The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular a...The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group （n = 55） and a diabetes and ischemic stroke group （n = 62）. We then performed ABI and BaPWV examinations for all patients. Compared with the diabe- tes-only group, we found decreased ABI and increased BaPWV in the diabetes and ischemic stroke group. Multivariate logistic regression analyses revealed that BaPWV and ABI were risk factors for ischemic stroke in patients with type 2 diabetes. Our findings indicate that decreased ABI and increased BaPWV are objective indicators of increased risk of ischemic stroke in patients with type 2 diabetes.展开更多
The current study presents a new protocol for local pulse wave velocity (PWV) measurement using dynamic MR sequences, which have a high temporal resolution (TR < 6 ms). MR images were obtained at two positions alon...The current study presents a new protocol for local pulse wave velocity (PWV) measurement using dynamic MR sequences, which have a high temporal resolution (TR < 6 ms). MR images were obtained at two positions along the common carotid artery, separated by a distance of 5 cm. In each phase of a MR series, carotid region was automatically extracted and then its area distension waveform could be obtained. Sixteen volunteers with no symptoms of cardiovascular diseases were studied. For local PWV estimation, three delay estimation principles were tested and produced the following values: intersecting tangents method (M1): 4.72 ± 1.40 m/s, second derivative method (M2): 4.94 ± 1.68 m/s and cross-correlation method (M3): 5.03 ± 1.17 m/s. The cross-correlation method showed a relative high reliability as its least standard deviation.展开更多
Objective:Acoustic radiation force impulse(ARFI)was applied to measure Shear wave velocity(SWV)of liver in patients with Wilson's disease(WD).To investigate the relationship between SWV and the serological indexes...Objective:Acoustic radiation force impulse(ARFI)was applied to measure Shear wave velocity(SWV)of liver in patients with Wilson's disease(WD).To investigate the relationship between SWV and the serological indexes of liver fibrosis,such as type Ⅳ collagen(CⅣ),hyaluronic acid(HA),type Ⅲ procollagen peptide(PⅢNP),laminin(LN),APRI score(Asparate Aminotransfer to Platelet Ratio Index),and FIB-4 index(FIB-4 index).The clinical efficacy of GandouTang(GDT)in the treatment of liver fibrosis in WD with damp-heat internalization was also observed.Methods:80 cases of WD patients who met the inclusion criteria were randomly divided into the treatment group and the control group,with 40 cases in each group.The control group was treated with Sodium Dimercaptopropylsulfonate(DMPS)and the treatment group was additionally treated with the traditional Chinese medicine GDT.One course for 8 days,a total of 6 courses.The levels of SwV and four serological indicators of liver fibrosis(PⅢNP,HA,CⅣ,LN),APRI score and FIB-4 index were compared before and after treatment.Pearson correlation test was used to analyze the correlation between SWV and HA,CⅣ,LN,PⅢNP,APRI score and FIB-4 index.The effects of GDT on SWV,liver fiber,APRI and FIB-4 were evaluated according to the treatment plan.Results:①The SWV was positively correlated with FIB-4(r=0.83),APRI(r=0.82),HA(r=0.87),CⅣ(r=0.71),LN(r=0.85)and PINP(r=0.77).②Before treatment,there were no significant differences in SWV level,PⅢNP,HA,CⅣ,LN,APRI and FIB-4 levels between two groups(P>0.05).After treatment,the levels of PⅢNP,HA,LN,SWV,APRI and FIB-4 in both groups were significantly decreased(P<0.05,P<0.01),and the levels in the treatment group were lower than those in the control group.There were no significant specific changes in CⅣ level(P>0.05).Conclusion:SWV value can reflect the degree of WD liver fibrosis,and is positively correlated with HA,PⅢNP,CⅣ,LN,FIB-4 index and APRI score.On the basis of the treatment of protecting liver and expelling copper with western medicine,plus the treatment of traditional Chinese medicine GDT can effectively improve the degree of liver fibrosis in WD patients with damp-heat accumulation.展开更多
目的:探讨基于极速成像技术的原发性高血压患者的脉象客观化研究。方法:对67例原发性高血压患者及63例健康人(对照组)行颈动脉极速成像技术检测及桡动脉脉象检测。应用法国Supersonic Aixplorer彩色多普勒超声诊断仪,内置UltraFast极速...目的:探讨基于极速成像技术的原发性高血压患者的脉象客观化研究。方法:对67例原发性高血压患者及63例健康人(对照组)行颈动脉极速成像技术检测及桡动脉脉象检测。应用法国Supersonic Aixplorer彩色多普勒超声诊断仪,内置UltraFast极速成像技术检测颈动脉脉搏波传导速度(pulse wave velocity,PWV),包括收缩期起始(beginning of the systole,BS)时及收缩期结束(ending of the systole,ES)时的PWV;应用DDMX-100脉象仪检测桡动脉脉象参数,包括h1、h3、h4、h5、h3/h1、h4/h1、h5/h1、w1、w2、w1/t、w2/t;分析两组数据,并采用Spearman非参数法对两种技术参数进行相关性分析。结果:原发性高血压组h1、h3、h3/h1、h4/h1、w2/t增高,h5/h1降低(P <0.05)。BS和ES时,高血压组的PWV均显著高于对照组(P <0.01)。对照组BS、ES时的PWV与h3/h1、h4/h1呈正相关(P <0.05),原发性高血压组BS、ES时的PWV与h4、h3/h1、h4/h1呈正相关(P <0.05)。结论:原发性高血压患者脉象参数与极速成像技术参数间具有良好的相关性,进一步完善了脉象的客观化研究。展开更多
文摘The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group （n = 55） and a diabetes and ischemic stroke group （n = 62）. We then performed ABI and BaPWV examinations for all patients. Compared with the diabe- tes-only group, we found decreased ABI and increased BaPWV in the diabetes and ischemic stroke group. Multivariate logistic regression analyses revealed that BaPWV and ABI were risk factors for ischemic stroke in patients with type 2 diabetes. Our findings indicate that decreased ABI and increased BaPWV are objective indicators of increased risk of ischemic stroke in patients with type 2 diabetes.
文摘The current study presents a new protocol for local pulse wave velocity (PWV) measurement using dynamic MR sequences, which have a high temporal resolution (TR < 6 ms). MR images were obtained at two positions along the common carotid artery, separated by a distance of 5 cm. In each phase of a MR series, carotid region was automatically extracted and then its area distension waveform could be obtained. Sixteen volunteers with no symptoms of cardiovascular diseases were studied. For local PWV estimation, three delay estimation principles were tested and produced the following values: intersecting tangents method (M1): 4.72 ± 1.40 m/s, second derivative method (M2): 4.94 ± 1.68 m/s and cross-correlation method (M3): 5.03 ± 1.17 m/s. The cross-correlation method showed a relative high reliability as its least standard deviation.
文摘三维超快成像是超声技术发展的重要方向.基于二维全采样阵列的传统三维成像方法需要较多成像阵元和采样通道,其紧密的阵元排列设计也客观上限制了阵列孔径大小和成像分辨率.行列寻址(row-column addressing,RCA)探头以行列检索的方式将通道数自N×N减少为N+N,从而极大地降低了阵列的硬件实现成本.本文仿真了中心频率为6MHz的128行+128列的RCA阵列,结合多角度平面波正交复合成像方法,通过延时叠加(delay and sum,DAS)波束合成、基于特征值分解(singular value decomposition,SVD)的杂波滤除和自相关多普勒速度求解算法,实现了血流仿体的多普勒成像,并分析了不同复合角度序列对成像效果的影响.定量分析表明,当角度数从5个增至33个时,-6 dB分辨率从0.986 mm提升至0.493 mm;当复合角度为17个时,功率多普勒图像的SNR可达30 dB,彩色多普勒沿直径方向的速度分布和真实值的平均误差约为26.0%.以上结果表明,基于RCA阵列的三维成像技术能够获得三维B-mode、功率多普勒和彩色多普勒图像,增大复合平面波角度数和角度范围可显著提高成像质量.本研究对于三维超快超声多普勒成像技术发展具有借鉴意义,相关方法有应用于血流血管成像,并进一步实现基于神经-血管耦合的组织功能监测与成像的潜力和前景.
基金Training Program for Young Qhuang Scholars[Chinese Medicine Education Letter(2022)No.256]Key Research and Development Program of Anhui Province(No.202204295107020001)+1 种基金Anhui Young Leaders Reserve Talent Project[No.4,Middle Development(2022)]National Natural Science Foundation of China(No.81973825,82104783)。
文摘Objective:Acoustic radiation force impulse(ARFI)was applied to measure Shear wave velocity(SWV)of liver in patients with Wilson's disease(WD).To investigate the relationship between SWV and the serological indexes of liver fibrosis,such as type Ⅳ collagen(CⅣ),hyaluronic acid(HA),type Ⅲ procollagen peptide(PⅢNP),laminin(LN),APRI score(Asparate Aminotransfer to Platelet Ratio Index),and FIB-4 index(FIB-4 index).The clinical efficacy of GandouTang(GDT)in the treatment of liver fibrosis in WD with damp-heat internalization was also observed.Methods:80 cases of WD patients who met the inclusion criteria were randomly divided into the treatment group and the control group,with 40 cases in each group.The control group was treated with Sodium Dimercaptopropylsulfonate(DMPS)and the treatment group was additionally treated with the traditional Chinese medicine GDT.One course for 8 days,a total of 6 courses.The levels of SwV and four serological indicators of liver fibrosis(PⅢNP,HA,CⅣ,LN),APRI score and FIB-4 index were compared before and after treatment.Pearson correlation test was used to analyze the correlation between SWV and HA,CⅣ,LN,PⅢNP,APRI score and FIB-4 index.The effects of GDT on SWV,liver fiber,APRI and FIB-4 were evaluated according to the treatment plan.Results:①The SWV was positively correlated with FIB-4(r=0.83),APRI(r=0.82),HA(r=0.87),CⅣ(r=0.71),LN(r=0.85)and PINP(r=0.77).②Before treatment,there were no significant differences in SWV level,PⅢNP,HA,CⅣ,LN,APRI and FIB-4 levels between two groups(P>0.05).After treatment,the levels of PⅢNP,HA,LN,SWV,APRI and FIB-4 in both groups were significantly decreased(P<0.05,P<0.01),and the levels in the treatment group were lower than those in the control group.There were no significant specific changes in CⅣ level(P>0.05).Conclusion:SWV value can reflect the degree of WD liver fibrosis,and is positively correlated with HA,PⅢNP,CⅣ,LN,FIB-4 index and APRI score.On the basis of the treatment of protecting liver and expelling copper with western medicine,plus the treatment of traditional Chinese medicine GDT can effectively improve the degree of liver fibrosis in WD patients with damp-heat accumulation.
文摘目的:探讨基于极速成像技术的原发性高血压患者的脉象客观化研究。方法:对67例原发性高血压患者及63例健康人(对照组)行颈动脉极速成像技术检测及桡动脉脉象检测。应用法国Supersonic Aixplorer彩色多普勒超声诊断仪,内置UltraFast极速成像技术检测颈动脉脉搏波传导速度(pulse wave velocity,PWV),包括收缩期起始(beginning of the systole,BS)时及收缩期结束(ending of the systole,ES)时的PWV;应用DDMX-100脉象仪检测桡动脉脉象参数,包括h1、h3、h4、h5、h3/h1、h4/h1、h5/h1、w1、w2、w1/t、w2/t;分析两组数据,并采用Spearman非参数法对两种技术参数进行相关性分析。结果:原发性高血压组h1、h3、h3/h1、h4/h1、w2/t增高,h5/h1降低(P <0.05)。BS和ES时,高血压组的PWV均显著高于对照组(P <0.01)。对照组BS、ES时的PWV与h3/h1、h4/h1呈正相关(P <0.05),原发性高血压组BS、ES时的PWV与h4、h3/h1、h4/h1呈正相关(P <0.05)。结论:原发性高血压患者脉象参数与极速成像技术参数间具有良好的相关性,进一步完善了脉象的客观化研究。
