单操作孔胸腔镜肺叶切除术治疗早期非小细胞肺癌的临床疗效

目的:探讨单操作孔胸腔镜手术(video-assisted thoracoscopic surgery,VATS)肺叶切除术对于早期肺癌患者手术治疗的临床效果。方法:回顾性分析2016年3月至2017年3月进行手术治疗的100例早期肺癌患者临床资料,分为观察组和对照组,各50例,观察组患者接受单操作孔VATS肺叶切除术或肺段切除治疗,对照组患者接受传统三孔式VATS肺叶切除术或肺段切除术治疗,比较两组患者的治疗效果、疼痛程度以及并发症发生率。结果:两组患者的手术时间、术中出血量、术中淋巴结清扫数目、术后下床时间、术后胸腔引流时间比较,差异均无统计学意义(P>0.05);观察组患者术后并发症发生率为4.0%(2/50),对照组患者术后并发症发生率为6.0%(3/50),组间比较,差异无统计学意义(χ2=0.211,P=0.646);观察组患者术后第7 d评分最小值(VASmin-d7)、术后第3 d及第7 d评分最大值(VASmax-d3、VASmax-d7)均低于对照组(P<0.05)。结论:单孔VATS肺癌根治术手术效果满意,安全可靠,创伤小,值得临床推广应用。

计算机辅助新药设计相关筛选数据库的研究进展

作者对计算机辅助新药设计与虚拟筛选相关的常用蛋白质、核酸、药效团数据库进行了总结,详细介绍了其构建内容(包括信息来源、数据内容、检索字段等)和使用方法等,并分析了数据库开发的问题和挑战,进而对其发展方向与对策提出见解。

A Brief Overview of a Few Popular and Important Protein Databases

Database is a repository of information. In today’s world there are different types of databases available. In this present review the focus is on a few popular and most widely used biological databases that store protein sequence and structure information. The databases that are of utmost importance to do basic biological research work are PDB, SCOP, CATH and UniProt/SwissProt and GenBank. These databases have different utilities & they play important roles in different fields of biology and bioinformatics. PDB provides the structural information of proteins, protein-complexes and proteins complexed with other macromolecules. SCOP & CATH store various annotations of protein sequences and structures. UniProt is a central repository of protein sequences & functions created by joining the information contained in SwissProt, TrEMBL.