In this research,a hydroxyl group functionalized metal-organic framework(MOF),UiO-66-(OH)_(2),was synthesized as a "on-off-on" fluore scent switching nanoprobe for highly sensitive and selective detection of...In this research,a hydroxyl group functionalized metal-organic framework(MOF),UiO-66-(OH)_(2),was synthesized as a "on-off-on" fluore scent switching nanoprobe for highly sensitive and selective detection of Fe^(3+),ascorbic acid(AA) and acid phosphatase(ACP).UiO-66-(OH)_(2) emits yellow-green light under ultraviolet light,when Fe^(3+) was added,Fe^(3+) was chelated with hydroxyl group,the electrons in the excited state S_1 of the MOF transferred to the half-filled 3 d orbits of Fe^(3+),resulting in fluorescence quenching because of the nonradiative electron/hole recombination annihilation.AA could reduce Fe^(3+) to Fe^(2+),which can destroy the electron transfer between UiO-66-(OH)_(2) and Fe^(3+) after AA adding,resulted in nonoccurrence of the nonradiative electron transfer,leading to the recovery of UiO-66-(OH)_(2) fluorescence intensity.The probe can also be used to detect ACP based on the enzymolysis of 2-phospho-L-ascorbic acid(AAP) to produce AA.Benefitting from the hydroxyl group and the characteristics of UiO-66,including the high porosity and large surface area,the developed UiO-66-(OH)_(2) showed extensive advantages as a fluorescent probe for detection of multi-component,such as high sensitivity and selectivity,colorimetric detection,fast response kinetics and easy to operate,economical and secure.This is the first time to use active group functionalized MOFs as a multicomponent sensor for these three substances detection.展开更多
In this study,a novel copper ion(Cu^(2+))crosslinked composites beads with components of sodium alginate(SA)as gel matrix and UiO-66-(COOH)_(2) metal organic framework(MOF)nanoparticle as functional fller could efecti...In this study,a novel copper ion(Cu^(2+))crosslinked composites beads with components of sodium alginate(SA)as gel matrix and UiO-66-(COOH)_(2) metal organic framework(MOF)nanoparticle as functional fller could efectively adsorb toxins in dialysate.The maximum adsorption capacity of the optimized composite beads(Cu-SA/U-4)for creatinine reached 125.0 mg/g with a positive synergistic efect based on Langmuir isotherm model and pseudo-second-order kinetic model,which was 1.75 times and 1.50 times that of single component beads(Cu-SA)and UiO-66-(COOH)_(2) nanoparticle respectively.Furthermore,when the dialysis performance using thin-flm nanofbrous composite(TFNC)membrane was comparable,introduction of Cu-SA/U-4 beads into the dialysate allowed the volume of dialysate reduced to one-tenth of that without beads.Therefore,the coordination of such highly efcient adsorbent beads and TFNC dialysis membrane can economize the usage of the dialysate and contributes to realize lightweight hemodialysis.More importantly,we not only prepared a kind of composite bead via carefully designed strategy,but also proposed widely applicable idea of using adsorbents in combination with dialysis membrane to realize lightweight or miniaturized hemodialysis.展开更多
基金supported by grants awarded by the National Natural Science Foundation of China(Nos.21505084,21775089)Natural Science Foundation Projects of Shandong Province(No.ZR2014BM029)+2 种基金Key Research and Development Program of Shandong Province(No.2017GSF19109)Innovation Project of Shandong Graduate Education(No.SDYY16091)Outstanding Youth Foundation of Shandong Province(No.ZR2017JL010)。
文摘In this research,a hydroxyl group functionalized metal-organic framework(MOF),UiO-66-(OH)_(2),was synthesized as a "on-off-on" fluore scent switching nanoprobe for highly sensitive and selective detection of Fe^(3+),ascorbic acid(AA) and acid phosphatase(ACP).UiO-66-(OH)_(2) emits yellow-green light under ultraviolet light,when Fe^(3+) was added,Fe^(3+) was chelated with hydroxyl group,the electrons in the excited state S_1 of the MOF transferred to the half-filled 3 d orbits of Fe^(3+),resulting in fluorescence quenching because of the nonradiative electron/hole recombination annihilation.AA could reduce Fe^(3+) to Fe^(2+),which can destroy the electron transfer between UiO-66-(OH)_(2) and Fe^(3+) after AA adding,resulted in nonoccurrence of the nonradiative electron transfer,leading to the recovery of UiO-66-(OH)_(2) fluorescence intensity.The probe can also be used to detect ACP based on the enzymolysis of 2-phospho-L-ascorbic acid(AAP) to produce AA.Benefitting from the hydroxyl group and the characteristics of UiO-66,including the high porosity and large surface area,the developed UiO-66-(OH)_(2) showed extensive advantages as a fluorescent probe for detection of multi-component,such as high sensitivity and selectivity,colorimetric detection,fast response kinetics and easy to operate,economical and secure.This is the first time to use active group functionalized MOFs as a multicomponent sensor for these three substances detection.
基金This work was supported by the Fundamental Research Funds for the Central Universities(2232020A-04)Shanghai Municipal Natural Science Foundation(19ZR1401300).
文摘In this study,a novel copper ion(Cu^(2+))crosslinked composites beads with components of sodium alginate(SA)as gel matrix and UiO-66-(COOH)_(2) metal organic framework(MOF)nanoparticle as functional fller could efectively adsorb toxins in dialysate.The maximum adsorption capacity of the optimized composite beads(Cu-SA/U-4)for creatinine reached 125.0 mg/g with a positive synergistic efect based on Langmuir isotherm model and pseudo-second-order kinetic model,which was 1.75 times and 1.50 times that of single component beads(Cu-SA)and UiO-66-(COOH)_(2) nanoparticle respectively.Furthermore,when the dialysis performance using thin-flm nanofbrous composite(TFNC)membrane was comparable,introduction of Cu-SA/U-4 beads into the dialysate allowed the volume of dialysate reduced to one-tenth of that without beads.Therefore,the coordination of such highly efcient adsorbent beads and TFNC dialysis membrane can economize the usage of the dialysate and contributes to realize lightweight hemodialysis.More importantly,we not only prepared a kind of composite bead via carefully designed strategy,but also proposed widely applicable idea of using adsorbents in combination with dialysis membrane to realize lightweight or miniaturized hemodialysis.
