Uterine fibroids are common in females of reproductive age and substantially affecting fertility and quality of life. Current management strategies mainly involve surgical interventions. For treatment, options availab...Uterine fibroids are common in females of reproductive age and substantially affecting fertility and quality of life. Current management strategies mainly involve surgical interventions. For treatment, options available are surgical and non-surgical, but the mode of management leans on several factors, such as severity of symptoms, patient’s age, myoma characteristics, desire to preserve uterus and fertility. Alternative approach to surgery for the treatment of symptomatic females with uterine myomas has been recognized. Ulipristal acetate (UPA) has been the first selective progesterone-receptor modulator (SPRM) approved for the pre-operative and long-term management of uterine fibroids. There are evidences promoting an important role for progesterone pathways in the pathophysiology of uterine fibroids which supports the use of ulipristal acetate. The availability of alternative choices to surgical intervention is very necessary especially for those willing to preserve uterus and fertility. One of the alternatives is with ulipristal acetate, which has been proven to treat fibroid symptoms effectively.展开更多
目的:建立醋酸优力司特片有关物质检查方法。方法:以碳十八烷基键合硅胶柱为填充剂,0.01 mol·L^(-1)磷酸二氢钾溶液-乙腈(35∶65)为流动相,流量为1.0 m L·min^(-1),检测波长为304 nm。结果:醋酸优利司特片主成分色谱峰与主要...目的:建立醋酸优力司特片有关物质检查方法。方法:以碳十八烷基键合硅胶柱为填充剂,0.01 mol·L^(-1)磷酸二氢钾溶液-乙腈(35∶65)为流动相,流量为1.0 m L·min^(-1),检测波长为304 nm。结果:醋酸优利司特片主成分色谱峰与主要降解产物色谱峰能得到较好的分离,对特定杂质N-去甲基醋酸优力司特进行了控制。结论:所建方法能较好地控制该产品的有关物质。展开更多
Unintended pregnancy rates remain high throughout the World and increase the risk of poor maternal and infant outcomes.Most of unintended pregnancies occur in women who were not using contraceptionor who became pregna...Unintended pregnancy rates remain high throughout the World and increase the risk of poor maternal and infant outcomes.Most of unintended pregnancies occur in women who were not using contraceptionor who became pregnant despite the reported use of contraception.Women who have had recent unprotected intercourse including those who have had another form of contraception fail are potential candidates for this intervention.Currently used em-ergency contraceptive methods are pills that contain combined estrogen-progesterone,only progestin,antiprogestins and copper intrauterine devices.The most common form of this type of contraception is oral progestin-only pills(levonorgestrel).The most effective method is copper intrauterine devices followed by anti-progestins and oral progestin-only pills.The major pathogenesis of oral emergency contraceptives is the prevention or delay of ovulation.Although conception is possible on only a few days of the cycle,emergency contraception is offered when indicated without regard to the timing of the menstrual cycle because of uncertainty in the timing of the ovulation.Levonorgestrel and E/P regimes are most effective as soon as possible after unprotected sexual intercourse.A linear relationship has been shown between ef-fectiveness and the time of dose.The effectiveness continues for 120 h,but it is recommended to be used within 72 h after intercourse.Intrauterine devices may prevent pregnancy when 5 d after ovulation.展开更多
文摘Uterine fibroids are common in females of reproductive age and substantially affecting fertility and quality of life. Current management strategies mainly involve surgical interventions. For treatment, options available are surgical and non-surgical, but the mode of management leans on several factors, such as severity of symptoms, patient’s age, myoma characteristics, desire to preserve uterus and fertility. Alternative approach to surgery for the treatment of symptomatic females with uterine myomas has been recognized. Ulipristal acetate (UPA) has been the first selective progesterone-receptor modulator (SPRM) approved for the pre-operative and long-term management of uterine fibroids. There are evidences promoting an important role for progesterone pathways in the pathophysiology of uterine fibroids which supports the use of ulipristal acetate. The availability of alternative choices to surgical intervention is very necessary especially for those willing to preserve uterus and fertility. One of the alternatives is with ulipristal acetate, which has been proven to treat fibroid symptoms effectively.
文摘目的:建立醋酸优力司特片有关物质检查方法。方法:以碳十八烷基键合硅胶柱为填充剂,0.01 mol·L^(-1)磷酸二氢钾溶液-乙腈(35∶65)为流动相,流量为1.0 m L·min^(-1),检测波长为304 nm。结果:醋酸优利司特片主成分色谱峰与主要降解产物色谱峰能得到较好的分离,对特定杂质N-去甲基醋酸优力司特进行了控制。结论:所建方法能较好地控制该产品的有关物质。
文摘Unintended pregnancy rates remain high throughout the World and increase the risk of poor maternal and infant outcomes.Most of unintended pregnancies occur in women who were not using contraceptionor who became pregnant despite the reported use of contraception.Women who have had recent unprotected intercourse including those who have had another form of contraception fail are potential candidates for this intervention.Currently used em-ergency contraceptive methods are pills that contain combined estrogen-progesterone,only progestin,antiprogestins and copper intrauterine devices.The most common form of this type of contraception is oral progestin-only pills(levonorgestrel).The most effective method is copper intrauterine devices followed by anti-progestins and oral progestin-only pills.The major pathogenesis of oral emergency contraceptives is the prevention or delay of ovulation.Although conception is possible on only a few days of the cycle,emergency contraception is offered when indicated without regard to the timing of the menstrual cycle because of uncertainty in the timing of the ovulation.Levonorgestrel and E/P regimes are most effective as soon as possible after unprotected sexual intercourse.A linear relationship has been shown between ef-fectiveness and the time of dose.The effectiveness continues for 120 h,but it is recommended to be used within 72 h after intercourse.Intrauterine devices may prevent pregnancy when 5 d after ovulation.
