A new unconjugated saliva estriol （SE<sub>3</sub>） determination by radioimmunoassay（<sup>3</sup>H-E<sub>3</sub>） was used to monitor 497 fetuses of late pregnancies, including ...A new unconjugated saliva estriol （SE<sub>3</sub>） determination by radioimmunoassay（<sup>3</sup>H-E<sub>3</sub>） was used to monitor 497 fetuses of late pregnancies, including 280 high-risk and217 normal pregnant women. The normal pregnant SE<sub>3</sub> values had been established by themeasurement of 1378 cases from 20 to 41 weeks of gestation. The results of SE<sub>3</sub> assaysrevealed that 1. In prenatal prediction of fetal well-being, the total false negative andfalse positive rates were 2.0% and 0.6%, respectively, the correct rate which was similarto that of serum free E<sub>3</sub> （SFE<sub>3</sub>） values was 97.4%, and was significantly higher thanthat of overnight 12-hour urine E<sub>3</sub>/C analyses as formerly reported. 2. There were 8 fetaldeathe in 11 cases with low SE<sub>3</sub> levels. No perinatal death occurred in the 486 cases withnormal SE<sub>3</sub> values, except one fetus who died of nuchal cord strangulation. It is highlyimportant that the saliva specimen be correctly collected and the technique ofmeasurement of SE<sub>3</sub> be carefully carried out. Our observations suggest that the clinicaluse of SE<sub>3</sub> assays are scientific, reliable, and it is more practicable than that of SFE3 as-says. The determination of SFE<sub>3</sub> can be replaced by SE<sub>3</sub> test for assessing fetal-placentalwell-being.展开更多
文摘A new unconjugated saliva estriol （SE<sub>3</sub>） determination by radioimmunoassay（<sup>3</sup>H-E<sub>3</sub>） was used to monitor 497 fetuses of late pregnancies, including 280 high-risk and217 normal pregnant women. The normal pregnant SE<sub>3</sub> values had been established by themeasurement of 1378 cases from 20 to 41 weeks of gestation. The results of SE<sub>3</sub> assaysrevealed that 1. In prenatal prediction of fetal well-being, the total false negative andfalse positive rates were 2.0% and 0.6%, respectively, the correct rate which was similarto that of serum free E<sub>3</sub> （SFE<sub>3</sub>） values was 97.4%, and was significantly higher thanthat of overnight 12-hour urine E<sub>3</sub>/C analyses as formerly reported. 2. There were 8 fetaldeathe in 11 cases with low SE<sub>3</sub> levels. No perinatal death occurred in the 486 cases withnormal SE<sub>3</sub> values, except one fetus who died of nuchal cord strangulation. It is highlyimportant that the saliva specimen be correctly collected and the technique ofmeasurement of SE<sub>3</sub> be carefully carried out. Our observations suggest that the clinicaluse of SE<sub>3</sub> assays are scientific, reliable, and it is more practicable than that of SFE3 as-says. The determination of SFE<sub>3</sub> can be replaced by SE<sub>3</sub> test for assessing fetal-placentalwell-being.
