期刊文献+
共找到1,625篇文章
< 1 2 82 >
每页显示 20 50 100
Scenario of Infection Prevention and Control Measures for Tuberculosis in Tuberculosis Inpatient and Outpatient Department in Tertiary Care Hospital 被引量:1
1
作者 Yogita Mistry Sangita Rajdev Summaiya Mullan 《Journal of Tuberculosis Research》 2016年第4期147-154,共8页
Tuberculosis is one of the most important infectious diseases in our country. Also nosocomial infection by tuberculosis can occur, which can be prevented by implementing simple, effective and affordable tuberculosis i... Tuberculosis is one of the most important infectious diseases in our country. Also nosocomial infection by tuberculosis can occur, which can be prevented by implementing simple, effective and affordable tuberculosis infection control measures in health care facilities. To evaluate the effectiveness of infection control measures, such study was planned. Questionnaires were administered to all doctors, healthcare workers and servants working in outdoor and indoor department of tuberculosis at tertiary care hospital to assess the knowledge, attitudes and practices on prevention and control of Tuberculosis infection. A scoring system was devised to grade them. One-time audit was also done in outpatient and inpatient department. The analysis showed scoring of poor for doctors, good for nurses and poor forward aids. There is a need to develop strategies for training of health care workers on regular basis in order to reduce the incidence of nosocomial infections. Audit result shows a good level of environmental control measures. Better knowledge, attitude and practices are helpful for the prevention and control of tuberculosis. Also environmental control measures are helpful to prevent infection. 展开更多
关键词 Infection prevention and control Measures tuberculosis tuberculosis Departments
下载PDF
Risk of Active Pulmonary Tuberculosis among Patients with Coal Workers'Pneumoconiosis:A Case-control Study in China 被引量:8
2
作者 JIN Yan FAN Jing Guang +4 位作者 PANG Jing WEN Ke ZHANG Pei Ying WANG Huan Qiang LI Tao 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2018年第6期448-453,共6页
The aim of this study was to estimate the association between occupational, environmental, behavioral risk factors, and active pulmonary tuberculosis(PTB) among coal workers' pneumoconiosis(CWP) patients. A matche... The aim of this study was to estimate the association between occupational, environmental, behavioral risk factors, and active pulmonary tuberculosis(PTB) among coal workers' pneumoconiosis(CWP) patients. A matched case-control study was conducted in 86 CWP patients with active PTB and 86 CWP controls without TB. A standardized questionnaire was used for risk factors assessment. Conditioned logistic regression analysis was used to identify associations between the risk factors and active PTB among CWP patients. The results showed that the stage of CWP, poor workplace ventilation, family history of TB, and exposure to TB were independent risk factors for active PTB in patients with CWP with which recommendations for improving work environments, and for case finding activities in patients with CWP could be made. 展开更多
关键词 肺炎双球菌 风险因素 肺结核 控制 盒子 工人 中国
下载PDF
The strategic framework of tuberculosis control and prevention in the elderly:a scoping review towards End TB targets 被引量:4
3
作者 Jun Li Pui-Hong Chung +3 位作者 Cyrus L.K.Leung Nobuyuki Nishikiori Emily Y.Y.Chan Eng-Kiong Yeoh 《Infectious Diseases of Poverty》 SCIE 2017年第1期605-616,共12页
With the rapid pace of population ageing,tuberculosis(TB)in the elderly increasingly becomes a public health challenge.Despite the increasing burden and high risks for TB in the elderly,targeted strategy has not been ... With the rapid pace of population ageing,tuberculosis(TB)in the elderly increasingly becomes a public health challenge.Despite the increasing burden and high risks for TB in the elderly,targeted strategy has not been well understood and evaluated.We undertook a scoping review to identify current TB strategies,research and policy gaps in the elderly and summarized the results within a strategic framework towards End TB targets.Databases of Embase,MEDLINE,Global health and EBM reviews were searched for original studies,review articles,and policy papers published in English between January 1990 and December 2015.Articles examining TB strategy,program,guideline or intervention in the elderly from public health perspective were included.Nineteen articles met the inclusion criteria.Most of them were qualitative studies,issued in high-and middle-income countries and after 2000.To break the chain of TB transmission and reactivation in the elderly,infection control,interventions of avoiding delay in diagnosis and containment are essential for preventing transmission,especially in elderly institutions and aged immigrants;screening of latent TB infection and preventive therapy had effective impacts on reducing the risk of reactivation and should be used less reluctantly in older people;optimizing early case-finding with a high index of suspicion,systematic screening for prioritized high-risk groups,initial empirical and adequate follow-up treatment with close monitoring and evaluation,as well as enhanced programmatic management are fundamental pillars for active TB elimination.Evaluation of TB epidemiology,risk factors,impacts and cost-effectiveness of interventions,adopting accurate and rapid diagnostic tools,shorter and less toxic preventive therapy,are critical issues for developing strategy in the elderly towards End TB targets.TB control strategies in the elderly were comprehensively mapped in a causal link pathway.The framework and principals identified in this study will help to evaluate and improve current program,develop targeted strategy,as well as raise more discussions on the research priority settings and policy transitions.Given the scarceness of policy and evaluated interventions,as well as the unawareness of shifting TB epidemiology and strategy especially in developing countries,the increasing need of a ready TB program for the elderly warrants further research. 展开更多
关键词 tuberculosis Aged/older people Strategy prevention and control of infectious disease Scoping review
原文传递
Tuberculosis infection prevention and control:why we need a whole systems approach 被引量:1
4
作者 Karina Kielmann Aaron S.Karat +11 位作者 Gimenne Zwama Christopher Colvin Alison Swartz Anna S.Voce Tom A.Yates Hayley MacGregor Nicky McCreesh Idriss Kallon Anna Vassall Indira Govender Janet Seeley Alison D.Grant 《Infectious Diseases of Poverty》 SCIE 2020年第3期97-100,共4页
Infection prevention and control(IPC)measures to reduce transmission of drug-resistant and drug-sensitive tuberculosis(TB)in health facilities are well described but poorly implemented.The implementation of TB IPC has... Infection prevention and control(IPC)measures to reduce transmission of drug-resistant and drug-sensitive tuberculosis(TB)in health facilities are well described but poorly implemented.The implementation of TB IPC has been assessed primarily through quantitative and structured approaches that treat administrative,environmental,and personal protective measures as discrete entities.We present an on-going project entitled Umoya omuhle(“good air”),conducted in two provinces of South Africa,that adopts an interdisciplinary,‘whole systems’approach to problem analysis and intervention development for reducing nosocomial transmission of Mycobacterium tuberculosis(Mtb)through improved IPC.We suggest that TB IPC represents a complex intervention that is delivered within a dynamic context shaped by policy guidelines,health facility space,infrastructure,organisation of care,and management culture.Methods drawn from epidemiology,anthropology,and health policy and systems research enable rich contextual analysis of how nosocomial Mtb transmission occurs,as well as opportunities to address the problem holistically.A‘whole systems’approach can identify leverage points within the health facility infrastructure and organisation of care that can inform the design of interventions to reduce the risk of nosocomial Mtb transmission. 展开更多
关键词 Drug-resistant tuberculosis Infection prevention and control Health system South Africa
原文传递
Identification and attribute analysis of key stakeholders who influence multidrug-resistant tuberculosis prevention and control in China
5
作者 Bin Chen Hongdan Bao +6 位作者 Xinyi Chen Kui Liu Ying Peng Wei Wang Fei Wang Jianmin Jiang Biao Xu 《Infectious Diseases of Poverty》 SCIE 2021年第4期102-102,共1页
Background There could be various stakeholders who influencing multidrug-resistant tuberculosis(MDR-TB)policy development and implementation,yet their attributes and roles remain unclear in practice.This study aimed t... Background There could be various stakeholders who influencing multidrug-resistant tuberculosis(MDR-TB)policy development and implementation,yet their attributes and roles remain unclear in practice.This study aimed to identify key stakeholders in the process of policy-making for MDR-TB control and prevention and to analyse the attributes and relationships of the stakeholders,providing evidence for further policy research on MDR-TB control.Methods This study was conducted from October 2018 to March 2019 and applied the stakeholder analysis guidelines and domestic stakeholder analysis.An initial candidate stakeholder list was developed by policy scanning.Ten experts were invited to identify these candidate stakeholders.The major attribute of these stakeholders were analysed using the Michell scoring method.Based on these results,the intertwined relationships among groups of stakeholders were analysed and mapped through a systematic scan of the policy and literature on MDR-TB control,as well as information obtained from the interviews.Results A list of 21 types of candidate stakeholders was developed after a literature review and policy scanning,of which 11 received 100%approval.After expert evaluation and identification(the total expert authority was 0.80),19 categories of stakeholders were approved and included in the stakeholder analysis.We categorized all of the stakeholders into three groups:(i)definitive stakeholders who are mainly involved in administrative departments and the Provincial Center for Disease Control and Prevention(CDC);(ii)expectant stakeholders who are mainly involved with MDR-TB patients,clinical departments of TB hospitals at different levels,community health care facilities,prefectural CDC and charity organizations;and(iii)latent stakeholders who mainly involved family members and neighbours of MDR-TB patients and TB related products manufacturers.Government departments and higher-level CDCs have strong decision-making power in developing MDR-TB control policies whereas the recommendations from service providers and the concerns of patients should be considered.Conclusions The MDR-TB prevention system was a multistakeholder cooperation system that was mainly led by government stakeholders.Enhancing communications with front-line service providers and patients on their unmet needs and evidence-based suggestions would highly benefit policy-making of MDR-TB prevention and control. 展开更多
关键词 Multidrug-resistant tuberculosis STAKEHOLDERS prevention and control
原文传递
The status quo and challenges of prevention and control of chronic obstructive pulmonary disease in China 被引量:5
6
作者 Yali Zheng Zhancheng Gao 《Global Health Journal》 2017年第1期56-61,共6页
Introduction Characterized as persistent and progressive pulmonary function declining,chronic obstructive pulmonary disease (COPD) can be accompanied by a systemic inflammatory response.A variety of psychiatric and so... Introduction Characterized as persistent and progressive pulmonary function declining,chronic obstructive pulmonary disease (COPD) can be accompanied by a systemic inflammatory response.A variety of psychiatric and somatic comorbidities can occur to the patients,such as depression,nutritional disorders,cardiovascular disease,and lung cancer.It is imposing great impacts on the quality of patients' life.In 2010 alone,the economic burden of COPD in the world was as high as 2.1 trillion dollars [1].The high prevalence,mortality,and morbidity have made this disease a major public health problem in socio-economic development with a rapidly aging population in China. 展开更多
关键词 pulmonary disease chronic OBSTRUCTIVE prevention and control DISEASE STATUS quo
下载PDF
Efficacy of integrating short-course chemotherapy with Chinese herbs to treat multi-drug resistant pulmonary tuberculosis in China: a study protocol 被引量:1
7
作者 Shun-Xian Zhang Lei Qiu +9 位作者 Cui Li Wei Zhou Li-Ming Tian Hui-Yong Zhang Zi-Feng Ma Xian-Wei Wu Xing Huang Yu-Wei Jiang Shao-Yan Zhang Zhen-Hui Lu 《Infectious Diseases of Poverty》 SCIE 2021年第6期90-105,共16页
Background:Tuberculosis(TB)causedMycobacterium tuberculosis(M.tb)is one of infectious disease that lead a large number of morbidity and mortality all over the world.Although no reliable evidence has been found,it is c... Background:Tuberculosis(TB)causedMycobacterium tuberculosis(M.tb)is one of infectious disease that lead a large number of morbidity and mortality all over the world.Although no reliable evidence has been found,it is considered that combining chemotherapeutic drugs with Chinese herbs can significantly improves the cure rate and the clinical therapeutic effect.Methods:Multi-drug resistant pulmonary tuberculosis(MDR-PTB,n=258)patients with Qi-yin deficiency syndrome will be randomly assigned into a treatment group(n=172)or control/placebo group(n=86).The treatment group will receive the chemotherapeutic drugs combined with Chinese herbs granules(1+3 granules),while the control group will receive the chemotherapeutic drugs combined with Chinese herbs placebo(1+3 placebo granules).In addition,MDR-PTB(n=312)patients with Yin deficiency lung heat syndrome will be randomly assigned to a treatment(n=208)or control/placebo(n=104)group.The treatment group will receive the chemotherapeutic regimen combined with Chinese herbs granules(2+4 granules),while the control group will receive the chemotherapeutic drugs and Chinese herbs placebo(2+4 placebo granules).The primary outcome is cure rate,the secondary outcomes included time to sputum culture conversion,lesion absorption rate and cavity closure rate.BACTEC^(TM)MGIT^(TM)automated mycobacterial detection system will be used to evaluate theM.tb infection and drug resistance.Chi-square test and Cox regression will be conducted with SAS 9.4 Statistical software to analyze the data.Discussion:The treatment cycle for MDR-PTB using standardized modern medicine could cause lengthy substantial side effects.Chinese herbs have been used for many years to treat MDR-PTB,but are without high-quality evidence.Hence,it is unknown whether Chinese herbs enhances the clinical therapeutic effect of synthetic drugs for treating MDR-PTB.Therefore,this study will be conducted to evaluate the clinical therapeutic effect of combining Chinese herbs and chemotherapeutic drugs to treat MDR-PTB cases.It will assist in screening new therapeutic drugs and establishing treatment plan that aims to improve the clinical therapeutic effect for MDR-PTB patients.Trial registration This trial was registered at ClinicalTrials.gov(ChiCTR1900027720)on 24 November 2019(prospective registered). 展开更多
关键词 pulmonary tuberculosis MULTIDRUG-RESISTANT Chemotherapeutic drug Chinese herbs Randomized controlled trial
原文传递
Achievements and challenges of the World Bank Loan/Department for International Development grant-assisted Tuberculosis Control Project in China 被引量:3
8
作者 KONG Peng JIANG Xu +2 位作者 ZHANG Ben JIANG Shi-wen LIU Bo 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第14期2216-2218,共3页
在 2002 年 3 月,中国的政府发射了世界银行 Loan/ 部门让国际支持发展的肺结核(TB ) 控制工程减少 TB 的流行和死亡。工程在政策开发产生了有希望的结果,立法的 TB 控制系统,耐心的治疗成功,资金管理,和介绍加强。考虑到全球 TB ... 在 2002 年 3 月,中国的政府发射了世界银行 Loan/ 部门让国际支持发展的肺结核(TB ) 控制工程减少 TB 的流行和死亡。工程在政策开发产生了有希望的结果,立法的 TB 控制系统,耐心的治疗成功,资金管理,和介绍加强。考虑到全球 TB 流行病和控制环境,考察工程的 TB 控制优先级是有用的,在它的实现附近总结成就和经验。 展开更多
关键词 世界银行贷款 控制项目 国际开发 中国政府 结核病 控制系统 控制环境 优先次序
原文传递
Rising challenge of multidrug-resistant tuberculosis in China:a predictive study using Markov modeling 被引量:3
9
作者 Bing-Ying Li Wen-Pei Shi +6 位作者 Chang-Ming Zhou Qi Zhao Vinod K Diwan Xu-Bin Zheng Yang Li Sven Hoffner Biao Xu 《Infectious Diseases of Poverty》 SCIE 2020年第3期57-64,共8页
Background:Multidrug-resistant tuberculosis(MDR-TB)is on the rise in China.This study used a dynamic Markov model to predict the longitudinal trends of MDR-TB in China by 2050 and to assess the effects of alternative ... Background:Multidrug-resistant tuberculosis(MDR-TB)is on the rise in China.This study used a dynamic Markov model to predict the longitudinal trends of MDR-TB in China by 2050 and to assess the effects of alternative control measures.Methods:Eight states of tuberculosis transmission were set up in the Markov model using a hypothetical cohort of 100000 people.The prevalence of MDR-TB and bacteriologically confirmed drug-susceptible tuberculosis(DS-TB+)were simulated and MDR-TB was stratified into whether the disease was treated with the recommended regimen or not.Results:Without any intervention changes to current conditions,the prevalence of DS-TB+was projected to decline 67.7%by 2050,decreasing to 20 per 100000 people,whereas that of MDR-TB was expected to triple to 58/100000.Furthermore,86.2%of the MDR-TB cases would be left untreated by the year of 2050.In the case where MDR-TB detection rate reaches 50%or 70%at 5%per year,the decline in prevalence of MDR-TB would be 25.9 and 36.2%respectively.In the case where treatment coverage was improved to 70%or 100%at 5%per year,MDR-TB prevalence in 2050 would decrease by 13.8 and 24.1%,respectively.If both detection rate and treatment coverage reach 70%,the prevalence of MDR-TB by 2050 would be reduced to 28/100000 by a 51.7%reduction.Conclusions:MDR-TB,especially untreated MDR-TB,would rise rapidly under China’s current MDR-TB control strategies.Interventions designed to promote effective detection and treatment of MDR-TB are imperative in the fights against MDR-TB epidemics. 展开更多
关键词 Multidrug-resistant tuberculosis Markov chains PREVALENCE prevention and control
原文传递
196例初治病原学阳性肺结核患者结核感染控制知识知晓情况调查
10
作者 姜晓颖 刘静 +4 位作者 张治国 张文 高孟秋 杨新婷 弭凤玲 《中国防痨杂志》 CAS CSCD 北大核心 2024年第2期213-220,共8页
目的:调查初治病原学阳性肺结核患者结核感染控制知识掌握情况,为有效开展结核感染控制和健康教育工作提供依据。方法:对2019年1月至2023年1月于首都医科大学附属北京胸科医院、北京市昌平区结核病防治所、北京市大兴区结核病预防控制... 目的:调查初治病原学阳性肺结核患者结核感染控制知识掌握情况,为有效开展结核感染控制和健康教育工作提供依据。方法:对2019年1月至2023年1月于首都医科大学附属北京胸科医院、北京市昌平区结核病防治所、北京市大兴区结核病预防控制中心纳入的196例初治病原学阳性肺结核患者进行结核感染控制知识知晓情况问卷调查,调查内容包括患者的基本信息、结核感染控制知识问卷、临床信息等;发出问卷196份,有效问卷196份,有效率为100.0%。统计调查对象结核感染控制知识知晓情况,分析影响其结核病防治核心信息知晓情况的因素。结果:196例调查对象结核感染控制知识总知晓率为64.4%(2649/4116)。多因素logistic回归分析结果显示,相对于初中及以下学历,大专/本科及以上学历者结核感染控制知识知晓率达标的可能性更高(OR=6.659,95%CI:1.995~22.220);相对于有结核病接触史者,无结核病接触史者结核感染控制知识知晓率达标的可能性更低(OR=0.218,95%CI:0.054~0.886)。结论:初治病原学阳性肺结核患者结核感染控制知识知晓率尚有待提高,初中及以下文化程度和无结核病接触史的患者结核感染控制知识知晓率相对较低,需针对这部分人群开展结核病预防控制健康教育工作。 展开更多
关键词 结核 感染控制 健康知识 态度 实践 问卷调查
下载PDF
2018-2022年四川省病原学阳性肺结核患者密切接触者筛查情况分析
11
作者 夏岚 刘双 +3 位作者 李婷 逯嘉 王丹霞 张灵麟 《中国防痨杂志》 CAS CSCD 北大核心 2024年第2期178-182,共5页
目的:分析2018-2022年四川省病原学阳性肺结核患者密切接触者的结核病筛查情况,为密切接触者的筛查和管理工作开展提供理论依据。方法:选取“结核病管理信息系统”中登记日期在2018年1月1日至2022年12月30日期间的病原学阳性肺结核患者... 目的:分析2018-2022年四川省病原学阳性肺结核患者密切接触者的结核病筛查情况,为密切接触者的筛查和管理工作开展提供理论依据。方法:选取“结核病管理信息系统”中登记日期在2018年1月1日至2022年12月30日期间的病原学阳性肺结核患者及其密切接触者(与病原学阳性肺结核患者在确诊3个月至开始抗结核治疗后14 d内直接接触的人员)作为调查对象,其中,2018年1月1日至2022年12月30日登记的病原学阳性肺结核患者的密切接触者均为筛查对象;2022年登记的病原学阳性肺结核患者的密切接触者为随访对象。分析不同时间、不同类型密切接触者结核病筛查及活动性肺结核检出情况。结果:2018-2022年四川省共报告病原学阳性肺结核患者99 273例,登记其密切接触者260 661名,其中260 291名密切接触者进行了结核病可疑症状筛查,症状筛查率为99.86%,共检出活动性肺结核患者2623例,平均检出率为1.01%。有结核病可疑症状的密切接触者的结核病检查率(98.50%,6425/6523)和检出率(4.54%,292/6425)均明显高于无结核病可疑症状密切接触者的结核病检查率(86.40%,219 247/253 768)和检出率(1.06%,2331/219 247),差异均有统计学意义(χ^(2)值分别为807.587和658.621,P值均<0.001)。家庭外密切接触者结核病检查率(96.53%,82 173/85 129)明显高于家庭内密切接触者(81.92%,143 499/175 162),差异有统计学意义(χ^(2)=10 595.710,P<0.001);家庭内密切接触者活动性肺结核检出率(1.58%,2264/143 499)明显高于家庭外密切接触者(0.44%,359/82 173),差异有统计学意义(χ^(2)=591.968,P<0.001)。对2022年新登记的42 078名病原学阳性肺结核患者密切接触者在患者诊断时开展症状筛查,39 056名(92.82%)开展了结核病检查,检出719例(1.84%)活动性肺结核患者;35.39%(9705/27 423)完成第2次随访(首次筛查6个月后),55.31%(5368/9705)接受结核病检查,检出2例(0.04%)活动性肺结核患者;仅7.08%(4072/57 474)完成第3次随访(首次筛查1年后),38.33%(1561/4072)接受了结核病检查,检出1例(0.06%)活动性肺结核患者。结论:2018-2022年四川省病原学阳性肺结核患者密切接触者筛查比例较高,但筛查效果不理想,应重视家庭外密切接触者结核病筛查工作,以及重视密切接触者首次筛查后6个月及1年后的随访工作。 展开更多
关键词 结核 接触者追踪 人群监测 传染病控制
下载PDF
健康教育在学校结核病防控中的价值研讨
12
作者 林晓珊 沈鸿程 《中国卫生标准管理》 2024年第5期19-23,共5页
目的研究学校结核病防控中应用健康教育的效果。方法于2021年1月—2022年12月时间段对某高中学校进行调查,选择该校三年级400名进行研究,其中1~5班采用常规校园疾病防控管理(200名),6~10班采用健康教育疾病防控管理模式(200名),观察指... 目的研究学校结核病防控中应用健康教育的效果。方法于2021年1月—2022年12月时间段对某高中学校进行调查,选择该校三年级400名进行研究,其中1~5班采用常规校园疾病防控管理(200名),6~10班采用健康教育疾病防控管理模式(200名),观察指标为健康知识水平、防控措施落实情况、新发结核病发生情况。结果6~10班学生结核病防控知识高于1~5班学生,差异有统计学意义(P<0.05);6~10班学生防控措施落实情况高于1~5班学生,差异有统计学意义(P<0.05);6~10班学生新发结核病发生为0,低于1~5班学生3例(1.50%),但差异无统计学意义(P>0.05);6~10班学生结核病主动汇报15例(7.50%),高于1~5班学生4例(2.00%),差异有统计学意义(P<0.05)。结论学校结核病防治过程中采用健康教育模式可以提升学生的健康知识水平,强化结核病防治措施落实效果,有效预防新发结核病发生,并提高其主动汇报率,改善学生预后效果。 展开更多
关键词 结核病防控 健康教育 健康知识水平 高中学校 防控措施 落实情况
下载PDF
2018—2021年新疆维吾尔自治区喀什地区肺结核患者家庭内密切接触者发病情况及影响因素分析
13
作者 樊晓蕾 买吾拉江·依马木 +6 位作者 彭孝旺 胡鹏远 王艳杰 阿丽米热·阿不力米提 买日哈巴·卡米力 王森路 向阳 《中国防痨杂志》 CAS CSCD 北大核心 2024年第4期390-396,共7页
目的:分析结核病高负担环境中肺结核患者家庭内密切接触者发病风险及影响因素。方法:从“中国疾病预防控制信息系统”子系统“结核病管理信息系统”中收集2018年1月1日至2021年12月31日新疆维吾尔自治区喀什地区12个县(市)确诊的肺结核... 目的:分析结核病高负担环境中肺结核患者家庭内密切接触者发病风险及影响因素。方法:从“中国疾病预防控制信息系统”子系统“结核病管理信息系统”中收集2018年1月1日至2021年12月31日新疆维吾尔自治区喀什地区12个县(市)确诊的肺结核患者作为指示病例,通过接触者筛查建立家庭内密切接触者队列,跟踪随访观察其发病情况。采用泊松回归模型分析指示病例的病原学特征、治疗状态、暴露情况,以及家庭内密切接触者既往肺结核病史等对其肺结核发病的影响因素。结果:截至2021年12月31日,共计调查了40182例肺结核指示病例、57142名家庭内密切接触者。在4年的随访期间,随访时间中位数(四分位数)为3.2(2.7,3.3)年,共计发现了3585例家庭内密切接触者肺结核续发患者,续发率为6.27%,共计观察180543人年,平均发病密度为1985.68/10万人年。其中,指示病例确诊后的第1年,其家庭内密切接触者肺结核发病率最高,约为3317.62/10万人年。泊松回归分析显示,指示病例病原学检测为涂阴、初治,家庭内密切接触者为男性、≥55岁、既往有肺结核接触史和肺结核病史均是家庭内密切接触者肺结核发病的危险因素[RR(95%CI)值分别为2.491(2.347~2.562)、1.221(1.102~1.354)、1.449(1.306~1.607)、8.451(6.388~11.179)、2.680(2.314~3.104)、4.479(3.852~5.207)]。结论:家庭内密切接触者是肺结核指示病例传播的高危人群,应加强家庭内密切接触者的筛查和宣传教育工作,尤其是其中的老年、男性、既往有肺结核接触史和肺结核病史者;也有必要在结核病高负担地区系统地扩大和加强家庭内密切接触者的追踪和预防性治疗策略。同时,建议在当前策略基础上纳入全部肺结核患者的密切接触者进行筛查,尤其是涂阴和仅分子生物学检测阳性患者。 展开更多
关键词 结核 家庭卫生 接触者追踪 队列研究 因素分析 统计学 传染病控制
下载PDF
2014-2020年广东省不同年龄段结核病患者耐药特征及应对防治策略
14
作者 卓文基 魏然 +6 位作者 陈燕梅 陈珣珣 余美玲 郭卉欣 梁鸿迪 梁静 赖晓宇 《实用医学杂志》 CAS 北大核心 2024年第5期702-707,共6页
目的 探究2014-2020年广东省期间各年龄段结核病患者的耐药特征与应对防治策略。方法 以2014-2020年广东省32个结核病耐药监测点中,确诊结核病患者的39 048株结核分枝杆菌(mycobacterium tuberculosis, MTB)临床分离株为研究对象,回顾... 目的 探究2014-2020年广东省期间各年龄段结核病患者的耐药特征与应对防治策略。方法 以2014-2020年广东省32个结核病耐药监测点中,确诊结核病患者的39 048株结核分枝杆菌(mycobacterium tuberculosis, MTB)临床分离株为研究对象,回顾性分析耐药结核病患者及实验室相关资料,并以年龄、地区进行分组,探讨MTB临床分离株对药物的耐药性趋势、耐药结核病(包括单耐药结核病(monodrug-resistant tuberculosis, MR-TB)、多耐药结核病(poly-resistant tuberculosis, PDR-TB)、耐多药结核病(multidrug-resistant tuberculosis, MDR-TB)和广泛耐药结核病(extensively drug-resistant tuberculosis, XDRTB)的发病率差异,以及MTB临床分离株对重点药物(利福平和氧氟沙星)的耐药情况。结果 2014-2020年广东省32个结核病耐药监测点患者MTB临床分离株对9种抗结核药物在不同年度间、不同年龄段间的耐药率差异均无统计学意义(均P> 0.05)。MTB临床分离株的单耐药率、多耐药率、耐多药率、广泛耐药率和总耐药率分别为14.46%、5.16%、4.58%、1.29%。儿童组患者MTB临床分离株单耐药率(15.4%)高于青壮年组及老年组;青壮年组(5.0%)和老年组(5.0%)患者MTB临床分离株耐多药率高于儿童组患者;老年组患者MTB临床分离株广泛耐药率(2.1%)高于儿童组及青壮年组,差异均有统计学意义(P <0.001)。来自珠三角地区的患者MTB临床分离株的单耐药率(14.8%)、多耐药率(5.3%)、耐多药率(4.7%)、广泛耐药率(1.4%)、耐氧氟沙星率(11.33%)和耐利福平率(6.92%)明显高于非珠三角地区,差异均有统计学意义(P <0.001)。结论 根据监测点数据,2014-2020年间,广东省耐药结核病的流行趋势平缓。但在特定人群(如儿童和老年人)中,耐药结核病的发病率较高,且珠三角地区的耐药结核病发病率和重点药物耐药率均高于广东省其他地区,值得进一步关注和采取防控策略。 展开更多
关键词 结核病 耐多药结核病 抗结核药物 珠三角地区 结核病防控
下载PDF
2015-2021年新疆和田地区新冠疫情前后肺结核发病趋势分析
15
作者 依里帕·依力哈木 努尔比耶·约麦尔 +3 位作者 武迪 时雨 郑彦玲 张利萍 《安徽医科大学学报》 CAS 北大核心 2024年第4期678-683,共6页
目的分析新疆和田地区肺结核发病特征及疫情前后发病趋势,为和田地区肺结核防控措施制定和效果评价提供参考依据。方法收集2015-2021年和田地区肺结核报告发病数据,建立连接点回归模型(JPR)和中断时间序列模型(ITS),分别探索肺结核的发... 目的分析新疆和田地区肺结核发病特征及疫情前后发病趋势,为和田地区肺结核防控措施制定和效果评价提供参考依据。方法收集2015-2021年和田地区肺结核报告发病数据,建立连接点回归模型(JPR)和中断时间序列模型(ITS),分别探索肺结核的发病特征及新疆新冠肺炎疫情防控措施对和田地区肺结核发病趋势的影响,并分析不同性别和年龄亚组发病差异。结果JPR模型结果显示,2015-2021年和田地区肺结核报告发病率总体呈先升后降趋势,转折点出现在2018年12月;男性发病率略高于女性,转折点和发病趋势与总体一致;各年龄亚组≥60岁组发病率最高,发病趋势也呈先上升后下降趋势,≤18岁年龄组发病率在2021年6月出现转折点,但趋势无统计学意义(P>0.05),19~59岁组与≥60岁组转折点与总体一致;ITS模型结果显示,自2020年1月起和田地区肺结核发病率明显下降,从2019年的319.28/10万下降到2021年的155.88/10万,同比下降51.16%,月均下降0.049/10万。结论2018年新疆将结核病筛查工作纳入全民健康体检,大量结核病例被发现,和田地区肺结核的报告发病数在2018年12月达到峰值,随后开始下降,而2020年1月起在新疆新冠疫情隔离措施的影响下,报告发病率呈现明显下降。随着疫情结束应关注可能涌现的潜伏结核患者,做好防疫工作。 展开更多
关键词 肺结核 趋势分析 连接点回归模型 中断时间序列 新型冠状病毒肺炎 疫情防控
下载PDF
宏基因组二代测序在实体器官移植感染防控中的应用
16
作者 满霖 李小杉 +5 位作者 王文静 钱婷 熊敏 杨航 陈静瑜 吴波 《器官移植》 CAS CSCD 北大核心 2024年第2期289-296,共8页
器官移植已成为多种终末期疾病的有效治疗手段,但器官移植受者术后需长期服用免疫抑制药,导致免疫功能低下,使得细菌、病毒和真菌感染的发生率相对较高。以病原学培养、免疫学检测和聚合酶链反应为代表的传统微生物检测方法被广泛用于... 器官移植已成为多种终末期疾病的有效治疗手段,但器官移植受者术后需长期服用免疫抑制药,导致免疫功能低下,使得细菌、病毒和真菌感染的发生率相对较高。以病原学培养、免疫学检测和聚合酶链反应为代表的传统微生物检测方法被广泛用于感染检测,但存在耗时长、需预先假定病原体等问题。宏基因组二代测序由于具有病原体检出率高、对病原谱检测全面的优点,近年来被广泛应用于器官移植领域的感染防控。本文就宏基因组二代测序技术在实体器官移植感染防控上的应用现状进行综述,以期对移植相关感染的诊断和治疗提供参考。 展开更多
关键词 器官移植 宏基因组二代测序 免疫抑制 肺部感染 供者来源性感染 感染防控 病原学检测 聚合酶链反应(PCR)
下载PDF
江苏省2012—2022年结核病防治进展及展望
17
作者 虞浩 竺丽梅 《江苏预防医学》 CAS 2023年第3期302-304,共3页
结核病是严重威胁人类健康的重大公共卫生问题,江苏省自2012年以来全面强化规划指引,不断完善结核病防治服务体系,各级政府加大经费投入,不断完善患者保障政策,优化实验室能力建设,狠抓学校结核病防控工作,全省结核病发病率逐年下降,各... 结核病是严重威胁人类健康的重大公共卫生问题,江苏省自2012年以来全面强化规划指引,不断完善结核病防治服务体系,各级政府加大经费投入,不断完善患者保障政策,优化实验室能力建设,狠抓学校结核病防控工作,全省结核病发病率逐年下降,各项的指标均达到规划的目标要求,多项工作指标居全国前列。本文回顾江苏省2012—2022年结核病防控工作策略措施和取得进展、成绩,总结工作存在的问题和面临的挑战,为实现健康江苏战略目标提供技术支撑。 展开更多
关键词 结核病 预防 控制 防治进展 江苏省
下载PDF
世界卫生组织人类健康中抗微生物药物耐药性的全球优先研究议题
18
作者 刘婷 肖园园(译) 吴安华(校) 《中国感染控制杂志》 CAS CSCD 北大核心 2023年第8期995-998,共4页
人类健康中的抗微生物药物耐药性全球研究议程确定了40个优先研究主题,旨在为2030年前的政策提供依据。抗微生物药物耐药性对人类健康构成了巨大威胁,据估计,2019年约有495万人的死亡与细菌耐药相关。2021年全球新增耐利福平和耐多药结... 人类健康中的抗微生物药物耐药性全球研究议程确定了40个优先研究主题,旨在为2030年前的政策提供依据。抗微生物药物耐药性对人类健康构成了巨大威胁,据估计,2019年约有495万人的死亡与细菌耐药相关。2021年全球新增耐利福平和耐多药结核病约45万例。此外,全球范围内侵袭性真菌感染正在增加,存在抗真菌药物耐药和诊断困难的挑战。 展开更多
关键词 抗微生物药物耐药 感染预防和控制 优先研究议程 耐药结核分枝杆菌 世界卫生组织细菌优先病原体 世界卫生组织真菌优先病原体 抗微生物药物管理
下载PDF
甘肃省高校学生肺结核防治信息知晓及宣传资料需求情况分析
19
作者 马玲 王铂 《卫生职业教育》 2023年第7期129-131,共3页
目的 了解甘肃省3所高校学生肺结核防治重点信息知晓及宣传资料需求情况,为后续开展肺结核防治健康教育工作提供参考。方法 随机抽取甘肃省3所高校845名在校大学生,通过微信平台和问卷星进行问卷调查,采用Excel进行数据收集和整理,使用S... 目的 了解甘肃省3所高校学生肺结核防治重点信息知晓及宣传资料需求情况,为后续开展肺结核防治健康教育工作提供参考。方法 随机抽取甘肃省3所高校845名在校大学生,通过微信平台和问卷星进行问卷调查,采用Excel进行数据收集和整理,使用SPSS 21.0软件进行数据分析。结果 学生肺结核防治重点信息总知晓率为71.70%,3所高校学生肺结核防治重点信息总知晓率比较差异有统计学意义(P<0.01),家庭常居住地为城镇的学生总知晓率显著高于农村学生(均P<0.001)。结论 甘肃省高校学生对肺结核防治重点信息知晓率不高,高校要利用微信等网络平台,借助视频等宣传材料,开展多维度的结核病知识宣传工作。 展开更多
关键词 学生 肺结核 防治信息 宣传资料
下载PDF
品管圈活动对提高老年肺结核患者规范化呼吸康复训练执行率的影响
20
作者 刘玲 刘晓玲 王进 《抗感染药学》 2023年第7期729-732,共4页
目的:探究品管圈活动对提高老年肺结核患者规范化呼吸康复训练执行率的影响,为改善老年肺结核患者的呼吸康复提供参考。方法:成立品管圈小组,选定“提高老年肺结核患者规范化呼吸康复训练执行率”作为活动主题,选取2023年1月—6月在南... 目的:探究品管圈活动对提高老年肺结核患者规范化呼吸康复训练执行率的影响,为改善老年肺结核患者的呼吸康复提供参考。方法:成立品管圈小组,选定“提高老年肺结核患者规范化呼吸康复训练执行率”作为活动主题,选取2023年1月—6月在南京市第二医院结核科住院治疗的60例老年肺结核患者作为研究对象,分析品管圈活动对提高老年肺结核患者呼吸康复训练执行率的效果。结果:通过实施品管圈活动,老年肺结核患者规范化呼吸康复训练的执行率由41.67%提高至78.79%,目标达成率为131.91%,进步率为89.08%;在品管圈的实施过程中,圈员的问题解决能力、责任心、沟通协调能力、自信心、团队凝聚力、积极性、品管手法与和谐度都得到了一定程度的提升。结论:品管圈活动的开展有效提高了医务人员分析问题、解决问题的能力,从而提高了临床的医疗服务水平,进而更好地确保了患者的治疗效果。 展开更多
关键词 品管圈 肺结核 呼吸康复训练 执行率
下载PDF
上一页 1 2 82 下一页 到第
使用帮助 返回顶部