Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumo...Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth. This study reviewed the biological properties of NK cells, the dynamic phenotypic changes of NK cells in the TME, and the communication between NK cells and other immune and nonimmune cells.展开更多
基金supported by the National Natural Science Foundation of China(No.81872200,and 31900558)the Hubei Provincial Youth Talents Program for Public Health China(No.WSJKRC2022013)+3 种基金Wuhan Young and Middle-aged Medical Backbone Talents Training Project China(No.WHQG201904)the Yellow Crane Talent Program of Wuhan City China(No.HHYC2019002)the Natural Science Foundation of Hubei Province China(No.2020CFB298)the Zhongnan Hospital of Wuhan University Science,Technology and Innovation Seed Fund(No.ZNPY2018090,and ZNPY2019002),China.
文摘Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth. This study reviewed the biological properties of NK cells, the dynamic phenotypic changes of NK cells in the TME, and the communication between NK cells and other immune and nonimmune cells.
