same population. Methods: This prospective observational study, conducted at the National Institute of Cardiovascular Diseases in Dhaka, Bangladesh, enrolled 200 patients with ischaemic cardiomyopathy and a depressed left ventricular ejection fraction (LVEF Results: In this study (n = 200) of ischaemic cardiomyopathy patients, the mean age was 58 years, with 76% of the patients being male. All study subjects received GDMT (Guideline-Directed Medical Therapy) for angina and heart failure. Those who received the modified released form of trimetazidine developed lesions during the 1st and 2nd follow-ups, during which the LVEF, LVIDd, and six-minute walk distance significantly improved (p Conclusion: The findings of the present study demonstrated that the addition of modified-release trimetazidine to GDMT can improve exercise capacity and left ventricular function in patients with ischaemic cardiomyopathy.展开更多
Objective:To analyze the effect of atorvastatin combined with trimetazidine in the treatment of elderly coronary artery disease and the effect on patients’cardiac function.Methods:60 cases of elderly coronary artery ...Objective:To analyze the effect of atorvastatin combined with trimetazidine in the treatment of elderly coronary artery disease and the effect on patients’cardiac function.Methods:60 cases of elderly coronary artery disease patients were divided into 2 groups by randomization method,and all of them received conventional symptomatic treatment,while atorvastatin was added to the control group and trimetazidine was combined with atorvastatin in the observation group,and the clinical indexes were compared.Results:After treatment,the angina attack,cardiac function indexes,and inflammatory factor levels of the observation group were better than those of the control group(P<0.05),and the differences in adverse reactions between the two groups were not significant(P>0.05).Conclusion:Combined treatment of coronary heart disease in the elderly with atorvastatin and trimetazidine can positively reduce angina symptoms,improve cardiac function,and reduce inflammatory reactions,and the effect is definite.展开更多
建立一种基于美国官方分析化学师协会(Association of Official Analytical Chemists,AOAC)方法检测黑果枸杞及其制品中花青素含量的改进pH示差法。考察了黑果枸杞及其制品中花青素的最佳提取和检测条件,通过液相色谱-三重四级杆串联质...建立一种基于美国官方分析化学师协会(Association of Official Analytical Chemists,AOAC)方法检测黑果枸杞及其制品中花青素含量的改进pH示差法。考察了黑果枸杞及其制品中花青素的最佳提取和检测条件,通过液相色谱-三重四级杆串联质谱法鉴别出黑果枸杞中花青素的具体化学结构,并计算出混合花青素的平均摩尔质量。通过分光光度法测得混合花青素的平均摩尔消光系数,对改进后的pH示差法进行方法学验证和花青素的含量测定。结果显示,最佳提取和检测条件如下:黑果枸杞花青素提取溶剂为盐酸-80%(体积分数)乙醇(3∶97,体积比),料液比为1∶100(g∶mL),提取温度为50℃,提取时间为30 min,缓冲溶液稀释5倍后静置平衡20 min。液相色谱-三重四级杆串联质谱法鉴别黑果枸杞中主要以矮牵牛素类花青素为主(占97.96%),黑果枸杞特有的混合花青素平均摩尔质量为912.7 g/mol,平均摩尔消光系数为29591 L/(mol·cm)。pH示差法改进后能够满足方法学验证要求,固体样品和液体样品最低检出限分别为28.2 mg/100 g、0.282 mg/100 mL。方法改进后花青素提取增长率均大于20%,静置平衡20 min后单次检测结果精密度小于0.3%。以矮牵牛素类花青素代替矢车菊素-3-O-葡萄糖苷计算花青素含量平均提高了2.41倍,能真实地反映黑果枸杞及其制品中花青素的含量。展开更多
为满足不同种类食品对大豆分离蛋白(soybean protein isolate,SPI)不同功能性的需求,本研究利用红外光谱快速采集70组不同pH值处理后SPI的数据,探讨pH值变化对SPI结构含量的影响。使用均值中心化、多元散射校正、标准正态变量变换和归...为满足不同种类食品对大豆分离蛋白(soybean protein isolate,SPI)不同功能性的需求,本研究利用红外光谱快速采集70组不同pH值处理后SPI的数据,探讨pH值变化对SPI结构含量的影响。使用均值中心化、多元散射校正、标准正态变量变换和归一化算法对红外光谱数据进行预处理,基于二维相关红外光谱提取特征波段,再利用偏最小二乘(partial least square,PLS)法和算术优化算法-随机森林(arithmetic optimization algorithm-random forests,AOA-RF)建立不同pH值条件下SPI结构及含量的预测模型。结果表明,经均值中心化和多元散射校正结合处理后,α-螺旋、β-折叠、β-转角和无规卷曲模型的相对标准偏差分别为1.29%、1.60%、1.37%、7.28%,两者结合对光谱数据的预处理效果最佳。预测α-螺旋和β-折叠含量最优模型为AOA-RF(特征波段),校正集决定系数为0.9350和0.9266,预测集决定系数为0.8568和0.8701;预测β-转角和无规卷曲含量最优模型为PLS(特征波段),校正集决定系数为0.9154和0.8817,预测集决定系数为0.8913和0.7843。本研究结果可为工业生产过程中产品质量快速检测和工艺条件控制提供理论支撑。展开更多
文摘Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ventricular function via echocardiography in the same population. Methods: This prospective observational study, conducted at the National Institute of Cardiovascular Diseases in Dhaka, Bangladesh, enrolled 200 patients with ischaemic cardiomyopathy and a depressed left ventricular ejection fraction (LVEF Results: In this study (n = 200) of ischaemic cardiomyopathy patients, the mean age was 58 years, with 76% of the patients being male. All study subjects received GDMT (Guideline-Directed Medical Therapy) for angina and heart failure. Those who received the modified released form of trimetazidine developed lesions during the 1st and 2nd follow-ups, during which the LVEF, LVIDd, and six-minute walk distance significantly improved (p Conclusion: The findings of the present study demonstrated that the addition of modified-release trimetazidine to GDMT can improve exercise capacity and left ventricular function in patients with ischaemic cardiomyopathy.
文摘Objective:To analyze the effect of atorvastatin combined with trimetazidine in the treatment of elderly coronary artery disease and the effect on patients’cardiac function.Methods:60 cases of elderly coronary artery disease patients were divided into 2 groups by randomization method,and all of them received conventional symptomatic treatment,while atorvastatin was added to the control group and trimetazidine was combined with atorvastatin in the observation group,and the clinical indexes were compared.Results:After treatment,the angina attack,cardiac function indexes,and inflammatory factor levels of the observation group were better than those of the control group(P<0.05),and the differences in adverse reactions between the two groups were not significant(P>0.05).Conclusion:Combined treatment of coronary heart disease in the elderly with atorvastatin and trimetazidine can positively reduce angina symptoms,improve cardiac function,and reduce inflammatory reactions,and the effect is definite.
文摘为满足不同种类食品对大豆分离蛋白(soybean protein isolate,SPI)不同功能性的需求,本研究利用红外光谱快速采集70组不同pH值处理后SPI的数据,探讨pH值变化对SPI结构含量的影响。使用均值中心化、多元散射校正、标准正态变量变换和归一化算法对红外光谱数据进行预处理,基于二维相关红外光谱提取特征波段,再利用偏最小二乘(partial least square,PLS)法和算术优化算法-随机森林(arithmetic optimization algorithm-random forests,AOA-RF)建立不同pH值条件下SPI结构及含量的预测模型。结果表明,经均值中心化和多元散射校正结合处理后,α-螺旋、β-折叠、β-转角和无规卷曲模型的相对标准偏差分别为1.29%、1.60%、1.37%、7.28%,两者结合对光谱数据的预处理效果最佳。预测α-螺旋和β-折叠含量最优模型为AOA-RF(特征波段),校正集决定系数为0.9350和0.9266,预测集决定系数为0.8568和0.8701;预测β-转角和无规卷曲含量最优模型为PLS(特征波段),校正集决定系数为0.9154和0.8817,预测集决定系数为0.8913和0.7843。本研究结果可为工业生产过程中产品质量快速检测和工艺条件控制提供理论支撑。
