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The migration of human lens epithelial cells induced by UV-irradiation in vitro
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作者 Jin Yao Guoxing Yuan +2 位作者 Yuan Liu Yi Shen Qin Jiang 《Journal of Nanjing Medical University》 2008年第3期143-147,共5页
Objective: Ultraviolet (UV) radiation is one of the important cataract risk factors, However, the pathogenesis is still poorly understood. The migration of human lens epithelial cells(HLECs) plays a Clucial role ... Objective: Ultraviolet (UV) radiation is one of the important cataract risk factors, However, the pathogenesis is still poorly understood. The migration of human lens epithelial cells(HLECs) plays a Clucial role in the remodeling of lens capsule and cataract formation. The purpose of this study is to investigate the mechanism of UV inducing cataractogenesis. Methods:The toxicity of UV-irradiation on HLECs was assessed by Methyl thiazolyl tetrazolium(MTT) assay. The activity of matrix metalloproteinase-2(MMP-2) was observed by Gelatin zymography. The migration of HLECs was examined by Cell Track Motility. Results:UV-irradiation does great harm to HLECs, and may induce apoptosis in the cells when UV higher than 15 mj/cm2. UV significantly increased MMP-2 activity in a timedependent manner. In addition, the irradiation could induce the migration of HLECs. Conclusion:UV-irradiation could induce the migration of HLECs by increasing the activity of MMP-2. 展开更多
关键词 uv hlecs migration mmp-2
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