Ulcerative colitis(UC), an idiopathic inflammatory disorder in the colon, has become a clinical challenge, owing to the increasing incidence and poor prognosis. The conventional treatments for UC including aminosalicy...Ulcerative colitis(UC), an idiopathic inflammatory disorder in the colon, has become a clinical challenge, owing to the increasing incidence and poor prognosis. The conventional treatments for UC including aminosalicylates, corticosteroids, and immunosuppressants, induce remission in only half of patients. Meanwhile, the treatments often come with serious side effects which can be life-threatening. Herbal medicine, one of the most common traditional Chinese medicine modalities, has been introduced for centuries into clinical treatment of many human diseases such as infections and functional disorders. Recently, the potential effectiveness of herbs has been suggested as the treatment of UC, as shown by a variety of clinical trials and experimental studies. The herbs reported in the literature include aloe vera gel, butyrate, tormentil extracts, wheat grass juice, and curcumin. In the review, bioactivity of the herbs and their involvement in UC treatment are discussed.展开更多
Endoscopic submucosal dissection(ESD)is the standard treatment for early-stage gastric cancer,but the large post-operative ulcers caused by ESD often lead to serious side effects.Post-ESD mu-cosal repair materials pro...Endoscopic submucosal dissection(ESD)is the standard treatment for early-stage gastric cancer,but the large post-operative ulcers caused by ESD often lead to serious side effects.Post-ESD mu-cosal repair materials provide a new option for the treatment of post-ESD ulcers.In this study,we developed a polyurethane/small intestinal submucosa(PU/SIS)hydrogel and investigated its effi-cacy for accelerating ESD-induced ulcer healing in a canine model.PU/SIS hydrogel possessed great biocompatibility and distinctive pH-sensitive swelling properties and protected GES-1 cells from acid attack through forming a dense film in acidic conditions in vitro.Besides,PU/SIS gels present a strong bio-adhesion to gastric tissues under acidic conditions,thus ensuring the reten-tion time of PU/SIS gels in vivo.In a canine model,PU/SIS hydrogel was easily delivered via endoscopy and adhered to the ulcer sites.PU/SIS hydrogel accelerated gastric ulcer healing at an early stage with more epithelium regeneration and slight inflammation.Our findings reveal PU/SIS hydrogel is a promising and attractive candidate for ESD-induced ulcer repair.展开更多
The interstitial solution carbon concentration and defects in continuously annealed Ti＋Nb bearing ULC- BH （ultra-low carbon bake hardening） steel samples are investigated by multi-functional internal friction appar...The interstitial solution carbon concentration and defects in continuously annealed Ti＋Nb bearing ULC- BH （ultra-low carbon bake hardening） steel samples are investigated by multi-functional internal friction apparatus, positron annihilation lifetime spectroscopy （PALS） and coincidence Doppler broadening spectroscopy （CDBS）. The relationship of internal friction peaks, interstitial solution carbon concentrations and movable dislocations in the sam- ples under different conditions is analyzed. A correlation of lifetime component v~ values with interstitial solution car- bon concentrations in the samples for different continuous annealing processes is established, while a correlation of li- fetime component r2 values with multi-vacancies, vacancy clusters, microvoids and other types of defects for various continuous annealing processes is also demonstrated. Furthermore, the average lifetime results illustrate the overall defect densities for various continuous annealing processes. The CDBS analysis reflects the chemical surroundings of the defects at the annihilation sites and reveals that the peak heights of the ratio curves relate to the total number of defects such as interstitial carbon atoms, dislocations, vacancies and other types of defects. The results show that in- ternal friction, PALS and CDBS are effective techniques to identify and characterize the interstitial solution carbon concentration, multi-vacancies, vacancy clusters, microvoids and other types of microscopic defects in annealed Ti＋ Nb bearing ULC-BH steel.展开更多
基金Supported by National Natural Science Foundation of China,No.81470828,No.81270472 and No.81070310Science and Tech-nology Program of Education Department of Jiangxi Province,No.GJJ13138Natural Science Foundation of Jiangxi Province,No.20142BAB205048
文摘Ulcerative colitis(UC), an idiopathic inflammatory disorder in the colon, has become a clinical challenge, owing to the increasing incidence and poor prognosis. The conventional treatments for UC including aminosalicylates, corticosteroids, and immunosuppressants, induce remission in only half of patients. Meanwhile, the treatments often come with serious side effects which can be life-threatening. Herbal medicine, one of the most common traditional Chinese medicine modalities, has been introduced for centuries into clinical treatment of many human diseases such as infections and functional disorders. Recently, the potential effectiveness of herbs has been suggested as the treatment of UC, as shown by a variety of clinical trials and experimental studies. The herbs reported in the literature include aloe vera gel, butyrate, tormentil extracts, wheat grass juice, and curcumin. In the review, bioactivity of the herbs and their involvement in UC treatment are discussed.
基金This work was supported by The National Key R&D Program of China(2017YFC1104702)Sichuan Science and Technology Program(2019JDRC0020)the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC18002).
文摘Endoscopic submucosal dissection(ESD)is the standard treatment for early-stage gastric cancer,but the large post-operative ulcers caused by ESD often lead to serious side effects.Post-ESD mu-cosal repair materials provide a new option for the treatment of post-ESD ulcers.In this study,we developed a polyurethane/small intestinal submucosa(PU/SIS)hydrogel and investigated its effi-cacy for accelerating ESD-induced ulcer healing in a canine model.PU/SIS hydrogel possessed great biocompatibility and distinctive pH-sensitive swelling properties and protected GES-1 cells from acid attack through forming a dense film in acidic conditions in vitro.Besides,PU/SIS gels present a strong bio-adhesion to gastric tissues under acidic conditions,thus ensuring the reten-tion time of PU/SIS gels in vivo.In a canine model,PU/SIS hydrogel was easily delivered via endoscopy and adhered to the ulcer sites.PU/SIS hydrogel accelerated gastric ulcer healing at an early stage with more epithelium regeneration and slight inflammation.Our findings reveal PU/SIS hydrogel is a promising and attractive candidate for ESD-induced ulcer repair.
基金Item Sponsored by National Key Technology Research and Development Program in 11th Five-Year Plan of China(2006BAE03A13)
文摘The interstitial solution carbon concentration and defects in continuously annealed Ti＋Nb bearing ULC- BH （ultra-low carbon bake hardening） steel samples are investigated by multi-functional internal friction apparatus, positron annihilation lifetime spectroscopy （PALS） and coincidence Doppler broadening spectroscopy （CDBS）. The relationship of internal friction peaks, interstitial solution carbon concentrations and movable dislocations in the sam- ples under different conditions is analyzed. A correlation of lifetime component v~ values with interstitial solution car- bon concentrations in the samples for different continuous annealing processes is established, while a correlation of li- fetime component r2 values with multi-vacancies, vacancy clusters, microvoids and other types of defects for various continuous annealing processes is also demonstrated. Furthermore, the average lifetime results illustrate the overall defect densities for various continuous annealing processes. The CDBS analysis reflects the chemical surroundings of the defects at the annihilation sites and reveals that the peak heights of the ratio curves relate to the total number of defects such as interstitial carbon atoms, dislocations, vacancies and other types of defects. The results show that in- ternal friction, PALS and CDBS are effective techniques to identify and characterize the interstitial solution carbon concentration, multi-vacancies, vacancy clusters, microvoids and other types of microscopic defects in annealed Ti＋ Nb bearing ULC-BH steel.
