目的研究CK5/6、CK14在三阴性乳腺癌(triple negativebreast carcinoma,TNBC)中的表达情况,并探讨基底细胞样乳腺癌(basal-like breast carcinoma,BLBC)与TNBC的关系。方法利用免疫组化方法从浸润性乳腺癌中筛选TNBC病例,然后利用CK5/6...目的研究CK5/6、CK14在三阴性乳腺癌(triple negativebreast carcinoma,TNBC)中的表达情况,并探讨基底细胞样乳腺癌(basal-like breast carcinoma,BLBC)与TNBC的关系。方法利用免疫组化方法从浸润性乳腺癌中筛选TNBC病例,然后利用CK5/6和CK14从TNBC中筛选出BLBC的病例,分析两者的临床与病理资料及免疫组化表达情况并复习有关文献。结果TNBC的发病率占浸润性乳腺癌的16.1%。TNBC中的CK5/6和CK14表达有正相关性(γ=0.463)。应用CK5/6、CK14从TNBC中筛选出的BLBC的百分率为54%。结论BLBC与TNBC有大部分交叉。CK5/6和CK14可以用来从TNBC中筛选出大部分的BLBC的病例。BLBC相对其他类型乳腺癌,预后不良,有必要将其从TN-BC中鉴别出来。展开更多
Objective: This study aimed to compare the efficacy and safety of neoadjuvant chemotherapy with TAC and TP regimens of triple negative breast cancer(TNBC). Methods: A total of 102 patients with TNBC were confirmed by ...Objective: This study aimed to compare the efficacy and safety of neoadjuvant chemotherapy with TAC and TP regimens of triple negative breast cancer(TNBC). Methods: A total of 102 patients with TNBC were confirmed by histopathology. They were divided into TAC group(52 cases) and TP group(50 cases). Group TAC: Docetaxel 75 mg/m2 or paclitaxel(taxol liposome) 135 mg/m2 on d1, pirarubicin 40 mg/m2 or epirubicin 75 mg/m2 on d2, cyclophosphamide 600 mg/m2 on d1; Group TP: Docetaxel 75 mg/m2 or paclitaxel(taxol liposome) 135 mg/m2 on d1, cisplatin 30 mg/m2 on d2–d4, with 21 days as a cycle. All patients underwent operation after 2–4 cycles of chemotherapy. The short-term effects and toxic and adverse effects were evaluated. Results: In TAC group, 5 cases(9.6%) had pathological complete release(pCR), 35 cases(67.3%) partial release(PR), 9 cases(17.3%) stable disease(SD), and the response rate(RR) was 76.9%. In TP group, 4 cases(8%) had pCR, 32 cases(64%) PR, 5 cases(10%) SD, and RR was 72%. In 102 patients, 12 patients with tumor progression after 2 cycles of chemotherapy, included 3 cases in TAC group, 9 cases in TP group. In TAC group, 2 cases occurred atrial premature contraction; while 3 cases developed grade 2 renal injury in TP group. In TAC group, grade 3–4 hematologic toxicity and alopecia was significantly higher than that in TP group, but grade 3–4 gastrointestinal reaction rate in TP group was significantly higher than TAC group. Conclusion: TAC and TP regimens all had certain efficacy in the neoadjuvant chemotherapy for TNBC, and the toxicity reactions can be tolerated.展开更多
文摘目的研究CK5/6、CK14在三阴性乳腺癌(triple negativebreast carcinoma,TNBC)中的表达情况,并探讨基底细胞样乳腺癌(basal-like breast carcinoma,BLBC)与TNBC的关系。方法利用免疫组化方法从浸润性乳腺癌中筛选TNBC病例,然后利用CK5/6和CK14从TNBC中筛选出BLBC的病例,分析两者的临床与病理资料及免疫组化表达情况并复习有关文献。结果TNBC的发病率占浸润性乳腺癌的16.1%。TNBC中的CK5/6和CK14表达有正相关性(γ=0.463)。应用CK5/6、CK14从TNBC中筛选出的BLBC的百分率为54%。结论BLBC与TNBC有大部分交叉。CK5/6和CK14可以用来从TNBC中筛选出大部分的BLBC的病例。BLBC相对其他类型乳腺癌,预后不良,有必要将其从TN-BC中鉴别出来。
文摘Objective: This study aimed to compare the efficacy and safety of neoadjuvant chemotherapy with TAC and TP regimens of triple negative breast cancer(TNBC). Methods: A total of 102 patients with TNBC were confirmed by histopathology. They were divided into TAC group(52 cases) and TP group(50 cases). Group TAC: Docetaxel 75 mg/m2 or paclitaxel(taxol liposome) 135 mg/m2 on d1, pirarubicin 40 mg/m2 or epirubicin 75 mg/m2 on d2, cyclophosphamide 600 mg/m2 on d1; Group TP: Docetaxel 75 mg/m2 or paclitaxel(taxol liposome) 135 mg/m2 on d1, cisplatin 30 mg/m2 on d2–d4, with 21 days as a cycle. All patients underwent operation after 2–4 cycles of chemotherapy. The short-term effects and toxic and adverse effects were evaluated. Results: In TAC group, 5 cases(9.6%) had pathological complete release(pCR), 35 cases(67.3%) partial release(PR), 9 cases(17.3%) stable disease(SD), and the response rate(RR) was 76.9%. In TP group, 4 cases(8%) had pCR, 32 cases(64%) PR, 5 cases(10%) SD, and RR was 72%. In 102 patients, 12 patients with tumor progression after 2 cycles of chemotherapy, included 3 cases in TAC group, 9 cases in TP group. In TAC group, 2 cases occurred atrial premature contraction; while 3 cases developed grade 2 renal injury in TP group. In TAC group, grade 3–4 hematologic toxicity and alopecia was significantly higher than that in TP group, but grade 3–4 gastrointestinal reaction rate in TP group was significantly higher than TAC group. Conclusion: TAC and TP regimens all had certain efficacy in the neoadjuvant chemotherapy for TNBC, and the toxicity reactions can be tolerated.
