Ugi-4CC(four-component condensation) reaction is one of isonitrile-based MCR's(multicomponent reactions), which is started with an amine, an aldehyde, a carboxylic acid and an isocyanide, after full use of the spe...Ugi-4CC(four-component condensation) reaction is one of isonitrile-based MCR's(multicomponent reactions), which is started with an amine, an aldehyde, a carboxylic acid and an isocyanide, after full use of the specialty of isonitrile and be used to build a series of compounds with different structural skeletons by using diverse inputs. In our work, two kinds of isonitriles were synthesized and a parallel synthesis of an α-acylarnino amide library was performed to modify the Ugi reaction conditions.展开更多
基金Foundation of the Key Laboratory of Pesticide Chemistry and Application,Ministry of Agriculture ( MOA ) ( No. MOAPCA200903)National Natural Science Foundation of China ( Nos. 20872071,20911120069 )+5 种基金Key Project of the Tianjin Natural Science Foundation ( 10JCZDJC17500 )The National Key Project for Basic Research ( 2010CB126105 )National Key Technology Research and Development Program ( 2011BAE06B05 )Common Specialized Research Fund of China Agriculture ( nyhyzx3-21,201103016 and 201003029)The Russian Foundation for Basic Research ( Nos RFBR 08-03-00376 a and RFBR /NNSF 08-03-92208 a)the Foundation of Achievements Transformation and Spreading of Tianjin Agricultural Science and Technology ( No. 201002250)
文摘Ugi-4CC(four-component condensation) reaction is one of isonitrile-based MCR's(multicomponent reactions), which is started with an amine, an aldehyde, a carboxylic acid and an isocyanide, after full use of the specialty of isonitrile and be used to build a series of compounds with different structural skeletons by using diverse inputs. In our work, two kinds of isonitriles were synthesized and a parallel synthesis of an α-acylarnino amide library was performed to modify the Ugi reaction conditions.
