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Malignant extra-gastrointestinal stromal tumor of the pancreas:Report of two cases and review of the literature 被引量:9
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作者 Yan-Tao Tian Hao Liu +6 位作者 Su-Sheng Shi Yi-Bin Xie Quan Xu Jian-Wei Zhang Dong-Bing Zhao Cheng-Feng Wang Ying-Tai Chen 《World Journal of Gastroenterology》 SCIE CAS 2014年第3期863-868,共6页
Gastrointestinal stromal tumors(GISTs)are mesenchymal tumors that arise from the gastrointestinal tract.In rare cases,these tumors are found in intra-abdominal sites unrelated to the gastrointestinal tract,such as the... Gastrointestinal stromal tumors(GISTs)are mesenchymal tumors that arise from the gastrointestinal tract.In rare cases,these tumors are found in intra-abdominal sites unrelated to the gastrointestinal tract,such as the mesentery,omentum and retroperitoneum.However,pancreatic extra-gastrointestinal stromal tumors are extremely rare,with only 14 previous cases reported.A 61-year-old man with no clinical symptoms had a routine check-up,during which an abdominal mass located in the pancreas tail was detected.Abdominal surgery was performed with resection of the pancreas tail and the spleen,and he was diagnosed with lowrisk GISTs.Another 60-year-old man with no clinical symptoms underwent Computed tomography which revealed a well-demarcated tumor,6 cm in diameter,in the head of the pancreas.He was diagnosed with pancreatic GISTs.Here,we describe two rare cases of pancreatic GISTs and review the cases previously reported in the literature. 展开更多
关键词 Gastrointestinal Stromal tumors extra-gastrointestinal Stromal tumors Pancreatic gastrointestinal stromal tumors
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Primary Extra-Gastrointestinal Stromal Tumor (GIST) arising from mesentery of small bowel and presenting as abdominal mass: A rare entity 被引量:1
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作者 Alok Kumar Tiwari Anil Kumar Choudhary +2 位作者 Hemant Khowal Poras Chaudhary Mohinder P. Arora 《Open Journal of Gastroenterology》 2013年第5期267-271,共5页
Introduction: Majority of mesenchymal tumors of gastrointestinal tract are Gastrointestinal Stromal Tumor (GIST). It is, however, a rare tumor, accounting for less than 1% of primary gastrointestinal (GI) neoplasms. T... Introduction: Majority of mesenchymal tumors of gastrointestinal tract are Gastrointestinal Stromal Tumor (GIST). It is, however, a rare tumor, accounting for less than 1% of primary gastrointestinal (GI) neoplasms. Though, these tumors are refractory to conventional chemotherapy or radiotherapy but show a good response to targeted adjuvant chemotherapy with tyrosine kinase inhibitors following surgical resection. Case Report: we report here a case of primary Extra-GIST tumor arising from mesentry of small bowel near duodeno-jejunal junction in a 69 years old male patient. The patient presented with a palpable mass in upper abdomen for past 15 days. On examination, a non-tender mobile lump of size around 17 × 10 cm, with bosselated surface and firm in consistency was palpable involving epigastric, left hypochondrium and umbilical region. Contrast enhanced computed tomography of abdomen revealed a heterogenous mesentric mass. On surgical intervention a mass was found involving mesentery near dudenojejunal junction without involvement of gastrointestinal tract. Complete surgical resection of the tumor was done and adjuvant chemotherapy with Imatinib mesylate was started as HPE revealing GIST with mitotic index of >10/50 HPF and 17 × 10 cm size placed the patient in high risk category. Patient was discharged on 12th of post-operative day with advice of regular follow-up. Conclusion: GIST occurrence is not restricted to bowel but can involve unusual sites also. The mainstay of treatment remains surgical resection with adequate margin. In cases where tumour has malignant potential (high mitotic figures on histopathology) adjuvent treatment with tyrosine kinase may prevent or delay relapse. 展开更多
关键词 extra-Gastrointestinal Stromal tumorS GIST Mesentric tumorS IMATINIB MESYLATE Abdominal Mass
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Extra-gastrointestinal Stromal Tumor :Clinical Characteristics,Diagnosis, Treatment, and Prognosis
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作者 赵善峰 闫丙健 周岩冰 《科教导刊》 2015年第10期147-149 182,182,共4页
Objective:To explore the clinicopathological characteristics,treatment and prognosis of extrogastrointestinal stromal tumor(EGIST).Methods:In our study,Clinicopathological data of EGISTs from January 2010 to October 2... Objective:To explore the clinicopathological characteristics,treatment and prognosis of extrogastrointestinal stromal tumor(EGIST).Methods:In our study,Clinicopathological data of EGISTs from January 2010 to October 2014were systematically investigated.Pathology results were rechecked.Patients also were followed Up.Prognostic factors were evaluated using Cox proportional hazard models and univariate and multivariate with Log-rank test.Results:An amount of EGISTs cases were selected due to inclusion criteria,including 28males and 26Females,with age from 18 To78 years(median,58).Patients were follwed up.12cases were dead.The 1-,3-,5-year survival rates were 91%,75%,66%.Patients undergoing R0 resection had a better 5-year overall survival rate than those undergoing R1 resection(75%vs46%,P<0.05).For patients with high risk of recurrence after surgery,the 5-year overall survival rate was 62%and 40%respectively(P<0.05).Conclusions:Tumor size,mitotic count and tumor rupture affect the prognosis of patients after resection of primary EGISTs independently.Adjuvant imatinib can effectively improve the prognosis of the patients with high risk of recurrence,and the survival rate of patients after surgery.Surgical resection is the main treatment of EGIST,and R0 resection helps to prolong the survival time. 展开更多
关键词 GASTROINTESTINAL STROMAL tumorS extra-gastrointest
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Hepatic gastrointestinal stromal tumor: Systematic review of an exceptional location 被引量:1
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作者 Alba Manuel-Vázquez Raquel Latorre-Fragua +1 位作者 Roberto de la Plaza-Llamas José Manuel Ramia 《World Journal of Meta-Analysis》 2019年第5期224-233,共10页
BACKGROUND A minor subset of primary gastrointestinal stromal tumors(GIST)can also arise outside the gastrointestinal tract,which is known as an extra-GIST(E-GIST).Primary GIST of the liver is an exceptional location.... BACKGROUND A minor subset of primary gastrointestinal stromal tumors(GIST)can also arise outside the gastrointestinal tract,which is known as an extra-GIST(E-GIST).Primary GIST of the liver is an exceptional location.AIM To characterize epidemiological,clinical and pathological features and options of treatments.METHODS We performed a systematic review to search for articles on primary hepatic GIST.RESULTS This review shows that right hepatic lobe was the most frequent location.Regarding pathological and immunohistochemical features,mitotic count was≥5/50 High Power Fields in more than 50%;and CD117 was negative in only 1 patient.More than 70%of patients had a lesion with high risk of malignancy.CONCLUSION The diagnosis of E-GIST must be considered in a liver mass.Rendering an accurate diagnosis is a challenge,as well as the confirmation of their primary or metastatic nature. 展开更多
关键词 GASTROINTESTINAL STROMAL tumors extra-gastrointestinal STROMAL tumor PRIMARY HEPATIC tumor CD117 PRIMARY HEPATIC GASTROINTESTINAL STROMAL tumor PRIMARY GASTROINTESTINAL STROMAL tumor of the liver
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Prevalence, diagnosis, and treatment of primary hepatic gastrointestinal stromal tumors 被引量:11
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作者 Xiao-Hui Qian Ying-Cai Yan +1 位作者 Bing-Qiang Gao Wei-Lin Wang 《World Journal of Gastroenterology》 SCIE CAS 2020年第40期6195-6206,共12页
Gastrointestinal stromal tumors(GIST), which is the most common mesenchymal tumor of the digestive tract, account for 1%-3% of gastrointestinal tumors. Primary stromal tumors outside the gastrointestinal tract are col... Gastrointestinal stromal tumors(GIST), which is the most common mesenchymal tumor of the digestive tract, account for 1%-3% of gastrointestinal tumors. Primary stromal tumors outside the gastrointestinal tract are collectively referred to as extra GISTs, and stromal tumors in different regions often have different prognoses. A primary hepatic GIST is a rare tumor with an unknown origin, which may be related to interstitial Cajal-like cells. Although primary hepatic GIST has certain characteristics on imaging, it lacks specific symptoms and signs;thus, the final diagnosis depends on pathological and genetic evidence. This review summarizes all cases of primary hepatic GIST described in the literature and comprehensively analyzes the detailed clinical data of all patients. In terms of treatment, local resection alone or with adjuvant therapy was the prioritized choice to obtain better disease-free survival and longer survival time. For advanced unresectable cases, imatinib mesylate was applied as the first-line chemotherapy agent. Moreover, transcatheter arterial chemoembolization,/by-nc/4.0/Manuscript source: Unsolicited manuscript radiofrequency ablation, and microwave ablation were shown to improve overall survival for selected patients. Liver transplantation was a final treatment option after resistance to chemotherapy developed. 展开更多
关键词 extra gastrointestinal stromal tumor Treatment Liver transplant Review
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Extra-Axial Anaplastic Pleomorphic Xanthoastrocytoma Mimicking Meningioma: A Case Report with Literature Review
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作者 Kaoutar Stitou Ilias Zahir +5 位作者 Oualid Mohammed Hmamouche Marouane Hammoud Faycal Lakhdar Mohammed Benzagmout Khalid Chakour Mohammed El Faiz Chaoui 《Open Journal of Modern Neurosurgery》 2024年第3期203-211,共9页
Background: A number of meningeal neoplastic lesions may radiologically and clinically simulate meningioma, include hemangiopericytomas, solitary fibrous tumors, schwannomas, hematolymphoid lesions, metastases, and ot... Background: A number of meningeal neoplastic lesions may radiologically and clinically simulate meningioma, include hemangiopericytomas, solitary fibrous tumors, schwannomas, hematolymphoid lesions, metastases, and others very rarely, also may clinically mimic meningiomas. Case Description: We present the case of A 28-year-old male patient, with no notable medical history, who presented with worsening headaches for 3 months, imbalance, and visual deficits, An initial MRI revealed extra-axial lesion involving the right Parieto-occipital, The tumor was hypointense on T1-weighted MR images, hyperintense signals on T2-weightedMR images, and heterogeneously enhanced suggestive of a meningioma, total resection was achieved, and the histopathological analysis confirmed the diagnosis of an angioblastic meningioma. However, 15 months later, the patient presented with the same initial visual complaints. A subsequent MRI showed lesion recurrence, leading to a second surgical intervention. The histopathological analysis confirmed the diagnosis of an anaplastic xanthoastrocytoma. Conclusion: This represents an unusual location for an anaplastic pleomorphic xanthoastrocytoma, which should broaden the differential diagnosis of extra-axial lesions. 展开更多
关键词 Anaplastic Features BRAF extra-axial High Mitotic Rate High Proliferation Index MENINGEAL Pleomorphic Xanthoastrocytoma
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Effect of serum testosterone and percent tumor volume on extra-prostatic extension and biochemical recurrence after laparoscopic radical prostatectomy 被引量:3
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作者 Eu Chang Hwang Seong Hyeon Yu +8 位作者 Yang Hyun Jo Seung I1 Jung Taek Won Kang Dong Deuk Kwon Chan Choi Suk Hee Heo Jun Eul Hwang Sung-Hoon Jung Tae-Young Jung 《Asian Journal of Andrology》 SCIE CAS CSCD 2016年第1期54-59,共6页
Several studies have revealed that the preoperative serum testosterone and percent tumor volume (PTV) predict extra-prostatic extension (EPE) and biochemical recurrence (BCR) after radical prostatectomy. This st... Several studies have revealed that the preoperative serum testosterone and percent tumor volume (PTV) predict extra-prostatic extension (EPE) and biochemical recurrence (BCR) after radical prostatectomy. This study investigated the prognostic significance of serum testosterone and PTV in relation to EPE and BCR after laparoscopic radical prostatectomy (LRP). We reviewed 520 patients who underwent LRP between 2004 and 2012. PTV was determined as the sum of all visually estimated tumor foci in every section. BCR was defined as two consecutive increases in the postoperative prostate-specific antigen (PSA) 〉0.2 ng ml^-1. The threshold for serum total testosterone was 3.0 ng ml^-1, Multivariate logistic regression was used to define the effect of variables on the risk of EPE and BCR. A low serum testosterone (〈3.0 ng ml^-1) was associated with a high serum PSA, Gleason score, positive core percentage of the prostate biopsy, PTV, and all pathological variables. On multivariate analysis, similar to previous studies, the serum PSA, biopsy positive core percentage, Gleason score, and pathological variables predicted EPE and BCR. In addition, low serum testosterone (〈3.0 ng ml^-1, adjusted OR, 8.52; 95% CI, 5.04-14.4, P = 0.001) predicted EPE and PTV (adjusted OR, 1.02; 95% CI, 1.01-1.05, P = 0.046) predicted BCR. In addition to previous predictors of EPE and BCR, low serum testosterone and PTV are valuable predictors of EPE and BCR after LRP. 展开更多
关键词 biochemical recurrence extra-prostatic extension prostate neoplasms prostatectomy TESTOSTERONE tumor burden
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Chordomas and Their Consideration in the Radiographic Differential of Extra-Axial Lesions of the Central Nervous
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作者 Shih-Shan Lang Jayesh P. Thawani +4 位作者 Anousheh Sayah Sriram Venneti Danielle Brewington Eric L. Zager Stephen J. Dante 《Open Journal of Modern Neurosurgery》 2012年第3期58-62,共5页
Due to the rare occurrence of chordomas extra-axially, these lesions have not earned a great deal of consideration in the clinical and radiographic differential diagnoses of extra-axial paraspinal lesions. We describe... Due to the rare occurrence of chordomas extra-axially, these lesions have not earned a great deal of consideration in the clinical and radiographic differential diagnoses of extra-axial paraspinal lesions. We describe a case of a patient with a surgically resected extra-axial chordoma and review the radiologic characteristics of chordomas as an entity in the spectrum of extra-axial lesions. A 47-year-old man presented to our institution with four months of intermittent parethesias, pain, and subjective weakness in the left leg. MR imaging of the lumbar spine demonstrated a large heterogeneously- enhancing paraspinal lesion extending from the left L3-4 neural foramen into the psoas muscle. The patient underwent a CT-guided needle biopsy demonstrating features consistent with a chordoma. He then underwent a left retroperitoneal approach and en bloc resection of the lesion from the vertebral column. Pathology confirmed chordoma as the diagnosis. EACs are a rare but important consideration in the diagnosis of extra-axial lesions of the central nervous system. 展开更多
关键词 CHORDOMA Primitive NOTOCHORD tumor extra-axial tumor Spine
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A Hybrid Mathematical Model of Tumor-Induced Angiogenesis with Blood Perfusion 被引量:1
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作者 Junping Meng Shoubin Dong +1 位作者 Liqun Tang Yi Jiang 《Tsinghua Science and Technology》 SCIE EI CAS 2014年第6期648-657,共10页
Angiogenesis, the growth of new blood vessel from existing ones, is a pivotal stage in cancer development,and is an important target for cancer therapy. We develop a hybrid mathematical model to understand the mechani... Angiogenesis, the growth of new blood vessel from existing ones, is a pivotal stage in cancer development,and is an important target for cancer therapy. We develop a hybrid mathematical model to understand the mechanisms behind tumor-induced angiogenesis. This model describes uptake of Tumor Angiogenic Factor(TAF)at extracellular level, uses partial differential equation to describe the evolution of endothelial cell density including TAF induced proliferation, chemotaxis to TAF, and haptotaxis to extracellular matrix. In addition we also consider the phenomenon of blood perfusion in the micro-vessels. The model produces sprout formation with realistic morphological and dynamical features, including the so-called brush border effect, the dendritic branching and fusing of the capillary sprouts forming a vessel network. The model also demonstrates the effects of individual mechanisms in tumor angiogenesis: Chemotaxis to TAF is the key driving mechanisms for the extension of sprout cell; endothelial proliferation is not absolutely necessary for sprout extension; haptotaxis to Extra Cellular Matrix(ECM) gradient provides additional guidance to sprout extension, suggesting potential targets for anti-angiogenic therapies. 展开更多
关键词 tumor angiogenesis extra Cellular Matrix(ECM) capillary network partial differential equation
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软组织内腱鞘巨细胞瘤的诊治:附33例病例分析 被引量:1
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作者 刘起昆 于小钧 +1 位作者 鲍远 康皓 《华中科技大学学报(医学版)》 CAS CSCD 北大核心 2024年第2期239-245,共7页
目的探讨罕见部位关节外型腱鞘滑膜巨细胞瘤(tenosynovial giant cell tumor,TSGCT)的临床特征、影像学表现及预后,以提高对该病的认识。方法检索文献中报道的病例,结合本院收治的2例患者资料进行回顾性分析。结果33例患者纳入本次研究... 目的探讨罕见部位关节外型腱鞘滑膜巨细胞瘤(tenosynovial giant cell tumor,TSGCT)的临床特征、影像学表现及预后,以提高对该病的认识。方法检索文献中报道的病例,结合本院收治的2例患者资料进行回顾性分析。结果33例患者纳入本次研究,其中男性17例,女性16例,平均年龄39.8岁,肿瘤最大直径平均值为7.2 cm。发病部位多为大腿、臀部及头颈部。主要的临床表现为单纯包块(39.4%)和疼痛伴肿胀(12.1%)。CT检查表现为等密度或稍低密度的软组织肿块,病灶内无钙化或骨化。MRI主要表现为T1WI低信号或等-低信号,T2WI大部分(95.2%)为混杂信号,增强多为不均匀强化。17例获得随访的患者术后发生复发或转移的风险为17.6%。结论完全关节外型TSGCT非常罕见。对于来源于下肢及头颈部、MRI表现为混杂信号、CT显示关节外来源的软组织肿块需要考虑到该病,手术能有效控制其进展。 展开更多
关键词 腱鞘滑膜巨细胞瘤 关节外病变 临床病理特征 诊断
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鼻窦冠状位与轴位CT平扫对鼻腔鼻窦恶性肿瘤诊断价值分析
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作者 李文航 王超 伍瑶斌 《中外医学研究》 2024年第30期69-72,共4页
目的:分析和对比鼻窦冠状位与轴位CT平扫对鼻腔鼻窦恶性肿瘤诊断价值。方法:选取2023年1—12月贵州省人民医院收治的50例鼻腔鼻窦恶性肿瘤患者作为研究对象,患者分别行鼻窦冠状位与轴位CT平扫检查诊断。以病理检查结果作为金标准,比较... 目的:分析和对比鼻窦冠状位与轴位CT平扫对鼻腔鼻窦恶性肿瘤诊断价值。方法:选取2023年1—12月贵州省人民医院收治的50例鼻腔鼻窦恶性肿瘤患者作为研究对象,患者分别行鼻窦冠状位与轴位CT平扫检查诊断。以病理检查结果作为金标准,比较鼻窦冠状位与轴位CT平扫对鼻腔鼻窦恶性肿瘤类型、肿瘤分期的诊断准确率。结果:病理检查出上皮性肿瘤32例、间叶性肿瘤11例、神经内分泌肿瘤7例,鼻窦冠状位平扫检查出上皮性肿瘤32例、间叶性肿瘤10例、神经内分泌肿瘤6例,轴位CT平扫检查出上皮性肿瘤26例、间叶性肿瘤11例、神经内分泌肿瘤7例。鼻窦冠状位CT平扫对鼻腔鼻窦恶性肿瘤类型的诊断准确率高于轴位CT平扫,差异有统计学意义(P<0.05)。鼻窦冠状位CT平扫对鼻腔鼻窦恶性肿瘤T1期、T2期、T3期、T4a期、T4b期等分期的诊断准确率高于轴位CT平扫,差异有统计学意义(P<0.05)。结论:与鼻窦轴位CT平扫比较,鼻窦冠状位CT平扫在鼻腔鼻窦恶性肿瘤诊断中具有较高的价值,能更好地显示肿瘤的位置、大小、侵犯范围及骨质破坏情况。 展开更多
关键词 鼻窦冠状位 轴位CT平扫 鼻腔鼻窦恶性肿瘤 诊断 价值
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四肢软组织肿瘤合成磁共振图像与常规磁共振图像质量对比的初步研究
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作者 邵楠楠 林松 +3 位作者 王立峰 孟帆 袁军辉 许春苗 《中国CT和MRI杂志》 2024年第3期174-176,共3页
目的 探讨四肢软组织肿瘤合成磁共振图像与常规磁共振图像质量比较。方法 回顾性分析2021年12月至2023年1月于河南省肿瘤医院行同时行合成磁共振及常规磁共振扫描的四肢软组织肿瘤患者40例。Kappa分析两名医师主观评分一致性;比较合成... 目的 探讨四肢软组织肿瘤合成磁共振图像与常规磁共振图像质量比较。方法 回顾性分析2021年12月至2023年1月于河南省肿瘤医院行同时行合成磁共振及常规磁共振扫描的四肢软组织肿瘤患者40例。Kappa分析两名医师主观评分一致性;比较合成磁共振与常规序列图像清晰度、图像伪影评分和肿瘤最长径差异。结果 两名医师对图像清晰度、图像伪影评分和肿瘤轴位最大径测量均一致性良好(Kappa值均>0.600)。Syn T1WI、con-T1WI序列图像清晰度比较,Syn T2WI、con-T2WI I序列图像清晰度比较,差异均无统计学意义(P=1.000,0.083),Syn T2STIR与con-dixon-water-T2WI序列图像清晰度比较,差异有统计学意义(P=0.025)。Syn T1WI、con-T1WI序列图像伪影评分比较,Syn T2WI、con-T2WI图像伪影评分比较,差异均无统计学意义(P=0.070、0.056),Syn T2STIR,con-dixon-water-T2WI图像伪影评分比较,差异有统计学意义(P=0.023)。合成磁共振成像测得肿瘤长径均值(63.21±37.90)mm,常规序列测得肿瘤长径均值(63.13±36.92)mm,二者图像所测得肿瘤长径差异无统计学意义(t=0.009,P=0.992)。结论 合成磁共振成像对四肢软组织肿瘤显示清晰,大小测量与常规序列一致,Syn T1WI、Syn T2WI具有较好的图像质量,Syn T2STIR图像清晰度略差于常规压脂序列,伪影较常规序列明显,有待改善。 展开更多
关键词 合成磁共振成像 图像清晰度 图像伪影 肿瘤轴位最大径
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腹盆腔原发性室管膜瘤1例并文献复习 被引量:5
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作者 罗荣奎 柳菊 +5 位作者 侯英勇 陆维祺 周宇红 宿杰.阿克苏 曾海英 谭云山 《临床与实验病理学杂志》 CAS CSCD 北大核心 2013年第9期996-1001,共6页
目的探讨颅脊髓外室管膜瘤临床病理特点、诊断和鉴别诊断。方法总结1例多次复发切除的腹盆腔原发性室管膜瘤临床病理特点,对患者3次手术切除标本进行形态学观察、免疫组化检测并文献复习。结果国内外文献报道颅脊髓外室管膜瘤(除去骶... 目的探讨颅脊髓外室管膜瘤临床病理特点、诊断和鉴别诊断。方法总结1例多次复发切除的腹盆腔原发性室管膜瘤临床病理特点,对患者3次手术切除标本进行形态学观察、免疫组化检测并文献复习。结果国内外文献报道颅脊髓外室管膜瘤(除去骶尾部)共44例,发生部位包括卵巢24例、子宫韧带6例、纵膈9例、肝1例、肺1例、小肠1例、网膜1例、子宫直肠间隙1例。其中国内报道的5例均发生于卵巢,而该例为腹腔及盆腔多发病灶,未累及卵巢,国内外尚未见报道。44例患者均为女性,中位年龄36岁(13~71岁),多数经历多次手术切除,瘤细胞常同时表达GFAP、ER、PR。该例患者初次发病年龄36岁,截止目前已经历3次手术,每次肿瘤形态不完全一致,血管周无细胞区以及乳头状结构在第三次手术切片中表现相对充分。3次手术肿瘤组织均表达GFAP、ER、PR。结论颅脊髓外室管膜瘤属低度恶性肿瘤,可多次切除,免疫表型具有一定的特征性。 展开更多
关键词 室管膜瘤 颅脊髓外 GFAP ER PR
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跨中、后颅窝轴外肿瘤及肿瘤样病变的影像学诊断 被引量:1
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作者 康立清 张云亭 +2 位作者 余桂荣 岳建坤 宋兆伟 《放射学实践》 2003年第12期875-877,共3页
目的 :提高对跨中、后颅窝轴外肿瘤及肿瘤样病变的影像学认识。方法 :60例经病理证实的跨中、后颅窝轴外肿瘤及肿瘤样病变按位置分为中央型和外侧型 ,后者又分中颅窝型、后颅窝型及骑跨型 ,分析各型构成情况及影像学特征。结果 :中央型... 目的 :提高对跨中、后颅窝轴外肿瘤及肿瘤样病变的影像学认识。方法 :60例经病理证实的跨中、后颅窝轴外肿瘤及肿瘤样病变按位置分为中央型和外侧型 ,后者又分中颅窝型、后颅窝型及骑跨型 ,分析各型构成情况及影像学特征。结果 :中央型 12例 ,脊索瘤 5例 ,垂体瘤 3例 ,鼻咽癌 2例 ,颅咽管瘤、脑膜瘤各 1例。外侧型 48例 ,三叉神经肿瘤 14例 ,脑膜瘤 12例 ,表皮样囊肿 11例 ,硬膜型海绵状血管瘤 4例 ,皮样囊肿、转移瘤各 2例 ,血管外皮瘤、颈静脉球瘤、鼻咽癌各 1例。多数病变可根据影像学特点做出诊断并明确范围。结论 :按位置特征对跨中、后颅窝轴外肿瘤及肿瘤样病变分型 ,有助于定性诊断及范围描述 。 展开更多
关键词 颅窝 肿瘤样病变 影像学诊断 轴外肿瘤
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盆腔器官外软组织肿瘤的CT诊断 被引量:19
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作者 张善华 吕桃珍 +2 位作者 王培军 李晓兵 钱大椿 《临床放射学杂志》 CSCD 北大核心 2001年第10期781-784,共4页
目的 探讨盆腔器官外软组织肿瘤的 CT表现及其诊断价值。材料与方法 回顾性分析经手术病理证实的 30例原发性盆腔器官外软组织良、恶性肿瘤的 CT表现。其中间叶源性肿瘤 15例 ,神经源性肿瘤 8例 ,胚胎残余组织源性肿瘤 5例 ,腹膜间皮... 目的 探讨盆腔器官外软组织肿瘤的 CT表现及其诊断价值。材料与方法 回顾性分析经手术病理证实的 30例原发性盆腔器官外软组织良、恶性肿瘤的 CT表现。其中间叶源性肿瘤 15例 ,神经源性肿瘤 8例 ,胚胎残余组织源性肿瘤 5例 ,腹膜间皮细胞肿瘤 2例。结果 原发于盆腔器官外软组织肿瘤较少见 ,CT表现为囊性肿块者均为良性 ,囊实性或实性者以恶性居多。虽然肿瘤来源于多种不同组织 ,但 CT表现可各有其特征。结论  CT是诊断盆腔器官外肿瘤的重要影像学手段 。 展开更多
关键词 盆腔器官外软组织肿瘤 CT 诊断 器官外肿瘤
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胃肠道外间质瘤的影像诊断新进展 被引量:29
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作者 贺敬红 李健丁 张瑞平 《世界华人消化杂志》 CAS 北大核心 2010年第1期54-57,共4页
自1983年Mazur和Clark提出胃肠道间质瘤的概念以来,目前已成为病理学和临床研究的热点.发生于胃肠道外的间质瘤(extra-gastrointestinal stromal tumors,EGIST)比较少见,其影像学表现在诊断中起着重要的作用.本文就EGIST的影像诊断现状... 自1983年Mazur和Clark提出胃肠道间质瘤的概念以来,目前已成为病理学和临床研究的热点.发生于胃肠道外的间质瘤(extra-gastrointestinal stromal tumors,EGIST)比较少见,其影像学表现在诊断中起着重要的作用.本文就EGIST的影像诊断现状作一综述. 展开更多
关键词 胃肠道外间质瘤 影像诊断 作用
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腹腔软组织平滑肌肿瘤临床病理分析 被引量:5
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作者 侯英勇 谭云山 +7 位作者 许建芳 王岫南 宿杰.阿克苏 周燕南 曾海英 高峰 郑爱华 朱雄增 《临床与实验病理学杂志》 CAS CSCD 北大核心 2006年第4期397-401,共5页
目的 探讨腹腔软组织平滑肌肿瘤临床病理、免疫组化、超微结构特点及鉴别诊断。方法 用desmin、α-SMA、MSA以及CD117、CD34为主的一组抗体对腹腔软组织原诊断为平滑肌瘤、平滑肌母细胞瘤及平滑肌肉瘤等病例进行研究,获得34例腹腔、系... 目的 探讨腹腔软组织平滑肌肿瘤临床病理、免疫组化、超微结构特点及鉴别诊断。方法 用desmin、α-SMA、MSA以及CD117、CD34为主的一组抗体对腹腔软组织原诊断为平滑肌瘤、平滑肌母细胞瘤及平滑肌肉瘤等病例进行研究,获得34例腹腔、系膜及腹膜后平滑肌肿瘤,其中2例行超微结构观察。结果男性8例,女性26例,年龄26~77岁,平均47.6岁,中位年龄48岁,其中腹膜后28例,肠系膜4例,腹腔2例,肿瘤直径5~18cm,平均9.86cm。梭形细胞型32例,其中1例伴有反应性破骨样巨细胞,1例有高度恶性软组织肉瘤区域(即去分化平滑肌肉瘤),上皮型和混合型各1例。此组抗体表达分别为desmin(21/22)、α-SMA(21/21)、MSA(21/21)、CD117(1/21)、CD34(1/21)、S-100蛋白(3/21)、PGP9.5(2/21)。超微结构可见基板、质膜下连续的微饮泡、胞质内丰富的密体和密斑,而细胞器较少。其中4例检测c-kit基因11号外显子序列,均为野生型。平滑肌瘤4例,其中2例分别健在5年和10年;交界性1例;平滑肌肉瘤29例,获访13例,11例(85.0%)在3年内复发、转移或死亡,1例5年后死亡,仅1例无瘤生存10年。结论腹腔软组织平滑肌肿瘤主要发生于腹膜后,女性多见,以恶性居多,肿瘤性坏死、核分裂象≥4/50 HPF及细胞明显异型性对判断恶性有重要参考价值。需与相同部位的胃肠道外间质瘤、恶性神经鞘膜瘤等鉴别。 展开更多
关键词 平滑肌肉瘤 腹膜后肿瘤 胃肠道外间质瘤 DESMIN CD117 诊断 鉴别
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CT与MRI诊断胃肠道外间质瘤的临床分析 被引量:14
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作者 彭志远 阳明 +1 位作者 施崇敏 杨敏 《医学影像学杂志》 2012年第9期1496-1499,共4页
目的分析胃肠道外间质瘤(EGIST)的影像表现,以提高对该病的影像诊断水平。方法回顾性分析经手术、病理证实的10例胃肠道外间质瘤的影像学资料。结果 10例中,高度侵袭危险性7例,中度侵袭危险性1例,低度侵袭危险性2例。肿瘤位于小肠系膜3... 目的分析胃肠道外间质瘤(EGIST)的影像表现,以提高对该病的影像诊断水平。方法回顾性分析经手术、病理证实的10例胃肠道外间质瘤的影像学资料。结果 10例中,高度侵袭危险性7例,中度侵袭危险性1例,低度侵袭危险性2例。肿瘤位于小肠系膜3例,回盲部肠系膜2例,大网膜1例,腹膜后1例,骶前间隙1例,直肠前间隙1例,多发1例,10例中共计12个肿块。肿瘤最大径3.8~25cm,平均11.3cm。肿块呈分叶状5个、不规则形4个、类圆形3个。CT平扫9个病灶密度不均匀,1个密度较均匀;MRI平扫2个信号不均匀;囊变和坏死发生率80%。CT或MRI增强11个肿块明显不均匀强化,1个中度较均匀强化。结论胃肠道外间质瘤的影像学表现有相对的特征性,通过病变的影像特点和结合临床资料综合分析,可提高其诊断准确性,能够为临床提供重要的诊断依据。 展开更多
关键词 胃肠道外间质瘤 体层摄影术 X线计算机 磁共振成像
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中轴区原发外周型原始神经外胚层肿瘤CT和MRI表现 被引量:3
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作者 江凯 王鹏 +6 位作者 王蓼 于志海 徐裕 王良炯 涂灿 邓生德 汪建华 《中国骨伤》 CAS 2016年第3期252-257,共6页
目的 :探讨中轴区原发外周型原始神经外胚层肿瘤(p PNETs)的CT和MRI表现,以提高对中轴区原发p PNETs的影像学认识。方法 :回顾性分析2008年10月至2014年5月期间经病理证实的10例中轴区原发p PNETs患者临床资料,其中男7例,女3例;年龄... 目的 :探讨中轴区原发外周型原始神经外胚层肿瘤(p PNETs)的CT和MRI表现,以提高对中轴区原发p PNETs的影像学认识。方法 :回顾性分析2008年10月至2014年5月期间经病理证实的10例中轴区原发p PNETs患者临床资料,其中男7例,女3例;年龄8~49岁,中位年龄23.6岁。术前经多排螺旋CT平扫3例,平扫并增强4例;5例经MRI平扫并增强扫描;其中2例同时行CT及MRI检查。结果 :骨内型6例,骨外型4例。发病部位及例数分别为骶椎3例,腰椎2例,颈椎1例,颈椎椎管1例,尾骨1例,右髂骨1例,骶前间隙1例。横断位最小肿瘤最大层面大小1.1 cm×1.2 cm,最大者8.0 cm×9.2 cm,中位大小4.4 cm×5.7 cm,其中6例最大径线&gt;5 cm。其中溶骨性破坏5例,2例伴钙化,混合性1例,2例无骨质破坏。CT以等密度为主,1例密度均匀,余6例密度不均,其中3例可见"浮冰"样改变,增强扫描1例中度强化,余3例明显强化,2例内见多发小血管。MRI在T1WI上5例均为等信号,在T2WI上均为稍高信号,信号不均,增强后5例均强化明显。2例伴椎体压缩性骨折,10例均未见骨膜反应,5例MRI检查无椎间盘破坏。结论:中轴区原发p PNETs以儿童及青年多见,肿块常较大。骨内型肿块常包绕椎体,并以椎前间隙为主,均伴椎体骨质破坏,溶骨性常见,椎体原发多见,附件原发或受累少见,可累及椎管,以前壁受累常见,可伴多发新生小血管;骨外型以深部软组织间隙常见,少数原发于椎管,多伴椎体骨质破坏,以溶骨性为主。不侵及椎间盘,椎间隙不窄。CT可伴"浮冰"征,以骨内型常见。MRI T1WI以等信号为主,T2WI以稍长信号为主,增强强化明显。 展开更多
关键词 外周型原始神经外胚层肿瘤 中轴区 CT MRI
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交界性肿瘤——腹壁外带状瘤的处理(附54例分析) 被引量:1
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作者 蔡三军 李澍 +1 位作者 李月云 傅红 《肿瘤》 CAS CSCD 北大核心 1993年第4期168-170,共3页
本文回顾性地分析了自1956至1986年间治疗的54例腹壁外带状瘤,探讨了该肿瘤的病因及治疗方式。由于该肿瘤极易复发,强调了三维广泛切除的重要性。对于手术切缘较近及切缘肿瘤组织阳性的病例,术后放射治行是一选择。对于肿瘤巨大、要行... 本文回顾性地分析了自1956至1986年间治疗的54例腹壁外带状瘤,探讨了该肿瘤的病因及治疗方式。由于该肿瘤极易复发,强调了三维广泛切除的重要性。对于手术切缘较近及切缘肿瘤组织阳性的病例,术后放射治行是一选择。对于肿瘤巨大、要行截肢术或行损伤较大手术才能解决肿瘤问题但本人无严重临床症状及功能障碍者,可带瘤生存,但需随访。 展开更多
关键词 腹壁外带状瘤 肿瘤 外科手术
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