BACKGROUND Insulin injection is the basic daily drug treatment for diabetic patients.AIM To evaluate the comparative impacts of continuous subcutaneous insulin infusion(CSII).METHODS Based on the treatment modality re...BACKGROUND Insulin injection is the basic daily drug treatment for diabetic patients.AIM To evaluate the comparative impacts of continuous subcutaneous insulin infusion(CSII).METHODS Based on the treatment modality received,the patients were allocated into two cohorts:The CSII group and the multiple daily injections(MDI)group,with each cohort comprising 210 patients.Comparative assessments were made regarding serum levels of serum-secreted frizzled-related protein 5,homocysteine,and C1q/TNF-related protein 9.Furthermore,outcomes such as fasting plasma glucose,2-hour postprandial glucose levels,pain assessment scores,and the incidence of complications were evaluated post-treatment.RESULTS The CSII group displayed notably lower fasting plasma glucose and 2-h postprandial glucose levels in comparison to the MDI group(P<0.05).Subsequent analysis post-treatment unveiled a significantly higher percentage of patients reporting no pain in the CSII group(60.00%)in contrast to the MDI group(36.19%)(P<0.05).Additionally,the CSII group exhibited a markedly reduced occurrence of fetal distress and premature rupture of membranes compared to the MDI group(P<0.05).However,there were no significant variances observed in other pregnancy outcomes between the two groups(P>0.05).A statistical analysis revealed a significant difference in the incidence of complications between the groups(χ^(2)=11.631,P=0.001).CONCLUSION The utilization of CSII via an insulin pump,as opposed to MDI,can significantly enhance the management of insulin administration in patients with GDM by diversifying the sites of insulin delivery.This approach not only promotes optimal glycemic control but also regulates metabolic factors linked to blood sugar,reducing the likelihood of adverse pregnancy outcomes and complications.The clinical relevance and importance of CSII in GDM management highlight its wide-ranging clinical usefulness.展开更多
目的探究胰岛素泵治疗儿童1型糖尿病的临床效果及安全性。方法计算机检索1995年1月至2018年2月在中国期刊全文数据库、万方数据库、维普中文科技期刊全文数据库、中国生物医学文献数据库、EMBase及Cochrane Library等中英文数据库发表...目的探究胰岛素泵治疗儿童1型糖尿病的临床效果及安全性。方法计算机检索1995年1月至2018年2月在中国期刊全文数据库、万方数据库、维普中文科技期刊全文数据库、中国生物医学文献数据库、EMBase及Cochrane Library等中英文数据库发表的关于胰岛素泵与胰岛素多次皮下注射治疗1型糖尿病的文献,主要观察指标包括血糖达标时间、胰岛素用量及低血糖发生率。对纳入文献进行方法学质量评价,应用Rev Man 5.2软件对2组患儿血糖达标时间、胰岛素用量及低血糖发生率进行Meta分析。结果按照纳入与排除标准最终纳入8篇文献,经文献质量评价,2组患儿基本资料具有可比性、研究数据明确可靠,均为B级质量。共564例患儿,其中观察组280例,对照组284例,观察组血糖达标时间短于对照组(P<0.00001,均数差=-1.73,95%置信区间:-1.97^-1.49),胰岛素用量低于对照组(P<0.00001,均数差=-10.32,95%置信区间:-11.19^-9.45),低血糖发生率低于对照组(P<0.00001,率差=-0.20,95%置信区间:-0.27^-0.14)。结论胰岛素泵治疗儿童1型糖尿病临床效果确切,可缩短血糖达标时间、减少胰岛素用量、降低低血糖发生率。展开更多
文摘BACKGROUND Insulin injection is the basic daily drug treatment for diabetic patients.AIM To evaluate the comparative impacts of continuous subcutaneous insulin infusion(CSII).METHODS Based on the treatment modality received,the patients were allocated into two cohorts:The CSII group and the multiple daily injections(MDI)group,with each cohort comprising 210 patients.Comparative assessments were made regarding serum levels of serum-secreted frizzled-related protein 5,homocysteine,and C1q/TNF-related protein 9.Furthermore,outcomes such as fasting plasma glucose,2-hour postprandial glucose levels,pain assessment scores,and the incidence of complications were evaluated post-treatment.RESULTS The CSII group displayed notably lower fasting plasma glucose and 2-h postprandial glucose levels in comparison to the MDI group(P<0.05).Subsequent analysis post-treatment unveiled a significantly higher percentage of patients reporting no pain in the CSII group(60.00%)in contrast to the MDI group(36.19%)(P<0.05).Additionally,the CSII group exhibited a markedly reduced occurrence of fetal distress and premature rupture of membranes compared to the MDI group(P<0.05).However,there were no significant variances observed in other pregnancy outcomes between the two groups(P>0.05).A statistical analysis revealed a significant difference in the incidence of complications between the groups(χ^(2)=11.631,P=0.001).CONCLUSION The utilization of CSII via an insulin pump,as opposed to MDI,can significantly enhance the management of insulin administration in patients with GDM by diversifying the sites of insulin delivery.This approach not only promotes optimal glycemic control but also regulates metabolic factors linked to blood sugar,reducing the likelihood of adverse pregnancy outcomes and complications.The clinical relevance and importance of CSII in GDM management highlight its wide-ranging clinical usefulness.
文摘目的探究胰岛素泵治疗儿童1型糖尿病的临床效果及安全性。方法计算机检索1995年1月至2018年2月在中国期刊全文数据库、万方数据库、维普中文科技期刊全文数据库、中国生物医学文献数据库、EMBase及Cochrane Library等中英文数据库发表的关于胰岛素泵与胰岛素多次皮下注射治疗1型糖尿病的文献,主要观察指标包括血糖达标时间、胰岛素用量及低血糖发生率。对纳入文献进行方法学质量评价,应用Rev Man 5.2软件对2组患儿血糖达标时间、胰岛素用量及低血糖发生率进行Meta分析。结果按照纳入与排除标准最终纳入8篇文献,经文献质量评价,2组患儿基本资料具有可比性、研究数据明确可靠,均为B级质量。共564例患儿,其中观察组280例,对照组284例,观察组血糖达标时间短于对照组(P<0.00001,均数差=-1.73,95%置信区间:-1.97^-1.49),胰岛素用量低于对照组(P<0.00001,均数差=-10.32,95%置信区间:-11.19^-9.45),低血糖发生率低于对照组(P<0.00001,率差=-0.20,95%置信区间:-0.27^-0.14)。结论胰岛素泵治疗儿童1型糖尿病临床效果确切,可缩短血糖达标时间、减少胰岛素用量、降低低血糖发生率。
