Role of different examination methods in colorectal cancer screening:Insights and future directions

Colorectal cancer is a malignant tumor with the third and second highest incidence and mortality rates worldwide,and its mortality rate is increasing annually.Colorectal cancer evolves gradually over a long period of time.The evolving process from colorectal adenoma to colorectal cancer takes approximately 10-15 years,providing a sufficiently long"window period"for early screening and diagnosis of colorectal cancer.The recurrence and mortality rates can be controlled at a low level with an early intervention.Metaxas et al summarized existing screening methods and their applicable scope in a recent publication.Moreover,they provide suggestions on how to improve adherence.This editorial provides a commentary on their article and discuss the roles of different screening methods in the early screening of colorectal cancer.

The application of ultra-wide-field fundus autofluorescence in early metastatic choroidal tumor screening

I am Dr.Ke Yao,from Eye Center,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,China.I write to present three cases with metastatic choroidal tumor using an ultra-wide-field scanning laser ophthalmoscope.