Objective:To investigate the clinical effects of applying the magnetic resonance double mismatch technique to endovascular treatment of acute anterior circulation,large vessel occlusion with cerebral infarction in an ...Objective:To investigate the clinical effects of applying the magnetic resonance double mismatch technique to endovascular treatment of acute anterior circulation,large vessel occlusion with cerebral infarction in an unknown time window.Methods:The research work was carried out in our hospital,the work was carried out from November 2018 to November 2019,the patients with acute anterior circulation large vessel occlusion with cerebral infarction who were treated in our hospital during this period,100 patients,50 patients with an unknown time window and 50 patients with definite time window were selected,and they were named as the experimental and control groups,given different examination methods,were given to investigate the clinical treatment effect.Results:Patients’data on HIHSS score before treatment,the incidence of intracranial hemorrhage and rate of Mrs≤2 rating after 90 days of treatment were not significantly different(P>0.05),which was not meaningful.The differences in data between the two groups concerning HIHSS scores were relatively significant before,and after treatment(P<0.05).Conclusion:The magnetic resonance double mismatch technique will be applied in the endovascular treatment of acute anterior circulation large vessel occlusion with cerebral infarction of unknown time window.展开更多
目的:观察 Solitaire AB 型支架取栓术治疗血栓栓塞造成的急性大脑中动脉闭塞或合并颈内动脉闭塞的效果。方法因急性血栓栓塞造成的单纯大脑中动脉闭塞患者5例、大脑中动脉闭塞合并同侧颈内动脉不同节段闭塞患者8例。13例患者在发病6 h...目的:观察 Solitaire AB 型支架取栓术治疗血栓栓塞造成的急性大脑中动脉闭塞或合并颈内动脉闭塞的效果。方法因急性血栓栓塞造成的单纯大脑中动脉闭塞患者5例、大脑中动脉闭塞合并同侧颈内动脉不同节段闭塞患者8例。13例患者在发病6 h 内接受了取栓治疗,利用 Solitaire AB 型支架取栓。结果13例患者中,10例闭塞血管再通、3例闭塞血管部分再通;出院时美国国立卫生研究院卒中量表(NIHSS)评分(中位数)为6(4)分,较术前 NIHSS 评分(中位数)19(4.5)分明显下降(P <0.01)。10例闭塞血管再通患者中,4例恢复良好(mRS 评分0~2分)、4例残疾(mRS 评分≥3分)、1例死于原发性肾病、1例死于心力衰竭;3例闭塞血管部分再通患者中,1例术后第90天随访 mRS 评分4分,2例因大面积脑梗死死亡。13例患者中,8例术后24 h 颅脑 CT 扫描示脑梗死灶内出血。结果 Solitaire AB 型支架取栓术治疗血栓栓塞造成的急性大脑中动脉闭塞或合并颈内动脉闭塞可获得较高的血管再通率,临床效果较好。展开更多
目的探讨颅脑CT血管成像(CTA)对判断急性脑梗死(ACI)患者预后的价值。方法对70例发病≤6 h ACI患者进行颅脑CTA检查,并评价患者入院时、出院时美国国立卫生研究院卒中量表(NIH-SS)评分和改良的Ranking量表(mRS)评分。结果CTA检...目的探讨颅脑CT血管成像(CTA)对判断急性脑梗死(ACI)患者预后的价值。方法对70例发病≤6 h ACI患者进行颅脑CTA检查,并评价患者入院时、出院时美国国立卫生研究院卒中量表(NIH-SS)评分和改良的Ranking量表(mRS)评分。结果CTA检查显示血管正常32例,大血管闭塞38例。血管闭塞组患者出院时NIHSS评分和mRS评分均高于无血管闭塞组,差异有统计学意义(P〈0.01,P〈0.001);两组出院时NIHSS评分、mRS评分均比入院时明显降低(均P〈0.001)。无血管闭塞组患者预后良好25例(78.1%),血管闭塞组预后良好17例(44.7%),两组差异有统计学意义(P〈0.01)。入院时NIHSS评分及CTA显示的血管状况与临床预后呈负相关(r=-0.25,P〈0.05;r=-0.73,P〈0.001),入院时NIHSS评分(OR 0.09,95%CI:0.07~0.12,P〈0.01)和血管是否闭塞(OR 0.12,95%CI:0.01~0.24,P〈0.05)与预后有关,是ACI预后的独立预测因素。无血管闭塞组患者进行溶栓或未溶栓治疗的预后良好比率(分别为66.7%、75.0%)差异无统计学意义(P〉0.05)。血管闭塞组溶栓治疗患者预后良好比率(58.8%)明显高于未溶栓治疗患者(31.8%)(P〈0.05)。结论血管闭塞的ACI患者预后较差,CTA对判断ACI患者的预后及选择溶栓治疗有意义。展开更多
目的研究动脉溶栓联合机械辅助治疗前后循环大动脉急性闭塞性脑梗死患者的有效性和安全性。方法 42例大动脉闭塞性脑梗死患者行动脉溶栓联合机械辅助治疗,分为前循环组(24例)、后循环组(18例),评估不同组别治疗前后的NIHSS评分(National...目的研究动脉溶栓联合机械辅助治疗前后循环大动脉急性闭塞性脑梗死患者的有效性和安全性。方法 42例大动脉闭塞性脑梗死患者行动脉溶栓联合机械辅助治疗,分为前循环组(24例)、后循环组(18例),评估不同组别治疗前后的NIHSS评分(National Institute of Health stroke scale)、GCS评分(Glasgow comascore,GCS)及治疗后血管再通率、BI(Barthel Index)优率、症状性颅内出血率、死亡率。结果前循环组卒中病因分型以心源性栓塞为主(15/24,62.5%),后循环组以动脉粥样硬化性血栓形成为主(5/18,72.2%),两组间比较,差异有统计学差异(P=0.026);前、后循环组患者,治疗后的NIHSS评分(8.3±4.9 vs.8.1±5.7)较治疗前(15.1±5.3vs.16.8±7.8)明显降低(P=0.001 vs.P=0.001)、GCS评分(13.9±4.4 vs.12.8±4.2)较治疗前(9.5±3.8 vs.9.6±3.7)明显提高(P=0.001 vs.P=0.021),后循环血管再通率(15/18,83.3%)有高于前循环(14/24,58.3%)趋势(P=0.830),前循环组患者颅内出血发生率(5/24,20.8%)明显高于后循环组(0,0%)(P=0.039),两组患者死亡率相似。结论动脉溶栓联合机械辅助治疗脑梗死能改善神经功能缺损,血管再通率高,更适用于后循环脑梗死的治疗。展开更多
文摘Objective:To investigate the clinical effects of applying the magnetic resonance double mismatch technique to endovascular treatment of acute anterior circulation,large vessel occlusion with cerebral infarction in an unknown time window.Methods:The research work was carried out in our hospital,the work was carried out from November 2018 to November 2019,the patients with acute anterior circulation large vessel occlusion with cerebral infarction who were treated in our hospital during this period,100 patients,50 patients with an unknown time window and 50 patients with definite time window were selected,and they were named as the experimental and control groups,given different examination methods,were given to investigate the clinical treatment effect.Results:Patients’data on HIHSS score before treatment,the incidence of intracranial hemorrhage and rate of Mrs≤2 rating after 90 days of treatment were not significantly different(P>0.05),which was not meaningful.The differences in data between the two groups concerning HIHSS scores were relatively significant before,and after treatment(P<0.05).Conclusion:The magnetic resonance double mismatch technique will be applied in the endovascular treatment of acute anterior circulation large vessel occlusion with cerebral infarction of unknown time window.
文摘目的探讨急性脑梗死患者脑血管异常与CT灌注成像(computed tomographic perfusion,CTP)参数的关系,以及对临床预后的影响。方法对75例发病6h内的颈内动脉系统急性脑梗死患者进行CT平扫、CTP及CT血管造影(CT angiography,CTA)检查,记录CTP各参数,同时评价病灶侧大血管情况;分别在发病时、发病第14天、发病第90天采用美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)、Barthel指数(Barthel index,BI)、改良的Rankin量表(modified rankinscale,mRS)评价临床神经功能缺损、日常生活能力及预后功能残疾水平。结果①75例患者CTA检查显示血管大致正常29例,大脑中动脉狭窄11例,大脑中动脉闭塞13例,颈内动脉狭窄6例,颈内动脉闭塞16例。②病灶侧血管狭窄组与血管闭塞组及血管正常组比较,患者缺血区脑血流(cerebral blood flow,CBF)异常面积、脑血容量(cerebral blood volume,CBV)异常面积、局部灌注达峰时间(time to peak,TTP)异常面积、梗死区相对CBF(relative CBF,rCBF)及相对CBV(relative CBV,rCBV)差异有统计学意义(P<0.05);其中血管闭塞组CTP的脑灌注参数异常改变均比血管正常组明显,且差异有统计学意义;血管狭窄组CTP的脑灌注参数仅CBF面积比血管正常组增加,且差异有统计学意义;血管闭塞组CTP的脑灌注异常范围(CBF面积、TTP面积、CBV面积)均明显大于血管狭窄组(P<0.05)。③患者发病时仅NIHSS评分在3组之间比较差异有统计学意义,血管正常组明显优于血管狭窄组和血管异常组;在发病第14天、发病第90天的NIHSS、BI、mRS评分在3组之间比较差异均有统计学意义(P<0.05),其中血管正常组各项评分均明显优于血管闭塞组患者(P<0.05)。结论急性脑梗死患者病灶侧血管异常与CTP显示的缺血范围相关,并且可以作为患者临床预后的评价指标。
文摘目的:观察 Solitaire AB 型支架取栓术治疗血栓栓塞造成的急性大脑中动脉闭塞或合并颈内动脉闭塞的效果。方法因急性血栓栓塞造成的单纯大脑中动脉闭塞患者5例、大脑中动脉闭塞合并同侧颈内动脉不同节段闭塞患者8例。13例患者在发病6 h 内接受了取栓治疗,利用 Solitaire AB 型支架取栓。结果13例患者中,10例闭塞血管再通、3例闭塞血管部分再通;出院时美国国立卫生研究院卒中量表(NIHSS)评分(中位数)为6(4)分,较术前 NIHSS 评分(中位数)19(4.5)分明显下降(P <0.01)。10例闭塞血管再通患者中,4例恢复良好(mRS 评分0~2分)、4例残疾(mRS 评分≥3分)、1例死于原发性肾病、1例死于心力衰竭;3例闭塞血管部分再通患者中,1例术后第90天随访 mRS 评分4分,2例因大面积脑梗死死亡。13例患者中,8例术后24 h 颅脑 CT 扫描示脑梗死灶内出血。结果 Solitaire AB 型支架取栓术治疗血栓栓塞造成的急性大脑中动脉闭塞或合并颈内动脉闭塞可获得较高的血管再通率,临床效果较好。
文摘目的探讨颅脑CT血管成像(CTA)对判断急性脑梗死(ACI)患者预后的价值。方法对70例发病≤6 h ACI患者进行颅脑CTA检查,并评价患者入院时、出院时美国国立卫生研究院卒中量表(NIH-SS)评分和改良的Ranking量表(mRS)评分。结果CTA检查显示血管正常32例,大血管闭塞38例。血管闭塞组患者出院时NIHSS评分和mRS评分均高于无血管闭塞组,差异有统计学意义(P〈0.01,P〈0.001);两组出院时NIHSS评分、mRS评分均比入院时明显降低(均P〈0.001)。无血管闭塞组患者预后良好25例(78.1%),血管闭塞组预后良好17例(44.7%),两组差异有统计学意义(P〈0.01)。入院时NIHSS评分及CTA显示的血管状况与临床预后呈负相关(r=-0.25,P〈0.05;r=-0.73,P〈0.001),入院时NIHSS评分(OR 0.09,95%CI:0.07~0.12,P〈0.01)和血管是否闭塞(OR 0.12,95%CI:0.01~0.24,P〈0.05)与预后有关,是ACI预后的独立预测因素。无血管闭塞组患者进行溶栓或未溶栓治疗的预后良好比率(分别为66.7%、75.0%)差异无统计学意义(P〉0.05)。血管闭塞组溶栓治疗患者预后良好比率(58.8%)明显高于未溶栓治疗患者(31.8%)(P〈0.05)。结论血管闭塞的ACI患者预后较差,CTA对判断ACI患者的预后及选择溶栓治疗有意义。
文摘目的研究动脉溶栓联合机械辅助治疗前后循环大动脉急性闭塞性脑梗死患者的有效性和安全性。方法 42例大动脉闭塞性脑梗死患者行动脉溶栓联合机械辅助治疗,分为前循环组(24例)、后循环组(18例),评估不同组别治疗前后的NIHSS评分(National Institute of Health stroke scale)、GCS评分(Glasgow comascore,GCS)及治疗后血管再通率、BI(Barthel Index)优率、症状性颅内出血率、死亡率。结果前循环组卒中病因分型以心源性栓塞为主(15/24,62.5%),后循环组以动脉粥样硬化性血栓形成为主(5/18,72.2%),两组间比较,差异有统计学差异(P=0.026);前、后循环组患者,治疗后的NIHSS评分(8.3±4.9 vs.8.1±5.7)较治疗前(15.1±5.3vs.16.8±7.8)明显降低(P=0.001 vs.P=0.001)、GCS评分(13.9±4.4 vs.12.8±4.2)较治疗前(9.5±3.8 vs.9.6±3.7)明显提高(P=0.001 vs.P=0.021),后循环血管再通率(15/18,83.3%)有高于前循环(14/24,58.3%)趋势(P=0.830),前循环组患者颅内出血发生率(5/24,20.8%)明显高于后循环组(0,0%)(P=0.039),两组患者死亡率相似。结论动脉溶栓联合机械辅助治疗脑梗死能改善神经功能缺损,血管再通率高,更适用于后循环脑梗死的治疗。