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辽东兰花岭地区古元古代Ⅰ型花岗岩类与辽吉A型花岗岩对比研究
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作者 顾玉超 鞠楠 +3 位作者 陈仁义 杨凤超 胥嘉 杨宏智 《地质通报》 CAS CSCD 北大核心 2024年第2期317-339,共23页
辽东半岛是华北克拉通胶-辽-吉古元古代活动带的重要组成部分,古元古代经历了复杂的构造演化过程,并记录了多期岩浆-变质作用,约2.2 Ga的辽吉A型花岗岩和1.89~1.85 Ga的巨斑状花岗岩、正长岩分别标志着辽东古元古代造山作用的开端和结... 辽东半岛是华北克拉通胶-辽-吉古元古代活动带的重要组成部分,古元古代经历了复杂的构造演化过程,并记录了多期岩浆-变质作用,约2.2 Ga的辽吉A型花岗岩和1.89~1.85 Ga的巨斑状花岗岩、正长岩分别标志着辽东古元古代造山作用的开端和结束。最新研究显示,2.20~2.15 Ga的岩浆作用形成了2种不同类型的花岗岩,它们可能具有不同的岩石成因和构造意义。在青城子铅锌矿集区北部采集的兰花岭、白砬子花岗闪长岩和黄泊辉绿岩,锆石U-Pb年龄分别为2177±19 Ma、2129±36 Ma、1876±29 Ma。花岗闪长岩的岩石成因类型、地球化学特征与典型的约2.2 Ga的辽吉A型花岗岩明显不同,属于弱过铝质、低钾钙碱性—碱性岩石,Zr、Hf、Nb、Rb含量较低,K_(2)O/Na_(2)O值、稀土元素总量极低,为典型的Ⅰ型花岗岩类。根据锆石Lu-Hf同位素分析,ε_(Hf)(t)值为-5.1~9.0,二阶段Hf模式年龄t_(DM2)为2089~2817 Ma,岩浆源区为约2.5 Ga的太古宙地壳物质和少量软流圈地幔物质。兰花岭地区花岗闪长岩具备岛弧或活动大陆边缘的地球化学亲缘属性,可能形成于弧岩浆俯冲挤压环境;结合形成于伸展环境的A型条痕状花岗岩特征,认为约2.2 Ga辽东地区古元古代活动带呈现总体伸展、局部挤压的构造环境,为洋壳板块向龙岗地块俯冲碰撞过程中或碰撞后的弧后盆地。 展开更多
关键词 弧岩浆作用 型花岗岩类 古元古代 锆石U-PB测年 LU-HF同位素 地质调查工程 辽东半岛
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扬子地块西缘峨山新元古代高分异Ⅰ型花岗岩地球化学特征及岩石成因
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作者 李光洁 陈永清 +1 位作者 尚志 刘世博 《地学前缘》 EI CAS CSCD 北大核心 2024年第3期20-39,共20页
峨山高分异Ⅰ型花岗岩位于扬子地块西缘,是扬子地块新元古代岩浆岩带的重要组成部分,对其源区、成因及其构造背景进行系统研究能够揭示新元古代地壳演化历史。本文对峨山高分异Ⅰ型花岗岩开展了LA-MC-ICP-MS锆石U-Pb定年及岩石地球化学... 峨山高分异Ⅰ型花岗岩位于扬子地块西缘,是扬子地块新元古代岩浆岩带的重要组成部分,对其源区、成因及其构造背景进行系统研究能够揭示新元古代地壳演化历史。本文对峨山高分异Ⅰ型花岗岩开展了LA-MC-ICP-MS锆石U-Pb定年及岩石地球化学研究。研究结果表明,峨山花岗岩主要由肉红色中粗粒花岗岩和灰白色中粗粒花岗岩组成,它们的形成年龄分别为(746±34)Ma(MSWD=4.2)和(732±30)Ma(MSWD=3.3)。全岩地球化学显示峨山花岗岩具有高SiO_(2)(70.32%~78.41%)、Na_(2)O(3.09%~3.94%)、K_(2)O(5.13%~7.35%)含量,低CaO(0.52%~0.90%)、TiO 2(0.001%~0.025%)、P_(2)O_(5)(0.061%~0.097%)含量,富集K、Rb、Th等元素,亏损Nb、P、Ti等元素的特征,与高分异Ⅰ型花岗岩特征一致。全岩Sr-Nd同位素结果显示,ε_(Nd)(t)=-10.8~-7.5,两阶段Nd模式年龄(T DM2)为2.3~2.0 Ga。结合区域地质研究,本次研究认为峨山高分异Ⅰ型花岗岩是在伸展的构造背景下,地幔或年轻下地壳熔融形成的岩浆底侵由中高钾玄武质岩和黑云母片麻岩组成的古元古代上地壳,经部分熔融产生母岩浆,后经高程度的分离结晶作用而形成的。 展开更多
关键词 高分异型花岗岩 构造背景 新元古代 扬子西缘
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8-isoPGF2α、Metrnl、LC3B-Ⅱ/LC3B-Ⅰ与T2MD患者血糖在目标范围内时间的相关性及预测糖尿病周围神经病变的价值
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作者 徐云 陈雪辉 +3 位作者 白立炜 耿锐娜 孟祥雨 覃艳 《海南医学》 CAS 2024年第10期1390-1395,共6页
目的探讨8-异前列腺素F2α(8-isoPGF2α)、镍纹样蛋白(Metrnl)、微管相关蛋白3B-Ⅱ(LC3B-Ⅱ)/微管相关蛋白-Ⅰ(LC3B-Ⅰ)与2型糖尿病(T2MD)患者血糖在目标范围内时间(TIR)的相关性及对糖尿病周围神经病变(DPN)预测价值。方法选取2020年5... 目的探讨8-异前列腺素F2α(8-isoPGF2α)、镍纹样蛋白(Metrnl)、微管相关蛋白3B-Ⅱ(LC3B-Ⅱ)/微管相关蛋白-Ⅰ(LC3B-Ⅰ)与2型糖尿病(T2MD)患者血糖在目标范围内时间(TIR)的相关性及对糖尿病周围神经病变(DPN)预测价值。方法选取2020年5月至2022年10月新乡医学院第一附属医院收治的187例T2DM患者进行前瞻性研究,根据是否合并DPN分为DPN组(n=48)和无DPN组(n=139)。比较两组患者及根据TIR四分位数分组的患者8-isoPGF2α、Metrnl、LC3B-Ⅱ/LC3B-Ⅰ水平,采用Pearson相关性分析8-isoPGF2α、Metrnl、LC3B-Ⅱ/LC3B-Ⅰ与TIR相关性,采用多因素Logistic回归分析DPN的相关影响因素;绘制受试者工作特征曲线(ROC)评价8-isoPGF2α、Metrnl、LC3B-Ⅱ预测DPN的价值。结果DPN组患者的TIR为(51.43±7.68)%,明显低于无DPN组的(56.94±8.12)%,差异有统计学意义(P<0.05);DPN组患者的8-isoPGF2α、Metrnl分别为(162.78±51.33)pg/mL、(259.18±74.42)pg/mL,明显高于无DPN组的(129.56±43.00)pg/mL、(208.37±65.61)pg/mL,LC3B-Ⅱ/LC3B-Ⅰ为0.89±0.27,明显低于无DPN组的1.15±0.31,差异均有统计学意义(P<0.05);根据TIR第25、50、75百分位数将全部患者分为Q1~Q4四组,8-isoPGF2α、Metrnl在Q4组最低,LC3B-Ⅱ/LC3B-Ⅰ在Q4组最高;8-isoPGF2α、Metrnl随着TIR降低逐渐升高,LC3B-Ⅱ/LC3B-Ⅰ随着TIR降低而降低,四组间比较差异均有统计学意义(P<0.05);Pearson相关性分析结果显示,8-isoPGF2α、Metrnl与TIR呈显著负相关(r=-0.786、-0.665,P<0.01),LC3B-Ⅱ/LC3B-Ⅰ与TIR呈显著正相关(r=0.711,P<0.01);多因素Logistic回归分析结果显示,TIR、LC3B-Ⅱ/LC3B-Ⅰ是DPN的独立相关保护因素(P<0.05),8-isoPGF2α、Metrnl是DPN的独立相关危险因素(P<0.05);ROC分析结果显示,单一指标中,Metrnl预测DPN的AUC最大(0.830),特异度最高(87.05%),8-isoPGF2α+Metrnl+LC3B-Ⅱ预测DPN的AUC为0.923(95%CI:0.875~0.957),大于Metrnl,预测敏感度为87.50%,特异度为85.61%(P<0.05)。结论8-isoPGF2α、Metrnl、LC3B-Ⅱ/LC3B-Ⅰ与T2MD患者TIR有关,均是患者并发DPN的预警因素。联合检测三者能为临床分层管理和早期识别DPN高风险人群提供参考。 展开更多
关键词 8-异前列腺素F2Α 镍纹样蛋白 微管相关蛋白3B-Ⅱ/微管相关蛋白- 2型糖尿病 血糖在目标范围内时间 糖尿病周围神经病变 相关性 预测价值
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基于子午流注理论指导刮痧治疗阴虚阳亢型Ⅰ级原发性高血压的疗效及对血清HCY、CRP的影响
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作者 方熙声 王凤德 《广东医学》 CAS 2024年第8期1022-1027,共6页
目的探究基于子午流注理论指导刮痧治疗阴虚阳亢型Ⅰ级原发性高血压的疗效及对血清同型半胱氨酸(HCY)、C反应蛋白(CRP)的影响。方法选取2019年12月1日至2021年12月31日期间就诊的阴虚阳亢型Ⅰ级原发性高血压患者58例作为研究对象。以数... 目的探究基于子午流注理论指导刮痧治疗阴虚阳亢型Ⅰ级原发性高血压的疗效及对血清同型半胱氨酸(HCY)、C反应蛋白(CRP)的影响。方法选取2019年12月1日至2021年12月31日期间就诊的阴虚阳亢型Ⅰ级原发性高血压患者58例作为研究对象。以数字随机表法分成研究组与对照组,每组患者29例,对照组以常规生活方式进行干预,研究组在对照组的常规生活方式干预的基础上加用基于子午流注理论指导刮痧的方式治疗,两组患者连续治疗3个月后,比较两组患者的治疗效果及对血清HCY、CRP的影响。结果治疗后,研究组患者在眩晕、失眠、耳鸣、五心烦热、腰膝酸软症状相较于治疗前均得到明显改善(P<0.05);与对照组比较,研究组患者治疗后的中医症状明显得到改善(P<0.05)。治疗后,两组患者的舒张压与收缩压均有所降低,且研究组患者的舒张压与收缩压明显低于对照组;与治疗前比较,研究组患者的舒张压与收缩压明显低于治疗前(P<0.05)。治疗后,两组患者的血清CRP、HCY水平均降低,且相较于对照组,研究组患者的血清CRP、HCY水平降低的程度更明显(P<0.05)。治疗后,两组患者的杜氏高血压生活质量量表中各维度的评分均升高,且研究组患者的杜氏高血压生活质量量表中各维度评分升高的更明显(P<0.05);与治疗前比较,治疗后两组患者的杜氏高血压生活质量量表中各维度的评分均明显提升(P<0.05)。结论基于子午流注理论的指导刮痧治疗阴虚阳亢型Ⅰ级EH患者能降低其血压水平及CRP、HCY指标水平,缓解其中医症状,并能提高其生活质量,起到标本兼治的作用,安全性高,值得在临床上推广。 展开更多
关键词 子午流注理论 刮痧 阴虚阳亢型 级原发性高血压
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松潘-甘孜地体青海吾和玛高分异Ⅰ型花岗岩的识别与岩石成因
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作者 陈敏 王雁鹤 +1 位作者 谷强 马庆 《地质通报》 CAS CSCD 北大核心 2024年第5期789-801,共13页
为探讨松潘-甘孜地体内青海吾和玛花岗质岩石的成因类型与岩石成因,对其开展了岩相学、地球化学、锆石U-Pb年代学和Lu-Hf同位素等研究。吾和玛花岗质岩石被确定为高分异的Ⅰ型花岗岩,其结晶年龄为216.6±4.3 Ma,为正长花岗岩,具有... 为探讨松潘-甘孜地体内青海吾和玛花岗质岩石的成因类型与岩石成因,对其开展了岩相学、地球化学、锆石U-Pb年代学和Lu-Hf同位素等研究。吾和玛花岗质岩石被确定为高分异的Ⅰ型花岗岩,其结晶年龄为216.6±4.3 Ma,为正长花岗岩,具有弱过铝质高钾钙碱性特征。岩石轻、重稀土元素分馏不明显((La/Yb)_(N)<7),轻稀土元素轻微富集,重稀土元素分布平缓,具有明显的负Eu异常(δEu=0.08~0.43),明显亏损Ba、Sr和高场强元素Nb、Ta、P、Ti,富集大离子亲石元素Rb、Th、U、K,ε_(Hf)(t)值为-2.54~1.32。吾和玛花岗质岩石的母岩浆是岩石圈拆沉作用引起软流圈上涌,诱发中元古代地壳物质(类似于变杂砂岩的物质)部分熔融形成长英质母岩浆,后期又受到斜长石、钾长石、磷灰石等矿物分离结晶作用的控制,经历了高程度的分异形成的。 展开更多
关键词 高分异型花岗岩 锆石U-PB LU-HF同位素 松潘-甘孜地体 地质调查工程 青海
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精细化气道管理对HFNC治疗EICU急性低氧性Ⅰ型呼吸衰竭患者的影响
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作者 李小喜 蒿景龙 +1 位作者 罗威 苏四霞 《临床研究》 2024年第7期177-180,共4页
目的探究精细化气道管理对经鼻高流量湿化氧疗(HFNC)治疗急诊科监护室(EICU)急性低氧性Ⅰ型呼吸衰竭患者氧合、血气的影响。方法选择2022年1月至2022年12月期间在周口市中心医院收治的112例急性低氧性Ⅰ型呼吸衰竭患者作为研究对象,参... 目的探究精细化气道管理对经鼻高流量湿化氧疗(HFNC)治疗急诊科监护室(EICU)急性低氧性Ⅰ型呼吸衰竭患者氧合、血气的影响。方法选择2022年1月至2022年12月期间在周口市中心医院收治的112例急性低氧性Ⅰ型呼吸衰竭患者作为研究对象,参照随机数表法将其分为对照组和观察组,各56例,对照组采用HFNC方式,观察组在对照组的基础上联合精细化管道护理进行干预。比较干预前及干预后(干预3 d后)两组患者的氧合指数及心率(HR)、呼吸频率(RR)、血气指标[二氧化碳分压(PaCO_(2))、动脉氧分压(PaO_(2))、血氧饱和度(SaO_(2))、pH值]、舒适程度[舒适状况评估量表(GCQ)]变化;探究两组患者干预期间不良反应发生差异。结果干预后,两组患者氧合指数有所提升,HR、RR有所下降,且观察组氧合指数高于对照组,HR及RR指标低于对照组,差异有统计学意义(P<0.05)。干预后,两组患者PaO_(2)、SaO_(2)、pH指标均有所提高,PaCO_(2)指标有所下降,且观察组的PaO_(2)、SaO_(2)、pH指标高于对照组,PaCO_(2)指标低于对照组,差异有统计学意义(P<0.05)。干预后,两组患者各项GCQ评分均有所提高,且观察组各项GCQ评分高于对照组,差异有统计学意义(P<0.05)。干预期间两组患者的胃肠胀气、吸入性肺炎、面罩压迫部位损伤、口咽不适及呼吸机相关性肺炎(VAP)发生率差异无统计学意义(P>0.05)。结论精细化气道管理可有效改善HFNC治疗EICU急性低氧性Ⅰ型呼吸衰竭患者的氧合指数及血气指标,帮助其舒适程度的提升。 展开更多
关键词 精细化气道管理 经鼻高流量湿化氧疗 急诊科监护室 急性低氧性型呼吸衰竭 氧合指数 血气指标
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比较关节镜肩胛下肌修补术与肌清理术治疗LafosseⅠ型肩胛下肌损伤的临床效果
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作者 马银川 《黑龙江医学》 2024年第15期1831-1833,共3页
目的:比较LafosseⅠ型肩胛下肌损伤采用关节镜肩胛下肌修补术与肌清理术治疗的临床效果。方法:选取2019年1月—2022年10月重庆市忠县人民医院收治的50例LafosseⅠ型肩胛下肌损伤患者作为研究对象,根据治疗方法的不同将其分为研究组(n=25... 目的:比较LafosseⅠ型肩胛下肌损伤采用关节镜肩胛下肌修补术与肌清理术治疗的临床效果。方法:选取2019年1月—2022年10月重庆市忠县人民医院收治的50例LafosseⅠ型肩胛下肌损伤患者作为研究对象,根据治疗方法的不同将其分为研究组(n=25)与对照组(n=25)。对照组给予关节镜肩胛下肌清理术治疗,研究组给予关节镜肩胛下肌修补术治疗,比较两组患者疼痛程度[视觉模拟评分(VAS)]、肩关节功能[美国肩肘外科学会肩关节评分(ASES)、美国加州大学肩关节评分(UCLA)]、肩关节活动度及并发症。结果:术后6个月,两组患者被动活动、静息VAS评分降低,ASES、UCLA评分提高,外旋、内旋、前屈角度增大,但研究组与对照组比较,差异无统计学意义(P>0.05);研究组并发症发生率(4.00%)与对照组(12.00%)比较,差异无统计学意义(P>0.05)。结论:关节镜肩胛下肌修补术与肌清理术用于治疗LafosseⅠ型肩胛下肌损伤,均能够减轻患者疼痛感,改善肩关节功能与活动度,具有较高的安全性。 展开更多
关键词 Lafosse 肩胛下肌损伤 关节镜 肩胛下肌修补术 肩胛下肌清理术
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氧化苦参碱对皮肤创面愈合中PCNA、α-SMA及Type Ⅰ collagen的影响 被引量:5
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作者 刘俊梅 刘彦红 +2 位作者 李娟 戴贵东 郑萍 《宁夏医学杂志》 CAS 2022年第1期10-13,共4页
目的探讨氧化苦参碱对小鼠皮肤创面愈合中血清增殖细胞核抗原(PCNA)、α-平滑肌肌动蛋白(α-SMA)及细胞Ⅰ型胶原蛋白(Type Ⅰ collagen)的影响。方法昆明小鼠背部手术制备1.5 cm×1.5 cm全层皮肤缺损创面模型。自第1 d始,除对照组... 目的探讨氧化苦参碱对小鼠皮肤创面愈合中血清增殖细胞核抗原(PCNA)、α-平滑肌肌动蛋白(α-SMA)及细胞Ⅰ型胶原蛋白(Type Ⅰ collagen)的影响。方法昆明小鼠背部手术制备1.5 cm×1.5 cm全层皮肤缺损创面模型。自第1 d始,除对照组给予等量生理盐水外,余各组分别按20、40、80 mg/kg给予氧化苦参碱。Van Gieson纤维胶原染色法观察小鼠背部皮肤创面组织胶原纤维的表达;免疫组学法评价创面组织中PCNA、α-SMA及Type Ⅰ collagen的表达。结果Van Gieson纤维胶原染色显示,氧化苦参碱可促进新生肉芽组织、毛细血管及新生纤维胶原生长。免疫组学研究显示,在第7 d时,氧化苦参碱20、40、80 mg/kg使小鼠皮肤创面组织中PCNA表达明显升高(P<0.05);在第9 d、11 d时,氧化苦参碱20 mg/kg使小鼠皮肤创面组织中α-SMA显著增加;氧化苦参碱20 mg/kg在第3 d、11 d,氧化苦参碱40 mg/kg在第3 d,氧化苦参碱80 mg/kg在第3 d、7 d引起Type Ⅰ collagen的表达显著升高(P<0.05)。结论氧化苦参碱能增加皮肤创面愈合中PCNA、α-SMA及Type Ⅰ collagen的表达。 展开更多
关键词 氧化苦参碱 创面愈合 血清增殖细胞核抗原 Α-平滑肌肌动蛋白 细胞型胶原蛋白
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Effects of Icariin on Expression of OPN mRNA and Type ⅠCollagen in Rat Osteoblasts in Vitro 被引量:8
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作者 肖强兵 陈安民 郭风劲 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2005年第6期690-692,共3页
To study the effects of Icariin on expression of osteopontin (OPN) mRNA and type Ⅰ collagen in rat osteoblasts in vitro and to explore its possible mechanisms in preventing osteoporosis. OB was isolated from calvar... To study the effects of Icariin on expression of osteopontin (OPN) mRNA and type Ⅰ collagen in rat osteoblasts in vitro and to explore its possible mechanisms in preventing osteoporosis. OB was isolated from calvaria of new-born new-born fetal Sprague-Dawley (SD) rats by means of modified sequential collagenase digestion and incubated in MEM medium and the cell morphology was observed under inverted phase contrast microscope, OB was identified by alkaline phosphatase (ALP) staining. Different concentration (0.1μg/mL, 1.0 μg/mL, 10 μ/mL) of Icariin was added to the OB and incubated. The effect of Icariin on the proliferation and osteogenesis of OB was monitored by MTT analysis. The expression of type l collagen was estimated with immunohistochemistry techniques. The expression levels of mRNA of OPN in the cells in every group were examined by reverse-transcriptase ploymerase chain reaction (RT-PCR). The expression of OPN mRNA and type Ⅰ collagen was strengthened gradually with the increase of Icariin concentration and peaked with 10 μg/mL Icariin on the 5th day. Icariin could significantly promote the expression of OPN mRNA and type Ⅰ collagen in rat osteoblasts in vitro. The levels of expression of OPN mRNA and type Ⅰ collagen were changed with different concentration of Icariin. Icariin could effectively prevent and treat osteoporosis and promote the bone formation. 展开更多
关键词 Ieariin osteoblast osteopontin type collagens immunohistoehemistry RT-PCR osteoporosis
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Features and imbibition mechanisms of Winsor Ⅰ type surfactant solution in oil-wet porous media 被引量:2
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作者 YU Fuwei JIANG Hanqiao +5 位作者 FAN Zhen XU Fei SU Hang CHENG Baoyang LIU Rengjing LI Junjian 《Petroleum Exploration and Development》 2019年第5期1006-1013,共8页
The relationship between NaCl concentration and the phase change behavior of microemulsion of anionic surfactant was characterized by the salinity scan experiments.The wettability of WinsorⅠtype surfactant solution(W... The relationship between NaCl concentration and the phase change behavior of microemulsion of anionic surfactant was characterized by the salinity scan experiments.The wettability of WinsorⅠtype surfactant solution(WⅠsolution)and the effect of NaCL concentration on phase change behavior of WⅠsolution and imbibition in oil-wet porous media were investigated by microfluidic experiments in this study.The WⅠsolution and WinsorⅠtype microemulsion are similar in wetting phase with stronger wettability than other phases.Two main mechanisms of WⅠsolution enhancing imbibitions recovery in oil wet porous media are the wetting phase drive and residual oil solubilization.Under the salinity condition of WinsorⅠtype microemulsion,the NaCl concentration has strong impact on the imbibition mechanism of WⅠsolution,the higher the NaCl concentration,the complex the imbibition process and the higher the imbibition efficiency will be.The NaCl concentration has strong impact on the solubilization ability to oil of the WⅠsolution,the higher the NaCl concentration,the stronger the solubility of the WⅠsolution to residual oil will be. 展开更多
关键词 porous media WETTABILITY Winsortype SURFACTANT IMBIBITION mechanism enhanced OIL recovery
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TypeⅠinositol 1, 4, 5-triphosphate receptors increase in kidney of mice with fulminant hepatic failure 被引量:7
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作者 Ying Wen Wei Cui Pei Liu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第16期2344-2348,共5页
AIM: To delineate the mechanisms of renal vasoconstriction in hepatorenal syndrome (HRS), we investigated the expression of type I inositol 1, 4, 5-triphosphate receptors (IP3R I) of kidney in mice with fulminant... AIM: To delineate the mechanisms of renal vasoconstriction in hepatorenal syndrome (HRS), we investigated the expression of type I inositol 1, 4, 5-triphosphate receptors (IP3R I) of kidney in mice with fulminant hepatic failure (FHF). METHODS: FHF was induced by lipopolysaccharide (LPS) in D-galactosamine (GAIN) sensitized BALB/c mice. There were 20 mice in normal saline (NS)-treated group, 20 mice in LPS-treated group, 20 mice in GaIN- treated group, and 60 mice in GalN/LPS-treated group (FHF group). Liver and kidney tissues were obtained at 2, 6, and 9 h after administration. The liver and kidney specimens were stained with hematoxylin-eosin for studying morphological changes under light microscope. The expression of IP3R I in kidney tissue was tested by immunohistochemistry, Western blot and reverse transcription (RT)-PCR. RESULTS: Kidney tissues were morphologically normal at all time points in all groups. IP3R I proteins were found localized in the plasma region of glomerular mesangial cells (GMC) and vascular smooth muscle cells (VSMC) in kidney by immunohistochemical staining. In kidney of mice with FHF at 6 h and 9 h IP3R I staining was upregulated. Results from Western blot demonstrated consistent and significant increment of IP3R I expression in mice with FHF at 6 h and 9 h (t = 3.16, P 〈 0.05; t = 5.43, P 〈 0.01). Furthermore, we evaluated IP3R I mRNA expression by RT-PCR and observed marked upregulation of IP3R I mRNA in FHF samples at 2 h, 6 h and 9 h compared to controls (t = 2.97, P 〈 0.05; t = 4.42, P 〈 0.01; t = 3.81, P 〈 0.01). CONCLUSION: The expression of IP3R I protein increased in GMC and renal VSMC of mice with FHF, possibly caused by up-regulation of IP3R I mRNA. 展开更多
关键词 Hepatorenal syndrome Fulminant hepatic failure type inositol 1 4 5-trisphophate receptors Glomerular mesangial cells Vascular smooth muscle cells
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Synthesis and high temperature thermoelectric transport properties of Si-based type-Ⅰ clathrates 被引量:3
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作者 邓书康 唐新峰 唐润生 《Chinese Physics B》 SCIE EI CAS CSCD 2009年第7期3084-3089,共6页
N-type Si-based type-Ⅰ clathrates with different Ga content were synthesized by combining the solid-state reaction method,melting method and spark plasma sintering (SPS) method.The effects of Ga composition on high... N-type Si-based type-Ⅰ clathrates with different Ga content were synthesized by combining the solid-state reaction method,melting method and spark plasma sintering (SPS) method.The effects of Ga composition on high temperature thermoelectric transport properties were investigated.The results show that at room temperature,the carrier concentration decreases, while the carrier mobility increases slightly with increasing Ga content.The Seebeck coefficient increases with increasing Ga content. Among all the samples,Ba7.93Ga17.13Si28.72exhibits higher Seebeck coefficient than the others and reaches -135μV·K^-1 at 1000 K.The sample prepared by this method exhibits very high electrical conductivity,and reaches 1.95x 10^5 S·m^-1 for Ba8.01Ga16.61Si28.93 at room temperature.The thermal conductivity of all samples is almost temperature independent in the temperature range of 300-1000 K,indicating the behaviour of a typical metal.The maximum ZT value of 0.75 is obtained at 1000 K for the compound Ba7.93Ga17.13Si28.72. 展开更多
关键词 type- clathrate thermoelectric materials SYNTHESIS
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Novel electrospun poly(ε-caprolactone)/type Ⅰ collagen nanofiber conduits for repair of peripheral nerve injury 被引量:1
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作者 Chun-Ming Yen Chiung-Chyi Shen +5 位作者 Yi-Chin Yang Bai-Shuan Liu Hsu-Tung Lee Meei-Ling Sheu Meng-Hsiun Tsai Wen-Yu Cheng 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第9期1617-1625,共9页
Recent studies have shown the potential of artificially synthesized conduits in the repair of peripheral nerve injury. Natural biopolymers have received much attention because of their biocompatibility. To investigate... Recent studies have shown the potential of artificially synthesized conduits in the repair of peripheral nerve injury. Natural biopolymers have received much attention because of their biocompatibility. To investigate the effects of novel electrospun absorbable poly(ε-caprolactone)/type Ⅰ collagen nanofiber conduits(biopolymer nanofiber conduits) on the repair of peripheral nerve injury, we bridged 10-mm-long sciatic nerve defects with electrospun absorbable biopolymer nanofiber conduits, poly(ε-caprolactone) or silicone conduits in Sprague-Dawley rats. Rat neurologica1 function was weekly evaluated using sciatic function index within8 weeks after repair. Eight weeks after repair, sciatic nerve myelin sheaths and axon morphology were observed by osmium tetroxide staining, hematoxylin-eosin staining, and transmission electron microscopy.S-100(Schwann cell marker) and CD4(inflammatory marker) immunoreactivities in sciatic nerve were detected by immunohistochemistry. In rats subjected to repair with electrospun absorbable biopolymer nanofiber conduits, no serious inflammatory reactions were observed in rat hind limbs, the morphology of myelin sheaths in the injured sciatic nerve was close to normal. CD4 immunoreactivity was obviously weaker in rats subjected to repair with electrospun absorbable biopolymer nanofiber conduits than in those subjected to repair with poly(ε-caprolactone) or silicone. Rats subjected to repair with electrospun absorbable biopolymer nanofiber conduits tended to have greater sciatic nerve function recovery than those receiving poly(ε-caprolactone) or silicone repair. These results suggest that electrospun absorbable poly(ε-caprolactone)/type Ⅰ collagen nanofiber conduits have the potential of repairing sciatic nerve defects and exhibit good biocompatibility. All experimental procedures were approved by Institutional Animal Care and Use Committee of Taichung Veteran General Hospital, Taiwan, China(La-1031218) on October 2, 2014. 展开更多
关键词 poly(ε-caprolactone) type collagen ELECTROSPINNING sciatic nerve nerve conduit immunohistostaining walking track analysis peripheral nerve injury
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关节镜肩胛下肌清理术与修补术治疗LafosseⅠ型肩胛下肌损伤的对比研究 被引量:2
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作者 张均泉 田家亮 +2 位作者 唐玮 邹毅 叶茂 《中国现代医学杂志》 CAS 北大核心 2023年第3期93-98,共6页
目的 比较关节镜肩胛下肌清理术与肩胛下肌修补术治疗LafosseⅠ型肩胛下肌损伤的疗效。方法选取2019年1月—2021年1月中国贵航集团三〇二医院收治的52例LafosseⅠ型肩胛下肌损伤患者,按随机数字表法分为对照组和研究组,每组26例。对照... 目的 比较关节镜肩胛下肌清理术与肩胛下肌修补术治疗LafosseⅠ型肩胛下肌损伤的疗效。方法选取2019年1月—2021年1月中国贵航集团三〇二医院收治的52例LafosseⅠ型肩胛下肌损伤患者,按随机数字表法分为对照组和研究组,每组26例。对照组给予关节镜肩胛下肌清理术,研究组给予关节镜肩胛下肌修补术。术后随访12个月观察疗效。比较两组手术前后肩关节活动、疼痛、肩关节功能变化情况,记录两组手术并发症发生情况。结果 两组术前、术后12个月肩关节前屈、内旋、外旋的差值比较,差异无统计学意义(P>0.05)。两组术前、术后3个月、术后6个月、术后12个月的疼痛视觉模拟评分(VAS)比较:(1)不同时间点的VAS评分有差异(P <0.05);(2)研究组与对照组的VAS评分无差异(P>0.05);(3)研究组与对照组的VAS评分变化趋势无差异(P>0.05)。两组术前、术后12个月肩关节美国加州大学洛杉矶(UCLA)评分、简明肩关节功能测试(SST)评分、美国肩肘外科学会肩关节评分(ASES)的差值比较,差异无统计学意义(P>0.05)。两组术前、术后12个月lift-off试验、Napoleno试验、Bear Hug test试验阳性率比较,差异无统计学意义(P>0.05)。两组并发症总发生率比较,差异无统计学意义(P>0.05)。结论 关节镜肩胛下肌修补术与肩胛下肌清理术均为治疗LafosseⅠ型肩胛下肌损伤的有效方法,两种手术方法均可明显提高患者肩关节活动度,减轻疼痛程度,改善肩关节功能,且安全性良好。 展开更多
关键词 肩胛下肌损伤 Lafosse 肩胛下肌修补术 肩胛下肌清理术 疗效
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一类广义Type Ⅰ函数的多目标优化问题
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作者 叶提芳 《江汉大学学报(自然科学版)》 2009年第3期17-19,共3页
对于非光滑多目标优化的模型,定义了几种广义Type Ⅰ函数,研究了广义Type Ⅰ函数的多目标优化问题,得到了有效解的最优性条件.
关键词 多目标优化 广义type 函数 有效解 弱有效解
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《Ⅰ型神经纤维瘤病多学科诊治指南(2023版)》解读 被引量:1
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作者 杨满红 王平 +1 位作者 夏迪 张清 《疑难病杂志》 CAS 2023年第11期1121-1125,共5页
Ⅰ型神经纤维瘤病(NF1)是由NF1基因突变导致的遗传性疾病,以神经纤维瘤为特征性表现,可累及全身多系统,往往合并脊柱侧凸、神经系统异常等,临床表现复杂且存在恶变风险,作为临床疑难病种其诊疗难度大。继我国2021版Ⅰ型神经纤维瘤病临... Ⅰ型神经纤维瘤病(NF1)是由NF1基因突变导致的遗传性疾病,以神经纤维瘤为特征性表现,可累及全身多系统,往往合并脊柱侧凸、神经系统异常等,临床表现复杂且存在恶变风险,作为临床疑难病种其诊疗难度大。继我国2021版Ⅰ型神经纤维瘤病临床诊疗专家共识后,最近我国罕见病联盟撰写并发表《Ⅰ型神经纤维瘤病多学科诊治指南(2023版)》,文章就其基因诊断、手术注意事项和骨科相关临床症状方面展开解读,以期推动该指南的临床应用。 展开更多
关键词 型神经纤维瘤病 疑难病 指南 解读
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透明质酸联合注射血小板血浆及A型肉毒毒素对猪真皮Ⅰ型胶原蛋白表达的影响 被引量:1
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作者 童玲 陈瑶 +3 位作者 王雪 杨艳 方洪伟 张振 《实用皮肤病学杂志》 2023年第2期67-71,共5页
目的探讨透明质酸联合A型肉毒毒素(botulinum toxin type-A,Botox A)和富含血小板血浆(platelet rich plasma,PRP)进行猪真皮内注射,检测真皮层成纤维细胞数目及Ⅰ型胶原蛋白mRNA分泌代谢的变化。方法采用巴马猪建立动物模型,使用交联... 目的探讨透明质酸联合A型肉毒毒素(botulinum toxin type-A,Botox A)和富含血小板血浆(platelet rich plasma,PRP)进行猪真皮内注射,检测真皮层成纤维细胞数目及Ⅰ型胶原蛋白mRNA分泌代谢的变化。方法采用巴马猪建立动物模型,使用交联透明质酸(cross-linked hyaluronic acid,HA)和非交联透明质酸(non-cross-linked hyaluronic acid,N-HA)分别与Botox A、PRP联合作为实验组(HA组、HA+Botox A组、HA+PRP组、N-HA组、N-HA+Botox A组、N-HA+PRP组),并与生理盐水组和正常组比较。于注射第1和4周后,通过组织切片染色、实时荧光定量聚合酶链反应(PCR)等方法,定性定量观察、比较真皮层成纤维细胞数量变化,真皮层Ⅰ型胶原蛋白mRNA分泌表达变化。结果HA组的成纤维细胞数量、Ⅰ型胶原蛋白mRNA表达量在第1周和第4周时比N-HA组高,并且HA+PRP组的成纤维细胞数量、Ⅰ型胶原蛋白mRNA表达水平显著高于同期HA+Botox A组、生理盐水组和正常组(P<0.05)。结论应用HA与PRP联合注射更易促进成纤维细胞的增殖和Ⅰ型胶原蛋白mRNA的表达,其主要机制可能是通过改变细胞外基质的理化性质进而促进真皮层细胞因子的合成,从而影响胶原合成。 展开更多
关键词 型胶原蛋白 成纤维细胞 透明质酸 富含血小板血浆 A型肉毒毒素
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Type Ⅰ kerogen-rich oil shale from the Democratic Republic of the Congo: mineralogical description and pyrolysis kinetics
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作者 Rajaa Bouamoud Ely Cheikh Moine +3 位作者 Raphaèl Mulongo-Masamba Adnane El Hamidi Mohammed Halim Said Arsalane 《Petroleum Science》 SCIE CAS CSCD 2020年第1期255-267,共13页
The Democratic Republic of the Congo holds important reserves of oil shale which is still under geological status.Herein,the characterization and pyrolysis kinetics of typeⅠkerogen-rich oil shale of the western Centr... The Democratic Republic of the Congo holds important reserves of oil shale which is still under geological status.Herein,the characterization and pyrolysis kinetics of typeⅠkerogen-rich oil shale of the western Central Kongo(CK)were investigated.X-ray diffraction,Fourier-transform infrared spectroscopy and thermal analysis(TG/DTA)showed that CK oil shale exhibits a siliceous mineral matrix with a consistent organic matter rich in aliphatic chains.The pyrolysis behavior of kerogen revealed the presence of a single mass loss between 300 and 550°C,estimated at 12.5%and attributed to the oil production stage.Non-isothermal kinetics was performed by determining the activation energy using the iterative isoconversional model-free methods and exhibits a constant value with E=211.5±4.7 kJ mol.1.The most probable kinetic model describing the kerogen pyrolysis mechanism was obtained using the Coats–Redfern and Arrhenius plot methods.The results showed a unique kinetic triplet confirming the nature of kerogen,predominantly typeⅠand reinforcing the previously reported geochemical characteristics of the CK oil shale.Besides,the calculation of thermodynamic parameters(ΔH~*,ΔS~*andΔG~*)corresponding to the pyrolysis of typeⅠkerogen revealed that the process is non-spontaneous,in agreement with DTA experiments. 展开更多
关键词 typekerogen PYROLYSIS kinetics Isoconversional methods MINERALOGY Central Kongo oil SHALE
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Type Ⅰ neurofibromatosis with spindle cell sarcoma: A case report
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作者 Yu Zhang Jiao-Jiao Chao +1 位作者 Xiu-Feng Liu Shu-Kui Qin 《World Journal of Clinical Cases》 SCIE 2019年第19期3104-3110,共7页
BACKGROUND Neurofibromatosis type Ⅰ(NF1) is the most frequent subtype of neurofibromatosis. Its related tumor-suppressor syndromes are characterized by a predisposition to multiple tumor types and other disorder pres... BACKGROUND Neurofibromatosis type Ⅰ(NF1) is the most frequent subtype of neurofibromatosis. Its related tumor-suppressor syndromes are characterized by a predisposition to multiple tumor types and other disorder presentations. In addition, the incidence of tumors is much higher in patients with neurofibromatosis type Ⅰ. However, there are very few reports at home and abroad on this topic. Here, we present a case of NF1 with spindle cell sarcoma.CASE SUMMARY A 50-year-old male was found to have a right axillary mass for 20 years.Specialist examination found cafe-au-lait spots on many parts of the skin,rounded nodules in the skin, a bulge in the right armpit, touching a lump(10 cm× 6 cm, hard, unclear boundary, poor mobility, local tenderness). The anterior side of the thigh felt weakened on the opposite side;in the right groin a swollen lymph node(hard, clear border, good mobility, local tenderness). According to the results of positron emission tomography/computed tomography, puncture pathology and immunohistochemistry, genetic testing, a diagnosis of NF1 with spindle cell sarcoma was confirmed. According to the genetic testing result, the patient was given a targeted treatment with crizotinib.CONCLUSION Surgery, chemotherapy and radiotherapy are the main treatment methods of NF1. However, with the continuous progress of molecular biology research,molecular targeted therapy may bring benefits for patients. 展开更多
关键词 NEUROFIBROMATOSIS type SPINDLE cell SARCOMA TARGETED therapy CRIZOTINIB Case report
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Significance of elevated serum concentration of type Ⅰ collagen metabolites and its correlation with serum interleukin 6 activities in multiple myeloma
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作者 侯健 黄隆安 +4 位作者 纪徐准 陈玉宝 王东星 屠小卿 孔宪涛 《Journal of Medical Colleges of PLA(China)》 CAS 1997年第3期231-234,共4页
In this study, serum concentrations of carboxyterminal propeptide of type Ⅰ collagen(PICP) and carboxyterminal cross-linked telopeptide of type Ⅰ collagen (ICTP), which represent the rates of synthesis and degradati... In this study, serum concentrations of carboxyterminal propeptide of type Ⅰ collagen(PICP) and carboxyterminal cross-linked telopeptide of type Ⅰ collagen (ICTP), which represent the rates of synthesis and degradation of type Ⅰ collagen, were determined by radioimmunoassay in 56 patients with multiple myeloma (MM) and 22 healthy controls. It was discovered that serum concentrations of both PICP and ICTP were higher in MM than those in healthy controls (P<0. 01 ). With the disease progressing and the number of bone lesions increasing,serum concentration of ICTP elevated while serum concentration of PICP showed no significant change. Neither serum PICP nor ICTP concentration was related to M-component classes. Our results indicated that serum ICTP concentration was a good serological marker to reflect severity of bone lesions in MM and elevated serum PICP concentration might be due to compensatory increase in type Ⅰ collagen synthesis. Moreover, we also found that serum ICTP concentrations in MM correlated with serum interleukin-6 (IL-6) activities (r= 0. 610, P< 0. 01),which confirms the effectiveness of IL-6 as an osteoclast activating factor. 展开更多
关键词 multiple MYELOMA METABOLITES of type COLLAGEN INTERLEUKIN 6
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