As a burgeoning research field, ultrasound-responsive materials have attracted intense interest in healthcare research. However, the basic mechanism of sonochemical effect in the quasi-solid state is far from being we...As a burgeoning research field, ultrasound-responsive materials have attracted intense interest in healthcare research. However, the basic mechanism of sonochemical effect in the quasi-solid state is far from being well understood than those in the solution. Herein, we showcase mechanochemical transformations of europium(Ⅲ) complexes in a supramolecular hydrogel matrix. With the combination of labile terpyridine-europium complexes(TPY-Eu^(3+)) as mechanochromic moieties and an ultrasound-responsive fluorogen(URF) as a molecular tweezer, the hydrogel produces a notable fluorescence change in response to ultrasound. The mechanochemical transformation was elucidated by molecular dynamics(MD) simulations, and fully probed and evidenced by electrochemical experiments, X-ray photoelectron spectroscopy(XPS), and attenuated total reflectance-Fourier transform infrared(ATR-FTIR) spectroscopy.展开更多
The scientific interest in capsules with the shell composed of fused microparticles is still growing due to a large number of practical applications.Well-designed capsules should ensure the safe cargo delivery and fac...The scientific interest in capsules with the shell composed of fused microparticles is still growing due to a large number of practical applications.Well-designed capsules should ensure the safe cargo delivery and facilitate its controlled release on demand.The biocompatibility and biodegradability are additional essential features of structures intended for biomedical use.This paper presents two kinds of ultrasound sensitive capsules:the first type with the homogeneous shell made of a monolayer of fine turmeric granules,and the other with Janus shell composed of two different materials i.e.turmeric granules and synthetic polystyrene particles.We demonstrated that plane ultrasonic waves with low intensity and high frequency and also focused ultrasound can act as a trigger for smooth liberation of a liquid cargo,in our case,the dispersion of probiotic preparation.The ultrasound-induced puncture of the shell was followed by unidirectional and controlled release of encapsulated payload.In case of Janus structures,in addition to sonication time and ultrasound frequency,distinct mechanical properties of two shell regions also influenced the course of content liberation process.We expect that the use of natural material such as turmeric granules for the formation of the shells of the ultrasound-responsive capsules can further increase the range of their potential applications.展开更多
基金supported by the National Key R&D Program of China(No.2018YFC0114900)National Natural Science Foundation of China(No.52103246,U1967217)+9 种基金Zhejiang Provincial Natural Science Foundation of China(Nos.LD22E050008,LD22A020002)China Postdoctoral Science Foundation(No.2021TQ0341,2020M671828)Ningbo Natural Science Foundation(No.2021J203,202003N4361)Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2019297)Key Research Program of Frontier Science,Chinese Academy of Sciences(No.QYZDB-SSW-SLH036)the Sino-German Mobility Program(No.M-0424)K.C.Wong Education Foundation(No.GJTD-2019–13)National Independent Innovation Demonstration Zone Shanghai Zhangjiang Major Projects(No.ZJZX2020014)the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(No.SN-ZJU-SIAS-003)Director Foundation of Ningbo Institute of Materials Technology and Engineering。
文摘As a burgeoning research field, ultrasound-responsive materials have attracted intense interest in healthcare research. However, the basic mechanism of sonochemical effect in the quasi-solid state is far from being well understood than those in the solution. Herein, we showcase mechanochemical transformations of europium(Ⅲ) complexes in a supramolecular hydrogel matrix. With the combination of labile terpyridine-europium complexes(TPY-Eu^(3+)) as mechanochromic moieties and an ultrasound-responsive fluorogen(URF) as a molecular tweezer, the hydrogel produces a notable fluorescence change in response to ultrasound. The mechanochemical transformation was elucidated by molecular dynamics(MD) simulations, and fully probed and evidenced by electrochemical experiments, X-ray photoelectron spectroscopy(XPS), and attenuated total reflectance-Fourier transform infrared(ATR-FTIR) spectroscopy.
基金This work was supported by the Polish National Science Centre(grant number 2015/19/B/ST3/03055,principal investigator:Z.J.Rozynek).
文摘The scientific interest in capsules with the shell composed of fused microparticles is still growing due to a large number of practical applications.Well-designed capsules should ensure the safe cargo delivery and facilitate its controlled release on demand.The biocompatibility and biodegradability are additional essential features of structures intended for biomedical use.This paper presents two kinds of ultrasound sensitive capsules:the first type with the homogeneous shell made of a monolayer of fine turmeric granules,and the other with Janus shell composed of two different materials i.e.turmeric granules and synthetic polystyrene particles.We demonstrated that plane ultrasonic waves with low intensity and high frequency and also focused ultrasound can act as a trigger for smooth liberation of a liquid cargo,in our case,the dispersion of probiotic preparation.The ultrasound-induced puncture of the shell was followed by unidirectional and controlled release of encapsulated payload.In case of Janus structures,in addition to sonication time and ultrasound frequency,distinct mechanical properties of two shell regions also influenced the course of content liberation process.We expect that the use of natural material such as turmeric granules for the formation of the shells of the ultrasound-responsive capsules can further increase the range of their potential applications.
