Dear Sir,UVA/riboflavin cross-linking （CXL） has been used clinically applied for the treatment of keratoconus and corneal edema via enhancement of corneal stiffness The safety of the corneal endothelium is of prime...Dear Sir,UVA/riboflavin cross-linking （CXL） has been used clinically applied for the treatment of keratoconus and corneal edema via enhancement of corneal stiffness The safety of the corneal endothelium is of prime importance during CXL treatment. In clinical practice, a corneal thickness （CT） of 400um has traditionally been regarded as the minimum treatable thickness, thereby avoiding damage to the corneal endothelium Although CXL has been applied to thinner corneas, using a hypoosmotic solution onto cornea and inducing edema . CXL safety still needs further evaluation because of lower relative concentration of collagen in the hydrated stroma . This study aims to evaluate the changes of corneal endothelial density （ECD） in cases where the CT is 〈400 um before iatrogenic corneal swelling and CXL treatment.展开更多
In this review,recent studies regarding riboflavin-ultraviolet A(UVA)collagen cross-linking for the treatment of acanthamoeba keratitis(AK)were reviewed.English written studies about acanthamoeba,keratitis,riboflavin ...In this review,recent studies regarding riboflavin-ultraviolet A(UVA)collagen cross-linking for the treatment of acanthamoeba keratitis(AK)were reviewed.English written studies about acanthamoeba,keratitis,riboflavin and collagen cross-linking were retrieved from PubMed search engine(www.ncbi.nlm.nih.gov/pubmed).Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK,experimental studies(in vivo and in vitro)failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen cross-linking.In conclusion,the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still debatable.It is necessary to conduct a prospective case-control study for clear guidance for clinicians.展开更多
目的:观察局部光化学疗法(Psoralen plus UVA,PUVA)治疗儿童白癜风的临床疗效及安全性。方法:采用小型UVA灯(电压220V,电流0.34A,功率25.4W,主波峰长365nm,辐照度为1070uw/cm2)治疗56例白癜风患儿,30次为一个疗程,共观察3个疗程。结果:...目的:观察局部光化学疗法(Psoralen plus UVA,PUVA)治疗儿童白癜风的临床疗效及安全性。方法:采用小型UVA灯(电压220V,电流0.34A,功率25.4W,主波峰长365nm,辐照度为1070uw/cm2)治疗56例白癜风患儿,30次为一个疗程,共观察3个疗程。结果:第一疗程、第二疗程及第三疗程结束后临床显效率分别达39.29%、48.21%和55.36%,未发现明显不良反应,其中病程短、局限性及面颈部白癜风患儿疗效佳。结论:局部PUVA治疗儿童白癜风安全、有效、不良反应小,小型UVA灯具有疗效好、治疗方便的优点。展开更多
文摘Dear Sir,UVA/riboflavin cross-linking （CXL） has been used clinically applied for the treatment of keratoconus and corneal edema via enhancement of corneal stiffness The safety of the corneal endothelium is of prime importance during CXL treatment. In clinical practice, a corneal thickness （CT） of 400um has traditionally been regarded as the minimum treatable thickness, thereby avoiding damage to the corneal endothelium Although CXL has been applied to thinner corneas, using a hypoosmotic solution onto cornea and inducing edema . CXL safety still needs further evaluation because of lower relative concentration of collagen in the hydrated stroma . This study aims to evaluate the changes of corneal endothelial density （ECD） in cases where the CT is 〈400 um before iatrogenic corneal swelling and CXL treatment.
基金The study is supported in part by a grant of Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(2016R1D1A1B03931724).
文摘In this review,recent studies regarding riboflavin-ultraviolet A(UVA)collagen cross-linking for the treatment of acanthamoeba keratitis(AK)were reviewed.English written studies about acanthamoeba,keratitis,riboflavin and collagen cross-linking were retrieved from PubMed search engine(www.ncbi.nlm.nih.gov/pubmed).Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK,experimental studies(in vivo and in vitro)failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen cross-linking.In conclusion,the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still debatable.It is necessary to conduct a prospective case-control study for clear guidance for clinicians.
文摘目的:观察局部光化学疗法(Psoralen plus UVA,PUVA)治疗儿童白癜风的临床疗效及安全性。方法:采用小型UVA灯(电压220V,电流0.34A,功率25.4W,主波峰长365nm,辐照度为1070uw/cm2)治疗56例白癜风患儿,30次为一个疗程,共观察3个疗程。结果:第一疗程、第二疗程及第三疗程结束后临床显效率分别达39.29%、48.21%和55.36%,未发现明显不良反应,其中病程短、局限性及面颈部白癜风患儿疗效佳。结论:局部PUVA治疗儿童白癜风安全、有效、不良反应小,小型UVA灯具有疗效好、治疗方便的优点。
