Effect of "Fuzheng Qingre Tonglin" prescription on rats with complicated urinary tract infection caused by ESBLs-producing Escherichia coli

Objective: To observe the effect of traditional Chinese medicine "Fuzheng Qingre Tonglin"prescription on rats with complicated urinary tract infection caused by extended-spectrumβ-lactamases (ESBLs)-producing Escherichia coli and its possible mechanism. Methods:Specific-pathogen-free female SD rats with 7-9 weeks old were randomly divided into model group, levofloxacin group, low-dose Fuzheng Qingre Tonglin group, high-dose Fuzheng Qingre Tonglin group, levofloxacin+Fuzheng Qingre Tonglin group (n=8 in each above group), and also there was a control group with 5 rats. Each group was administered intragastrically 2 days after model establishment for 14 consecutive days. The general condition of the rats was observed. Renal pathological changes were observed by light microscopy under hematoxylin-eosin staining. The number of white blood cells and the percentage of neutral particles (NEUT%) were detected. ELISA was used for the determination of C-reactive protein (CRP), CD4+, CD8+ in the blood, and secretory immunoglobulin A (SIgA), N-acetyl-β-D-glucosidase (NAG) molecules in urine. Results: There were a large number of inflammatory cells in the kidney of the model group and the levofloxacin group. The inflammatory cells in the treatment group were significantly reduced. The NEUT% and CRP in the blood of each treatment group and the NAG in the urine were significantly lower than those in the model group (P<0.05), except levofloxacin group. Compared with the model group, except for the levofloxacin group, serum CD4 concentration and CD4/CD8 ratio in the other treatment groups were significantly decreased, and CD8 molecules were significantly increased (P<0.05). Conclusion: "Fuzheng Qingre Tonglin" can alleviate systemic and local inflammation of complicated urinary tract infections in rats. It may also have the effect of re-sensing the insensitive antibacterial drug to bacteria and may have the function of regulating immune function and protecting kidney function in rats.

Disseminated osteomyelitis after urinary tract infection in immunocompetent adult:A case report

BACKGROUND Urinary tract infection(UTI)is one of the most common bacterial infections.Acute pyelonephritis or upper urinary tract infection is often accompanied by bacteremia;however,bacteremia resolves in most cases without complication.Rarely,complications due to bacteremia occur.One of these is osteomyelitis.It mainly affects the lumbar vertebral bodies,and rarely affects other site.CASE SUMMARY An 80-year-old woman presented to the hospital with a two-month history of pain in both legs.Two months ago,she was admitted to the hospital for fever,flank pain,and urinary frequency and was diagnosed with bacteremic UTI.During hospitalization,she complained of pain in both legs;however,the pain resolved shortly after,and no abnormalities were observed on physical examination.Therefore,she was placed on 2-wk antibiotic therapy for UTI without further evaluation for leg pain.However,pain recurred after discharge and persisted;therefore,an imaging test was performed.Bone scan and magnetic resonance imaging suggested osseous infection in both femurs,tibiae and patellae.Surgical treatment was performed,and tissue-and bone cultures revealed Escherichia coli,a previously observed pathogen,which demonstrated same antibiotic sensitivities,as noted in previous UTI.She was diagnosed with disseminated osteomyelitis,as a complication of UTI,and was placed on an 8-wk antibiotic therapy.CONCLUSION Indication for osteomyelitis should be high regardless of bone pain at sites other than lumbar spine after or during UTI.

Recurrence of urinary tract infections in postmenopausal diabetic women using different antibiotics

Objectives: Postmenopausal women with diabetes mellitus (DM) have an increased incidence of urinary tract infections (UTI) compared to women without DM. The aim of this study is to compare recurrence rates of UTI in postmenopausal women with DM after treatment with nitrofurantoin, the agent of first choice following the Dutch guidelines, with two other common prescribed antibiotics trimethoprim and norfloxacin. Methods: We used a PHARMO database with pharmacy dispensing data. A total of 8534 postmenopausal (>55 years) women with DM who received a first course of nitrofurantoin, trimethoprim or norfloxacin were included. The UTI recurrence rates after treatment with these three different antimicrobial agents were compared. Recurrence was defined as a second prescription for nitrofurantoin, trimethoprim or norfloxacin or a first with fosfomycin, amoxicillin, fluoroquinolones, or trimethoprim/sulfamethoxazole between 6 and 30 days after inclusion. Results: Postmenopausal women with DM had significantly more UTI recurrences when they were treated with nitrofurantoin (22.7%) compared to trimethoprim (17.7%) or norfloxacin (14.2%) irrespective of the treatment duration. There was a trend that longer treatment duration was associated with higher recurrence rates. Conclusions: Postmenopausal women with DM had more UTI recurrences when they are treated with nitrofurantoin, agent of first choice, compared to trimethoprim or norfloxacin.

Effect of"Fuzheng Qingretonglin"decoction on complex urinary tract infection in rats by regulating NLRP3 inflammasome pathway

Obiective:To investigate whether"Fuzheng Qingretonglin"decoction can reduce urinary tract damage caused by complex urinary tract infection caused by drug resistant Escherichia coli by regulating Nod-like receptor pyrin domain3 inflammasome,and to explore the feasibility of this decoction combined with levofloxacin in the treatment of complex urinary tract infection caused by drug resistant bacteria.Methods:SD rats were divided into five groups:sham group,model group,levofloxacin group(Lev group),levofloxacin+Fuzheng Qingre Tonglin decoction group(FZ+lev group),and Fuzheng Qingre Tonglin decoction group(FZQRTL group).After the experiment,urine was taken for bacterial culture to determine the urinary tract infection of rats in each group;HE staining was used to observe the pathological changes of kidney and bladder tissues in rats;The expression of NLRP3 in kidney and bladder tissues was detected by immunohistochemistry;The expression of IL-1βand IL-18 in serum of rats was detected by ELISA;The expressions of NLRP3,ASC and Caspase-1 were detected by Western blotting.Results:The positive rate of urine bacteria culture in the sham group was 0%,the positive rate of urine bacteria culture in the model group was 100%;and the positive rate of urine bacteria culture in the FZ+lev group was 37.50%,which was statistically different from that in the model group(P<0.05).A large number of inflammatory cells were observed in the kidney and bladder tissues of the model group by HE staining,while the number of inflammatory cells in the kidney and bladder tissues of the Lev group and FZQRTL group was significantly reduced compared with that of the model group.The FZ+lev group in the number and structure of inflammatory cells in kidney and bladder were similar to the sham group.The NLRP3 immunohistochemistry of kidney and bladder tissue in FZ+lev groups and FZQRTL groups was significantly different from that in model group(P<0.001).The levels of IL-1βand IL-18 in serum of Lev group,FZQRTL group and FZ+lev group were significantly decreased by ELISA compared with model group(P<0.001).The levels of IL-1βand IL-18 in the FZ+lev groups were significantly lower than in the Lev group and FZQRTL group,and the differences were statistically significant(P<0.05).The protein expressions of NLRP3,ASC and Caspase-1 in the Lev group,FZQRTL group and FZ+lev group were significantly lower than those in the model group(P<0.001).The protein expressions of NLRP3,ASC and Caspase-1 in the FZ+lev groups were significantly lower than in the Lev group and FZQRTL group,and the differences were statistically significant(P<0.05).Conclusions:"Fuzheng Qingretonglin"decoction may have a protective effect on the kidney and bladder of rats with complex urinary tract infection caused by drug-resistant Escherichia coli by inhibiting the activation of NLRP3 inflammatory bodies,and TCM combined with levofloxacin has a better therapeutic effect than TCM or levofloxacin alone.

A review of complications after ureteral reconstruction

Objective:This study aimed to provide a comprehensive overview of the complications unique to ureteral reconstruction in adults,emphasizing their presentation,diagnosis,and management in the treatment of ureteral structure disease.Methods:This review involves an in-depth analysis of existing literature and case studies pertaining to ureteral reconstruction,with a focus on examining the range of complications that can arise post-surgery.Special attention is given to the presentation of each complication,the diagnostic process involved,and the subsequent management strategies.Results:Ureteral reconstruction can treat ureteral stricture disease with low morbidity;however,complications,although uncommon,can have severe consequences.The most notable complications include urinary extravasation,stricture recurrence,urinary tract infections,compartment syndrome,symptomatic vesicoureteral reflux,and Boari flap necrosis.Each complication presents unique diagnostic challenges and requires specific management approaches.Conclusion:Ureteral reconstruction is a highly effective treatment for ureteral stricture disease.Having a strong understanding of the potential complications that patients may experience following ureteral reconstruction is not only critical to adequately counsel patients but also facilitate prompt diagnosis and management of complications when they arise.

Chinese Herbal Medicine and Acupuncture Used for Rehabilitation of the Impaired Urinary System in Patients with Paraplegia—A Report of 52 Cases

Infection of the urinary system is frequently seen in the paraplegic patients with urinary complications,which is one of the main reasons for the late death in such cases. The effects of the therapeutic method adopted for the urinary rehabilitation are directly related to the life quality and survival time of the paraplegic patients. Since 1999-2002, the authors had applied Chinese herbal medicine combined with acupuncture for the urinary rehabilitation in 52 paraplegic patients, with quite good therapeuticresults as reported in the following.

Antibiotic resistance patterns of urinary tract pathogens in Turkish children

Background:Knowledge of local antimicrobial resistance patterns is essential for evidence-based empirical antibiotic prescribing.We aimed to investigate the distribution and changes in causative agents of urinary tract infections in children and the resistance rates,and to recommend the most appropriate antibiotics.Methods:In this retrospective study,we evaluated causative agents and antimicrobial resistance in urine isolates from the positive community from September 2014 to April 2016 in a single hospital in Ankara,Turkey.Results:A total of 850 positive urine cultures were identified,of which 588(69.2%)were from girls and 262(30.8%)were from boys.Their mean age was 36.5±45.0 months.The most common causative agent was Escherichia coli(64.2%of cases)followed by Klebsiella pneumoniae(14.9%).The overall resistance to ampicillin(62.6%),cephalothin(44.2%),co-trimoxazole(29.8%)and cefuroxime(28.7%)was significant.No resistance to imipenem was detected in the isolates.The least resistance was for amikacin,ceftriaxone,ciprofloxacin and cefepime(0.1,2.4,7.5 and 8.3%,respectively).Imipenem was the most active agent against E.coli followed by amikacin(0.2%),ceftriaxone(2.7%)and nitrofurantoin(5.1%).High resistance rates to nitrofurantoin were detected in K.pneumoniae,Proteus and Enterobacteriae.Conclusions:E.coli was the most common causative agent of urinary tract infection in children.Ampicillin,trimethoprim-sulfometaxazole,cephalothin and cefuroxim had the highest resistance rates against urinary tract pathogens in our center.For oral empirical antibiotherapy,cefixime is the most appropriate choice so as to include Klebsiella strains.

基于隐结构模型的复杂性尿路感染方药规律分析

目的运用隐结构模型分析法,挖掘复杂性尿路感染(cUTI)的用药规律。方法计算机检索CNKI、万方数据知识服务平台、维普网、中国生物医学文献数据库、PubMed、Cochrane Library中有关中医药治疗cUTI的文献,检索时间为建库至2022年9月,利用Office Excel 2019软件建立并规范数据库,运用隐结构模型学习、综合聚类及频数分析等方法分析数据库,总结cUTI的用药规律。结果共纳入文献335篇,涉及中药254味,频率>0.35%的中药65味,功效以清热药、利水渗湿药、补虚药为主。药性多为寒、平,药味多甘、苦、淡,主归肺、肾经。隐结构分析共得到隐变量17个,结合专业知识后综合聚类为4类,推断cUTI的常见证候为膀胱湿热证、肾阳亏虚证、阴虚内热证、热毒蕴结证,代表方剂分别为八正散、真武汤、六味地黄丸、五味消毒饮等。结论cUTI的治疗以清湿热贯穿始终,其病机复杂,多为虚实夹杂之侯,病性偏实者着重祛湿热并适当配伍养阴药,利水通淋而不伤阴,病性偏虚者重补虚并适当配伍清湿热药避免湿热羁留。

接受上尿路结石输尿管镜治疗患者术后泌尿系统感染前瞻预控护理效果观察

目的:观察于接受上尿路结石输尿管镜治疗患者护理中引入针对术后泌尿系感染问题的前瞻预控护理所取得的效果。方法:选取2021年1月至2023年9月于中国人民解放军联勤保障部队第九一〇医院接受输尿管镜治疗的上尿路结石病例200例为观察样本,采用随机数字表法分为对照组与试验组,每组各100例。对照组遵循尿路结石输尿管镜治疗常规护理模式开展护理,试验组在接受上述护理的基础之上加用针对术后泌尿系感染事件的前瞻预控护理干预,对干预后各观察指标进行对比分析。结果:试验组术后泌尿系感染发生率低于对照组(χ^(2)=7.680,P=0.006),各项生活质量综合评定问卷(GQOLI-74)评分高于对照组(t=35.206、21.366、29.361、26.318,P均<0.001)。结论:针对上尿路结石输尿管镜治疗患者术后泌尿系感染问题引入前瞻预控护理机制,有利于提高护理人员感染防控知信行水平,可降低术后泌尿系感染率。

哌拉西林/他唑巴坦治疗成人复杂性尿路感染的真实世界研究

目的 探讨哌拉西林/他唑巴坦治疗成人复杂性尿路感染(cUTI)的有效性和安全性。方法 回顾性分析2021年1月1日至2023年12月31日我院成人c UTI患者资料352例,所有患者均使用哌拉西林/他唑巴坦。观察患者的病原菌检出情况,治疗后的临床有效率、微生物清除率、不良反应发生情况及治疗费用。结果 352例患者中,有54例患者有病原菌培养结果,以产超广谱β-内酰胺酶大肠埃希菌为主(48.1%)。所有患者的临床有效率为94.3%,微生物清除率为81.5%,不良反应发生率为1.4%。临床有效患者中的男性比例、泌尿外科治疗患者比例均显著高于临床无效患者,而移植科治疗患者比例、合并移植肾患者比例均显著低于临床无效患者(P<0.05)。根据病原菌对哌拉西林/他唑巴坦的敏感性分为目标治疗组和经验性治疗组的分析结果显示,两组患者的临床有效率比较,差异无统计学意义(P=0.902 5)。结论 哌拉西林/他唑巴坦治疗成人cUTI的疗效显著,安全性较好。

也谈儿童肾盂输尿管连接处梗阻手术后泌尿系感染的影响因素

肾盂输尿管连接处梗阻(ureteropelvic junction obstruction,UPJO)是导致儿童病理性肾积水的最常见原因。目前,腹腔镜下肾盂输尿管成形术(laparoscopic pyeloplasty,LP)已逐渐成为UPJO的首选手术方式。泌尿系感染(urinary tract infection,UTI)是肾盂输尿管成形术后常见早期并发症之一。UTI可导致病程延长,严重者甚至可诱发尿源性脓毒血症;也可导致术后吻合口再狭窄,影响手术成功率。本文旨在分析和阐述儿童UPJO手术后UTI的影响因素,以期提高临床对于UPJO手术后UTI的认识,进而采取相应措施预防UTI的发生,缩短UTI病程,提高手术成功率。

1例复杂性尿路感染合并继发性癫痫患者的药物治疗分析

目的:临床药师通过参与1例复杂性尿路感染患者的治疗过程,从初始抗感染治疗失败原因分析、协助调整治疗方案和抗菌药物不良反应识别等方面作为工作切入点,为临床抗感染治疗提供思路及参考依据。方法:临床药师在查阅指南和文献资料等循证证据基础上,结合临床疗效评估和诱发癫痫药物相关性辨识,协助医生调整抗感染治疗方案。结果:患者通过2次抗感染药物调整后治疗有效且癫痫未再发生。结论:对于复杂性尿路感染患者,应重视真菌性尿培养结果。对于老年糖尿病伴血清白蛋白降低患者,在使用厄他培南治疗时需警惕癫痫的发生。

微生物检验在尿路感染预防和诊治中的观察

目的研究微生物检测在预防和治疗尿道感染中的重要性。方法计划对2023年3月1日至2023年8月31日期间我院收治的86例尿路感染患者进行研究。通过随机数字表法,将这86例患者分为试验组和参考组,每组各43例。参考组将在常规检测后接受抗生素治疗,而试验组则会根据微生物检验结果进行个体化治疗。比较两组之间的诊断准确率和治疗有效性。结果(1)经过微生物检验确认病原体后,试验组患者的假阴性结果明显减少,成功诊断了41例病例,诊断准确率高达95.35%,与采用常规检测的参考组相比存在显著统计学差异(P<0.05)。(2)根据微生物检验结果进行治疗后,在试验组中有25例患者在10天内完全消除相关症状,并且16例患者在20 d内完全康复。治疗效果为95.35%,与参考组相比具有显著差异(P<0.05)。此外,试验组仅有3例患者出现复发情况,复发率为6.98%,明显低于参考组(P<0.05)。结论在尿路感染的临床预防和诊治过程中,可以利用微生物检验方法提升对患者的准确诊断率,进而增强治疗效果。同时,还能够评估患者是否具有高风险,并有效地预防尿路感染的发生。

呋喃妥因对脊髓损伤伴耐甲氧西林金黄色葡萄球菌复杂性尿路感染的临床疗效分析

目的分析呋喃妥因对脊髓损伤伴耐甲氧西林金黄色葡萄球菌(MRSA)复杂性尿路感染的临床疗效。方法选择广东省工伤康复医院2022年1月~12月收治的脊髓损伤伴有MRSA复杂性尿路感染患者33例为研究对象。采用自身对照试验,分别于呋喃妥因治疗前、治疗7 d和治疗14 d进行血清炎症指标、尿常规指标检测,并观察药物不良反应和评估疗效。结果治疗7 d或14 d后,血清炎症指标白细胞(WBC)、中性粒细胞百分比(NEUT%)、C反应蛋白(CRP)和降钙素原(PCT)均比治疗前降低,差异有统计学意义(P<0.05);尿常规指标中的亚硝酸盐(U-NIT)、白细胞脂酶(LE)和尿细菌培养数的阳性率均比治疗前降低,差异有统计学意义(P<0.001);治疗7 d和14 d的不良反应发生率比较,差异无统计学意义(P>0.05);治疗14 d的总有效率达92.3%,高于治疗7 d的总有效率(85.0%),但差异无统计学意义(P>0.05),治疗后总有效例数29例(87.9%)。结论呋喃妥因可减轻脊髓损伤伴MRSA复杂性尿路感染患者的炎症反应,有效抑制MRSA,可治疗复杂性尿路感染。

复杂性尿路感染243例病原菌构成及药敏分析

目的分析复杂性尿路感染的病原菌构成及耐药性,为临床合理使用抗菌药物提供依据。方法收集四川省人民医院2014年1月—2016年12月的复杂性尿路感染243例,对临床资料及实验室检查进行回顾分析。结果 243例复杂性尿路感染共分离出289株病原菌,其中革兰阴性菌211株(73%)、革兰阳性菌55株(19.1%)、真菌23株(7.9%),主要病原菌为大肠埃希菌、肺炎克雷伯菌、屎肠球菌、粪肠球菌、光滑念珠菌及白念珠菌;医院获得复杂性尿路感染分离的肺炎克雷伯菌、肠球菌、光滑念珠菌,较社区获得复杂性尿路感染分离高。主要革兰阴性菌仅对碳青霉烯、哌拉西林/三唑巴坦、阿米卡星的敏感性较好,敏感率在80%以上,其中医院获得复杂性尿路感染分离的大肠埃希菌和肺炎克雷伯菌,除对碳青霉烯类保持高度敏感外,敏感率在92.9%以上,其余常用抗菌药物的敏感性均有不同程度下降,大肠埃希菌和肺炎克雷伯菌中ESBLs检出率分别为59%和44%;肠球菌对利奈唑胺100%敏感,屎肠球菌对万古霉素耐药率达13.8%;8株白念珠菌对常用抗真菌药物均敏感,9株光滑念珠菌中仅2株对氟康唑敏感。结论复杂性尿路感染病原菌以革兰阴性菌为主,ESBLs检出率高,耐药率较高,临床应根据复杂因素及病原菌和药敏结果合理选择抗菌药物。

输尿管镜术后泌尿道感染发病率及其危险因素

目的探讨输尿管镜术后感染的发病率及其危险因素。方法回顾性分析2002—2011年某院接受输尿管镜检查或输尿管镜下碎石术患者,收集其年龄、性别、既往史、合并症、尿常规、尿培养、血常规、是否留置导尿管或输尿管内支架以及抗菌药物的使用等临床资料,对所得数据进行分析。结果输尿管镜术后泌尿道感染的发病率为3.77%(20/531),其中输尿管镜检查术后泌尿道感染的发病率为5.84%(9/154),高于输尿管镜碎石术后的2.92%(11/377)(χ2=5.47,P=0.02)。术后感染患者以肾盂肾炎最常见(15例),分离主要病原菌为大肠埃希菌(6株)。预防性使用不同种类抗菌药物者泌尿道感染发病率差异无统计学意义(P=0.185)。菌尿症、肾积水、留置导尿管、术后无内支架管置入、未预防性使用抗菌药物患者泌尿道感染发病率较高(均P<0.05)。结论菌尿症、肾积水、留置导尿管、术后无内支架管置入、输尿管镜检查术、未预防性使用抗菌药物是输尿管镜术后泌尿道感染的危险因素。

老年患者尿路感染临床特点及中医辨证治疗

目的探讨老年患者尿路感染的临床特点、发病机理和中医分段辨证治疗。方法根据老年患者全身和局部的免疫防御功能下降而易患尿路感染且有症状不典型、复杂性、病情较严重等特点,阐明了该病的发病机制是以脾肾虚衰(正虚)为本,以湿热蕴结下焦(感邪)为标,即正虚邪实,故在临床治疗上应重视调理整体功能状况,采用急性发作阶段和非急性发作期2个阶段分别施以清热、化湿、通淋、止血,补益脾肾、佐以通淋等辨证治疗,标本兼顾。结果中医药治疗老年尿路感染采用分期论治,具有疗效高、不良反应少、远期疗效稳定的特点。结论中医药治疗老年尿路感染具有较大的潜力和优势,值得进一步研究。

抗菌药物在复杂性细菌性尿路感染中的合理应用

目的探讨复杂性细菌性尿路感染致病菌分布、耐药性特点和抗菌药物的合理应用。方法回顾分析2004年1月~2009年1月华中科技大学同济医学院附属同济医院188例住院复杂性尿路感染患者的临床资料及药敏实验结果。结果革兰阴性杆菌占69.1%（其中大肠埃希菌占40.4%,肺炎克雷白杆菌占8.5%）,球菌占26.6%（其中粪肠球菌占10.6%,屎肠球菌占7.4%,凝固酶阴性葡萄球菌占3.7%）,真菌占4.3%。76例大肠埃希菌产ESBL阳性率为48.2%,对阿莫西林/克拉维酸、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、头孢西丁、阿米卡星、碳青霉烯类、呋喃妥因的耐药率较低,而对氨苄西林、哌拉西林、头孢类、喹诺酮类的耐药率较高。结论大肠埃希菌仍为目前住院的复杂尿路感染的主要致病菌,耐药性高,且常呈多重耐药,而且是最常见的产超广谱β-内酰胺酶菌株的细菌,临床治疗应尽量根据药敏实验调整抗菌药物。

复发性尿路感染的细菌检验和药敏情况及治疗分析

目的:分析复发性尿路感染的细菌检验和药敏对治疗影响并探讨治疗对策。方法:86例复发性尿路感染患者分析其尿细菌培养及药敏情况,并把患者分成培养阳性组和阴性组,分析对治疗的影响。采用分期长疗程治疗及根据尿细菌培养及敏感试验和临床验证选用抗生素,并观察其疗效。结果:86例患者中30例(34.9%)尿细菌培养阳性,其中大肠埃希菌24例(80%)。总治愈率为89.5%(77/86),治愈的26例细菌培养阳性组和51例细菌培养阴性组在治疗期、巩固期、维持期和总疗程方面均差异无统计学意义。共进行药敏试验587药次,能用于门诊作长疗程的口服药计137药次。口服药中敏感和中介的68药次中,临床表现敏感的仅58药次(9.88%)。结论:复发性尿路感染的尿细菌检验对指导长疗程治疗有局限性,应采用分期治疗方法、并根据药敏试验及临床验证方法选用抗生素。

思维导图在经腹全子宫切除术后并发症预防护理中的应用

目的探讨思维导图式健康教育对经腹全子宫切除术患者并发症发生的影响。方法选择符合纳入标准的经腹全子宫手术患者139例，将2013年2～8月收治的60例患者设为对照组，2013年9月至2014年5月收治的79例患者设为导图组，两组术后均按妇科良性肿瘤治疗、护理常规进行，并针对经腹全子宫切除术后常见并发症进行健康教育。对照组采用随机的口头宣教方式进行健康教育，导图组予思维导图式健康教育。结果导图组切口愈合不良、腹部胀气、尿路感染、下肢静脉血栓发生率低于对照组，除下肢静脉血栓外，其他三项两组发生率比较，差异有统计学意义（均P〈0．05）。结论思维导图式健康教育可降低经腹全子宫切除术后并发症发生率，促进患者术后早日康复。