Application of three-dimensional speckle tracking technique in measuring left ventricular myocardial function in patients with diabetes

BACKGROUND Diabetic cardiomyopathy is considered as a chronic complication of diabetes mellitus(DM).Therefore,early detection of left ventricular systolic function(LVSF)damage in DM is essential.AIM To explore the use of the three-dimensional speckle tracking technique(3D-STI)for measuring LVSF in DM patients via meta-analysis.METHODS The electronic databases were retrieved from the initial accessible time to 29 April 2023.The current study involved 9 studies,including 970 subjects.We carried out this meta-analysis to estimate myocardial function in DM compared with controls according to myocardial strain attained by 3D-STI.RESULTS Night articles including 970 subjects were included.No significant difference was detected in the left ventricular ejection fraction between the control and the diabetic group(P>0.05),while differences in global longitudinal strain,global circumferential strain,global radial strain,and global area strain were markedly different between the controls and DM patients(all P<0.05).CONCLUSION The 3D-STI could be applied to accurately measure early LVSF damage in patients with DM.

Left Ventricular Systolic Strain of the Cardiac Allograft Evaluated with Three-dimensional Speckle Tracking Echocardiography

Three-dimensional speckle tracking echocardiography was employed to evaluate the changes of left ventricular systolic strain in 23 heart transplant recipients at 1 st, 3rd, 6th and 12th month after heart transplantation, and 23 healthy subjects served as controls. The three-dimensional full-volume echocardiographic images of left ventricle were recorded and then were analyzed using EchoPAC software. The strain curves and peak systolic strain values for each segment and overall left ventricular wall were obtained. Left ventricular global peak longitudinal strain （GPSL）, global peak radial strain （GPSR）, global peak circumferential strain （GPSC） and global peak area strain （GPSA） were measured and then statistically analyzed. There were no significant differences in left ventricular ejection fraction （LVEF） and cardiac output （CO） between heart transplant recipients and controls. The GPSL in heart transplant recipients at 1st month after surgery was significantly lower than that in controls, but close to the normal value at 3rd month after surgery and later. The GPSC, GPSA and GPSR were significantly lower in heart transplant recipients at 1 st, 3rd, 6th and 12th month after surgery than those in controls. It is suggested that three-dimensional speckle tracking echocardiography can be used for monitoring changes of left ventricular systolic strains and evaluating left ventricular systolic function in cardiac allograft.

Value of myocardial function in children with Kawasaki disease by two-dimensional and three-dimensional ultrasound speckle tracking

Objective:To investigate the value of two-dimensional ultrasound speckle tracking(2D-STI)and three-dimensional ultrasound speckle tracking(3D-STI)in evaluating myocardial function in children with Kawasaki disease.Methods 92 children with Kawasaki disease admitted to our hospital from February 2017 to February 2019 were retrospectively analyzed.50 children who underwent 3D-STI examination were taken as observation group and 42 children who underwent 2D-STI examination were taken as control group.The left ventricular systolic function index,storage time and analysis time of the image,the diameter of coronary artery,the strain difference of left ventricular basal segment,middle segment,apical segment and whole segment were observed.Results The levels of left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular myocardial mass(LVMI)in the observation group were higher than those in the control group(P<0.05),but there was no statistical difference in left ventricular ejection fraction(LVEF)between the two groups(P>0.05).The storage time and analysis time of the image in the observation group were significantly lower than those in the control group(P<0.05).The left coronary artery(LCA)and right coronary artery(RCA)in the observation group were higher than those in the control group(P<0.05).There was no statistical difference between left anterior descending(LAD)in the two groups(P>0.05).The longitudinal peak systolic strain(LS),circumferential peak systolic strain(CS)and radial peak systolic strain(RS)in the observation group were higher than those in the control group(P<0.05).The global longitudinal peak strain(GLS),global circumferential peak strain(GCS)and global radial peak strain(GRS)in the observation group were higher than those in the control group(P<0.05).LS and CS in the middle segment of the observation group were higher than those in the control group(P<0.05).Conclusions Compared with 2D-STI,3D-STI can objectively and accurately reflect the myocardial function of children with Kawasaki disease.

Correlation between three-dimensional speckle tracking parameters and serum index changes during left ventricular remodeling in patients with coronary heart disease

Objective:To study the correlation between three-dimensional speckle tracking parameters and serum index changes during left ventricular remodeling in patients with coronary heart disease. Methods: Patients who were diagnosed with coronary heart disease and angina pectoris in our hospital between March 2015 and May 2017 were selected as the CHD group of the study, and the healthy subjects who received medical examination in our hospital during the same period were taken as the control group;the three-dimensional speckle tracking parameters, peripheral blood signal molecule expression as well as serum cytokine and collagen metabolism index levels of the two groups were measured.Results: GLS and AGS levels in CHD group were significantly lower than those in control group whereas GCS and GRS levels were not significantly different from those in control group, and peripheral blood Notch1, Hes1, NF-κB and PKC expression intensity as well as serum sTWEAK, FGF23, TGF-β1, GDF15, sSema4D, CaN, MMP14, PINP and ICTP contents were significantly higher than those of control group;GLS and AGS levels in CHD group were negatively correlated with peripheral blood Notch1, Hes1, NF-κB and PKC expression intensity as well as serum sTWEAK, FGF23, TGF-β1, GDF15, sSema4D, CaN, MMP14, PINP and ICTP contents.Conclusions:The changes of three-dimensional speckle tracking parameters GLS and AGS in patients with coronary heart disease are closely related to the changes in signal pathway function, cytokine secretion and collagen metabolism during left ventricular remodeling.

Correlation between three-dimensional speckle tracking imaging parameter and the cardiotoxicity of chemotherapeutics in patients with lung cancer chemotherapy

Objective: To study the correlation between three-dimensional speckle tracking imaging (3D-STI) parameter global area strain (GAS) and the cardiotoxicity of chemotherapeutics in patients with lung cancer chemotherapy. Methods: Patients with lung cancer who underwent chemotherapy in the Second Affiliated Hospital of Xi'an Medical University between February 2016 and May 2017 were selected as the chemotherapy group, the healthy subjects who received physical examination during the same period were selected as the control group, the 3D-STI examination was performed and GAS was calculated;the serum was collected to determine the contents of cardiotoxicity markers as well as apoptosis and oxidative stress indexes, and the peripheral blood was collected to determine the expression of apoptosis and oxidative stress molecules. Results: GAS level, serum ALDH2 and CAT contents as well as peripheral blood Keap1 and Bcl-2 expression intensity of chemotherapy group were lower than those of control group whereas serum Copeptin, CK-MB, cTnI, cMyBP-c, sTWEAK, sFas, MDA and 8-isoPGF2α contents as well as peripheral blood Nrf-2, gp91phox, p22 phox and Caspase-3 expression intensity were significantly higher than those of control group;the GAS level in chemotherapy group was negatively correlated with serum Copeptin, CK-MB, cTnI, cMyBP-c, sTWEAK, sFas, MDA and 8-isoPGF2α contents as well as peripheral blood Nrf-2, gp91phox, p22 phox and Caspase-3 expression intensity, and positively correlated with serum ALDH2 and CAT contents as well as peripheral blood Keap1 and Bcl-2 expression intensity. Conclusion: The changes of 3D-STI parameter GAS in patients with lung cancer chemotherapy can reflect the degree of cardiotoxicity induced by oxidative stress and apoptosis.

Evaluation of left ventricular systolic dyssynchrony by two-dimensional speckle tracking imaging and real-time three-dimensional echocardiography

Background Two-dimensional speckle tracking imaging （2D-STI） and real-time three-dimensional echocardiography （RT-3DE） have more advantages in evaluating left ventricular （LV） systolic dyssynchrony than traditional echocardiographic techniques. The study aimed to evaluate LV dyssynchrony parameters by both 2D-STI and RT-3DE, and the correlation between these two techniques. Methods A total of 43 chronic heart failure （CHF） patients and 27 healthy volunteers were enrolled. There were 23 dyssynchrony parameters selected to evaluate left ventricular systolic synchronization, involving 15 from 2D-STI and 8 from RT-3DE. Results Few of the dyssynchrony parametersshowednegative correlations with LV ejection fraction （LVEF） in the CHF group. The difference between time to peak-systolic radial strain of the anteroseptal and posterior segments at the level of papillary muscles [AS-P（RS）] from 2D-STI showed positive correlations with parts of the parameters from RT-3DE （P 〈 0.05）. Conclusions LV systolic dysfunction does not correlate with dyssynchrony. Moreover, there is a weak association between 2D-STI and RT-3DE in assessment of left ventricular dyssynchrony.

实时三维超声联合二维斑点追踪技术评估肝硬化患者右心室功能的价值

目的 探讨实时三维超声检查(RT-3DE)联合二维斑点追踪(2D-STI)技术评估肝硬化患者右心室功能的应用价值。方法 选取91例临床确诊的肝硬化患者,根据Child-Pugh分级标准分为A组、B组、C组,另外选取30例健康体检者作为对照组,应用RT-3DE获得右心室射血分数(RVEF)、右心室舒张末期容积(RVEDV)、右心室收缩末期容积(RVESV)及右心室每搏输出量(RVSV),应用2D-STI获得右心室游离壁应变(RVFWSL)、右心室整体纵向应变(RV4CSL)。结果 与对照组、A组及B组相比,C组RVEDV、RVESV升高,RVEF及RVFWSL、RV4CSL减低,差异有统计学意义(P<0.05);与对照组、A组相比,B组RVEDV、RVESV升高,RVEF及RVFWSL减低,差异有统计学意义(P<0.05);与对照组相比,A组RVESV升高,RVEF及RVFWSL、RV4CSL减低,差异有统计学意义(P<0.05)。相关性分析显示RVEDV、RVESV与肝功能分级呈正相关,RVEF、RVFWSL及RV4CSL与肝功能分级呈负相关。结论 RT-3DE和2DSTI能够定量评估肝硬化患者右心室的功能改变,具有显著的临床意义。

实时三维斑点追踪成像评价乳腺癌蒽环类化疗对左心室功能的影响

目的探讨实时三维斑点追踪成像(RT3D-STI)评价应用蒽环类化疗药物的乳腺癌患者左心室功能的价值。资料与方法对59例应用6个周期蒽环类药物化疗的乳腺癌患者进行随访,于化疗前、化疗第2、4、6个周期后行常规超声心动图及RT3DSTI检查,观察常规二维参数及RT3D-STI参数:三维应变(3DS)、整体纵向应变(GLS)、整体径向应变(GRS)、整体圆周应变(GCS)、左心室扭转角度(LVtw)以及左心室射血分数(LVEF),计算心肌综合指数(MCI)。对比化疗前后不同周期常规参数、RT3D-STI参数,绘制RT3D-STI相关参数受试者工作特征曲线,并比较RT3D-STI各参数与药物累积剂量之间的相关性。结果①二维常规参数:与对照组及化疗前比较,化疗第6周期E/A、Em、Em/Am较低(P<0.05)。②三维参数:与对照组及化疗前比较,LVtw、MCI在化疗第2、4、6周期较低(P<0.05);3DS、GLS在化疗第4、6周期较低(P<0.05);LVEF在第6周期减低(P<0.05)。③LVtw、MCI的受试者工作特征曲线下面积分别为0.891、0.873,MCI敏感度为98.3%,LVtw特异度为75.7%。④LVtw、MCI、3DS与药物剂量呈显著负相关(r=-0.803、-0.776、-0.768,P<0.01)。结论RT3D-STI可早期监测蒽环类化疗药物对乳腺癌患者左心室功能的影响。

三维斑点追踪技术评价高血压患者左室旋转及扭转

目的:应用三维斑点追踪成像技术(3D-STE)分析不同构型原发性高血压(EH)患者左心室旋转及扭转特征。方法:将106例EH患者分为4组:左室正常构型(LVN)组(n=30)、向心性重构(CCR)组(n=31)、向心性肥厚(CCH)组(n=29)及离心性肥厚(ECH)组(n=16);选取健康者(n=30)作为正常对照组;测量各组参数:左心射血分数(LVEF)、左室心底水平旋转角度峰值(Prot-B)、心尖水平旋转角度峰值(Prot-A)、整体旋转角度峰值(LVrot)和整体扭转角度峰值(LVtw),比较各组指标间的差异。结果:高血压各组左室心肌质量指数高于正常对照组,且呈递增趋势(P<0.05);与正常对照组、LVN组、ECH组比较,CCR组和CCH组左室后壁舒张末期厚度、室间隔舒张末期厚度、相对壁厚度增高(P<0.05)。正常对照组、LVN组、CCR组与CCH组间LVEF差异无统计学意义(P>0.05),而ECH组的LVEF显著低于其他各组(P<0.05)。与正常对照组比较,LVN组、CCR组、CCH组的Prot-A,Prot-B,LVrot及LVtw均明显增强(P<0.05),3组间呈递增趋势(P<0.05);ECH组的Prot-A,Prot-B,LVrot及LVtw显著低于其他各组(P<0.05)。结论:3D-STE通过评价不同构型EH患者左室旋转及扭转特征,可反映左室收缩功能的改变。

实时三维斑点追踪技术评价早期冠心病左心室收缩功能

目的:应用超声实时三维斑点追踪技术(RT3D-STI)定量分析冠心病患者早期左心室节段收缩功能,探讨其在冠心病诊断中的应用价值。方法:搜集有胸闷、心绞痛病史,常规超声心动图未见室壁运动异常而经冠状动脉造影证实为冠心病的患者35例(冠心病组)及正常对照组21例,通过三维全容积图像获取左心室心肌收缩末期17节段"牛眼图",定量分析各节段收缩功能。结果:冠心病组缺血节段亚组与对照组、非缺血节段亚组比较,纵向应变(SLS)、圆击应变(SCS)、径向应变(SRS)、面积应变(SAS)差异均有统计学意义(P<0.05),而对照组与非缺血节段亚组间各参数比较差异均无统计学意义(P>0.05);应用ROC曲线分析表明SAS曲线下面积最大,且所有节段三维应变参数中以SAS>-26.5%检测缺血心肌节段的敏感度(83.3%)、特异度(80.3%)较好。结论:RT3D-STI可以定量评估冠心病早期左室节段收缩功能,SAS能很好地识别缺血心肌节段,在冠心病早期诊断中有较高的应用价值。

超声二维斑点追踪技术评价妊娠高血压综合征患者左心室扭转

目的探讨超声二维斑点追踪成像(STI)技术检测妊娠高血压综合征(PIH)患者左心室扭转的临床价值。方法收集34例PIH患者(PIH组)和31名正常初产妇(对照组),采集基底水平左心室短轴清晰二维图像,运用QLab软件进行脱机分析,获得两组内膜旋转峰值、外膜旋转峰值、平面旋转峰值及平面扭转峰值,并进行统计学比较。结果与对照组比较,PIH组内膜旋转峰值、外膜旋转峰值、平面扭转、平面旋转峰值均显著增高(P均<0.05)。结论超声二维STI技术可以评价PIH患者左心室旋转和扭转运动。

超声评价甲状腺功能减退症患者左心室功能研究进展

甲状腺功能减退可直接或间接引起心脏功能的改变,且在亚临床阶段左心室局部心肌功能即已发生改变,随着超声技术的发展,临床上应用其评价甲减患者左心室功能改变越来越受到重视。本文就超声技术评价甲减患者左心室功能的研究进展进行综述。

不同超声背向散射信号提取技术的临床应用

超声成像是目前临床上应用最广泛的医学成像方式之一。随着超声背向散射信号提取技术的发展,背向散射信号被越来越广泛地应用于临床。随着超声背向散射信号提取技术的发展,超声图像将实现质的飞跃,超声成像的临床应用也将开拓出更加广阔的空间。本文对几种不同超声背向散射信号提取技术的原理、临床应用及影响因素进行综述。

三维斑点追踪技术在心脏疾病中的应用进展

三维斑点追踪成像技术(3D-STI)是新近发展起来的一项超声心动图新技术,可以三维立体追踪心肌运动,能更准确、更真实地评价心脏功能。本文就目前3D-STI技术在临床中的应用进展做一综述。

三维斑点追踪成像技术预测心脏再同步化治疗短期疗效的研究

目的探讨三维斑点追踪成像(3DT)技术评价左心室收缩同步性,预测心脏再同步化治疗(CRT)短期疗效的临床价值。方法接受CRT治疗的心力衰竭患者18例,于CRT术前及术后1个月用常规超声测量左心室舒张末期容积(LVEDV)、收缩末期容积(LVESV)及射血分数(LVEF)。采用3DT技术分析左心室16节段面积应变达峰时间最大差(A-Max-Ts)和标准差(A-Ts-SD)。将术后LVESV缩小≥15%定义为CRT短期治疗有效。18例患者中,CRT短期治疗有效组11例,CRT短期治疗无效组7例。结果与术前比较,有效组术后LVEDV和LVESV减小,LVEF增高,A-Max-Ts和A-Ts-SD缩短(P﹤0.05);无效组各参数比较差异均无统计学意义。有效组术前A-Max-Ts和A-Ts-SD大于无效组(P﹤0.05),其余参数比较差异均无统计学意义。有效组术后LVEDV和LVESV较无效组减小,LVEF增高,A-Max-Ts和A-Ts-SD缩短(P﹤0.05)。A-Ts-SD是预测LVESV≥15%的独立因素,A-Ts-SD为48.2 ms时预测CRT短期疗效的敏感性和特异性分别为100%和83.3%。结论 CRT短期即可改善左心室收缩同步性。3DT技术能准确评价左心室收缩同步性,预测CRT短期疗效。

二维斑点追踪技术评价不同冠脉病变支数对冠心病患者左室解旋运动的影响

目的探讨二维斑点追踪(2DSTI)技术评价不同冠脉病变支数对冠心病患者左室解旋运动的影响,为准确评估冠心病患者左室舒张功能提供依据。方法 75例疑为冠心病的患者根据冠脉造影结果分为冠心病组45例(其中单支病变组27例和多支病变组18例)和对照组30例。应用2DSTI技术测量左室峰值扭转角度(Ptw)、峰值扭转角速度(PTV)、收缩末期扭转角度(AVCtw)、等容舒张末期扭转角度(MVOtw)、等容舒张期左室解旋率(Untw-R)、解旋速度峰值(PUV)、解旋角速度达峰时间(T-PUV)及解旋减半时间(UHT)。结果与对照组比较,冠心病组患者Ptw、PTV及PUV差异无统计学意义;冠心病组Untw-R低于对照组(P﹤0.001),T-PUV和UHT高于对照组(P﹤0.001)。多支病变组患者Untw-R和PUV明显低于单支病变组,T-PUV和UHT较对照组明显延长,差异有统计学意义(P﹤0.05)。结论冠心病患者左室解旋运动出现明显减低与延迟,多支冠脉狭窄患者左室解旋运动减低与延迟较单支冠脉狭窄患者更为明显。

超声斑点追踪成像评价自发性高血压大鼠左室局部收缩功能的研究

目的应用超声斑点追踪成像(STI)技术观察自发性高血压大鼠(SHR)左室节段心肌径向应变、圆周应变及应变率的特点。方法健康Wistar大鼠10只作为对照组,SHR组10只,分别测量两组大鼠左室射血分数和短轴缩短率,以及左室短轴乳头肌平面径向、圆周方向的应变及应变率。然后处死大鼠,HE及Masson三色法染色,观察心肌纤维化的变化。结果两组大鼠左室射血分数和短轴缩短率比较差异无统计学意义。两组径向应变和径向应变率曲线分布一致,圆周应变和圆周应变率曲线分布不一致。与对照组比较,SHR组6个节段径向应变和径向应变率均减小(P<0.05),前间隔、前壁、侧壁及后间隔的圆周应变率均减小(P<0.05);6个节段圆周应变组间比较差异无统计学意义(P>0.05)。SHR早期心肌病理改变以血管周围纤维化为主,伴有间质纤维化的改变。结论 SHR左室局部心肌径向、圆周方向的应变及应变率较Wistar大鼠普遍减低,两组大鼠径向及圆周应变的分布与总体纤维化程度的综合表现有关。

斑点追踪成像评价原发性高血压病人左心室扭转及解旋功能

目的应用斑点追踪成像检测原发性高血压病人左心室扭转及解旋运动的变化,探讨其临床意义。方法选取原发性高血压病人61例,其中室间隔肥厚组28例,非室间隔肥厚组33例,另选健康志愿者30例为正常对照组。应用斑点追踪成像计算左心室峰值扭转角度(Ptw)、收缩期末扭转角度(AVCtw)、等容舒张期末扭转角度(MVOtw)和解旋率(UntwR)。结果与正常对照组相比,Ptw、AVCtw、MVOtw在室间隔肥厚组及非室间隔肥厚组均增大(F=14.86～16.70,q=5.69～32.05,P<0.05);与正常对照组及非室间隔肥厚组相比,室间隔肥厚组的UntwR减小(F=18.55,q=6.53、18.90,P<0.05)。结论原发性高血压病人左心室扭转运动增大,解扭转运动在高血压室间隔肥厚病人减低,斑点追踪成像为高血压病人心肌运动的评价提供了一个新途径。

三维斑点追踪技术联合颈动脉血管超声预测冠状动脉狭窄程度的价值

目的探讨三维斑点追踪技术联合颈动脉血管超声预测冠状动脉粥样硬化性心脏病(以下简称冠心病)患者冠状动脉狭窄程度的价值。方法 188例冠心病患者根据冠状动脉狭窄程度不同分为4组:重度组30例、中度组33例、轻度组31例、对照组(无冠状动脉狭窄)94例,应用颈动脉血管超声测量各组脉搏波传导速度(PWVβ)、膨大指数(AI)、动脉顺应性(AC)、僵硬度系数(β)、弹性模量(Eρ),三维斑点追踪技术测量左室整体径向收缩期峰值应变(GRS)、左室整体纵向收缩期峰值应变(GLS)、左室整体面积收缩期峰值应变(GAS)、左室整体圆周收缩期峰值应变(GCS),比较各组上述参数的差异。分析冠状动脉狭窄程度与AC、Eρ、AI、β、PWVβ、GAS、GCS、GRS、GLS的相关性;绘制受试者工作特征(ROC)曲线评估各参数单独及联合应用对冠状动脉狭窄程度的预测价值。结果各组左室GAS、GCS、GRS、GLS比较差异均有统计学意义(均P<0.001)。重度组GAS、GCS、GRS、GLS均低于中度组、轻度组、对照组(均P<0.05);中度组GAS、GCS、GRS、GLS均低于轻度组、对照组(均P<0.05)。各组Eρ、AI、β、PWVβ比较差异均有统计学意义(均P<0.001)。重度组Eρ、AI、β、PWVβ均高于中度组、轻度组、对照组,AC低于中度组、轻度组、对照组(均P<0.05);中度组Eρ、AI、β、PWVβ均高于轻度和对照组,AC低于轻度组和对照组(均P<0.05)。相关性分析显示,冠状动脉狭窄程度与Eρ、AI、β、PWVβ均呈正相关,与AC、GAS、GCS、GRS、GLS均呈负相关(均P<0.05)。ROC曲线分析显示,Eρ、AI、β、PWVβ、AC、GAS、GCS、GRS、GLS及其联合预测冠状动脉狭窄的曲线下面积分别为0.789、0.548、0.699、0.646、0.886、0.759、0.765、0.730、0.736、0.985;联合应用的曲线下面积高于各参数单独应用(均P<0.05)。结论三维斑点追踪技术联合颈动脉血管超声能准确预测冠心病患者冠状动脉狭窄程度,具有较好的临床应用价值。

实时三维超声联合二维斑点追踪成像评价原发性高血压患者左心房功能

目的采用实时三维超声(RT-3DE)及二维斑点追踪成像(2D-STI)评估原发性高血压患者左心房形态和功能。方法收集70例原发性高血压患者,根据左心房内径指数将其分为左心房无扩大(NLAE)组(n=35)和左心房扩大(LAE)组(n=35),并收集35名健康志愿者为对照组。应用RT-3DE检测最大、最小和收缩前左心房容积(LAVmax、LAVmin、LAVpre),计算左心房每搏输出量(LASV)、总射血分数(LAEF)、主动射血分数(LAaEF)和被动排空分数(LApEF)。采用2D-STI计算左心房壁的收缩期、舒张早期和晚期平均峰值应变率(mSRs、mSRe、mSRa)。比较3组间上述参数的差异,分析2D-STI与RT-3DE测量参数的相关性。结果与对照组比较,NLAE组LAaEF、mSRa增高,LApEF、mSRs、mSRe降低(P均<0.05);与NLAE组比较,LAE组LAVmax、LAVpre、LAVmin、LASV、LAaEF、mSRa增高,LAEF、LApEF、mSRs、mSRe降低(P均<0.05)。NLAE组和LAE组中,mSRs与LAEF(r=0.70、0.77)、mSRe与LApEF(r=0.80、0.82)、mSRa与LAaEF(r=0.87、0.89)呈明显正相关(P均<0.01)。结论原发性高血压患者左心房在重构前即已发生功能改变;RT-3DE和2D-STI技术可用于评价原发性高血压患者左心房结构和功能。