Pancreatic ductal adenocarcinoma is speculated to become the second leading cause of cancer-related mortality by 2030,a high mortality rate considering the number of cases.Surgery and chemotherapy are the main treatme...Pancreatic ductal adenocarcinoma is speculated to become the second leading cause of cancer-related mortality by 2030,a high mortality rate considering the number of cases.Surgery and chemotherapy are the main treatment options,but they are burdensome for patients.A clear histological diagnosis is needed to determine a treatment plan,and endoscopic ultrasound(EUS)-guided tissue acquisition(TA)is a suitable technique that does not worsen the cancer-specific prognosis even for lesions at risk of needle tract seeding.With the development of personalized medicine and precision treatment,there has been an increasing demand to increase cell counts and collect specimens while preserving tissue structure,leading to the development of the fine-needle biopsy(FNB)needle.EUS-FNB is rapidly replacing EUS-guided fine-needle aspiration(FNA)as the procedure of choice for EUS-TA of pancreatic cancer.However,EUS-FNA is sometimes necessary where the FNB needle cannot penetrate small hard lesions,so it is important clinicians are familiar with both.Given these recent developments,we present an up-to-date review of the role of EUS-TA in pancreatic cancer.Particularly,technical aspects,such as needle caliber,negative pressure,and puncture methods,for obtaining an adequate specimen in EUS-TA are discussed.展开更多
目的分析上颌窦穿刺冲洗治疗儿童急慢性鼻窦炎的临床疗效。方法将320例儿童（7~12岁）急慢性鼻窦炎患者采用随机平行试验设计,分为实验组160例和对照组160例,两组均服用鼻窦炎口服液1次10 m l,每日3次,实验组在鼻腔黏膜麻醉下行上颌窦穿...目的分析上颌窦穿刺冲洗治疗儿童急慢性鼻窦炎的临床疗效。方法将320例儿童（7~12岁）急慢性鼻窦炎患者采用随机平行试验设计,分为实验组160例和对照组160例,两组均服用鼻窦炎口服液1次10 m l,每日3次,实验组在鼻腔黏膜麻醉下行上颌窦穿刺,用0.9%氯化钠溶液加甲硝唑注射液反复冲洗后,窦腔内注入地塞米松5mg,每周一次;鼻腔内滴1%呋喃西林麻黄素液,3次/d,15 d为一个疗程。对照组口服广谱抗生素＋鼻腔内滴1%呋喃西林麻黄素液,3次/d,15 d为一个疗程。治疗结束后每月复查1次,6个月后进行疗效评定。结果实验组的治愈率84.38%,总有效率98.75%,均显著高于对照组,两组间比较有显著性差异（P〈0.01）。结论上颌窦穿刺冲洗结合鼻窦炎口服液治疗儿童急、慢性鼻窦炎疗效可靠,穿刺前充分评估患儿病情,实施健康教育,加强心理护理是上颌窦穿刺治疗顺利进行的基础,也是上颌窦穿刺成功的重要保证。展开更多
文摘Pancreatic ductal adenocarcinoma is speculated to become the second leading cause of cancer-related mortality by 2030,a high mortality rate considering the number of cases.Surgery and chemotherapy are the main treatment options,but they are burdensome for patients.A clear histological diagnosis is needed to determine a treatment plan,and endoscopic ultrasound(EUS)-guided tissue acquisition(TA)is a suitable technique that does not worsen the cancer-specific prognosis even for lesions at risk of needle tract seeding.With the development of personalized medicine and precision treatment,there has been an increasing demand to increase cell counts and collect specimens while preserving tissue structure,leading to the development of the fine-needle biopsy(FNB)needle.EUS-FNB is rapidly replacing EUS-guided fine-needle aspiration(FNA)as the procedure of choice for EUS-TA of pancreatic cancer.However,EUS-FNA is sometimes necessary where the FNB needle cannot penetrate small hard lesions,so it is important clinicians are familiar with both.Given these recent developments,we present an up-to-date review of the role of EUS-TA in pancreatic cancer.Particularly,technical aspects,such as needle caliber,negative pressure,and puncture methods,for obtaining an adequate specimen in EUS-TA are discussed.
文摘目的分析上颌窦穿刺冲洗治疗儿童急慢性鼻窦炎的临床疗效。方法将320例儿童（7~12岁）急慢性鼻窦炎患者采用随机平行试验设计,分为实验组160例和对照组160例,两组均服用鼻窦炎口服液1次10 m l,每日3次,实验组在鼻腔黏膜麻醉下行上颌窦穿刺,用0.9%氯化钠溶液加甲硝唑注射液反复冲洗后,窦腔内注入地塞米松5mg,每周一次;鼻腔内滴1%呋喃西林麻黄素液,3次/d,15 d为一个疗程。对照组口服广谱抗生素＋鼻腔内滴1%呋喃西林麻黄素液,3次/d,15 d为一个疗程。治疗结束后每月复查1次,6个月后进行疗效评定。结果实验组的治愈率84.38%,总有效率98.75%,均显著高于对照组,两组间比较有显著性差异（P〈0.01）。结论上颌窦穿刺冲洗结合鼻窦炎口服液治疗儿童急、慢性鼻窦炎疗效可靠,穿刺前充分评估患儿病情,实施健康教育,加强心理护理是上颌窦穿刺治疗顺利进行的基础,也是上颌窦穿刺成功的重要保证。
